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VVRSHAQCWLTDMDGVLVREEHALPGAAEFLQTLVDKERPFLVLTNNSIFTPRDLAARLARSGLTVPESS IWTSALATAAFLDGQLPGGSAYVIGEAGLTTALHEVGYTLTDVEPDFVVLGETRTYSFEAITRAIRLILG GARFIATNPDVTGPSAEGPLPATGSVAAMITKATGREPYFVGKPNPMMFRSALNRIEAHSENTVMVGDRM DTDVVAGIEAGLDTILVLTGSTAVEDIERYPFRPSRVLPSIAEAIELI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2451 | - | - | 100% (258) | HAD-superfamily protein hydrolase, subfamily protein IIA |
| M. smegmatis MC2 155 | MSMEG_3753 | - | 3e-30 | 34.58% (240) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_0867 | - | 9e-20 | 25.48% (263) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1718 | - | 4e-27 | 33.05% (233) | phosphatase |
| M. gilvum PYR-GCK | Mflv_3511 | - | 5e-25 | 32.19% (233) | HAD family hydrolase |
| M. tuberculosis H37Rv | Rv1692 | - | 4e-27 | 33.05% (233) | phosphatase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0641 | - | 2e-26 | 30.35% (257) | HAD-superfamily hydrolase |
| M. marinum M | MMAR_2497 | - | 3e-28 | 32.62% (233) | phosphatase |
| M. avium 104 | MAV_3079 | - | 4e-28 | 34.33% (233) | HAD-superfamily protein hydrolase, subfamily protein IIA |
| M. thermoresistible (build 8) | TH_1551 | - | 4e-29 | 34.73% (239) | PROBABLE PHOSPHATASE |
| M. ulcerans Agy99 | MUL_1681 | - | 3e-28 | 32.62% (233) | phosphatase |
| M. vanbaalenii PYR-1 | Mvan_2196 | - | 1e-134 | 91.05% (257) | HAD family hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2451|M.smegmatis_MC2_155 -------------MVRSHAQCWLTDMDGVLVREEHALPGAAEFLQTLVDK
Mvan_2196|M.vanbaalenii_PYR-1 MTSRLLATADRLDDVRSTPQCWLTDMDGVLVREEHALPGAAEFLQRLIDR
Mb1718|M.bovis_AF2122/97 -----------MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSR
Rv1692|M.tuberculosis_H37Rv -----------MKSIAQEHDCLLIDLDGTVFCGRQPTGGAVQSLSQVRSR
MMAR_2497|M.marinum_M -----------MKNIAQEYDCLLIDLDGTVFRGSQPTEGAVESLDEVTAR
MUL_1681|M.ulcerans_Agy99 -----------MKNIAQEYDCLLIDLDGTVFRGSQPTEGAVESLDEVTAR
MAV_3079|M.avium_104 --------MSGVKTLAQQHDCLLIDLDGTAFRGRSPTEGAVQALARLPGR
Mflv_3511|M.gilvum_PYR-GCK -----------MSTLAQQHDCLLLDLDGTVFRGHEPTPGAVDTLAGVDTR
TH_1551|M.thermoresistible__bu -----------VNSVAQHHDCLLLDLDGTVFRGHEPTPGAVESLRTVAAR
MAB_0641|M.abscessus_ATCC_1997 ----------------MTVGGVLFDIDGVLVTSWEPIDGAAQALKALEND
* *:**. . . **.: * :
MSMEG_2451|M.smegmatis_MC2_155 ERPFLVLTNNSIFTPRDLAARLARSGLTVPESSIWTSALATAAFLDGQLP
Mvan_2196|M.vanbaalenii_PYR-1 ERPFLVLTNNSIFTPRDLAARLARSGLAVPENAIWTSALATAGFLADQLP
Mb1718|M.bovis_AF2122/97 K---LFVTNNASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLA
Rv1692|M.tuberculosis_H37Rv K---LFVTNNASRSADEVAAHLCELGFTATGEDVVTSAQSAAHLLAGQLA
MMAR_2497|M.marinum_M K---LFVTNNASRSAGEVAVHLRELGFTATSEDVVTSAQSAAHLLAAALP
MUL_1681|M.ulcerans_Agy99 K---LFVTNNASRSAGEVAVHLRELGFTATSEDVVTSAQSAAHLLAAALP
MAV_3079|M.avium_104 A---LFVTNNASRSAGEVAAHLTELGFTATADDVATSAQSAAHLLAGQLP
Mflv_3511|M.gilvum_PYR-GCK I---LFVTNNASRSAGQVSDHLCELGFSAAPPDVVTSAQSAARLLAEQLP
TH_1551|M.thermoresistible__bu T---LYVTNNASRAPGEVAEHLRSLGFAAAAEDVVTSAQSAARLLATTLP
MAB_0641|M.abscessus_ATCC_1997 DIRRCFLTNTTSRTRVQIAELLSAAGLAVPADEVITAAMLTADHVITQH-
:**.: : ::: * *::.. : *:* :* :
MSMEG_2451|M.smegmatis_MC2_155 GGS-AYVIGEAGLTTALHEVGYTLT---DVEPDFVVLG-ETRTYSFEAIT
Mvan_2196|M.vanbaalenii_PYR-1 GGS-AYVIGEAGLTTALHEAGYTLT---DIDPDFVVLG-ETRTYSFEAIT
Mb1718|M.bovis_AF2122/97 PGARVLIVGTEALANEVAAVGLRPVRRFEDRPDAVVQG-LSMTTGWSDLA
Rv1692|M.tuberculosis_H37Rv PGARVLIVGTEALANEVAAVGLRPVRRFEDRPDAVVQG-LSMTTGWSDLA
MMAR_2497|M.marinum_M PGSKVLVVGTDALADEISAAGLRPVRRFEDQPDAVVQG-LSLTIGWPELA
MUL_1681|M.ulcerans_Agy99 PGSKVLVVGTDALADEISAAGLRPVRRFEDQPDAVVQG-LSLTIGWPELA
MAV_3079|M.avium_104 AGAPVLIVGTEALAGEIAAVGLRPVRRYDDGPVAVVQG-LSMTIGWPDLA
Mflv_3511|M.gilvum_PYR-GCK SGAKVLVVGTDSLADEVSNVGLAPVREYSEGPAAVVQG-HNPETAWQILA
TH_1551|M.thermoresistible__bu AGAPVLVLGTEALAEEVRAVGLEPVRQFADRPVAVVQG-ISQQTGWPELA
MAB_0641|M.abscessus_ATCC_1997 PGARCYLLNDGDITADMAGVDFVES--LSDDPDVIILGGAGPQFDHVALS
*: ::. :: : .. * :: * ::
MSMEG_2451|M.smegmatis_MC2_155 RAIRLILGGARFIATNPDVTGPSAEGPLPATGSVAAMITKATGREPYFVG
Mvan_2196|M.vanbaalenii_PYR-1 KAVRLILGGARFIATNPDVTGPSAEGPLPATGSVAAMITKATGREPYFVG
Mb1718|M.bovis_AF2122/97 EAALAIRAGALWVAANVDPTLPTERGLLPGNGSMVAALRTATGMDPRVAG
Rv1692|M.tuberculosis_H37Rv EAALAIRAGALWVAANVDPTLPTERGLLPGNGSMVAALRTATGMDPRVAG
MMAR_2497|M.marinum_M EAALAIRAGALWVAANVDKTLPTERGLLPGNGSLVAALRTATGAQPQVAG
MUL_1681|M.ulcerans_Agy99 EAALAIRAGALWVAANVDKTLPTERGLLPGNGSFVAALRTATGAQPQVAG
MAV_3079|M.avium_104 EAALAIRAGAVWVAANIDLTLPTERGLLPGNGSLVAAVAAATGATPQVAG
Mflv_3511|M.gilvum_PYR-GCK EAALAIRSGALWVAANVDRTLPSERGLLPGNGSMVAALRAATDSEPQVAG
TH_1551|M.thermoresistible__bu EAALAIRAGAWWVATNADRTLPSERGLLPGNGAMIAALRAATDREPEVAG
MAB_0641|M.abscessus_ATCC_1997 RVYELMAQGIPVVAMHRNAVWSTREGLRVDTGVYLAGMEQVSGRKAVAVG
.. : * :* : : . .: .* .* * : .:. . .*
MSMEG_2451|M.smegmatis_MC2_155 KPNPMMFRSALNRIEAHSENTVMVGDRMDTDVVAGIEAGLDTILVLTGS-
Mvan_2196|M.vanbaalenii_PYR-1 KPNPMMFRSALNRIEAHSESTVMVGDRMDTDVVAGIEAGLETILVLTGS-
Mb1718|M.bovis_AF2122/97 KPAPALMTEAVARGDFRAA--LVVGDRLDTDIEGANAAGLPSLMVLTGVN
Rv1692|M.tuberculosis_H37Rv KPAPALMTEAVARGDFRAA--LVVGDRLDTDIEGANAAGLPSLMVLTGVN
MMAR_2497|M.marinum_M KPGPQLMKDAVGRGDFRAP--LVIGDRLDTDIEGANAAGLPSLMVLTGVS
MUL_1681|M.ulcerans_Agy99 KPGPQLMKDAVGRGDFRAP--LVIGDRLDTDIEGANAAGLPSLMVLTGVS
MAV_3079|M.avium_104 KPAPALLRDAAARGDFRAP--LVIGDRLDTDIEGANAAGLPSLLVLTGVN
Mflv_3511|M.gilvum_PYR-GCK KPAPALMADALSRGDFQTP--LVVGDRLDTDIAGANAARLPSLMVLCGVN
TH_1551|M.thermoresistible__bu KPQATLMLDALSRGSFERP--LVVGDRLDTDIAGANNAGLPSLLVLTGVN
MAB_0641|M.abscessus_ATCC_1997 KPAPAGFQLAAERMGCEPDQVVMVGDDLHVDVLAAQVVGMTGVLVRTGK-
** . : * * . :::** :..*: .. . : ::* *
MSMEG_2451|M.smegmatis_MC2_155 TAVEDIERYPFRPS------------------RVLPSIAEAIELI-----
Mvan_2196|M.vanbaalenii_PYR-1 TTIDDVERYPFRPS------------------RVLPSIAEAIELV-----
Mb1718|M.bovis_AF2122/97 SAWDAVYAEPVRRPTYIGHDLRSLHQ-DSKLLAVAPQPGWQIDVGGG-AV
Rv1692|M.tuberculosis_H37Rv SAWDAVYAEPVRRPTYIGHDLRSLHQ-DSKLLAVAPQPGWQIDVGGG-AV
MMAR_2497|M.marinum_M SARDAVHADPVCRPTYIGHDLRSLRQ-DRATLAVAPQAGWRVQVDGA-AV
MUL_1681|M.ulcerans_Agy99 SARDAVHADPVCRPTYIGHDLRSLRQ-DRATLAVAPQAGWRVQVDGA-AV
MAV_3079|M.avium_104 SARDAVYAKPARRPTYIGHDLRALHQ-DAAALAVAPQPGWRVDVGDT-AI
Mflv_3511|M.gilvum_PYR-GCK NAADAIWAVEDERPGFLAEDLRALTAHAADVLRIAPDPAWRVDVTEK-AV
TH_1551|M.thermoresistible__bu DAADAIWAVPGERPDLIAADLRSLHT-PAEELRVAPHPAWRVDLNDGGTI
MAB_0641|M.abscessus_ATCC_1997 FRQDTLDRWAADQY--------------------AMQPAYVVDSVADLPP
: : . ::
MSMEG_2451|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2196|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1718|M.bovis_AF2122/97 TVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRP-LRIEAGDER
Rv1692|M.tuberculosis_H37Rv TVCANGDVDDLEFIDDGLSIVRAVASAVWEARAADLHQRP-LRIEAGDER
MMAR_2497|M.marinum_M TVSANG-----EQAGDDLSIVRAVACAVWDA---QFDGRP-FTVNGGDDH
MUL_1681|M.ulcerans_Agy99 TVSANG-----EQAGDDLSIVRAVACAVWDA---QFDGRP-FTVNGGDDH
MAV_3079|M.avium_104 TVSGDGRD---DGSGDGLSVVRAVASAVWGS----PDAGT-LPIRAGDDR
Mflv_3511|M.gilvum_PYR-GCK TVSSTG-----TTASDPLAPVRAIAAAVWESGIGRR------PIVGADDA
TH_1551|M.thermoresistible__bu RVTSTG-----ADPGDPLSVVRAVAHAVWTADLVTTGDTAGLPIIGADDA
MAB_0641|M.abscessus_ATCC_1997 LLSGL---------------------------------------------
MSMEG_2451|M.smegmatis_MC2_155 -----------------------
Mvan_2196|M.vanbaalenii_PYR-1 -----------------------
Mb1718|M.bovis_AF2122/97 ARAALQRWSLMRSDHPVTSVGTQ
Rv1692|M.tuberculosis_H37Rv ARAALQRWSLMRSDHPVTSVGTQ
MMAR_2497|M.marinum_M AWEGLHRWSLVHSE---------
MUL_1681|M.ulcerans_Agy99 AWERLHRWSLVHSE---------
MAV_3079|M.avium_104 ARAALARWSLVRTD---------
Mflv_3511|M.gilvum_PYR-GCK ARQAVERWSLASAAID-------
TH_1551|M.thermoresistible__bu ARAALHRWALSPFRID-------
MAB_0641|M.abscessus_ATCC_1997 -----------------------