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RVVGIRRTGSDRVEVAALTDTGDAVRVLAGLDEFWCDPTAHLAEEPAGAVLPRDEVTLVPPVLPGAKVIC IGLNYLKHVAEGSYGAEPLPEFPTLFARWPSTLTVDGAQIPVPTDEEGLDWEGEVVAWVGRELSCATADE ALDAVVGYSTFNDVTARRAQKITSQWILGKNADRSGPLGPLVPAHDVGDLRDGLRVRTRVNGTTVQDAST DEMVYTVGETLAHISRTLTLRPGDLLATGTPSGVGYARTPAWLLHPGDHVEVEVEKLGVLRNTIVASQRR PAHN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2478 | - | - | 100% (285) | fumarylacetoacetate hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2382 | - | 3e-28 | 32.93% (246) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2007 | - | 7e-26 | 33.63% (223) | putative HpcE protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 2e-31 | 34.17% (240) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 3e-32 | 35.60% (250) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 2e-31 | 34.17% (240) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 1e-31 | 35.39% (243) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4355 | - | 1e-31 | 35.37% (246) | fumarylacetoacetate (FAA) hydrolase family protein |
| M. marinum M | MMAR_1718 | - | 2e-34 | 37.04% (243) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 1e-33 | 34.57% (243) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. thermoresistible (build 8) | TH_2040 | - | 5e-33 | 35.04% (254) | POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD |
| M. ulcerans Agy99 | MUL_1956 | - | 3e-34 | 35.42% (240) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 9e-32 | 35.10% (245) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1718|M.marinum_M -----MRLGRIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPNFTGR
MUL_1956|M.ulcerans_Agy99 -------------------------------MTAREIAEDPFGTPNFTGR
MAV_3844|M.avium_104 -----MRLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTGR
Mb3017c|M.bovis_AF2122/97 -------------------------------MTAREIAEHPFGTPTFTGR
Rv2993c|M.tuberculosis_H37Rv -------------------------------MTAREIAEHPFGTPTFTGR
MLBr_01689|M.leprae_Br4923 -------------------------------MFARELAEYPFGELTFTGR
Mflv_4230|M.gilvum_PYR-GCK -----MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTGR
Mvan_2132|M.vanbaalenii_PYR-1 -----MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTGR
TH_2040|M.thermoresistible__bu -----MRLGRIASPDGVAFVSIEGPPDEP-TAVAREIAEHPFGTPEFTGR
MAB_4355|M.abscessus_ATCC_1997 MRLYTTDRGIARQGADGHFSLLDLPFDDIGALLR--YSDTDTAARALASR
MSMEG_2478|M.smegmatis_MC2_155 MRVVGIRRTGSDRVEVAALTDTGDAVRVLAGLDEFWCDPTAHLAEEPAGA
:.
MMAR_1718|M.marinum_M SWPLADVRLLAPILAS-KVVCVGKNYTDH-------IAEMGGQTGPTPAD
MUL_1956|M.ulcerans_Agy99 SWPLADVRLLAPILAS-KVVCVGKNYTGH-------IAEMGGQTGPTPAD
MAV_3844|M.avium_104 SWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGEATGPVPAD
Mb3017c|M.bovis_AF2122/97 SWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGGRP---PAD
Rv2993c|M.tuberculosis_H37Rv SWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGGRP---PAD
MLBr_01689|M.leprae_Br4923 SWPLADVRLLAPMLAS-KVVCIGKNYADH-------IVEMGGQTGLASAD
Mflv_4230|M.gilvum_PYR-GCK QWPLADVRLLAPILAS-KVVCMGKNYAAH-------IEEMGGGT---FED
Mvan_2132|M.vanbaalenii_PYR-1 QWPLADVRLLAPILAS-KVVCMGKNYAAH-------IEEMGGGT---FED
TH_2040|M.thermoresistible__bu QWSLADVRLLAPILAS-KVVCMGKNYAAH-------VDEMGGET---VPH
MAB_4355|M.abscessus_ATCC_1997 VVDSDHVSLAPVILRPGKILAVGLNYLSHAEEALEKFASIGRRDVQLPAE
MSMEG_2478|M.smegmatis_MC2_155 VLPRDEVTLVPPVLPGAKVICIGLNYLKH-------VAEGSYGAEPLPEF
.* * . :* *::.:* ** * . . .
MMAR_1718|M.marinum_M PVIFLKPNTAIVGPNVPIRLPAN-ASPVHFEGELAIVIGRPCKDVSAAQA
MUL_1956|M.ulcerans_Agy99 PVIFLKSNTAIVGPNVPIRLPAN-ASPVHFEGELAIVIGRPCKDVSAAQA
MAV_3844|M.avium_104 PVIFLKPNTAIIGPNVPIRLPAN-ASPVHFEGELAVVIGRPCKDVSAAQA
Mb3017c|M.bovis_AF2122/97 PVIFLKPNTAIIGPNTPIRLPAN-ASPVHFEGELAIVIGRACKDVPAAQA
Rv2993c|M.tuberculosis_H37Rv PVIFLKPNTAIIGPNTPIRLPAN-ASPVHFEGELAIVIGRACKDVPAAQA
MLBr_01689|M.leprae_Br4923 PVIFLKPNTAIIGPNVPIRLPAN-ASPVHFEGELALVVGRSCKDVPAVQA
Mflv_4230|M.gilvum_PYR-GCK PIIFLKPNTAIIGPYTPIQLPAD-ADPVHFEGELAAVIGRPCKDVPASRA
Mvan_2132|M.vanbaalenii_PYR-1 PIIFLKPNTAIIGPNTPIQLPAD-ANPVHFEGELAAVIGRPCKDVPASRA
TH_2040|M.thermoresistible__bu PVIFIKPNTSIIGPNVPIQLPVD-ADPVHHEGELAVVIGRPCKDVPAARA
MAB_4355|M.abscessus_ATCC_1997 PNIQIVAGSAVQADGRPLMLPVATPHHVDYEGELAVVIGRAGFAIRTDQA
MSMEG_2478|M.smegmatis_MC2_155 PTLFARWPSTLTVDGAQIPVPTD-EEGLDWEGEVVAWVGRELSCATADEA
* : ::: : :*. :. ***:. :** : .*
MMAR_1718|M.marinum_M VDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPWIVTD
MUL_1956|M.ulcerans_Agy99 VDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPWIVTD
MAV_3844|M.avium_104 AENILGYTIGNDVSARDQQR------SDGQWTRAKGHDTFCPVGPWIVTD
Mb3017c|M.bovis_AF2122/97 VDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPWIVTD
Rv2993c|M.tuberculosis_H37Rv VDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPWIVTD
MLBr_01689|M.leprae_Br4923 VDCILGYTIGNDMSARDQQR------ADGQWTRAKGHDTFCPVGPWIVTD
Mflv_4230|M.gilvum_PYR-GCK AENILGYTIANDVSARDQQK------KDGQWMRAKGHDTFCPVGPWIVTD
Mvan_2132|M.vanbaalenii_PYR-1 AENILGYTIANDVSARDQQQ------KDGQWMRAKGHDTFCPVGPWIVTD
TH_2040|M.thermoresistible__bu ADVILGYTVANDVTARNQQR------ADGQWTRAKGHDTFCPVGPWIVTD
MAB_4355|M.abscessus_ATCC_1997 WGHVAGLSIINDVSARDIQQRAYTGDPAASIGIAKSFDTFKPLGPCLVTA
MSMEG_2478|M.smegmatis_MC2_155 LDAVVGYSTFNDVTARRAQK------ITSQWILGKNADRSGPLGPLVPAH
: * : **::** *: .. .*. * *:** : :
MMAR_1718|M.marinum_M V---DPADLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGDL
MUL_1956|M.ulcerans_Agy99 V---DPAGLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGDL
MAV_3844|M.avium_104 LNPLDPGDLELRTEVNGEVKQRSRTSLLIHDIGSIVEWISAVMTLLPGDL
Mb3017c|M.bovis_AF2122/97 LAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGDL
Rv2993c|M.tuberculosis_H37Rv LAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGDL
MLBr_01689|M.leprae_Br4923 LGPLDPADLELRTAVNGEVKQHSRTSLMIHGIGAIMEWISAVMTLLPGDL
Mflv_4230|M.gilvum_PYR-GCK I---DPSDLEIRTEVNGELKQHSRTSLMIHDIGAIIEWISSVMTLLPGDL
Mvan_2132|M.vanbaalenii_PYR-1 L---DPSDLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWISAVMTLLPGDL
TH_2040|M.thermoresistible__bu V---DPTDLELRTEVNGEVRQRSRTSLMIHDIGAIIEWVSRVMTLLPGDL
MAB_4355|M.abscessus_ATCC_1997 DEFTEKVDLRLQTRVNGDLRQDDRTGNLIHSIPELIAYISRYHTLEPGDV
MSMEG_2478|M.smegmatis_MC2_155 DVGDLRDGLRVRTRVNGTTVQDASTDEMVYTVGETLAHISRTLTLRPGDL
.*.::* *** * *. ::: : : :* ** ***:
MMAR_1718|M.marinum_M ILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKS-----
MUL_1956|M.ulcerans_Agy99 ILTGTPAGVGPIED-------GDTVSITIEGIDTLTNPVVRKGKS-----
MAV_3844|M.avium_104 ILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKS-----
Mb3017c|M.bovis_AF2122/97 ILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKP-----
Rv2993c|M.tuberculosis_H37Rv ILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKP-----
MLBr_01689|M.leprae_Br4923 ILTGTPAGVGPVED-------GDIVSITVEGIGTLTNPVVRKGKS-----
Mflv_4230|M.gilvum_PYR-GCK ILTGTPEGVGPLEH-------GDTVSITVEGIGTLSNPVVRKGKS-----
Mvan_2132|M.vanbaalenii_PYR-1 ILTGTPEGVGPLEH-------GDSVSITVEGIGTLTNPVVRKGRS-----
TH_2040|M.thermoresistible__bu ILTGTPEGVGPIEH-------GDTVAVTIENIGTLTNPVVRKGKK-----
MAB_4355|M.abscessus_ATCC_1997 IATGSPRGAGQFTDRYLRP--GDVVEISIEHLGTLTNSVQARQSTGTGQS
MSMEG_2478|M.smegmatis_MC2_155 LATGTPSGVGYARTPAWLLHPGDHVEVEVEKLGVLRNTIVASQRRPAHN-
: **:* *.* ** * : :* :..* *.:
MMAR_1718|M.marinum_M ---
MUL_1956|M.ulcerans_Agy99 ---
MAV_3844|M.avium_104 ---
Mb3017c|M.bovis_AF2122/97 ---
Rv2993c|M.tuberculosis_H37Rv ---
MLBr_01689|M.leprae_Br4923 ---
Mflv_4230|M.gilvum_PYR-GCK ---
Mvan_2132|M.vanbaalenii_PYR-1 ---
TH_2040|M.thermoresistible__bu ---
MAB_4355|M.abscessus_ATCC_1997 PLR
MSMEG_2478|M.smegmatis_MC2_155 ---