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MRLYTTDRGIGREDRHGILALLDLPHRDLGELLSDTGLDPARDATVTDEVALTDVAVLAPVIRPGKILII GLNYPSHAKEALAAFAAMGRDDIVMPTEPNMQLIAGSATTGTDHTIKLPAIAPDEVDYEGELAVVIGRST HAVSVEEAWKHVAGLTIANDVGARDIQRRAMTGDAAASIGVAKSFDTFKPLGPCLVTADEFSDGVDLTLQ TYVNGELRQDDRTGSFIYPIPELIAHLSRYQTLQPGDVICTGTPCGAGAFTGRFLRSGDTVEVAIERIGL LRNRVSAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4361 | - | - | 100% (288) | fumarylacetoacetate hydrolase family protein |
| M. abscessus ATCC 19977 | MAB_4355 | - | 3e-97 | 62.50% (288) | fumarylacetoacetate (FAA) hydrolase family protein |
| M. abscessus ATCC 19977 | MAB_3299c | - | 4e-33 | 41.03% (234) | hypothetical protein MAB_3299c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 2e-33 | 39.74% (234) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 2e-32 | 40.93% (237) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 2e-33 | 39.74% (234) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 7e-33 | 39.74% (234) | putative hydrolase |
| M. marinum M | MMAR_1718 | - | 1e-33 | 39.74% (234) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 6e-36 | 41.45% (234) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. smegmatis MC2 155 | MSMEG_2382 | - | 3e-34 | 41.88% (234) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. thermoresistible (build 8) | TH_3311 | - | 4e-36 | 37.66% (231) | PUTATIVE putative HpcE protein |
| M. ulcerans Agy99 | MUL_1956 | - | 2e-32 | 38.89% (234) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_2132 | - | 7e-31 | 39.24% (237) | 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3017c|M.bovis_AF2122/97 -----------------------------------MTAREIAEHPFGTPT
Rv2993c|M.tuberculosis_H37Rv -----------------------------------MTAREIAEHPFGTPT
MMAR_1718|M.marinum_M MRLGR----IASPDG-----VAFASIEGELDNPGAMTAREIAEHPFGTPN
MUL_1956|M.ulcerans_Agy99 -----------------------------------MTAREIAEDPFGTPN
MAV_3844|M.avium_104 MRLGR----IASPDG-----VAFVSIEGELDNPAEMIAREIAEHPFGTPN
MLBr_01689|M.leprae_Br4923 -----------------------------------MFARELAEYPFGELT
Mflv_4230|M.gilvum_PYR-GCK MRLGR----IASPDG-----VAFVAVEGPPDDPAAAVAREIAEHPFGTPT
Mvan_2132|M.vanbaalenii_PYR-1 MRLGR----IASPDG-----VAFVAIEGPPDDPGGAVAREIAEHPFGNPT
MSMEG_2382|M.smegmatis_MC2_155 MRLGR----IASPDG-----VAFVSIEG--DGPD-AVCKEIAEHPFGNPN
MAB_4361|M.abscessus_ATCC_1997 MRLYTTDRGIGREDR-----HGILALLDLPHRDLGELLSDTGLDPARDAT
TH_3311|M.thermoresistible__bu MRLINQGGRLKIDVDGLAADVEKTSDYRFSADPQEIYARWEEFTAWASAA
.
Mb3017c|M.bovis_AF2122/97 FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAE-------MGGRP--
Rv2993c|M.tuberculosis_H37Rv FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAE-------MGGRP--
MMAR_1718|M.marinum_M FTGRSWPLADVRLLAPILAS-KVVCVGKNYTDHIAE-------MGGQTGP
MUL_1956|M.ulcerans_Agy99 FTGRSWPLADVRLLAPILAS-KVVCVGKNYTGHIAE-------MGGQTGP
MAV_3844|M.avium_104 FTGRSWPLADVRLLAPILAS-KVVCVGKNYADHIAE-------MGEATGP
MLBr_01689|M.leprae_Br4923 FTGRSWPLADVRLLAPMLAS-KVVCIGKNYADHIVE-------MGGQTGL
Mflv_4230|M.gilvum_PYR-GCK FTGRQWPLADVRLLAPILAS-KVVCMGKNYAAHIEE-------MGGGT--
Mvan_2132|M.vanbaalenii_PYR-1 FTGRQWPLADVRLLAPILAS-KVVCMGKNYAAHIEE-------MGGGT--
MSMEG_2382|M.smegmatis_MC2_155 FTGRSWPLADVRLLAPILAS-KVIAVGKNYAAHAEE-------MGGVA--
MAB_4361|M.abscessus_ATCC_1997 VT-DEVALTDVAVLAPVIRPGKILIIGLNYPSHAKEALAAFAAMGRDDIV
TH_3311|M.thermoresistible__bu DLSGGDPIVEAELGPPVPRPAQVFAIGINYRDHMDE-------AGLSE--
.:.:. : .*: . ::. :* ** * * *
Mb3017c|M.bovis_AF2122/97 -PADPVIFLKPNTAIIGPNTPIRLPANA-SPVHFEGELAIVIGRACKDVP
Rv2993c|M.tuberculosis_H37Rv -PADPVIFLKPNTAIIGPNTPIRLPANA-SPVHFEGELAIVIGRACKDVP
MMAR_1718|M.marinum_M TPADPVIFLKPNTAIVGPNVPIRLPANA-SPVHFEGELAIVIGRPCKDVS
MUL_1956|M.ulcerans_Agy99 TPADPVIFLKSNTAIVGPNVPIRLPANA-SPVHFEGELAIVIGRPCKDVS
MAV_3844|M.avium_104 VPADPVIFLKPNTAIIGPNVPIRLPANA-SPVHFEGELAVVIGRPCKDVS
MLBr_01689|M.leprae_Br4923 ASADPVIFLKPNTAIIGPNVPIRLPANA-SPVHFEGELALVVGRSCKDVP
Mflv_4230|M.gilvum_PYR-GCK -FEDPIIFLKPNTAIIGPYTPIQLPADA-DPVHFEGELAAVIGRPCKDVP
Mvan_2132|M.vanbaalenii_PYR-1 -FEDPIIFLKPNTAIIGPNTPIQLPADA-NPVHFEGELAAVIGRPCKDVP
MSMEG_2382|M.smegmatis_MC2_155 -PEDPVIFLKPNTAIIGPNVPIQLPADA-DPVHHEGELAIVIGRPCKDVP
MAB_4361|M.abscessus_ATCC_1997 MPTEPNMQLIAGSATTGTDHTIKLPAIAPDEVDYEGELAVVIGRSTHAVS
TH_3311|M.thermoresistible__bu -PEAPFVFTKFPAAITGPYDVIELPDGS---VDWEVELVAVIGRRAHRVS
* : :* *. *.** : *. * **. *:** : *.
Mb3017c|M.bovis_AF2122/97 AAQAVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPW
Rv2993c|M.tuberculosis_H37Rv AAQAVDNILGYTIGNDVSARDQQQ------SDGQWTRAKGHDTFCPVGPW
MMAR_1718|M.marinum_M AAQAVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPW
MUL_1956|M.ulcerans_Agy99 AAQAVDNILGYTIGNDVSARDQQK------SDGQWTRAKGHDTFCPVGPW
MAV_3844|M.avium_104 AAQAAENILGYTIGNDVSARDQQR------SDGQWTRAKGHDTFCPVGPW
MLBr_01689|M.leprae_Br4923 AVQAVDCILGYTIGNDMSARDQQR------ADGQWTRAKGHDTFCPVGPW
Mflv_4230|M.gilvum_PYR-GCK ASRAAENILGYTIANDVSARDQQK------KDGQWMRAKGHDTFCPVGPW
Mvan_2132|M.vanbaalenii_PYR-1 ASRAAENILGYTIANDVSARDQQQ------KDGQWMRAKGHDTFCPVGPW
MSMEG_2382|M.smegmatis_MC2_155 AARAAEFILGYTIGNDVSARDQQR------KDGQWMRAKGHDTFCPLGPW
MAB_4361|M.abscessus_ATCC_1997 VEEAWKHVAGLTIANDVGARDIQRRAMTGDAAASIGVAKSFDTFKPLGPC
TH_3311|M.thermoresistible__bu ERDGWNYVAGLTVGQDLSERELQLS---GPPPQQFNLGKSYTGFAPIGPA
. . : * *:.:*:. *: * . .*.. * *:**
Mb3017c|M.bovis_AF2122/97 IVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLL
Rv2993c|M.tuberculosis_H37Rv IVTDLAPFDPADLELRTVVNGDVKQHARTSLMIHDIGAIVEWISAIMTLL
MMAR_1718|M.marinum_M IVTDV---DPADLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLL
MUL_1956|M.ulcerans_Agy99 IVTDV---DPAGLELRTEVNGAVKQHARTSLMIHDVGAIVEWISAVMTLL
MAV_3844|M.avium_104 IVTDLNPLDPGDLELRTEVNGEVKQRSRTSLLIHDIGSIVEWISAVMTLL
MLBr_01689|M.leprae_Br4923 IVTDLGPLDPADLELRTAVNGEVKQHSRTSLMIHGIGAIMEWISAVMTLL
Mflv_4230|M.gilvum_PYR-GCK IVTDI---DPSDLEIRTEVNGELKQHSRTSLMIHDIGAIIEWISSVMTLL
Mvan_2132|M.vanbaalenii_PYR-1 IVTDL---DPSDLEIRTEVNGDVKQRSRTSLMIHDIGAIIEWISAVMTLL
MSMEG_2382|M.smegmatis_MC2_155 IVTDL---DPSDVELRTEVNGQVRQRSRTSLLLHDIGRLVEWTSAVMTLL
MAB_4361|M.abscessus_ATCC_1997 LVTADEFSDGVDLTLQTYVNGELRQDDRTGSFIYPIPELIAHLSRYQTLQ
TH_3311|M.thermoresistible__bu VVTLDEFADPADVEISTTLSGELMQLARTRDVFFSVPQLVAYLSQILPLL
:** * .: : * :.* : * ** .:. : :: * .*
Mb3017c|M.bovis_AF2122/97 PGDLILTGTPAGVGPIE-------DGDTVSITIEGIGTLTNPVVRKGKP-
Rv2993c|M.tuberculosis_H37Rv PGDLILTGTPAGVGPIE-------DGDTVSITIEGIGTLTNPVVRKGKP-
MMAR_1718|M.marinum_M PGDLILTGTPAGVGPIE-------DGDTVSITIEGIGTLTNPVVRKGKS-
MUL_1956|M.ulcerans_Agy99 PGDLILTGTPAGVGPIE-------DGDTVSITIEGIDTLTNPVVRKGKS-
MAV_3844|M.avium_104 PGDLILTGTPAGVGPIE-------DGDTVSITIEGIGTLTNPVVRKGKS-
MLBr_01689|M.leprae_Br4923 PGDLILTGTPAGVGPVE-------DGDIVSITVEGIGTLTNPVVRKGKS-
Mflv_4230|M.gilvum_PYR-GCK PGDLILTGTPEGVGPLE-------HGDTVSITVEGIGTLSNPVVRKGKS-
Mvan_2132|M.vanbaalenii_PYR-1 PGDLILTGTPEGVGPLE-------HGDSVSITVEGIGTLTNPVVRKGRS-
MSMEG_2382|M.smegmatis_MC2_155 PGDVILTGTPEGVGPIE-------DGDTVSITVEGIGTLTNPVVRKGKK-
MAB_4361|M.abscessus_ATCC_1997 PGDVICTGTPCGAGAFTG--RFLRSGDTVEVAIERIGLLRNRVSAA----
TH_3311|M.thermoresistible__bu PGDLIFTGTPSGIGWARTPKRFIDSDDELVTRAEGIGEMRHRFTRADRSV
***:* **** * * .* : * *. : : .
Mb3017c|M.bovis_AF2122/97 --------
Rv2993c|M.tuberculosis_H37Rv --------
MMAR_1718|M.marinum_M --------
MUL_1956|M.ulcerans_Agy99 --------
MAV_3844|M.avium_104 --------
MLBr_01689|M.leprae_Br4923 --------
Mflv_4230|M.gilvum_PYR-GCK --------
Mvan_2132|M.vanbaalenii_PYR-1 --------
MSMEG_2382|M.smegmatis_MC2_155 --------
MAB_4361|M.abscessus_ATCC_1997 --------
TH_3311|M.thermoresistible__bu AKGNRING