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MRLYTTDRGIARQGADGHFSLLDLPFDDIGALLRYSDTDTAARALASRVVDSDHVSLAPVILRPGKILAV GLNYLSHAEEALEKFASIGRRDVQLPAEPNIQIVAGSAVQADGRPLMLPVATPHHVDYEGELAVVIGRAG FAIRTDQAWGHVAGLSIINDVSARDIQQRAYTGDPAASIGIAKSFDTFKPLGPCLVTADEFTEKVDLRLQ TRVNGDLRQDDRTGNLIHSIPELIAYISRYHTLEPGDVIATGSPRGAGQFTDRYLRPGDVVEISIEHLGT LTNSVQARQSTGTGQSPLR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4355 | - | - | 100% (299) | fumarylacetoacetate (FAA) hydrolase family protein |
| M. abscessus ATCC 19977 | MAB_4361 | - | 3e-97 | 62.50% (288) | fumarylacetoacetate hydrolase family protein |
| M. abscessus ATCC 19977 | MAB_3299c | - | 2e-31 | 38.86% (229) | hypothetical protein MAB_3299c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 3e-34 | 41.74% (230) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 1e-29 | 38.26% (230) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 3e-34 | 41.74% (230) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 8e-32 | 39.13% (230) | putative hydrolase |
| M. marinum M | MMAR_1718 | - | 1e-32 | 39.57% (230) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 2e-34 | 41.74% (230) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2007 | - | 2e-32 | 39.37% (221) | putative HpcE protein |
| M. thermoresistible (build 8) | TH_2040 | - | 3e-31 | 39.48% (233) | POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD |
| M. ulcerans Agy99 | MUL_1956 | - | 2e-31 | 38.70% (230) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 6e-31 | 38.86% (229) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1718|M.marinum_M -----MRLGRIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPNFTGR
MUL_1956|M.ulcerans_Agy99 -------------------------------MTAREIAEDPFGTPNFTGR
MAV_3844|M.avium_104 -----MRLGRIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTGR
Mb3017c|M.bovis_AF2122/97 -------------------------------MTAREIAEHPFGTPTFTGR
Rv2993c|M.tuberculosis_H37Rv -------------------------------MTAREIAEHPFGTPTFTGR
MLBr_01689|M.leprae_Br4923 -------------------------------MFARELAEYPFGELTFTGR
Mflv_4230|M.gilvum_PYR-GCK -----MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTGR
Mvan_2132|M.vanbaalenii_PYR-1 -----MRLGRIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTGR
TH_2040|M.thermoresistible__bu -----MRLGRIASPDGVAFVSIEGPPDEP-TAVAREIAEHPFGTPEFTGR
MAB_4355|M.abscessus_ATCC_1997 MRLYTTDRGIARQGADGHFSLLDLPFDDIGALLR--YSDTDTAARALASR
MSMEG_2007|M.smegmatis_MC2_155 -MRLINLDGRIHLVTGDGVVDVAKASEQRFGPDPQDLYQHWDAFQEWART
: . :
MMAR_1718|M.marinum_M SWPLADVRLLAPILAS-----KVVCVGKNYTDH-------IAEMGGQTGP
MUL_1956|M.ulcerans_Agy99 SWPLADVRLLAPILAS-----KVVCVGKNYTGH-------IAEMGGQTGP
MAV_3844|M.avium_104 SWPLADVRLLAPILAS-----KVVCVGKNYADH-------IAEMGEATGP
Mb3017c|M.bovis_AF2122/97 SWPLADVRLLAPILAS-----KVVCVGKNYADH-------IAEMGGRP--
Rv2993c|M.tuberculosis_H37Rv SWPLADVRLLAPILAS-----KVVCVGKNYADH-------IAEMGGRP--
MLBr_01689|M.leprae_Br4923 SWPLADVRLLAPMLAS-----KVVCIGKNYADH-------IVEMGGQTGL
Mflv_4230|M.gilvum_PYR-GCK QWPLADVRLLAPILAS-----KVVCMGKNYAAH-------IEEMGGGT--
Mvan_2132|M.vanbaalenii_PYR-1 QWPLADVRLLAPILAS-----KVVCMGKNYAAH-------IEEMGGGT--
TH_2040|M.thermoresistible__bu QWSLADVRLLAPILAS-----KVVCMGKNYAAH-------VDEMGGET--
MAB_4355|M.abscessus_ATCC_1997 VVDSDHVSLAPVILRPG----KILAVGLNYLSHAEEALEKFASIGRRDVQ
MSMEG_2007|M.smegmatis_MC2_155 AALPAPSARVGTIGSPAPLPRQVFAVGLNYDDH-------ATESGLSK--
: . ::..:* ** * . *
MMAR_1718|M.marinum_M TPADPVIFLKPNTAIVGPNVPIRLPAN-ASPVHFEGELAIVIGRPCKDVS
MUL_1956|M.ulcerans_Agy99 TPADPVIFLKSNTAIVGPNVPIRLPAN-ASPVHFEGELAIVIGRPCKDVS
MAV_3844|M.avium_104 VPADPVIFLKPNTAIIGPNVPIRLPAN-ASPVHFEGELAVVIGRPCKDVS
Mb3017c|M.bovis_AF2122/97 -PADPVIFLKPNTAIIGPNTPIRLPAN-ASPVHFEGELAIVIGRACKDVP
Rv2993c|M.tuberculosis_H37Rv -PADPVIFLKPNTAIIGPNTPIRLPAN-ASPVHFEGELAIVIGRACKDVP
MLBr_01689|M.leprae_Br4923 ASADPVIFLKPNTAIIGPNVPIRLPAN-ASPVHFEGELALVVGRSCKDVP
Mflv_4230|M.gilvum_PYR-GCK -FEDPIIFLKPNTAIIGPYTPIQLPAD-ADPVHFEGELAAVIGRPCKDVP
Mvan_2132|M.vanbaalenii_PYR-1 -FEDPIIFLKPNTAIIGPNTPIQLPAD-ANPVHFEGELAAVIGRPCKDVP
TH_2040|M.thermoresistible__bu -VPHPVIFIKPNTSIIGPNVPIQLPVD-ADPVHHEGELAVVIGRPCKDVP
MAB_4355|M.abscessus_ATCC_1997 LPAEPNIQIVAGSAVQADGRPLMLPVATPHHVDYEGELAVVIGRAGFAIR
MSMEG_2007|M.smegmatis_MC2_155 -PEHPVIFTKFVSSITGPVETVQLPAG---SVDWEVELVVVMGRGGRNIP
.* * ::: . .: **. *. * **. *:** :
MMAR_1718|M.marinum_M AAQAVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPW
MUL_1956|M.ulcerans_Agy99 AAQAVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPW
MAV_3844|M.avium_104 AAQAAENILGYTIGNDVSARDQQR------SDGQWTRAKGHDTFCPVGPW
Mb3017c|M.bovis_AF2122/97 AAQAVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPW
Rv2993c|M.tuberculosis_H37Rv AAQAVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPW
MLBr_01689|M.leprae_Br4923 AVQAVDCILGYTIGNDMSARDQQR------ADGQWTRAKGHDTFCPVGPW
Mflv_4230|M.gilvum_PYR-GCK ASRAAENILGYTIANDVSARDQQK------KDGQWMRAKGHDTFCPVGPW
Mvan_2132|M.vanbaalenii_PYR-1 ASRAAENILGYTIANDVSARDQQQ------KDGQWMRAKGHDTFCPVGPW
TH_2040|M.thermoresistible__bu AARAADVILGYTVANDVTARNQQR------ADGQWTRAKGHDTFCPVGPW
MAB_4355|M.abscessus_ATCC_1997 TDQAWGHVAGLSIINDVSARDIQQRAYTGDPAASIGIAKSFDTFKPLGPC
MSMEG_2007|M.smegmatis_MC2_155 EDRAWEFVAGVSVGQDLSERDLQLAG----PAPQFSLAKSHAGFSPIGPE
:* : * :: :*:: *: * . **.. * *:**
MMAR_1718|M.marinum_M IVTDV---DPADLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLL
MUL_1956|M.ulcerans_Agy99 IVTDV---DPAGLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLL
MAV_3844|M.avium_104 IVTDLNPLDPGDLELRTEVNGEVKQRSRTSLLIHDIGSIVEWISAVMTLL
Mb3017c|M.bovis_AF2122/97 IVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLL
Rv2993c|M.tuberculosis_H37Rv IVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLL
MLBr_01689|M.leprae_Br4923 IVTDLGPLDPADLELRTAVNGEVKQHSRTSLMIHGIGAIMEWISAVMTLL
Mflv_4230|M.gilvum_PYR-GCK IVTDI---DPSDLEIRTEVNGELKQHSRTSLMIHDIGAIIEWISSVMTLL
Mvan_2132|M.vanbaalenii_PYR-1 IVTDL---DPSDLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWISAVMTLL
TH_2040|M.thermoresistible__bu IVTDV---DPTDLELRTEVNGEVRQRSRTSLMIHDIGAIIEWVSRVMTLL
MAB_4355|M.abscessus_ATCC_1997 LVTADEFTEKVDLRLQTRVNGDLRQDDRTGNLIHSIPELIAYISRYHTLE
MSMEG_2007|M.smegmatis_MC2_155 LVTVDELPDPDDLELGAEINGETVQHSRTSQLIFPVSNLIAYLSDTVELY
:** : .*.: : :** * **. :*. : :: ::* *
MMAR_1718|M.marinum_M PGDLILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKS-
MUL_1956|M.ulcerans_Agy99 PGDLILTGTPAGVGPIED-------GDTVSITIEGIDTLTNPVVRKGKS-
MAV_3844|M.avium_104 PGDLILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKS-
Mb3017c|M.bovis_AF2122/97 PGDLILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKP-
Rv2993c|M.tuberculosis_H37Rv PGDLILTGTPAGVGPIED-------GDTVSITIEGIGTLTNPVVRKGKP-
MLBr_01689|M.leprae_Br4923 PGDLILTGTPAGVGPVED-------GDIVSITVEGIGTLTNPVVRKGKS-
Mflv_4230|M.gilvum_PYR-GCK PGDLILTGTPEGVGPLEH-------GDTVSITVEGIGTLSNPVVRKGKS-
Mvan_2132|M.vanbaalenii_PYR-1 PGDLILTGTPEGVGPLEH-------GDSVSITVEGIGTLTNPVVRKGRS-
TH_2040|M.thermoresistible__bu PGDLILTGTPEGVGPIEH-------GDTVAVTIENIGTLTNPVVRKGKK-
MAB_4355|M.abscessus_ATCC_1997 PGDVIATGSPRGAGQFTDR--YLRPGDVVEISIEHLGTLTNSVQARQSTG
MSMEG_2007|M.smegmatis_MC2_155 PGDVIFTGTPSGVGMGRNPKRFLAPGDELRTYITGVGEFTQRFVTADSAS
***:* **:* *.* . ** : : :. ::: .
MMAR_1718|M.marinum_M -------
MUL_1956|M.ulcerans_Agy99 -------
MAV_3844|M.avium_104 -------
Mb3017c|M.bovis_AF2122/97 -------
Rv2993c|M.tuberculosis_H37Rv -------
MLBr_01689|M.leprae_Br4923 -------
Mflv_4230|M.gilvum_PYR-GCK -------
Mvan_2132|M.vanbaalenii_PYR-1 -------
TH_2040|M.thermoresistible__bu -------
MAB_4355|M.abscessus_ATCC_1997 TGQSPLR
MSMEG_2007|M.smegmatis_MC2_155 VAPRS--