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VTELPTHVDIRDVSLRDGLQIEDPIPLSAKLELLASIAATGVTEMEATAFVSPSKVPALADAAELAAELH NFPGIEFSALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRASAEATAQIAEITAIAHDSDASVEV IIATAWDCPFDGPTAPQRVIDIVTAATDAGADRMAIADTIGTATPRRVGDLIALVRPLVGDTPLGAHFHN TRGAGLASAFAAVSAGVTRLDASVGGLGGCPFAPGASGNIAVEDLVYLLRDSGIHTEVDLDAAIAAARVA QDVVGHSLPSSLLRAGDRILG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4466 | - | - | 100% (301) | pyruvate carboxyltransferase |
| M. gilvum PYR-GCK | Mflv_1522 | - | 1e-09 | 28.57% (140) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_4198 | - | 1e-06 | 26.32% (152) | pyruvate carboxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3564c | - | 2e-10 | 30.71% (140) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv3534c | - | 2e-10 | 30.71% (140) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4650c | - | 1e-124 | 72.73% (297) | putative pyruvate carboxyltransferase |
| M. marinum M | MMAR_1493 | - | 1e-122 | 73.65% (296) | hypothetical protein MMAR_1493 |
| M. avium 104 | MAV_4025 | - | 1e-120 | 74.83% (294) | pyruvate carboxyltransferase |
| M. smegmatis MC2 155 | MSMEG_2072 | - | 1e-139 | 83.28% (299) | 3-hydroxy-3-methylglutaryl-CoA lyase |
| M. thermoresistible (build 8) | TH_4346 | - | 5e-40 | 32.78% (299) | PUTATIVE putative hydroxymethylglutaryl-CoA lyase |
| M. ulcerans Agy99 | MUL_2447 | - | 1e-123 | 73.99% (296) | hypothetical protein MUL_2447 |
| M. vanbaalenii PYR-1 | Mvan_1894 | - | 1e-149 | 89.04% (301) | pyruvate carboxyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4466|M.gilvum_PYR-GCK ---------------------MTELPTHVDIRDVSLRDGLQIED-PIPLS
Mvan_1894|M.vanbaalenii_PYR-1 ---------------------MSELPGHVDIRDVSLRDGLQIED-PIPLS
MSMEG_2072|M.smegmatis_MC2_155 ----------------------MDLPTHVDIREVCLRDGLQIEQ-PIPLS
MMAR_1493|M.marinum_M ------------------------MTTHVTIREVALRDGLQIEK-PVPLS
MUL_2447|M.ulcerans_Agy99 ------------------------MTTHVTIREVALRDGLQIEK-PVPLS
MAV_4025|M.avium_104 ----------------------------MAIREVALRDGLQIEA-PIPLS
MAB_4650c|M.abscessus_ATCC_199 ----------------------MSLPEHVSIREVLLRDGLQLET-PIALA
TH_4346|M.thermoresistible__bu VTVPSPVAPPSRDAAGSARPALPGLPDSIELVEVGLRDGLQAVTRPVPTA
Mb3564c|M.bovis_AF2122/97 ----------------------MTDMWDVRITDTSLRDGSHHKRHQFTKD
Rv3534c|M.tuberculosis_H37Rv ----------------------MTDMWDVRITDTSLRDGSHHKRHQFTKD
: : :. **** : ..
Mflv_4466|M.gilvum_PYR-GCK AKLELLASIAATGVTEMEATAFVSPSKVPALADAAELAAELHNFPGIEFS
Mvan_1894|M.vanbaalenii_PYR-1 AKLELLAAIAATGVREMEATAFVSPSKVPALADAADLAAELRNFPDIEFS
MSMEG_2072|M.smegmatis_MC2_155 AKLEILEAIAATGVREIEATAFVSPSKVPALADAAELAAELHRFPDVEFS
MMAR_1493|M.marinum_M AKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAELHSYPDIEFS
MUL_2447|M.ulcerans_Agy99 AKLELLAAVAATGVREVEATAFVSPSKVPSMADAAELAAELHSYPDIEFS
MAV_4025|M.avium_104 AKLELLAAVAATGVREVEATAFVSPSKVPSMADAADLAAHLADYPDIEFS
MAB_4650c|M.abscessus_ATCC_199 DKLKLLEAVAATGVREVEATAFVSPTKMPALADAAELAAQLHHYPDIEFS
TH_4346|M.thermoresistible__bu EKVAIVEGLINAGFRTIEAVSFAHPKVLPQLADAEAVMAAVPRPPDVTYR
Mb3564c|M.bovis_AF2122/97 EVGAIVAALDAAGVPVIEVTHGDG-------LGGSSFNYGFSKTPEQELI
Rv3534c|M.tuberculosis_H37Rv EVGAIVAALDAAGVPVIEVTHGDG-------LGGSSFNYGFSKTPEQELI
:: .: :*. :*.. .. . . *
Mflv_4466|M.gilvum_PYR-GCK ALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRASAEATAQIAEIT
Mvan_1894|M.vanbaalenii_PYR-1 ALVASPNGAKRAIAAGLRSIEYVVSAADGHSRANVGRSSAEATAQIPEIV
MSMEG_2072|M.smegmatis_MC2_155 ALVASPNGAKRAIAAGLHSIEYVVSAADSHSKANVGRSSAEATAQIADIV
MMAR_1493|M.marinum_M ALVASPNGARRAIAAGLHAIEYVVAASNSFSMANVGRSTADATDQISEIL
MUL_2447|M.ulcerans_Agy99 ALVASPNGARRAIAAGLHAIEYVVAASNSFSMANVGRSTADATDQISEIL
MAV_4025|M.avium_104 ALVASPNGARRAVAAGLRAIEYVVAADDTFSAANVGRTSAEATEQIGDIV
MAB_4650c|M.abscessus_ATCC_199 ALVASPNGAKRALAAGFTSLEYVVSAADGHSRANVGISSAEAIARIQEIV
TH_4346|M.thermoresistible__bu GLVPNLRGAHRAVACGLDEWVLVVSADEEVSVRNQRRTVEQMLTELPGVA
Mb3564c|M.bovis_AF2122/97 KLAAAT---AKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEAD
Rv3534c|M.tuberculosis_H37Rv KLAAAT---AKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEAD
*.. : .: * : : . : : .
Mflv_4466|M.gilvum_PYR-GCK AIAHDSD---ASVEVIIATAWDCPFDGPTAPQRVIDIVTAATDAGADRMA
Mvan_1894|M.vanbaalenii_PYR-1 AIAHDSG---VSVEVIVATAWDCPFDGPTAPQRVVDIVTAAADGGVDRLA
MSMEG_2072|M.smegmatis_MC2_155 AIAHDSD---TSVEVIIATAWDCPFDGPTDPQRVLDIVSAAVEYGADRLA
MMAR_1493|M.marinum_M AIGRDGE---VTVEVIVATAWDCPFDGAVAPQQVLDIAATAVGQGVDRFS
MUL_2447|M.ulcerans_Agy99 AIGRDGE---VTVEVIVATAWDCPFDGAVAPQQVLDIAATAVDQGVDRFS
MAV_4025|M.avium_104 AIAHDGPGPPVTVEVVIATAWDSPFEGPTPPQRVLDIAAAARDRGADRLS
MAB_4650c|M.abscessus_ATCC_199 TLARGAD---ATVEVIVACSWDCPFDGPTAQKRVLDIMQRARDWGADRYA
TH_4346|M.thermoresistible__bu ALARESG---VRLIVAVACAFFAPARGPVPRQEYLRVVDAAVDTGVDALY
Mb3564c|M.bovis_AF2122/97 VSIQHFG---LARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVY
Rv3534c|M.tuberculosis_H37Rv VSIQHFG---LARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVY
. : : : . :. * :
Mflv_4466|M.gilvum_PYR-GCK IADTIGTATPRRVGDLIALVRPLVG-DTPLGAHFHNTRGAGLASAFAAVS
Mvan_1894|M.vanbaalenii_PYR-1 IADTIGTATPRRVSDLIGMVRPRIV-DIPLGAHFHNTRGAGLASAYAAVS
MSMEG_2072|M.smegmatis_MC2_155 VADTIGTTTPRRVTTLVQQVRPLIG-DLPLGAHFHNTRGAGLASAYAAVQ
MMAR_1493|M.marinum_M IADTIGTATPGRVSALIAQLGPVLG-DMPLGAHFHNTRGSGLASAYAAVC
MUL_2447|M.ulcerans_Agy99 IADTIGTATPGRVSALIAQLGPVLG-DMPLGAHFHNTRGSGLASAYAAVC
MAV_4025|M.avium_104 IADTIGTATPGRVSSLIAQLLPVIG-DMPLGGHFHNTRGCGLASAYAAVG
MAB_4650c|M.abscessus_ATCC_199 LADTIGTATPRRVANLIAAVRSIIG-DAPLGAHFHNTRGSGLASAYAAVQ
TH_4346|M.thermoresistible__bu LACTTGQEHPGEVAERVGEVRRRHP-AVRVGVHLHNRNGFAAANAIAAMQ
Mb3564c|M.bovis_AF2122/97 VVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVR
Rv3534c|M.tuberculosis_H37Rv VVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVR
:. : * * : : :* * *: * . *.: **:
Mflv_4466|M.gilvum_PYR-GCK AGVTRLDASVGGLGGCPFAPG---ASGNIAVEDLVYLLRDSGIHTEVDLD
Mvan_1894|M.vanbaalenii_PYR-1 AGVTRLDASVGGLGGCPFAPG---ASGNIAVEDLVYLLRDSGIHVDVDLE
MSMEG_2072|M.smegmatis_MC2_155 AGITRLDASVGGLGGCPFAPG---ASGNIATEDLVYLLRDSDIGVDIDLR
MMAR_1493|M.marinum_M SGVTRLDASVGGLGGCPFAPG---ATGNIATEDLVYLLADSGFAVDVDLA
MUL_2447|M.ulcerans_Agy99 SGVTRLDASVGGLGGCPFAPG---ATGNIATEDLVYLLADSGFAVDVDLA
MAV_4025|M.avium_104 AGVTRLDASVGGLGGCPFAPG---ATGNIATEDLVYLLTDSGFDVDVDLQ
MAB_4650c|M.abscessus_ATCC_199 SGVTRLDSSIGGLGGCPFAPG---ATGNIATEDLAYLLRDSDVNVDINLD
TH_4346|M.thermoresistible__bu AGAAWLEGSFCGLGGDLWFPGDPSVLGNAPMEDLIHLCDALGVRTGISLP
Mb3564c|M.bovis_AF2122/97 AGAKQIDGSCRRFG-----AG----AGNAPVEALIGVFDKIGVKTGIDFF
Rv3534c|M.tuberculosis_H37Rv AGAKQIDGSCRRFG-----AG----AGNAPVEALIGVFDKIGVKTGIDFF
:* ::.* :* .* ** . * * : .. . :.:
Mflv_4466|M.gilvum_PYR-GCK AAIAAAR----------------------------------VAQDVVGHS
Mvan_1894|M.vanbaalenii_PYR-1 SAIEAAR----------------------------------VAQDAVGHE
MSMEG_2072|M.smegmatis_MC2_155 AAIEAAR----------------------------------VAQRAVGHD
MMAR_1493|M.marinum_M AAIAAAE----------------------------------VAKAVVGHD
MUL_2447|M.ulcerans_Agy99 AAIAAAE----------------------------------VAKAVVGHD
MAV_4025|M.avium_104 AAIAAAG----------------------------------VAKTLVGHD
MAB_4650c|M.abscessus_ATCC_199 AAIAAAQ----------------------------------IVQEVVGHE
TH_4346|M.thermoresistible__bu DYLDVAR----------------------------------LAEQLTGVP
Mb3564c|M.bovis_AF2122/97 DIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVP
Rv3534c|M.tuberculosis_H37Rv DIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVP
.* *
Mflv_4466|M.gilvum_PYR-GCK LPSSLLRAGDRILG--------------------------
Mvan_1894|M.vanbaalenii_PYR-1 LPSSLLRAGDRILG--------------------------
MSMEG_2072|M.smegmatis_MC2_155 LPSALLRAGDRILG--------------------------
MMAR_1493|M.marinum_M LPGALLRAGDRIRS--------------------------
MUL_2447|M.ulcerans_Agy99 LPGALLRAGDRIRS--------------------------
MAV_4025|M.avium_104 LPSALLRAGDRRRS--------------------------
MAB_4650c|M.abscessus_ATCC_199 VPSALLRAGDRLLN--------------------------
TH_4346|M.thermoresistible__bu TTAFVARGGSRHDLATAQWSETV-----------------
Mb3564c|M.bovis_AF2122/97 ASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
Rv3534c|M.tuberculosis_H37Rv ASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
.. : *.*.*