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GISAYEQAVLDRLDETLMVDLTVALVRSAGENPPGEEAATVRTLADAAAALDLEVDETQVEPGRDNISVT LNGGSGPGLLMLGHTDVVPAGTGWTTDPFGGVLRDGRIYGRGTSDMKGGLAAALAAMAALRGAGLSGPVE LAALVDEEENGKGIRAYVDAVHRNYLGCITAEPTDLQTIIGARGASYVRVEIHGKACHAGNPDDGANAIY GAAAAIAEIERLHRELARQPHPLLGAATWSVGQVHGGTAGAIVPDECVLVADRRLLPGESGADVVDGLRT RLTGLADRGLSVDVSMPMEMPPFQTPADADLVLTAESALADAGGPGLPVGGWTAACDGGFIARDLGVPVV VLGPGSVTEQAHRADESVAVEQLLVAARAYVLTALRLLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2491 | - | - | 100% (390) | acetylornithine deacetylase |
| M. smegmatis MC2 155 | MSMEG_3397 | - | 7e-25 | 27.32% (399) | acetylornithine deacetylase |
| M. smegmatis MC2 155 | MSMEG_2100 | - | 2e-17 | 26.94% (438) | peptidase family protein M20/M25/M40 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2165c | - | 2e-13 | 24.66% (442) | hypothetical protein Mb2165c |
| M. gilvum PYR-GCK | Mflv_2180 | - | 2e-15 | 27.60% (366) | dipeptidase |
| M. tuberculosis H37Rv | Rv2141c | - | 2e-13 | 24.66% (442) | hypothetical protein Rv2141c |
| M. leprae Br4923 | MLBr_01288 | - | 7e-15 | 26.05% (380) | hypothetical protein MLBr_01288 |
| M. abscessus ATCC 19977 | MAB_2102 | - | 2e-13 | 25.23% (436) | hypothetical protein MAB_2102 |
| M. marinum M | MMAR_4235 | dapE | 2e-14 | 26.39% (379) | succinyl-diaminopimelate desuccinylase DapE |
| M. avium 104 | MAV_1349 | dapE | 1e-18 | 28.88% (367) | dipeptidase |
| M. thermoresistible (build 8) | TH_1840 | dapE | 2e-14 | 28.25% (361) | PROBABLE SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE DAPE |
| M. ulcerans Agy99 | MUL_0954 | dapE | 2e-14 | 26.39% (379) | succinyl-diaminopimelate desuccinylase |
| M. vanbaalenii PYR-1 | Mvan_4515 | - | 6e-15 | 26.46% (359) | dipeptidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2180|M.gilvum_PYR-GCK ---------------------------------MLDLHADPIALTAALVD
Mvan_4515|M.vanbaalenii_PYR-1 ---------------------------------MLDLHGDPIALTAALVD
TH_1840|M.thermoresistible__bu --------------------------------VALDLHGDPIALTAALVD
MMAR_4235|M.marinum_M ---------------------------------MLDLRGDPIDLTAALID
MUL_0954|M.ulcerans_Agy99 ---------------------------------MLDLRGDPIDLTAALID
MAV_1349|M.avium_104 ---------------------------------MLDLTGDPVALTAALVD
Mb2165c|M.bovis_AF2122/97 -------------------MTDETGASSDHSDDVAQVVSRLIRFDTTNSG
Rv2141c|M.tuberculosis_H37Rv -------------------MTDETGASSDHSDDVAQVVSRLIRFDTTNSG
MLBr_01288|M.leprae_Br4923 MQKTKVLRSLVVAVVGKVTVTVETDVLVNPSDDVVEVVSRLIRFDTTNTG
MAB_2102|M.abscessus_ATCC_1997 ----------------------MTSVNPAPEDEVVDLVSTLIRFDTSNTG
MSMEG_2491|M.smegmatis_MC2_155 -----------------MGISAYEQAVLDRLDETLMVDLTVALVRSAGEN
: . :: .
Mflv_2180|M.gilvum_PYR-GCK IPSESRHEARIADAIEAALREQTTGFEVVRNGD----AVLARTHFGRPSR
Mvan_4515|M.vanbaalenii_PYR-1 IPSESRHEKRIADEIETALREQTAGFEIVRNGD----AVLARTDFGRPSR
TH_1840|M.thermoresistible__bu IPSESRHEQRIADEIETALREQTRGFEVIRNGN----AVLARTNHGRPTR
MMAR_4235|M.marinum_M IPSESRDEARIADEVEAALRAQTSGFEIIRNGN----AVLARTRLNRPSR
MUL_0954|M.ulcerans_Agy99 IPSESRDEARIADEVEAALRAQTSGFEIIRNGN----AVLARTRLNRPSR
MAV_1349|M.avium_104 IPSESRDEARLADEVEAALRSQTSGFEIVRNGN----AVLARTDRGRPSR
Mb2165c|M.bovis_AF2122/97 EPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSSR
Rv2141c|M.tuberculosis_H37Rv EPGTTKGEAECARWVAEQLAEVGYQPEYVESGAPGRGNVFARLAGADSSR
MLBr_01288|M.leprae_Br4923 DPETTRGEAECAQWVASQLAEVGYQPEYLESGAPGRGNVFARLAGEDSSR
MAB_2102|M.abscessus_ATCC_1997 ELETTKGEAECARWIQQQLEEVGYTCEYVEAGAPGRGNLFARLPGASSDR
MSMEG_2491|M.smegmatis_MC2_155 PPGEEAATVRTLADAAAALDLEVDETQVEPGRD----NISVTLNGGSGPG
. * : : .
Mflv_2180|M.gilvum_PYR-GCK --VLLAGHTDTVPAADN------LPSRLADGILHGCGTSDMKSGDAVFLH
Mvan_4515|M.vanbaalenii_PYR-1 --VLLAGHIDTVPAADN------LPSRLADGVLHGCGTSDMKAGDAVFLH
TH_1840|M.thermoresistible__bu --VLLAGHTDTVPAADN------LPSRRVGDLLYGCGTSDMKSGDAVFLH
MMAR_4235|M.marinum_M --VLLAGHLDTVPVADN------LPSRRADGQLHGCGAADMKSGDAVFLH
MUL_0954|M.ulcerans_Agy99 --VLLAGHLDTVPVADN------LPSRRADGQLHGCGAADMKSGDAVFLH
MAV_1349|M.avium_104 --VLLAGHLDTVPVAGN------LPSRREDGDLYGCGTADMKSGDAVFLH
Mb2165c|M.bovis_AF2122/97 GALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIV
Rv2141c|M.tuberculosis_H37Rv GALLIHGHLDVVPAEPAEWSVHPFSGAIEDGYVWGRGAVDMKDMVGMMIV
MLBr_01288|M.leprae_Br4923 GALLIHGHLDVVPAETAEWSVHPFSGAVEGGQVWGRGAIDMKDMVGMMIV
MAB_2102|M.abscessus_ATCC_1997 GALLIHGHLDVVPAEAPDWSVHPFSGAVNDGYVWGRGAVDMKDMVGMMIA
MSMEG_2491|M.smegmatis_MC2_155 --LLMLGHTDVVPAGTG-WTTDPFGGVLRDGRIYGRGTSDMKGGLAAALA
:*: ** *.**. : . .. : * *: *** . :
Mflv_2180|M.gilvum_PYR-GCK LAATVVDP---AHDITLVMYDCEEIEASANGLGRIERELPEWLAADVAIL
Mvan_4515|M.vanbaalenii_PYR-1 LAATVAEP---AHDITLVMYDCEEIEASANGLGRIERELPEWLAADVAIL
TH_1840|M.thermoresistible__bu LAATVTEP---AHDITLVMYDCEEIEAAANGLGRIERELPDWLRADVAIL
MMAR_4235|M.marinum_M LAATVAEP---VHDLTLVFYDCEEIEAAANGLGRIERELPEWLSADVAIL
MUL_0954|M.ulcerans_Agy99 LAATVAEP---VHDLTLVFYDCEEIEAAANGLGRIERELPEWLSADVAIL
MAV_1349|M.avium_104 LAATVADP---AHDLTLVMYDCEEIDAAANGLGRIQRELPDWLSADVAIL
Mb2165c|M.bovis_AF2122/97 VARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGITEAI
Rv2141c|M.tuberculosis_H37Rv VARHLRQAAIVPPRDLVFAFVADEEHGGKYGSHWLVDNRPDLFDGITEAI
MLBr_01288|M.leprae_Br4923 VARQLKQAGIAPPRDLVFAFVADEEHGGSYGSQWLVDNRPDLFDGVTEAI
MAB_2102|M.abscessus_ATCC_1997 IARYFKRSGIVPPRDLVWAFVSDEENGGKWGSQWLVDNRPDLFEGITEAI
MSMEG_2491|M.smegmatis_MC2_155 AMAALRGAG--LSGPVELAALVDEEENGKGIRAYVDAVHRNYLGCITAEP
. . :* . . : : : .
Mflv_2180|M.gilvum_PYR-GCK GEP----------SGG-----YIEAGCQGTLRVVVRATGTRAHSARSWLG
Mvan_4515|M.vanbaalenii_PYR-1 GEP----------SGG-----LIEAGCQGTLRVIVRATGTRAHSARSWLG
TH_1840|M.thermoresistible__bu GEP----------SGG-----FIEAGCQGTLRMVISTTGTRAHSARSWLG
MMAR_4235|M.marinum_M GEP----------TSG-----YIEAGCQGTLRVVISATGTRAHSARSWLG
MUL_0954|M.ulcerans_Agy99 GEP----------TSG-----YIEAGCQGTLRVVISATGTRAHSARSWLG
MAV_1349|M.avium_104 GEP----------TGG-----YIEAGCQGTLRVVVSATGTRAHSARSWLG
Mb2165c|M.bovis_AF2122/97 GEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGS-MVHD
Rv2141c|M.tuberculosis_H37Rv GEVGGFSLTVPRHDGGERRLYLIETAEKGIQWMRLTARGRAGHGS-MVHD
MLBr_01288|M.leprae_Br4923 GEVGGFSLTVPCRNGGERRLYLIETAEKGMQWMRLTARGRAGHGS-MVHN
MAB_2102|M.abscessus_ATCC_1997 GEVGGFSLTVPRRQGGERRLYLLETAEKGIAWMRLTAKARAGHGS-MVHE
MSMEG_2491|M.smegmatis_MC2_155 TDL------------------QTIIGARGASYVRVEIHGKACHAGNPDDG
: . :* : : . *..
Mflv_2180|M.gilvum_PYR-GCK DNAVHKLGDVLARLT-------------------------AYRARSVDID
Mvan_4515|M.vanbaalenii_PYR-1 DNAIHKLSDVLARLR-------------------------SYQARSVDID
TH_1840|M.thermoresistible__bu DNAIHKLAPVLDRLS-------------------------DYRARSVDID
MMAR_4235|M.marinum_M DNAIHKLSAVLDRLA-------------------------RYPARSVDID
MUL_0954|M.ulcerans_Agy99 DNAIHKLSAVLDRLA-------------------------RYPARSVDID
MAV_1349|M.avium_104 DNAIHKLGAVLQRLA-------------------------GYQARSVEID
Mb2165c|M.bovis_AF2122/97 QNAVTAVCEAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLA
Rv2141c|M.tuberculosis_H37Rv QNAVTAVCEAVARLGRHQFPLVCTDTVAQFLAVVGEETGLAFDLDSPDLA
MLBr_01288|M.leprae_Br4923 QNAVTAVAEAVARLGRHQFPLVTTDTVVQFLAAISEETGLEFDIGSPDLE
MAB_2102|M.abscessus_ATCC_1997 DNAVTAVAEAVAKLGRHRFPLVLTEAVTQFLGAVAEETGYDFDPDSPDLE
MSMEG_2491|M.smegmatis_MC2_155 ANAIYGAAAAIAEIERLHR--------------------ELARQPHPLLG
**: .: .: :
Mflv_2180|M.gilvum_PYR-GCK GCTYREG-------------LSAVRIDGGVAGNVIPDAASVTVNFRFAPD
Mvan_4515|M.vanbaalenii_PYR-1 GCVYREG-------------LSAVRIDGGVAGNVIPDAASVTVNFRFAPD
TH_1840|M.thermoresistible__bu GCVYREG-------------LSAVRIDGGVAGNVIPDAASVTVNFRFAPD
MMAR_4235|M.marinum_M GCTYREG-------------LSAVRVDGGVAGNVIPDAASVTVNYRFAPD
MUL_0954|M.ulcerans_Agy99 GCTYREG-------------LSAVRVDGGVAGNVIPDAASVTVNYRFAPD
MAV_1349|M.avium_104 GCTYREG-------------LSAVRIDGGVAGNVIPDAAAVTVNFRFAPD
Mb2165c|M.bovis_AF2122/97 GTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAEAVVDCRVLPG
Rv2141c|M.tuberculosis_H37Rv GTIDKLGPMARMLKAVLHDTANPTMLKAGYKANVVPATAEAVVDCRVLPG
MLBr_01288|M.leprae_Br4923 GAIEKLGPMARMLKAVLYDTANPTVLKAGYKVNVVPATAEAMVDCRILPG
MAB_2102|M.abscessus_ATCC_1997 GTVAKLGSIGKIVGATLRDTANPTMLKAGYKANVIPATAEAVIDCRVLPG
MSMEG_2491|M.smegmatis_MC2_155 AATWSVG-----------------QVHGGTAGAIVPDECVLVADRRLLPG
. * :..* ::* . : *. *.
Mflv_2180|M.gilvum_PYR-GCK RTIEQAHAHVLEVFD-----GLDVEIELT-------DSAAGALPGLSRPA
Mvan_4515|M.vanbaalenii_PYR-1 RSVEQAYAHVREVFD-----RLDVTIELT-------DAAAGALPGLTRPA
TH_1840|M.thermoresistible__bu RTVEQAERHVREVFD-----GLDVRMELT-------DAAGGALPGLQQPA
MMAR_4235|M.marinum_M RSVPAALQHVREVFD-----GLDVQIEQT-------DAAAGALPGLAQPA
MUL_0954|M.ulcerans_Agy99 RSVPAALQHVREVFD-----GLDVQIEQT-------DAAAGALPGLAQPA
MAV_1349|M.avium_104 RSPAEALQHVRDVLD-----GLDVRIEQT-------DAAAGALPGLSQPA
Mb2165c|M.bovis_AF2122/97 RR--AAFEAEVDALI-----GPDVTREWVSDLPSYETTFDGDLVAAMNAA
Rv2141c|M.tuberculosis_H37Rv RR--AAFEAEVDALI-----GPDVTREWVSDLPSYETTFDGDLVAAMNAA
MLBr_01288|M.leprae_Br4923 RQ--AAFEAAIDELI-----GPDVTREWIKDLPPYETAFDGDLVDAMNAA
MAB_2102|M.abscessus_ATCC_1997 RL--EAFEREVDEII-----GPDVEREWVQLLPAYETTFDGDLVDAMNAA
MSMEG_2491|M.smegmatis_MC2_155 ESGADVVDGLRTRLTGLADRGLSVDVSMPMEMPPFQTPADADLVLTAESA
. . : .* . . . * ..*
Mflv_2180|M.gilvum_PYR-GCK AAALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDP-------NLAH
Mvan_4515|M.vanbaalenii_PYR-1 AAALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDP-------NLAH
TH_1840|M.thermoresistible__bu AAQLVAAAGGQVRAKYGWTDVARFAALGVPAVNYGPGDP-------NLAH
MMAR_4235|M.marinum_M AKALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDP-------NLAH
MUL_0954|M.ulcerans_Agy99 AKALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDP-------NLAH
MAV_1349|M.avium_104 AKALVEAAGGRVRAKYGWTDVARFAALGIPALNFGPGDP-------NLAH
Mb2165c|M.bovis_AF2122/97 VLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDFTSLFH
Rv2141c|M.tuberculosis_H37Rv VLAVDPDGRTVPYMLSGGTDAKAFARLGIRCFGFSPLRLPPDLDFTSLFH
MLBr_01288|M.leprae_Br4923 VLAVDPDGRTVPYMASGGTDAKAFARLGIRCFGFTPLRLPPELDFTALFH
MAB_2102|M.abscessus_ATCC_1997 VLEFDPEARTVPYMLSGGTDAKAFARLGIRCFGFAPLKLPPELDFASLFH
MSMEG_2491|M.smegmatis_MC2_155 LADAGGPGLPVGGWTAACDGGFIARDLGVPVVVLGPGSVT------EQAH
. . . **: . * *
Mflv_2180|M.gilvum_PYR-GCK RVDEHVEVAQITAVTDMLRRYLIG---
Mvan_4515|M.vanbaalenii_PYR-1 RVDESVDVAQITAVTDMLRRYLIG---
TH_1840|M.thermoresistible__bu KSDEHVDVTAITAVTDVLRRYLSG---
MMAR_4235|M.marinum_M CRDERVPVATITTVADTLRRYLST---
MUL_0954|M.ulcerans_Agy99 CRDERVPVATITTVADTLRRYLST---
MAV_1349|M.avium_104 RRDERVAVAAITAAADLLRGYLSG---
Mb2165c|M.bovis_AF2122/97 GVDERVPIDGLRFGTEVLTHLLTHC--
Rv2141c|M.tuberculosis_H37Rv GVDERVPIDGLRFGTEVLTHLLTHC--
MLBr_01288|M.leprae_Br4923 GVDERVSIDALKFGIDVLAHFLTHC--
MAB_2102|M.abscessus_ATCC_1997 GVDERVPVDALTFGTKVLQHFLLNH--
MSMEG_2491|M.smegmatis_MC2_155 RADESVAVEQLLVAARAYVLTALRLLG
** * : :