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M. thermoresistible (build 8) TH_2040 ()

annotation: POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE)
coordinates: 4006568 - 4007353
length: 262

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2040-100% (262)POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE)
M. thermoresistible (build 8)TH_3311-8e-2533.18% (211) PUTATIVE putative HpcE protein
M. thermoresistible (build 8)TH_4414-2e-2129.09% (220) PUTATIVE fumarylacetoacetate (FAA) hydrolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3017c-1e-11078.81% (236) 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
M. gilvum PYR-GCKMflv_4230-1e-13183.14% (261) 5-carboxymethyl-2-hydroxymuconate Delta-isomerase
M. tuberculosis H37RvRv2993c-1e-11078.81% (236) 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
M. leprae Br4923MLBr_01689-1e-10675.73% (239) putative hydrolase
M. abscessus ATCC 19977MAB_3299c-1e-12481.61% (261) hypothetical protein MAB_3299c
M. marinum MMMAR_1718-1e-12379.55% (264) 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
M. avium 104MAV_3844-1e-12280.15% (267) 5-carboxymethyl-2-hydroxymuconate delta-isomerase
M. smegmatis MC2 155MSMEG_2382-1e-12680.84% (261) 5-carboxymethyl-2-hydroxymuconate delta-isomerase
M. ulcerans Agy99MUL_1956-1e-10978.39% (236) 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase
M. vanbaalenii PYR-1Mvan_2132-1e-13083.14% (261) 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_1718|M.marinum_M               MRLGRIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPNFTGRSWPLA
MUL_1956|M.ulcerans_Agy99           --------------------------MTAREIAEDPFGTPNFTGRSWPLA
Mb3017c|M.bovis_AF2122/97           --------------------------MTAREIAEHPFGTPTFTGRSWPLA
Rv2993c|M.tuberculosis_H37Rv        --------------------------MTAREIAEHPFGTPTFTGRSWPLA
MLBr_01689|M.leprae_Br4923          --------------------------MFARELAEYPFGELTFTGRSWPLA
MAV_3844|M.avium_104                MRLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTGRSWPLA
Mflv_4230|M.gilvum_PYR-GCK          MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTGRQWPLA
Mvan_2132|M.vanbaalenii_PYR-1       MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTGRQWPLA
MAB_3299c|M.abscessus_ATCC_199      MRLGRIASPDGVAFVSIEGEDGREESAIAREIAEHPFGTPTFTGRQWPLA
MSMEG_2382|M.smegmatis_MC2_155      MRLGRIASPDGVAFVSIEG-DGPD--AVCKEIAEHPFGNPNFTGRSWPLA
TH_2040|M.thermoresistible__bu      MRLGRIASPDGVAFVSIEG-PPDEPTAVAREIAEHPFGTPEFTGRQWSLA
                                                                .:*:** ***   ****.*.**

MMAR_1718|M.marinum_M               DVRLLAPILASKVVCVGKNYTDHIAEMGGQTGPTPADPVIFLKPNTAIVG
MUL_1956|M.ulcerans_Agy99           DVRLLAPILASKVVCVGKNYTGHIAEMGGQTGPTPADPVIFLKSNTAIVG
Mb3017c|M.bovis_AF2122/97           DVRLLAPILASKVVCVGKNYADHIAEMGGRP---PADPVIFLKPNTAIIG
Rv2993c|M.tuberculosis_H37Rv        DVRLLAPILASKVVCVGKNYADHIAEMGGRP---PADPVIFLKPNTAIIG
MLBr_01689|M.leprae_Br4923          DVRLLAPMLASKVVCIGKNYADHIVEMGGQTGLASADPVIFLKPNTAIIG
MAV_3844|M.avium_104                DVRLLAPILASKVVCVGKNYADHIAEMGEATGPVPADPVIFLKPNTAIIG
Mflv_4230|M.gilvum_PYR-GCK          DVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFLKPNTAIIG
Mvan_2132|M.vanbaalenii_PYR-1       DVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FEDPIIFLKPNTAIIG
MAB_3299c|M.abscessus_ATCC_199      DVRLLAPILASKVVAMGKNYAAHAAEMGGDP---PESPVIFIKPNTSIIG
MSMEG_2382|M.smegmatis_MC2_155      DVRLLAPILASKVIAVGKNYAAHAEEMGGVA---PEDPVIFLKPNTAIIG
TH_2040|M.thermoresistible__bu      DVRLLAPILASKVVCMGKNYAAHVDEMGGET---VPHPVIFIKPNTSIIG
                                    *******:*****:.:****: *  ***  .      *:**:*.**:*:*

MMAR_1718|M.marinum_M               PNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNILGYTIGNDVS
MUL_1956|M.ulcerans_Agy99           PNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNILGYTIGNDVS
Mb3017c|M.bovis_AF2122/97           PNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNILGYTIGNDVS
Rv2993c|M.tuberculosis_H37Rv        PNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNILGYTIGNDVS
MLBr_01689|M.leprae_Br4923          PNVPIRLPANASPVHFEGELALVVGRSCKDVPAVQAVDCILGYTIGNDMS
MAV_3844|M.avium_104                PNVPIRLPANASPVHFEGELAVVIGRPCKDVSAAQAAENILGYTIGNDVS
Mflv_4230|M.gilvum_PYR-GCK          PYTPIQLPADADPVHFEGELAAVIGRPCKDVPASRAAENILGYTIANDVS
Mvan_2132|M.vanbaalenii_PYR-1       PNTPIQLPADANPVHFEGELAAVIGRPCKDVPASRAAENILGYTIANDVS
MAB_3299c|M.abscessus_ATCC_199      PGLPIQLPPSATEVHHEGELAIVIGRPCKDVPAARAAENILGYTIGNDVS
MSMEG_2382|M.smegmatis_MC2_155      PNVPIQLPADADPVHHEGELAIVIGRPCKDVPAARAAEFILGYTIGNDVS
TH_2040|M.thermoresistible__bu      PNVPIQLPVDADPVHHEGELAVVIGRPCKDVPAARAADVILGYTVANDVT
                                    *  **:** .*  **.***** *:**.****.* :*.: *****:.**::

MMAR_1718|M.marinum_M               ARDQQKSDGQWTRAKGHDTFCPVGPWIVTDV---DPADLELRTEVNGAVK
MUL_1956|M.ulcerans_Agy99           ARDQQKSDGQWTRAKGHDTFCPVGPWIVTDV---DPAGLELRTEVNGAVK
Mb3017c|M.bovis_AF2122/97           ARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLAPFDPADLELRTVVNGDVK
Rv2993c|M.tuberculosis_H37Rv        ARDQQQSDGQWTRAKGHDTFCPVGPWIVTDLAPFDPADLELRTVVNGDVK
MLBr_01689|M.leprae_Br4923          ARDQQRADGQWTRAKGHDTFCPVGPWIVTDLGPLDPADLELRTAVNGEVK
MAV_3844|M.avium_104                ARDQQRSDGQWTRAKGHDTFCPVGPWIVTDLNPLDPGDLELRTEVNGEVK
Mflv_4230|M.gilvum_PYR-GCK          ARDQQKKDGQWMRAKGHDTFCPVGPWIVTDI---DPSDLEIRTEVNGELK
Mvan_2132|M.vanbaalenii_PYR-1       ARDQQQKDGQWMRAKGHDTFCPVGPWIVTDL---DPSDLEIRTEVNGDVK
MAB_3299c|M.abscessus_ATCC_199      ARDHQRADGQWTRAKGHDTFCPLGPWIVTDL---DPADLEIRTEVNGQVR
MSMEG_2382|M.smegmatis_MC2_155      ARDQQRKDGQWMRAKGHDTFCPLGPWIVTDL---DPSDVELRTEVNGQVR
TH_2040|M.thermoresistible__bu      ARNQQRADGQWTRAKGHDTFCPVGPWIVTDV---DPTDLELRTEVNGEVR
                                    **::*: **** **********:*******:   ** .:*:** *** ::

MMAR_1718|M.marinum_M               QHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
MUL_1956|M.ulcerans_Agy99           QHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
Mb3017c|M.bovis_AF2122/97           QHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPAGVGPIEDGDTVSI
Rv2993c|M.tuberculosis_H37Rv        QHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPAGVGPIEDGDTVSI
MLBr_01689|M.leprae_Br4923          QHSRTSLMIHGIGAIMEWISAVMTLLPGDLILTGTPAGVGPVEDGDIVSI
MAV_3844|M.avium_104                QRSRTSLLIHDIGSIVEWISAVMTLLPGDLILTGTPAGVGPIEDGDTVSI
Mflv_4230|M.gilvum_PYR-GCK          QHSRTSLMIHDIGAIIEWISSVMTLLPGDLILTGTPEGVGPLEHGDTVSI
Mvan_2132|M.vanbaalenii_PYR-1       QRSRTSLMIHDIGAIIEWISAVMTLLPGDLILTGTPEGVGPLEHGDSVSI
MAB_3299c|M.abscessus_ATCC_199      QRSRTSLLLHDVGAIVEWVSAVMTLLPGDVILTGTPEGVGPIVDGDTVSV
MSMEG_2382|M.smegmatis_MC2_155      QRSRTSLLLHDIGRLVEWTSAVMTLLPGDVILTGTPEGVGPIEDGDTVSI
TH_2040|M.thermoresistible__bu      QRSRTSLMIHDIGAIIEWVSRVMTLLPGDLILTGTPEGVGPIEHGDTVAV
                                    *::****::*.:* ::** * :*******:****** ****: .** *::

MMAR_1718|M.marinum_M               TIEGIGTLTNPVVRKGKS
MUL_1956|M.ulcerans_Agy99           TIEGIDTLTNPVVRKGKS
Mb3017c|M.bovis_AF2122/97           TIEGIGTLTNPVVRKGKP
Rv2993c|M.tuberculosis_H37Rv        TIEGIGTLTNPVVRKGKP
MLBr_01689|M.leprae_Br4923          TVEGIGTLTNPVVRKGKS
MAV_3844|M.avium_104                TIEGIGTLTNPVVRKGKS
Mflv_4230|M.gilvum_PYR-GCK          TVEGIGTLSNPVVRKGKS
Mvan_2132|M.vanbaalenii_PYR-1       TVEGIGTLTNPVVRKGRS
MAB_3299c|M.abscessus_ATCC_199      TIEGIGTLSNPVVRKAK-
MSMEG_2382|M.smegmatis_MC2_155      TVEGIGTLTNPVVRKGKK
TH_2040|M.thermoresistible__bu      TIENIGTLTNPVVRKGKK
                                    *:*.*.**:******.: