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KLTTFAAADGRTVVGIHRGDTIDVVGVDNMRELIKLTRGNPAEIERRVTGSVPAAGGRLLAPIKPTKLIH TAGNFKEHEDESKRVGWSHNVGPWIVFMQNVDAIVGPEDGIRYPDHLTKELDYELELSVVINQDVGEFAP EDAMNYVAGYVIFNDVTARDIQRDEMKSGVFGFCKGIDSFCPIGPWIVTADEIPNPHDLKMELRVNGEPR QESHSSRMWTTIPEILARYSPLGYSAGDIVTTGTVSGVAGFRVDAEDYYLRVGDSVECEVEKIGVLRNTV VPWNGTAEAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2098 | - | - | 100% (291) | fumarylacetoacetate hydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_2382 | - | 7e-29 | 35.69% (283) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2007 | - | 2e-20 | 31.76% (233) | putative HpcE protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 3e-27 | 34.92% (252) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 7e-27 | 34.28% (283) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 3e-27 | 34.92% (252) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 6e-27 | 35.78% (232) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_4361 | - | 7e-32 | 36.98% (265) | fumarylacetoacetate hydrolase family protein |
| M. marinum M | MMAR_1718 | - | 6e-28 | 33.57% (283) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 3e-29 | 34.63% (283) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. thermoresistible (build 8) | TH_2040 | - | 2e-26 | 33.92% (283) | POSSIBLE 2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD |
| M. ulcerans Agy99 | MUL_1956 | - | 9e-25 | 34.48% (232) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 8e-28 | 35.34% (283) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1718|M.marinum_M --MRLG----RIASPDGVAFASIEGELDNPGAMTAREIAEHPFGTPNFTG
MUL_1956|M.ulcerans_Agy99 --------------------------------MTAREIAEDPFGTPNFTG
MAV_3844|M.avium_104 --MRLG----RIASPDGVAFVSIEGELDNPAEMIAREIAEHPFGTPNFTG
Mb3017c|M.bovis_AF2122/97 --------------------------------MTAREIAEHPFGTPTFTG
Rv2993c|M.tuberculosis_H37Rv --------------------------------MTAREIAEHPFGTPTFTG
MLBr_01689|M.leprae_Br4923 --------------------------------MFARELAEYPFGELTFTG
Mflv_4230|M.gilvum_PYR-GCK --MRLG----RIASPDGVAFVAVEGPPDDPAAAVAREIAEHPFGTPTFTG
Mvan_2132|M.vanbaalenii_PYR-1 --MRLG----RIASPDGVAFVAIEGPPDDPGGAVAREIAEHPFGNPTFTG
TH_2040|M.thermoresistible__bu --MRLG----RIASPDGVAFVSIEGPPDEP-TAVAREIAEHPFGTPEFTG
MAB_4361|M.abscessus_ATCC_1997 --MRLYTTDRGIGREDRHGILALLDLPHRDLGELLSDTGLDPARDATVT-
MSMEG_2098|M.smegmatis_MC2_155 MKLTTFAAADGRTVVGIHRGDTIDVVGVDNMRELIKLTRGNPAEIERRVT
* .
MMAR_1718|M.marinum_M RSWPLADVRLLAPILAS-KVVCVGKNYTDH-------IAEMGGQTGPTPA
MUL_1956|M.ulcerans_Agy99 RSWPLADVRLLAPILAS-KVVCVGKNYTGH-------IAEMGGQTGPTPA
MAV_3844|M.avium_104 RSWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGEATGPVPA
Mb3017c|M.bovis_AF2122/97 RSWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGGRP---PA
Rv2993c|M.tuberculosis_H37Rv RSWPLADVRLLAPILAS-KVVCVGKNYADH-------IAEMGGRP---PA
MLBr_01689|M.leprae_Br4923 RSWPLADVRLLAPMLAS-KVVCIGKNYADH-------IVEMGGQTGLASA
Mflv_4230|M.gilvum_PYR-GCK RQWPLADVRLLAPILAS-KVVCMGKNYAAH-------IEEMGGGT---FE
Mvan_2132|M.vanbaalenii_PYR-1 RQWPLADVRLLAPILAS-KVVCMGKNYAAH-------IEEMGGGT---FE
TH_2040|M.thermoresistible__bu RQWSLADVRLLAPILAS-KVVCMGKNYAAH-------VDEMGGET---VP
MAB_4361|M.abscessus_ATCC_1997 DEVALTDVAVLAPVIRPGKILIIGLNYPSHAKEALAAFAAMGRDDIVMPT
MSMEG_2098|M.smegmatis_MC2_155 GSVPAAGGRLLAPIKPT-KLIHTAGNFKEHE------DESKRVGWSHNVG
. . :. :***: . *:: . *: *
MMAR_1718|M.marinum_M DPVIFLKPNTAIVGPNVPIRLPANA-SPVHFEGELAIVIGRPCKDVSAAQ
MUL_1956|M.ulcerans_Agy99 DPVIFLKSNTAIVGPNVPIRLPANA-SPVHFEGELAIVIGRPCKDVSAAQ
MAV_3844|M.avium_104 DPVIFLKPNTAIIGPNVPIRLPANA-SPVHFEGELAVVIGRPCKDVSAAQ
Mb3017c|M.bovis_AF2122/97 DPVIFLKPNTAIIGPNTPIRLPANA-SPVHFEGELAIVIGRACKDVPAAQ
Rv2993c|M.tuberculosis_H37Rv DPVIFLKPNTAIIGPNTPIRLPANA-SPVHFEGELAIVIGRACKDVPAAQ
MLBr_01689|M.leprae_Br4923 DPVIFLKPNTAIIGPNVPIRLPANA-SPVHFEGELALVVGRSCKDVPAVQ
Mflv_4230|M.gilvum_PYR-GCK DPIIFLKPNTAIIGPYTPIQLPADA-DPVHFEGELAAVIGRPCKDVPASR
Mvan_2132|M.vanbaalenii_PYR-1 DPIIFLKPNTAIIGPNTPIQLPADA-NPVHFEGELAAVIGRPCKDVPASR
TH_2040|M.thermoresistible__bu HPVIFIKPNTSIIGPNVPIQLPVDA-DPVHHEGELAVVIGRPCKDVPAAR
MAB_4361|M.abscessus_ATCC_1997 EPNMQLIAGSATTGTDHTIKLPAIAPDEVDYEGELAVVIGRSTHAVSVEE
MSMEG_2098|M.smegmatis_MC2_155 PWIVFMQNVDAIVGPEDGIRYPDHLTKELDYELELSVVINQDVGEFAPED
: : : *. *: * . :..* **: *:.: ..
MMAR_1718|M.marinum_M AVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPWIVT
MUL_1956|M.ulcerans_Agy99 AVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPWIVT
MAV_3844|M.avium_104 AAENILGYTIGNDVSARDQQR------SDGQWTRAKGHDTFCPVGPWIVT
Mb3017c|M.bovis_AF2122/97 AVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPWIVT
Rv2993c|M.tuberculosis_H37Rv AVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPWIVT
MLBr_01689|M.leprae_Br4923 AVDCILGYTIGNDMSARDQQR------ADGQWTRAKGHDTFCPVGPWIVT
Mflv_4230|M.gilvum_PYR-GCK AAENILGYTIANDVSARDQQK------KDGQWMRAKGHDTFCPVGPWIVT
Mvan_2132|M.vanbaalenii_PYR-1 AAENILGYTIANDVSARDQQQ------KDGQWMRAKGHDTFCPVGPWIVT
TH_2040|M.thermoresistible__bu AADVILGYTVANDVTARNQQR------ADGQWTRAKGHDTFCPVGPWIVT
MAB_4361|M.abscessus_ATCC_1997 AWKHVAGLTIANDVGARDIQRRAMTGDAAASIGVAKSFDTFKPLGPCLVT
MSMEG_2098|M.smegmatis_MC2_155 AMNYVAGYVIFNDVTARDIQRDE---MKSGVFGFCKGIDSFCPIGPWIVT
* . : * .: **: **: *: . .*. *:* *:** :**
MMAR_1718|M.marinum_M DV---DPADLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGD
MUL_1956|M.ulcerans_Agy99 DV---DPAGLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLLPGD
MAV_3844|M.avium_104 DLNPLDPGDLELRTEVNGEVKQRSRTSLLIHDIGSIVEWISAVMTLLPGD
Mb3017c|M.bovis_AF2122/97 DLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGD
Rv2993c|M.tuberculosis_H37Rv DLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLLPGD
MLBr_01689|M.leprae_Br4923 DLGPLDPADLELRTAVNGEVKQHSRTSLMIHGIGAIMEWISAVMTLLPGD
Mflv_4230|M.gilvum_PYR-GCK DI---DPSDLEIRTEVNGELKQHSRTSLMIHDIGAIIEWISSVMTLLPGD
Mvan_2132|M.vanbaalenii_PYR-1 DL---DPSDLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWISAVMTLLPGD
TH_2040|M.thermoresistible__bu DV---DPTDLELRTEVNGEVRQRSRTSLMIHDIGAIIEWVSRVMTLLPGD
MAB_4361|M.abscessus_ATCC_1997 ADEFSDGVDLTLQTYVNGELRQDDRTGSFIYPIPELIAHLSRYQTLQPGD
MSMEG_2098|M.smegmatis_MC2_155 ADEIPNPHDLKMELRVNGEPRQESHSSRMWTTIPEILARYSPLG-YSAGD
: .* :. *** :* ::. : : :: * .**
MMAR_1718|M.marinum_M LILTGTPAGVG----PIE-----DGDTVSITIEGIGTLTNPVVRKGKS--
MUL_1956|M.ulcerans_Agy99 LILTGTPAGVG----PIE-----DGDTVSITIEGIDTLTNPVVRKGKS--
MAV_3844|M.avium_104 LILTGTPAGVG----PIE-----DGDTVSITIEGIGTLTNPVVRKGKS--
Mb3017c|M.bovis_AF2122/97 LILTGTPAGVG----PIE-----DGDTVSITIEGIGTLTNPVVRKGKP--
Rv2993c|M.tuberculosis_H37Rv LILTGTPAGVG----PIE-----DGDTVSITIEGIGTLTNPVVRKGKP--
MLBr_01689|M.leprae_Br4923 LILTGTPAGVG----PVE-----DGDIVSITVEGIGTLTNPVVRKGKS--
Mflv_4230|M.gilvum_PYR-GCK LILTGTPEGVG----PLE-----HGDTVSITVEGIGTLSNPVVRKGKS--
Mvan_2132|M.vanbaalenii_PYR-1 LILTGTPEGVG----PLE-----HGDSVSITVEGIGTLTNPVVRKGRS--
TH_2040|M.thermoresistible__bu LILTGTPEGVG----PIE-----HGDTVAVTIENIGTLTNPVVRKGKK--
MAB_4361|M.abscessus_ATCC_1997 VICTGTPCGAG----AFTGRFLRSGDTVEVAIERIGLLRNRVSAA-----
MSMEG_2098|M.smegmatis_MC2_155 IVTTGTVSGVAGFRVDAEDYYLRVGDSVECEVEKIGVLRNTVVPWNGTAE
:: *** *.. ** * :* *. * * *
MMAR_1718|M.marinum_M --
MUL_1956|M.ulcerans_Agy99 --
MAV_3844|M.avium_104 --
Mb3017c|M.bovis_AF2122/97 --
Rv2993c|M.tuberculosis_H37Rv --
MLBr_01689|M.leprae_Br4923 --
Mflv_4230|M.gilvum_PYR-GCK --
Mvan_2132|M.vanbaalenii_PYR-1 --
TH_2040|M.thermoresistible__bu --
MAB_4361|M.abscessus_ATCC_1997 --
MSMEG_2098|M.smegmatis_MC2_155 AS