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RLINLDGRIHLVTGDGVVDVAKASEQRFGPDPQDLYQHWDAFQEWARTAALPAPSARVGTIGSPAPLPRQ VFAVGLNYDDHATESGLSKPEHPVIFTKFVSSITGPVETVQLPAGSVDWEVELVVVMGRGGRNIPEDRAW EFVAGVSVGQDLSERDLQLAGPAPQFSLAKSHAGFSPIGPELVTVDELPDPDDLELGAEINGETVQHSRT SQLIFPVSNLIAYLSDTVELYPGDVIFTGTPSGVGMGRNPKRFLAPGDELRTYITGVGEFTQRFVTADSA SVAPRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2007 | - | - | 100% (287) | putative HpcE protein |
| M. smegmatis MC2 155 | MSMEG_2382 | - | 1e-35 | 42.65% (211) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2478 | - | 7e-26 | 33.63% (223) | fumarylacetoacetate hydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 3e-34 | 38.86% (211) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 9e-33 | 39.34% (211) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 3e-34 | 38.86% (211) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 1e-32 | 38.60% (215) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3299c | - | 7e-35 | 42.65% (211) | hypothetical protein MAB_3299c |
| M. marinum M | MMAR_1718 | - | 9e-32 | 38.79% (214) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 1e-33 | 40.19% (214) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. thermoresistible (build 8) | TH_3311 | - | 4e-82 | 51.96% (281) | PUTATIVE putative HpcE protein |
| M. ulcerans Agy99 | MUL_1956 | - | 1e-29 | 37.38% (214) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 9e-32 | 39.34% (211) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3017c|M.bovis_AF2122/97 -----------------------------------MTAREIAEHPFGTPT
Rv2993c|M.tuberculosis_H37Rv -----------------------------------MTAREIAEHPFGTPT
MMAR_1718|M.marinum_M ---------MRLGRIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPN
MUL_1956|M.ulcerans_Agy99 -----------------------------------MTAREIAEDPFGTPN
MAV_3844|M.avium_104 ---------MRLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPN
MLBr_01689|M.leprae_Br4923 -----------------------------------MFARELAEYPFGELT
Mflv_4230|M.gilvum_PYR-GCK ---------MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPT
Mvan_2132|M.vanbaalenii_PYR-1 ---------MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPT
MAB_3299c|M.abscessus_ATCC_199 ---------MRLGRIASPDGVAFVSIEGEDGREESAIAREIAEHPFGTPT
MSMEG_2007|M.smegmatis_MC2_155 MRLINLDGRIHLVTGDGVVDVAKASEQRFGPDPQDLYQHWDAFQEWARTA
TH_3311|M.thermoresistible__bu MRLINQGGRLKIDVDGLAADVEKTSDYRFSADPQEIYARWEEFTAWASAA
: :.
Mb3017c|M.bovis_AF2122/97 FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMGGRP---PADPVI
Rv2993c|M.tuberculosis_H37Rv FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMGGRP---PADPVI
MMAR_1718|M.marinum_M FTGRSWPLADVRLLAPILAS-KVVCVGKNYTDHIAEMGGQTGPTPADPVI
MUL_1956|M.ulcerans_Agy99 FTGRSWPLADVRLLAPILAS-KVVCVGKNYTGHIAEMGGQTGPTPADPVI
MAV_3844|M.avium_104 FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAEMGEATGPVPADPVI
MLBr_01689|M.leprae_Br4923 FTGRSWPLADVRLLAPMLAS-KVVCIGKNYADHIVEMGGQTGLASADPVI
Mflv_4230|M.gilvum_PYR-GCK FTGRQWPLADVRLLAPILAS-KVVCMGKNYAAHIEEMGGGT---FEDPII
Mvan_2132|M.vanbaalenii_PYR-1 FTGRQWPLADVRLLAPILAS-KVVCMGKNYAAHIEEMGGGT---FEDPII
MAB_3299c|M.abscessus_ATCC_199 FTGRQWPLADVRLLAPILAS-KVVAMGKNYAAHAAEMGGDP---PESPVI
MSMEG_2007|M.smegmatis_MC2_155 ALPAPSARVG-TIGSPAPLPRQVFAVGLNYDDHATESGLSK---PEHPVI
TH_3311|M.thermoresistible__bu DLSGGDPIVEAELGPPVPRPAQVFAIGINYRDHMDEAGLSE---PEAPFV
. . : .* . :*..:* ** * * * *.:
Mb3017c|M.bovis_AF2122/97 FLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNI
Rv2993c|M.tuberculosis_H37Rv FLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRACKDVPAAQAVDNI
MMAR_1718|M.marinum_M FLKPNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNI
MUL_1956|M.ulcerans_Agy99 FLKSNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPCKDVSAAQAVDNI
MAV_3844|M.avium_104 FLKPNTAIIGPNVPIRLPANASPVHFEGELAVVIGRPCKDVSAAQAAENI
MLBr_01689|M.leprae_Br4923 FLKPNTAIIGPNVPIRLPANASPVHFEGELALVVGRSCKDVPAVQAVDCI
Mflv_4230|M.gilvum_PYR-GCK FLKPNTAIIGPYTPIQLPADADPVHFEGELAAVIGRPCKDVPASRAAENI
Mvan_2132|M.vanbaalenii_PYR-1 FLKPNTAIIGPNTPIQLPADANPVHFEGELAAVIGRPCKDVPASRAAENI
MAB_3299c|M.abscessus_ATCC_199 FIKPNTSIIGPGLPIQLPPSATEVHHEGELAIVIGRPCKDVPAARAAENI
MSMEG_2007|M.smegmatis_MC2_155 FTKFVSSITGPVETVQLPAGS--VDWEVELVVVMGRGGRNIPEDRAWEFV
TH_3311|M.thermoresistible__bu FTKFPAAITGPYDVIELPDGS--VDWEVELVAVIGRRAHRVSERDGWNYV
* * ::* ** :.** .: *. * **. *:** : :. . : :
Mb3017c|M.bovis_AF2122/97 LGYTIGNDVSARDQQQS---DGQWTRAKGHDTFCPVGPWIVTDLAPFDPA
Rv2993c|M.tuberculosis_H37Rv LGYTIGNDVSARDQQQS---DGQWTRAKGHDTFCPVGPWIVTDLAPFDPA
MMAR_1718|M.marinum_M LGYTIGNDVSARDQQKS---DGQWTRAKGHDTFCPVGPWIVTDV---DPA
MUL_1956|M.ulcerans_Agy99 LGYTIGNDVSARDQQKS---DGQWTRAKGHDTFCPVGPWIVTDV---DPA
MAV_3844|M.avium_104 LGYTIGNDVSARDQQRS---DGQWTRAKGHDTFCPVGPWIVTDLNPLDPG
MLBr_01689|M.leprae_Br4923 LGYTIGNDMSARDQQRA---DGQWTRAKGHDTFCPVGPWIVTDLGPLDPA
Mflv_4230|M.gilvum_PYR-GCK LGYTIANDVSARDQQKK---DGQWMRAKGHDTFCPVGPWIVTDI---DPS
Mvan_2132|M.vanbaalenii_PYR-1 LGYTIANDVSARDQQQK---DGQWMRAKGHDTFCPVGPWIVTDL---DPS
MAB_3299c|M.abscessus_ATCC_199 LGYTIGNDVSARDHQRA---DGQWTRAKGHDTFCPLGPWIVTDL---DPA
MSMEG_2007|M.smegmatis_MC2_155 AGVSVGQDLSERDLQLAGPAP-QFSLAKSHAGFSPIGPELVTVDELPDPD
TH_3311|M.thermoresistible__bu AGLTVGQDLSERELQLSGPPPQQFNLGKSYTGFAPIGPAVVTLDEFADPA
* ::.:*:* *: * *: .*.: *.*:** :** **
Mb3017c|M.bovis_AF2122/97 DLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPA
Rv2993c|M.tuberculosis_H37Rv DLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGDLILTGTPA
MMAR_1718|M.marinum_M DLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPA
MUL_1956|M.ulcerans_Agy99 GLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGDLILTGTPA
MAV_3844|M.avium_104 DLELRTEVNGEVKQRSRTSLLIHDIGSIVEWISAVMTLLPGDLILTGTPA
MLBr_01689|M.leprae_Br4923 DLELRTAVNGEVKQHSRTSLMIHGIGAIMEWISAVMTLLPGDLILTGTPA
Mflv_4230|M.gilvum_PYR-GCK DLEIRTEVNGELKQHSRTSLMIHDIGAIIEWISSVMTLLPGDLILTGTPE
Mvan_2132|M.vanbaalenii_PYR-1 DLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWISAVMTLLPGDLILTGTPE
MAB_3299c|M.abscessus_ATCC_199 DLEIRTEVNGQVRQRSRTSLLLHDVGAIVEWVSAVMTLLPGDVILTGTPE
MSMEG_2007|M.smegmatis_MC2_155 DLELGAEINGETVQHSRTSQLIFPVSNLIAYLSDTVELYPGDVIFTGTPS
TH_3311|M.thermoresistible__bu DVEISTTLSGELMQLARTRDVFFSVPQLVAYLSQILPLLPGDLIFTGTPS
.:*: : :.* * :** ::. : :: ::* : * ***:*:****
Mb3017c|M.bovis_AF2122/97 GVGP-------IEDGDTVSITIEGIGTLTNPVVRKGKP---------
Rv2993c|M.tuberculosis_H37Rv GVGP-------IEDGDTVSITIEGIGTLTNPVVRKGKP---------
MMAR_1718|M.marinum_M GVGP-------IEDGDTVSITIEGIGTLTNPVVRKGKS---------
MUL_1956|M.ulcerans_Agy99 GVGP-------IEDGDTVSITIEGIDTLTNPVVRKGKS---------
MAV_3844|M.avium_104 GVGP-------IEDGDTVSITIEGIGTLTNPVVRKGKS---------
MLBr_01689|M.leprae_Br4923 GVGP-------VEDGDIVSITVEGIGTLTNPVVRKGKS---------
Mflv_4230|M.gilvum_PYR-GCK GVGP-------LEHGDTVSITVEGIGTLSNPVVRKGKS---------
Mvan_2132|M.vanbaalenii_PYR-1 GVGP-------LEHGDSVSITVEGIGTLTNPVVRKGRS---------
MAB_3299c|M.abscessus_ATCC_199 GVGP-------IVDGDTVSVTIEGIGTLSNPVVRKAK----------
MSMEG_2007|M.smegmatis_MC2_155 GVGMGRNPKRFLAPGDELRTYITGVGEFTQRFVTAD-SASVAPRS--
TH_3311|M.thermoresistible__bu GIGWARTPKRFIDSDDELVTRAEGIGEMRHRFTRADRSVAKGNRING
*:* : .* : *:. : : ..