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MTVREPSPYTPRAELRDVTLRDGLQLTAKTLPTELKIEVVRELLRLGVPALEIGSMARADLVPTLADTLD VVAALTPEELDRCWIWVATPRHVEKAAAAGARKFQYCLSASDAHNKANIGRDTETSVAAMPDAIRIAHEA GGEIQLCIATAFTCPFDGLVDPQRVWGIAADPRTSGAVDIVVCDTIGQAIPTQVSALIHGLHPVNPERRI VFHGHDTWGLGVANTLAAIDAGATMVDGSLGGLGGCPFAPGASGNTSSEDLLFALRPDWLTPSAFESLVL LSEKILAELGEPNRSKAAQGARSKARAFGWVIDA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2024 | - | - | 100% (314) | hydroxymethylglutaryl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_2072 | - | 3e-51 | 40.32% (253) | 3-hydroxy-3-methylglutaryl-CoA lyase |
| M. smegmatis MC2 155 | MSMEG_4150 | - | 4e-08 | 22.31% (251) | 4-hydroxy-2-ketovalerate aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3498c | mhpE | 1e-08 | 26.00% (250) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_4466 | - | 9e-50 | 40.32% (253) | pyruvate carboxyltransferase |
| M. tuberculosis H37Rv | Rv3469c | mhpE | 1e-08 | 26.00% (250) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4650c | - | 4e-41 | 35.32% (252) | putative pyruvate carboxyltransferase |
| M. marinum M | MMAR_1493 | - | 3e-45 | 38.28% (256) | hypothetical protein MMAR_1493 |
| M. avium 104 | MAV_4025 | - | 2e-47 | 39.86% (276) | pyruvate carboxyltransferase |
| M. thermoresistible (build 8) | TH_4346 | - | 3e-25 | 30.83% (253) | PUTATIVE putative hydroxymethylglutaryl-CoA lyase |
| M. ulcerans Agy99 | MUL_2447 | - | 1e-45 | 38.28% (256) | hypothetical protein MUL_2447 |
| M. vanbaalenii PYR-1 | Mvan_1894 | - | 2e-51 | 41.11% (253) | pyruvate carboxyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1493|M.marinum_M ------------------------MTTHVTIREVALRDGLQIEK-PVPLS
MUL_2447|M.ulcerans_Agy99 ------------------------MTTHVTIREVALRDGLQIEK-PVPLS
MAV_4025|M.avium_104 ----------------------------MAIREVALRDGLQIEA-PIPLS
Mflv_4466|M.gilvum_PYR-GCK ---------------------MTELPTHVDIRDVSLRDGLQIED-PIPLS
Mvan_1894|M.vanbaalenii_PYR-1 ---------------------MSELPGHVDIRDVSLRDGLQIED-PIPLS
MAB_4650c|M.abscessus_ATCC_199 ----------------------MSLPEHVSIREVLLRDGLQLET-PIALA
TH_4346|M.thermoresistible__bu VTVPSPVAPPSRDAAGSARPALPGLPDSIELVEVGLRDGLQAVTRPVPTA
MSMEG_2024|M.smegmatis_MC2_155 ----------------MTVREPSPYTPRAELRDVTLRDGLQLTAKTLPTE
Mb3498c|M.bovis_AF2122/97 -------------------MLMTATHREPIVLDTTVRDGSYAVNFQYTDD
Rv3469c|M.tuberculosis_H37Rv -------------------MLMTATHREPIVLDTTVRDGSYAVNFQYTDD
: :. :*** .
MMAR_1493|M.marinum_M AKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAELHSYPDIEFS
MUL_2447|M.ulcerans_Agy99 AKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAELHSYPDIEFS
MAV_4025|M.avium_104 AKLELLAAVAATGVREVEATAFVSPSKVPSMADAADLAAHLADYPDIEFS
Mflv_4466|M.gilvum_PYR-GCK AKLELLASIAATGVTEMEATAFVSPSKVPALADAAELAAELHNFPGIEFS
Mvan_1894|M.vanbaalenii_PYR-1 AKLELLAAIAATGVREMEATAFVSPSKVPALADAADLAAELRNFPDIEFS
MAB_4650c|M.abscessus_ATCC_199 DKLKLLEAVAATGVREVEATAFVSPTKMPALADAAELAAQLHHYPDIEFS
TH_4346|M.thermoresistible__bu EKVAIVEGLINAGFRTIEAVSFAHPKVLPQLADAEAVMAAVPRPPDVTYR
MSMEG_2024|M.smegmatis_MC2_155 LKIEVVRELLRLGVPALEIGSMARADLVPTLADTLDVVAALTPEELDRCW
Mb3498c|M.bovis_AF2122/97 DVRRIVGDLDAAGIPYIEIGHGVTIG-----AAAAQGPAAHTDEEYFRAA
Rv3469c|M.tuberculosis_H37Rv DVRRIVGDLDAAGIPYIEIGHGVTIG-----AAAAQGPAAHTDEEYFRAA
:: : *. :* . * : *
MMAR_1493|M.marinum_M ALVASPNGARRAIAAGLHAIEYVVAASNSFSMANVGRSTADATDQISEIL
MUL_2447|M.ulcerans_Agy99 ALVASPNGARRAIAAGLHAIEYVVAASNSFSMANVGRSTADATDQISEIL
MAV_4025|M.avium_104 ALVASPNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQIGDIV
Mflv_4466|M.gilvum_PYR-GCK ALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRASAEATAQIAEIT
Mvan_1894|M.vanbaalenii_PYR-1 ALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRSSAEATAQIPEIV
MAB_4650c|M.abscessus_ATCC_199 ALVASPNGAKRALAAGFTSLEYVVSAADGHSRANVGISSAEAIARIQEIV
TH_4346|M.thermoresistible__bu GLVPNLRGAHRAVACGLDEWVLVVSADEEVSVRNQRRTVEQMLTELPGVA
MSMEG_2024|M.smegmatis_MC2_155 IWVATPRHVEKAAAAGARKFQYCLSASDAHNKANIGRDTETSVAAMPDAI
Mb3498c|M.bovis_AF2122/97 RSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVE
Rv3469c|M.tuberculosis_H37Rv RSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVE
* . . . * : . . :
MMAR_1493|M.marinum_M AIGRDGE---VTVEVIVATAWDCPFDGAVAPQQVLDIAATAVGQGVDRFS
MUL_2447|M.ulcerans_Agy99 AIGRDGE---VTVEVIVATAWDCPFDGAVAPQQVLDIAATAVDQGVDRFS
MAV_4025|M.avium_104 AIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVLDIAAAARDRGADRLS
Mflv_4466|M.gilvum_PYR-GCK AIAHDSD---ASVEVIIATAWDCPFDGPTAPQRVIDIVTAATDAGADRMA
Mvan_1894|M.vanbaalenii_PYR-1 AIAHDSG---VSVEVIVATAWDCPFDGPTAPQRVVDIVTAAADGGVDRLA
MAB_4650c|M.abscessus_ATCC_199 TLARGAD---ATVEVIVACSWDCPFDGPTAQKRVLDIMQRARDWGADRYA
TH_4346|M.thermoresistible__bu ALARESG---VRLIVAVACAFFAPARGPVPRQEYLRVVDAAVDTGVDALY
MSMEG_2024|M.smegmatis_MC2_155 RIAHEAG---GEIQLCIATAFTCPFDGLVDPQRVWGIAADPRTSGAVDIV
Mb3498c|M.bovis_AF2122/97 RAQSKG----------LEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVY
Rv3469c|M.tuberculosis_H37Rv RAQSKG----------LEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVY
. : : . . *.
MMAR_1493|M.marinum_M IADTIGTATPGRVSALIAQLGPVLGDMPLGAHFHNTRGSGLASAYAAVCS
MUL_2447|M.ulcerans_Agy99 IADTIGTATPGRVSALIAQLGPVLGDMPLGAHFHNTRGSGLASAYAAVCS
MAV_4025|M.avium_104 IADTIGTATPGRVSSLIAQLLPVIGDMPLGGHFHNTRGCGLASAYAAVGA
Mflv_4466|M.gilvum_PYR-GCK IADTIGTATPRRVGDLIALVRPLVGDTPLGAHFHNTRGAGLASAFAAVSA
Mvan_1894|M.vanbaalenii_PYR-1 IADTIGTATPRRVSDLIGMVRPRIVDIPLGAHFHNTRGAGLASAYAAVSA
MAB_4650c|M.abscessus_ATCC_199 LADTIGTATPRRVANLIAAVRSIIGDAPLGAHFHNTRGSGLASAYAAVQS
TH_4346|M.thermoresistible__bu LACTTGQEHPGEVAERVGEVRRRHPAVRVGVHLHNRNGFAAANAIAAMQA
MSMEG_2024|M.smegmatis_MC2_155 VCDTIGQAIPTQVSALIHGLHPVNPERRIVFHGHDTWGLGVANTLAAIDA
Mb3498c|M.bovis_AF2122/97 VVDTTGTFLPEDARRYVEALRGAS-DVSVGFHGHNNLAMAVANTLEAFDA
Rv3469c|M.tuberculosis_H37Rv VVDTTGTFLPEDARRYVEALRGAS-DVSVGFHGHNNLAMAVANTLEAFDA
: * * * . : : : * *: . . *.: *. :
MMAR_1493|M.marinum_M GVTRLDASVGGLGG--------CPFAPG---ATGNIATEDLVYLLADS--
MUL_2447|M.ulcerans_Agy99 GVTRLDASVGGLGG--------CPFAPG---ATGNIATEDLVYLLADS--
MAV_4025|M.avium_104 GVTRLDASVGGLGG--------CPFAPG---ATGNIATEDLVYLLTDS--
Mflv_4466|M.gilvum_PYR-GCK GVTRLDASVGGLGG--------CPFAPG---ASGNIAVEDLVYLLRDS--
Mvan_1894|M.vanbaalenii_PYR-1 GVTRLDASVGGLGG--------CPFAPG---ASGNIAVEDLVYLLRDS--
MAB_4650c|M.abscessus_ATCC_199 GVTRLDSSIGGLGG--------CPFAPG---ATGNIATEDLAYLLRDS--
TH_4346|M.thermoresistible__bu GAAWLEGSFCGLGG--------DLWFPGDPSVLGNAPMEDLIHLCDAL--
MSMEG_2024|M.smegmatis_MC2_155 GATMVDGSLGGLGG--------CPFAPG---ASGNTSSEDLLFALRPD--
Mb3498c|M.bovis_AF2122/97 GADFLDGTLMGFGRGAGNCQIECLVAALQ--RRGHLAAVDLDRIFDAARS
Rv3469c|M.tuberculosis_H37Rv GADFLDGTLMGFGRGAGNCQIECLVAALQ--RRGHLAAVDLDRIFDAARS
*. ::.:. *:* . *: . **
MMAR_1493|M.marinum_M -----------------GFAVDVDLAAAIAAAEVAKAVVGHDLPGALLRA
MUL_2447|M.ulcerans_Agy99 -----------------GFAVDVDLAAAIAAAEVAKAVVGHDLPGALLRA
MAV_4025|M.avium_104 -----------------GFDVDVDLQAAIAAAGVAKTLVGHDLPSALLRA
Mflv_4466|M.gilvum_PYR-GCK -----------------GIHTEVDLDAAIAAARVAQDVVGHSLPSSLLRA
Mvan_1894|M.vanbaalenii_PYR-1 -----------------GIHVDVDLESAIEAARVAQDAVGHELPSSLLRA
MAB_4650c|M.abscessus_ATCC_199 -----------------DVNVDINLDAAIAAAQIVQEVVGHEVPSALLRA
TH_4346|M.thermoresistible__bu -----------------GVRTGISLPDYLDVARLAEQLTGVPTTAFVARG
MSMEG_2024|M.smegmatis_MC2_155 -----------------WLTPSAFESLVLLSEKILAELGEPNRSKAAQGA
Mb3498c|M.bovis_AF2122/97 DMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQT
Rv3469c|M.tuberculosis_H37Rv DMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQT
. : .
MMAR_1493|M.marinum_M GDRIRS-----------------
MUL_2447|M.ulcerans_Agy99 GDRIRS-----------------
MAV_4025|M.avium_104 GDRRRS-----------------
Mflv_4466|M.gilvum_PYR-GCK GDRILG-----------------
Mvan_1894|M.vanbaalenii_PYR-1 GDRILG-----------------
MAB_4650c|M.abscessus_ATCC_199 GDRLLN-----------------
TH_4346|M.thermoresistible__bu GSRHDLATAQWSETV--------
MSMEG_2024|M.smegmatis_MC2_155 RSKARAFGWVIDA----------
Mb3498c|M.bovis_AF2122/97 AKSHAGQWLSPQDIDRVVVGMRA
Rv3469c|M.tuberculosis_H37Rv AKSHAGQWLSPQDIDRVVVGMRA
.