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LMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEE YFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVK SHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLE AFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEIS FGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3469c | mhpE | - | 100% (336) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv3534c | - | 6e-39 | 31.49% (308) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv2967c | pca | 1e-06 | 23.29% (146) | pyruvate carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3498c | mhpE | 0.0 | 100.00% (336) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_1522 | - | 4e-38 | 31.05% (306) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0626 | - | 4e-40 | 31.49% (308) | 4-hydroxy-2-ketovalerate aldolase |
| M. marinum M | MMAR_5021 | - | 1e-37 | 30.52% (308) | 4-hydroxy-2-oxovalerate aldolase |
| M. avium 104 | MAV_0627 | - | 9e-39 | 31.37% (306) | 4-hydroxy-2-ketovalerate aldolase |
| M. smegmatis MC2 155 | MSMEG_4150 | - | 2e-40 | 31.17% (308) | 4-hydroxy-2-ketovalerate aldolase |
| M. thermoresistible (build 8) | TH_0371 | - | 5e-39 | 30.84% (308) | PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) |
| M. ulcerans Agy99 | MUL_4095 | - | 3e-38 | 30.52% (308) | 4-hydroxy-2-ketovalerate aldolase |
| M. vanbaalenii PYR-1 | Mvan_4391 | - | 1e-39 | 32.14% (308) | 4-hydroxy-2-ketovalerate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_0627|M.avium_104 ----------MTTDIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIV
TH_0371|M.thermoresistible__bu ----------MTTDIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIV
Mflv_1522|M.gilvum_PYR-GCK ---------MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIV
MMAR_5021|M.marinum_M ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
MUL_4095|M.ulcerans_Agy99 ----------------MTGIWDVRITDTSLRDGSHHKRHQFIKEEVGAIV
MAB_0626|M.abscessus_ATCC_1997 MGSDTSTQLLGTDGIFFDAAWDVRVTDTSLRDGSHHKRHQFTADEVRAIV
MSMEG_4150|M.smegmatis_MC2_155 -----------------MTMTRLFITDVTLRDGMHAIGHRYDRGQVREIA
Mvan_4391|M.vanbaalenii_PYR-1 -----------------MTTT-VYVQDVTLRDGMHAIRHRISPRNVARIA
Rv3469c|M.tuberculosis_H37Rv -------------MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIV
Mb3498c|M.bovis_AF2122/97 -------------MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIV
: *.::*** : .: :* *.
MAV_0627|M.avium_104 AALDVAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIA
TH_0371|M.thermoresistible__bu AALDTAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
Mflv_1522|M.gilvum_PYR-GCK AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIA
MMAR_5021|M.marinum_M AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTAKEAKIA
MUL_4095|M.ulcerans_Agy99 AALDAAGVPVIEVTHGDGLGGSSFNYGFSKTSEQELIKLAAQTAKEAKIA
MAB_0626|M.abscessus_ATCC_1997 AALDGAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAQTATNAKIA
MSMEG_4150|M.smegmatis_MC2_155 AALDEAGVDAIEVGHGDGLNGSSLAYGFSRHSDLSYIHEAASVTRRAKLA
Mvan_4391|M.vanbaalenii_PYR-1 AALDRAGVDAIEVAHGDGLAGSSLSYGPGSHTDWEWIDAVAGAVTNATVT
Rv3469c|M.tuberculosis_H37Rv GDLDAAGIPYIEIGHGVTIG-AAAAQGPAAHTDEEYFRAARSVVRNARLG
Mb3498c|M.bovis_AF2122/97 GDLDAAGIPYIEIGHGVTIG-AAAAQGPAAHTDEEYFRAARSVVRNARLG
. ** **: **: ** : :: * . .: . : . .. .: :
MAV_0627|M.avium_104 FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
TH_0371|M.thermoresistible__bu FLMLPGVGTKDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
Mflv_1522|M.gilvum_PYR-GCK FLMLPGVGTKEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLET
MMAR_5021|M.marinum_M FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLET
MUL_4095|M.ulcerans_Agy99 FLMLPGVGTKEDIKEAQDNGGSICRIATHCTEADVSIQHLGLARELGLET
MAB_0626|M.abscessus_ATCC_1997 FLMLPGVGTKEDIIEAQGNGGSICRIATHCTEADVSIQHFGLARERGLET
MSMEG_4150|M.smegmatis_MC2_155 CVLLPGIGTIEDLKRARDSGIELVRIATHCTEADVSAQHISAAVELGFHV
Mvan_4391|M.vanbaalenii_PYR-1 TLLLPGIGTVAQLDEAYRRGVRSVRVATHCTEADIAAQHIAHARELGMDV
Rv3469c|M.tuberculosis_H37Rv AVIVPALARIETVDLAG-DYLDFLRICVIATEFELVMPFVERAQSKGLEV
Mb3498c|M.bovis_AF2122/97 AVIVPALARIETVDLAG-DYLDFLRICVIATEFELVMPFVERAQSKGLEV
:::*.:. : * *:.. .** :: .. * . *:..
MAV_0627|M.avium_104 VGFLMMSHTIPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
TH_0371|M.thermoresistible__bu VGFLMMAHTIPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAA
Mflv_1522|M.gilvum_PYR-GCK VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSA
MMAR_5021|M.marinum_M VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
MUL_4095|M.ulcerans_Agy99 VGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
MAB_0626|M.abscessus_ATCC_1997 VGFLMMSHTISPEKLAKQARIMADAGCQCVYVVDSAGALVLDGVADRVAA
MSMEG_4150|M.smegmatis_MC2_155 SGFLMMSSATTPENIGVQAAKMESYGAQCVYIADSAGNLTPAGTTARFQA
Mvan_4391|M.vanbaalenii_PYR-1 SGFLMMSHMAQPADLAAQAKLMESFGAQSVYVTDSGGRLTMHDVRDRVLA
Rv3469c|M.tuberculosis_H37Rv SIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA
Mb3498c|M.bovis_AF2122/97 SIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEA
*: : * :. . . * : **:.*: * : .. . *
MAV_0627|M.avium_104 LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
TH_0371|M.thermoresistible__bu LVAELGDDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGN
Mflv_1522|M.gilvum_PYR-GCK LVAELGDDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGN
MMAR_5021|M.marinum_M LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
MUL_4095|M.ulcerans_Agy99 LVAELGEDAQVGFHGHENLGLGVANSVEAVRAGAKQIDGSVRRFGAGAGN
MAB_0626|M.abscessus_ATCC_1997 VVAELGSDAQVGFHGHENLGLGVANSIEAVRAGAKQIDGSTRRFGAGAGN
MSMEG_4150|M.smegmatis_MC2_155 LEAALDGATQRGIHAHENLSLSVANTVVAVENGARRVDAALAGMGAGAGN
Mvan_4391|M.vanbaalenii_PYR-1 YRDVLAPSTQIGIHAHENLSLAVANSVAAVEAGATRVDASLAGQGAGAGN
Rv3469c|M.tuberculosis_H37Rv LRGAS--DVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGN
Mb3498c|M.bovis_AF2122/97 LRGAS--DVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGN
.. *:*.*:**.:.***:: *. ** :*.: * ****
MAV_0627|M.avium_104 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
TH_0371|M.thermoresistible__bu APVEALIGVFDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMG
Mflv_1522|M.gilvum_PYR-GCK APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MMAR_5021|M.marinum_M APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MUL_4095|M.ulcerans_Agy99 APVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMG
MAB_0626|M.abscessus_ATCC_1997 APVEALIGVFDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMG
MSMEG_4150|M.smegmatis_MC2_155 CPIEAFIAVANKYGWEHGCELFKLQDAAEDLVRPLQDRPVRVDRQTLTLG
Mvan_4391|M.vanbaalenii_PYR-1 CPIEPFVAVADLFGWKHGCDLFALQDAADDIVRPLRDRPVRVDRETLTLG
Rv3469c|M.tuberculosis_H37Rv CQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFG
Mb3498c|M.bovis_AF2122/97 CQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFG
. :* ::.. : * . :: : *** . : :* : :*
MAV_0627|M.avium_104 YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
TH_0371|M.thermoresistible__bu YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
Mflv_1522|M.gilvum_PYR-GCK YSGVYSSFLKHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MMAR_5021|M.marinum_M YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MUL_4095|M.ulcerans_Agy99 YSGVYSSFLKHAVRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEI
MAB_0626|M.abscessus_ATCC_1997 YSGVYSSFLKHAIRQGERYGVPAHQLLHRAGERKLIGGQEDQLIDIALEI
MSMEG_4150|M.smegmatis_MC2_155 YAGVYSSFLRHAERAANEFDIDVREIILEIGRRELIGGQEDMIIDVALDL
Mvan_4391|M.vanbaalenii_PYR-1 FAGVYSSFLRHAEDASARYGVDTRAILVEVGRRGLIGGQEDMIVDIALSL
Rv3469c|M.tuberculosis_H37Rv FHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVG
Mb3498c|M.bovis_AF2122/97 FHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVG
: *: * :.* . . .: . :: . .. . :* .:
MAV_0627|M.avium_104 KREQESGAAAAR-
TH_0371|M.thermoresistible__bu KRELEEQAGSTA-
Mflv_1522|M.gilvum_PYR-GCK KREQEAEATRA--
MMAR_5021|M.marinum_M KREQESGQVASRR
MUL_4095|M.ulcerans_Agy99 KREQESGQVASRR
MAB_0626|M.abscessus_ATCC_1997 QRENAANGQ----
MSMEG_4150|M.smegmatis_MC2_155 AAHQSAQSPNRTG
Mvan_4391|M.vanbaalenii_PYR-1 SAGVP--------
Rv3469c|M.tuberculosis_H37Rv MRA----------
Mb3498c|M.bovis_AF2122/97 MRA----------