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TTHVTIREVALRDGLQIEKPVPLSAKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAELHSYPD IEFSALVASPNGARRAIAAGLHAIEYVVAASNSFSMANVGRSTADATDQISEILAIGRDGEVTVEVIVAT AWDCPFDGAVAPQQVLDIAATAVGQGVDRFSIADTIGTATPGRVSALIAQLGPVLGDMPLGAHFHNTRGS GLASAYAAVCSGVTRLDASVGGLGGCPFAPGATGNIATEDLVYLLADSGFAVDVDLAAAIAAAEVAKAVV GHDLPGALLRAGDRIRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1493 | - | - | 100% (298) | hypothetical protein MMAR_1493 |
| M. marinum M | MMAR_5021 | - | 2e-06 | 24.21% (285) | 4-hydroxy-2-oxovalerate aldolase |
| M. marinum M | MMAR_1506 | - | 3e-05 | 28.35% (127) | 4-hydroxy-2-oxovalerate aldolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3564c | - | 9e-07 | 28.68% (129) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_4466 | - | 1e-122 | 73.65% (296) | pyruvate carboxyltransferase |
| M. tuberculosis H37Rv | Rv3534c | - | 9e-07 | 28.68% (129) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | MLBr_01828 | PPE | 2e-05 | 24.32% (222) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4650c | - | 1e-113 | 69.28% (293) | putative pyruvate carboxyltransferase |
| M. avium 104 | MAV_4025 | - | 1e-131 | 81.48% (297) | pyruvate carboxyltransferase |
| M. smegmatis MC2 155 | MSMEG_2072 | - | 1e-126 | 74.32% (296) | 3-hydroxy-3-methylglutaryl-CoA lyase |
| M. thermoresistible (build 8) | TH_4346 | - | 1e-37 | 32.20% (295) | PUTATIVE putative hydroxymethylglutaryl-CoA lyase |
| M. ulcerans Agy99 | MUL_2447 | - | 1e-163 | 99.66% (298) | hypothetical protein MUL_2447 |
| M. vanbaalenii PYR-1 | Mvan_1894 | - | 1e-122 | 75.43% (293) | pyruvate carboxyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3564c|M.bovis_AF2122/97 ---------------------------------------------MTDMW
Rv3534c|M.tuberculosis_H37Rv ---------------------------------------------MTDMW
MMAR_1493|M.marinum_M -----------------------------------------------MTT
MUL_2447|M.ulcerans_Agy99 -----------------------------------------------MTT
MAV_4025|M.avium_104 --------------------------------------------------
Mflv_4466|M.gilvum_PYR-GCK --------------------------------------------MTELPT
Mvan_1894|M.vanbaalenii_PYR-1 --------------------------------------------MSELPG
MSMEG_2072|M.smegmatis_MC2_155 ---------------------------------------------MDLPT
MAB_4650c|M.abscessus_ATCC_199 ---------------------------------------------MSLPE
TH_4346|M.thermoresistible__bu -----------------------VTVPSPVAPPSRDAAGSARPALPGLPD
MLBr_01828|M.leprae_Br4923 MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSVYAEMADELVA
Mb3564c|M.bovis_AF2122/97 DVRITDTSLRDGSHHKRHQFTKD------EVGAIVAALDAAGVPVIEVTH
Rv3534c|M.tuberculosis_H37Rv DVRITDTSLRDGSHHKRHQFTKD------EVGAIVAALDAAGVPVIEVTH
MMAR_1493|M.marinum_M HVTIREVALRDGLQIEK-PVPLS------AKLELLAAVAATGVREVEATA
MUL_2447|M.ulcerans_Agy99 HVTIREVALRDGLQIEK-PVPLS------AKLELLAAVAATGVREVEATA
MAV_4025|M.avium_104 -MAIREVALRDGLQIEA-PIPLS------AKLELLAAVAATGVREVEATA
Mflv_4466|M.gilvum_PYR-GCK HVDIRDVSLRDGLQIED-PIPLS------AKLELLASIAATGVTEMEATA
Mvan_1894|M.vanbaalenii_PYR-1 HVDIRDVSLRDGLQIED-PIPLS------AKLELLAAIAATGVREMEATA
MSMEG_2072|M.smegmatis_MC2_155 HVDIREVCLRDGLQIEQ-PIPLS------AKLEILEAIAATGVREIEATA
MAB_4650c|M.abscessus_ATCC_199 HVSIREVLLRDGLQLET-PIALA------DKLKLLEAVAATGVREVEATA
TH_4346|M.thermoresistible__bu SIELVEVGLRDGLQAVTRPVPTA------EKVAIVEGLINAGFRTIEAVS
MLBr_01828|M.leprae_Br4923 LLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMAAHYETMATAY
: : . ** .. : .: : : ..
Mb3564c|M.bovis_AF2122/97 GDG-------LGGSSFNYGFSKTPEQELIKLAAAT---------------
Rv3534c|M.tuberculosis_H37Rv GDG-------LGGSSFNYGFSKTPEQELIKLAAAT---------------
MMAR_1493|M.marinum_M FVSPSKVPSMADAAELAAELHSYPDIEFSALVASPNG-------------
MUL_2447|M.ulcerans_Agy99 FVSPSKVPSMADAAELAAELHSYPDIEFSALVASPNG-------------
MAV_4025|M.avium_104 FVSPSKVPSMADAADLAAHLADYPDIEFSALVASPNG-------------
Mflv_4466|M.gilvum_PYR-GCK FVSPSKVPALADAAELAAELHNFPGIEFSALVASPNG-------------
Mvan_1894|M.vanbaalenii_PYR-1 FVSPSKVPALADAADLAAELRNFPDIEFSALVASPNG-------------
MSMEG_2072|M.smegmatis_MC2_155 FVSPSKVPALADAAELAAELHRFPDVEFSALVASPNG-------------
MAB_4650c|M.abscessus_ATCC_199 FVSPTKMPALADAAELAAQLHHYPDIEFSALVASPNG-------------
TH_4346|M.thermoresistible__bu FAHPKVLPQLADAEAVMAAVPRPPDVTYRGLVPNLRG-------------
MLBr_01828|M.leprae_Br4923 ITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNEIDYVRMWVEA
: .
Mb3564c|M.bovis_AF2122/97 ------------------AKEARIAFLMLPGVGTKDDIKEARDNGGSICR
Rv3534c|M.tuberculosis_H37Rv ------------------AKEARIAFLMLPGVGTKDDIKEARDNGGSICR
MMAR_1493|M.marinum_M -----------------ARRAIAAGLHAIEYVVAASNSFSMANVGRSTAD
MUL_2447|M.ulcerans_Agy99 -----------------ARRAIAAGLHAIEYVVAASNSFSMANVGRSTAD
MAV_4025|M.avium_104 -----------------ARRAVAAGLRAIEYVVAADDTFSAANVGRTSAE
Mflv_4466|M.gilvum_PYR-GCK -----------------AKRAIAAGLRSIEYVVSAADGHSRANVGRASAE
Mvan_1894|M.vanbaalenii_PYR-1 -----------------AKRAIAAGLRSIEYVVSAADGHSRANVGRSSAE
MSMEG_2072|M.smegmatis_MC2_155 -----------------AKRAIAAGLHSIEYVVSAADSHSKANVGRSSAE
MAB_4650c|M.abscessus_ATCC_199 -----------------AKRALAAGFTSLEYVVSAADGHSRANVGISSAE
TH_4346|M.thermoresistible__bu -----------------AHRAVACGLDEWVLVVSADEEVSVRNQRRTVEQ
MLBr_01828|M.leprae_Br4923 AIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQPSPTAPSQSPQ
. . .
Mb3564c|M.bovis_AF2122/97 IATHCTEADVSIQHFG---LARELGLETVGFLMMAHTIA-----------
Rv3534c|M.tuberculosis_H37Rv IATHCTEADVSIQHFG---LARELGLETVGFLMMAHTIA-----------
MMAR_1493|M.marinum_M ATDQISEILAIGRDGE---VTVEVIVATAWDCPFDGAVA-----------
MUL_2447|M.ulcerans_Agy99 ATDQISEILAIGRDGE---VTVEVIVATAWDCPFDGAVA-----------
MAV_4025|M.avium_104 ATEQIGDIVAIAHDGPGPPVTVEVVIATAWDSPFEGPTP-----------
Mflv_4466|M.gilvum_PYR-GCK ATAQIAEITAIAHDSD---ASVEVIIATAWDCPFDGPTA-----------
Mvan_1894|M.vanbaalenii_PYR-1 ATAQIPEIVAIAHDSG---VSVEVIVATAWDCPFDGPTA-----------
MSMEG_2072|M.smegmatis_MC2_155 ATAQIADIVAIAHDSD---TSVEVIIATAWDCPFDGPTD-----------
MAB_4650c|M.abscessus_ATCC_199 AIARIQEIVTLARGAD---ATVEVIVACSWDCPFDGPTA-----------
TH_4346|M.thermoresistible__bu MLTELPGVAALARESG---VRLIVAVACAFFAPARGPVP-----------
MLBr_01828|M.leprae_Br4923 VQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFSGFDPWLPSLGN
:
Mb3564c|M.bovis_AF2122/97 ------PEKLAAQARIMADAG-----------------------------
Rv3534c|M.tuberculosis_H37Rv ------PEKLAAQARIMADAG-----------------------------
MMAR_1493|M.marinum_M ------PQQVLDIAATAVGQG-----------------------------
MUL_2447|M.ulcerans_Agy99 ------PQQVLDIAATAVDQG-----------------------------
MAV_4025|M.avium_104 ------PQRVLDIAAAARDRG-----------------------------
Mflv_4466|M.gilvum_PYR-GCK ------PQRVIDIVTAATDAG-----------------------------
Mvan_1894|M.vanbaalenii_PYR-1 ------PQRVVDIVTAAADGG-----------------------------
MSMEG_2072|M.smegmatis_MC2_155 ------PQRVLDIVSAAVEYG-----------------------------
MAB_4650c|M.abscessus_ATCC_199 ------QKRVLDIMQRARDWG-----------------------------
TH_4346|M.thermoresistible__bu ------RQEYLRVVDAAVDTG-----------------------------
MLBr_01828|M.leprae_Br4923 PLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLAAAFASGNPVTI
. *
Mb3564c|M.bovis_AF2122/97 -----CQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGL
Rv3534c|M.tuberculosis_H37Rv -----CQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGL
MMAR_1493|M.marinum_M -----VDRFSIADTIGTATPGRVSALIAQLGPVLG-DMPLGAHFHNTRGS
MUL_2447|M.ulcerans_Agy99 -----VDRFSIADTIGTATPGRVSALIAQLGPVLG-DMPLGAHFHNTRGS
MAV_4025|M.avium_104 -----ADRLSIADTIGTATPGRVSSLIAQLLPVIG-DMPLGGHFHNTRGC
Mflv_4466|M.gilvum_PYR-GCK -----ADRMAIADTIGTATPRRVGDLIALVRPLVG-DTPLGAHFHNTRGA
Mvan_1894|M.vanbaalenii_PYR-1 -----VDRLAIADTIGTATPRRVSDLIGMVRPRIV-DIPLGAHFHNTRGA
MSMEG_2072|M.smegmatis_MC2_155 -----ADRLAVADTIGTTTPRRVTTLVQQVRPLIG-DLPLGAHFHNTRGA
MAB_4650c|M.abscessus_ATCC_199 -----ADRYALADTIGTATPRRVANLIAAVRSIIG-DAPLGAHFHNTRGS
TH_4346|M.thermoresistible__bu -----VDALYLACTTGQEHPGEVAERVGEVRRRHP-AVRVGVHLHNRNGF
MLBr_01828|M.leprae_Br4923 GFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILPLLTAPLAVATA
: * : :
Mb3564c|M.bovis_AF2122/97 GVANSVAAVRAGAKQIDGSCRRFG-----AG-------------------
Rv3534c|M.tuberculosis_H37Rv GVANSVAAVRAGAKQIDGSCRRFG-----AG-------------------
MMAR_1493|M.marinum_M GLASAYAAVCSGVTRLDASVGGLGGCPFAPG-------------------
MUL_2447|M.ulcerans_Agy99 GLASAYAAVCSGVTRLDASVGGLGGCPFAPG-------------------
MAV_4025|M.avium_104 GLASAYAAVGAGVTRLDASVGGLGGCPFAPG-------------------
Mflv_4466|M.gilvum_PYR-GCK GLASAFAAVSAGVTRLDASVGGLGGCPFAPG-------------------
Mvan_1894|M.vanbaalenii_PYR-1 GLASAYAAVSAGVTRLDASVGGLGGCPFAPG-------------------
MSMEG_2072|M.smegmatis_MC2_155 GLASAYAAVQAGITRLDASVGGLGGCPFAPG-------------------
MAB_4650c|M.abscessus_ATCC_199 GLASAYAAVQSGVTRLDSSIGGLGGCPFAPG-------------------
TH_4346|M.thermoresistible__bu AAANAIAAMQAGAAWLEGSFCGLGGDLWFPGDP-----------------
MLBr_01828|M.leprae_Br4923 GAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPSMPTLASIPTPT
. *.: *.: : : : ..
Mb3564c|M.bovis_AF2122/97 --------------------------AGNAPVEALIGVFD----------
Rv3534c|M.tuberculosis_H37Rv --------------------------AGNAPVEALIGVFD----------
MMAR_1493|M.marinum_M -------------------------ATGNIATEDLVYLLA----------
MUL_2447|M.ulcerans_Agy99 -------------------------ATGNIATEDLVYLLA----------
MAV_4025|M.avium_104 -------------------------ATGNIATEDLVYLLT----------
Mflv_4466|M.gilvum_PYR-GCK -------------------------ASGNIAVEDLVYLLR----------
Mvan_1894|M.vanbaalenii_PYR-1 -------------------------ASGNIAVEDLVYLLR----------
MSMEG_2072|M.smegmatis_MC2_155 -------------------------ASGNIATEDLVYLLR----------
MAB_4650c|M.abscessus_ATCC_199 -------------------------ATGNIATEDLAYLLR----------
TH_4346|M.thermoresistible__bu ------------------------SVLGNAPMEDLIHLCD----------
MLBr_01828|M.leprae_Br4923 PMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGYLVGRLPSTARGVV
. * : :
Mb3564c|M.bovis_AF2122/97 KIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKH
Rv3534c|M.tuberculosis_H37Rv KIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKH
MMAR_1493|M.marinum_M DSGFAVDVDLAAAIAAAE--------------------------------
MUL_2447|M.ulcerans_Agy99 DSGFAVDVDLAAAIAAAE--------------------------------
MAV_4025|M.avium_104 DSGFDVDVDLQAAIAAAG--------------------------------
Mflv_4466|M.gilvum_PYR-GCK DSGIHTEVDLDAAIAAAR--------------------------------
Mvan_1894|M.vanbaalenii_PYR-1 DSGIHVDVDLESAIEAAR--------------------------------
MSMEG_2072|M.smegmatis_MC2_155 DSDIGVDIDLRAAIEAAR--------------------------------
MAB_4650c|M.abscessus_ATCC_199 DSDVNVDINLDAAIAAAQ--------------------------------
TH_4346|M.thermoresistible__bu ALGVRTGISLPDYLDVAR--------------------------------
MLBr_01828|M.leprae_Br4923 GTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKVTPFDSSGSP----
.. . ..
Mb3564c|M.bovis_AF2122/97 AVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVT
Rv3534c|M.tuberculosis_H37Rv AVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVT
MMAR_1493|M.marinum_M --VAKAVVGHDLPGALLRAGDRIRS-------------------------
MUL_2447|M.ulcerans_Agy99 --VAKAVVGHDLPGALLRAGDRIRS-------------------------
MAV_4025|M.avium_104 --VAKTLVGHDLPSALLRAGDRRRS-------------------------
Mflv_4466|M.gilvum_PYR-GCK --VAQDVVGHSLPSSLLRAGDRILG-------------------------
Mvan_1894|M.vanbaalenii_PYR-1 --VAQDAVGHELPSSLLRAGDRILG-------------------------
MSMEG_2072|M.smegmatis_MC2_155 --VAQRAVGHDLPSALLRAGDRILG-------------------------
MAB_4650c|M.abscessus_ATCC_199 --IVQEVVGHEVPSALLRAGDRLLN-------------------------
TH_4346|M.thermoresistible__bu --LAEQLTGVPTTAFVARGGSRHDLATAQWSETV----------------
MLBr_01828|M.leprae_Br4923 NPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTFSDSPRAPML
. .. : .*
Mb3564c|M.bovis_AF2122/97 H-------------------------
Rv3534c|M.tuberculosis_H37Rv H-------------------------
MMAR_1493|M.marinum_M --------------------------
MUL_2447|M.ulcerans_Agy99 --------------------------
MAV_4025|M.avium_104 --------------------------
Mflv_4466|M.gilvum_PYR-GCK --------------------------
Mvan_1894|M.vanbaalenii_PYR-1 --------------------------
MSMEG_2072|M.smegmatis_MC2_155 --------------------------
MAB_4650c|M.abscessus_ATCC_199 --------------------------
TH_4346|M.thermoresistible__bu --------------------------
MLBr_01828|M.leprae_Br4923 PRTWGADPTFCYNAADIGPAGGWDDE