For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TSAAAIPTVILNDDNTMPVIGLGVGELSDAEAEQSVLAALEAGYRLIDTAAAYGNEAAVGRAIAKSGVPR GELFVTTKLATDDLGFQSSQDALRASLERLGLDYVDLYLIHWPAGSQGTYVDSWGGLMKLKELGLTRSIG VSNFHAQHLDDIIGLSFFTPAVNQIELHPLLNQAELRAVNAEHGIVTEAYSPLGVGSLLSNPAVTAIADA QDRTPAQVLIRWSLQLGNVVISRSSSPERIKSNLDVFDFELTADQMAALDGLDEGTRFRPDPETYTGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2161 | - | - | 100% (279) | 2,5-didehydrogluconate reductase |
| M. vanbaalenii PYR-1 | Mvan_1769 | - | 9e-63 | 45.65% (276) | 2,5-didehydrogluconate reductase |
| M. vanbaalenii PYR-1 | Mvan_2555 | - | 6e-09 | 25.45% (279) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2996 | - | 1e-104 | 66.91% (278) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4205 | - | 1e-135 | 85.30% (279) | 2,5-didehydrogluconate reductase |
| M. tuberculosis H37Rv | Rv2971 | - | 1e-103 | 66.55% (278) | oxidoreductase |
| M. leprae Br4923 | MLBr_01669 | - | 1e-101 | 63.67% (278) | putative oxidoreductase of Aldo/keto reductase family |
| M. abscessus ATCC 19977 | MAB_1528c | - | 2e-71 | 51.12% (268) | oxidoreductase |
| M. marinum M | MMAR_1744 | - | 1e-98 | 63.47% (271) | oxidoreductase |
| M. avium 104 | MAV_4483 | - | 1e-95 | 62.59% (278) | 2,5-diketo-D-gluconic acid reductase B |
| M. smegmatis MC2 155 | MSMEG_2407 | - | 1e-121 | 77.90% (276) | morphine 6-dehydrogenase |
| M. thermoresistible (build 8) | TH_1364 | - | 1e-114 | 71.74% (276) | PROBABLE OXIDOREDUCTASE |
| M. ulcerans Agy99 | MUL_1987 | - | 2e-98 | 63.10% (271) | oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2161|M.vanbaalenii_PYR-1 MTS-------AAAIPTVILNDDNTMPVIGLGVGELSDAEAEQSVLAALEA
Mflv_4205|M.gilvum_PYR-GCK MTS-------AAAIPTVTLNDDNTMPVIGLGVGELSDAETEQAVTAALEA
MSMEG_2407|M.smegmatis_MC2_155 MTASH---GQAAAIPTVTLNDDNTLPVVGIGVGELSDSEAERSVSAALEA
TH_1364|M.thermoresistible__bu MTSSP---GEAAATPTVTLNDDRSMPVLGLGVGELSDDEAERAVAAALEA
MMAR_1744|M.marinum_M -MPG----APSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEI
MUL_1987|M.ulcerans_Agy99 MMPG----APSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEI
Mb2996|M.bovis_AF2122/97 MTGE----SGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEI
Rv2971|M.tuberculosis_H37Rv MTGE----SGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEI
MLBr_01669|M.leprae_Br4923 MMPS----TPRTSIPSITLNDENTMPLLGLGVAELSEDETERAVLAALEI
MAV_4483|M.avium_104 MTVIDEIYSSSSAIPTVALNDEAKMPVLGLGVAKLSDEETESSVLAALEA
MAB_1528c|M.abscessus_ATCC_199 ----------------MTLNSGTTIPQLGYGVWQVPDDQARAAVSAALQV
: **. .:* :* ** :.: ::. :* ***:
Mvan_2161|M.vanbaalenii_PYR-1 GYRLIDTAAAYGNEAAVGRAIAKSGVPRGELFVTTKLATDDLGFQSSQDA
Mflv_4205|M.gilvum_PYR-GCK GYRLIDTAAAYGNEAAVGRAIAASGVPRDELFVTTKLATEDAGFQSSQDA
MSMEG_2407|M.smegmatis_MC2_155 GYRLIDTAAAYGNEAAVGRAIAASGIPRDEIYVTTKLATPDQGFTSSQAA
TH_1364|M.thermoresistible__bu GYRLIDTAASYGNEAGVGRAIAASGLPREEIFVTTKLATTDQGFQSSQDA
MMAR_1744|M.marinum_M GCRLIDTAAAYGNEAAVGRAIAASGIPRAELFVTTKVATADHGFTASREA
MUL_1987|M.ulcerans_Agy99 GCRLIDTAAAYGNEAAVGRALAASGIPRAELFVTTKVATADHGFTASREA
Mb2996|M.bovis_AF2122/97 GCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEA
Rv2971|M.tuberculosis_H37Rv GCRLIDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEA
MLBr_01669|M.leprae_Br4923 GCRLIDTAAAYGNEAAVSRAIAASGIPRAQLFVTTKLATPDQGFTKSQDA
MAV_4483|M.avium_104 GCRLIDTAASYGNEAAVGRAIAASGIPREELFVTTKLGTSRQGFHSAQES
MAB_1528c|M.abscessus_ATCC_199 GYRSIDTAKIYDNEAGTGAAIAESGIPRGDVFLTTKLWNSDQGYDNALRA
* * **** *.***... *:* **:.* ::::***: . *: : :
Mvan_2161|M.vanbaalenii_PYR-1 LRASLERLGLDYVDLYLIHWPAGSQGTYVDSWGGLMKLKELGLTRSIGVS
Mflv_4205|M.gilvum_PYR-GCK LRASLERLGLDYVDLYLIHWPVSQQGKHVDSWGGLMKSKEVGLTRSIGVA
MSMEG_2407|M.smegmatis_MC2_155 ARASLERLGLDYVDLYLIHWPGGDTSKYVDSWGGLMKVKEDGIARSIGVC
TH_1364|M.thermoresistible__bu VRASLERLGLEYVDLYLIHWPAGEQGKYVDSWGGFLKIREDGLTRSIGVS
MMAR_1744|M.marinum_M CKASLDRLGLDYVDLYLIHWPAPAAGKYVDAFGGLIQARGEGFTRSIGVS
MUL_1987|M.ulcerans_Agy99 CKASLDRLGLDYVDLYLIHWPAPAVGKYVDAFGGLIQARGEGFTRSIGVS
Mb2996|M.bovis_AF2122/97 CRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVS
Rv2971|M.tuberculosis_H37Rv CRASLDRLGLDYVDLYLIHWPAPPVGKYVDAWGGMIQSRGEGHARSIGVS
MLBr_01669|M.leprae_Br4923 CNASLDRLGMDYVDLYLIHWPAPPVGQYVDAWGGMIQSRGEGHARSIGVC
MAV_4483|M.avium_104 CKESLDRLGLDYLDLYLIHWPAPKLGKYVESFEGMIEARERGHVRSIGVS
MAB_1528c|M.abscessus_ATCC_199 FDASLERLGTDYVDLYLIHWPVPELDEYVASFKALQRIQADGRAKAIGVS
**:*** :*:******** . :* :: .: . : * .::***.
Mvan_2161|M.vanbaalenii_PYR-1 NFHAQHLDDIIGLSFFTPAVNQIELHPLLNQAELRAVNAEHGIVTEAYSP
Mflv_4205|M.gilvum_PYR-GCK NFHGHHLDDIISLSFFTPAVNQIELHPLLNQAELRAVNAEHGIATEAYGP
MSMEG_2407|M.smegmatis_MC2_155 NFGAEDLETIVSLTYFTPAVNQIELHPLLNQAALREVNAGYNIVTEAYGP
TH_1364|M.thermoresistible__bu NFDEEYLSDIIDLSFVTPAVNQIELHPLLNQADLRKVHAERNVLTQAYSP
MMAR_1744|M.marinum_M NFTEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTP
MUL_1987|M.ulcerans_Agy99 NFTEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTP
Mb2996|M.bovis_AF2122/97 NFTAEHIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCP
Rv2971|M.tuberculosis_H37Rv NFTAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCP
MLBr_01669|M.leprae_Br4923 NFTEEHLSAIIDLTFVTPAVNQIELHPLLNQDEMRKSNAQHNVITQSYTP
MAV_4483|M.avium_104 NFTEDLLATVIEETDEVPAVNQVELHPRLNQAELRQVHAQHDVTTQSYSP
MAB_1528c|M.abscessus_ATCC_199 NFTVDNLKRLIDETGEVPALNQIELHPRFTQPELRAFHAEYGIATEAWSP
** . : :: : .**:**:**** :.* :* :* : *::: *
Mvan_2161|M.vanbaalenii_PYR-1 LGVGSLLSNPAVTAIADAQDRTPAQVLIRWSLQLGNVVISRSSSPERIKS
Mflv_4205|M.gilvum_PYR-GCK LGVGNLLSHSAVNAIAEAHGRTPAQVLIRWSLQLGNIVIPRSSSPERIRS
MSMEG_2407|M.smegmatis_MC2_155 LGVGRLLDHPAVTAIAEAHGRTAAQVLLRWSIQLGNVVISRSANPERIAS
TH_1364|M.thermoresistible__bu LGVGNLLADPTIGAVAQAHGKSPAQVLLRWNLQLGNAVVVRSSNPDRMRE
MMAR_1744|M.marinum_M LALGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIAT
MUL_1987|M.ulcerans_Agy99 LALGQLADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIVT
Mb2996|M.bovis_AF2122/97 LALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIAS
Rv2971|M.tuberculosis_H37Rv LALGRLLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIAS
MLBr_01669|M.leprae_Br4923 LVLGRLMDNSTLTAIAAEYGKTPAQVLLRWNLQLGNAVVFRSAKAEHIAS
MAV_4483|M.avium_104 LGVGRLIEEPTVTTIAAEYGRTPAQVLVRWNLQLDNVVVSRSSKPERVAE
MAB_1528c|M.abscessus_ATCC_199 LGQGTILEDATIGAIAQAHDVSAAQVILRWHLQLGNVVIPKSVTPARIAA
* * : ..:: ::* :.:**::** :**.* *: * . ::
Mvan_2161|M.vanbaalenii_PYR-1 NLDVFDFELTADQMAALDGLDEG-TRFRPDPETYTGS-------------
Mflv_4205|M.gilvum_PYR-GCK NIDVFGFELSEEQMSTLNGLDDG-TRFRPDPETYSGS-------------
MSMEG_2407|M.smegmatis_MC2_155 NLDVFGFELTADEMETLNGLDDG-TRFRPDPATYTGS-------------
TH_1364|M.thermoresistible__bu NLAVFDFELTDDEMNTINGMDNG-TRYRPDPXXGEGAAAEHQSADSAAGT
MMAR_1744|M.marinum_M NLDVFEFELASQHMDAINGLNDG-TRLREDPMTFAGV-------------
MUL_1987|M.ulcerans_Agy99 NLDVFEFELASQHMDAINGLNDG-TRLREDPMTFAGV-------------
Mb2996|M.bovis_AF2122/97 NFDVFDFELAAEHMDALGGLNDG-TRVREDPLTYAGT-------------
Rv2971|M.tuberculosis_H37Rv NFDVFDFELAAEHMDALGGLNDG-TRVREDPLTYAGT-------------
MLBr_01669|M.leprae_Br4923 NFDVFDFELAVNHMDAMNELHDG-TRLRPDPETYAGS-------------
MAV_4483|M.avium_104 NLDVFDFTLEPEHMEAIEGLHDG-TRVLHDPMTFMGT-------------
MAB_1528c|M.abscessus_ATCC_199 NFDVFGFELSTDEVERITALDASDGRIGPDPTTFNLH-------------
*: ** * * :.: : :. . * **
Mvan_2161|M.vanbaalenii_PYR-1 -------------------------------------------
Mflv_4205|M.gilvum_PYR-GCK -------------------------------------------
MSMEG_2407|M.smegmatis_MC2_155 -------------------------------------------
TH_1364|M.thermoresistible__bu AVPGHPVRRGGCARRQRRPGTAADHLLHRRSDGLSVEQVDHQR
MMAR_1744|M.marinum_M -------------------------------------------
MUL_1987|M.ulcerans_Agy99 -------------------------------------------
Mb2996|M.bovis_AF2122/97 -------------------------------------------
Rv2971|M.tuberculosis_H37Rv -------------------------------------------
MLBr_01669|M.leprae_Br4923 -------------------------------------------
MAV_4483|M.avium_104 -------------------------------------------
MAB_1528c|M.abscessus_ATCC_199 -------------------------------------------