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STPALNDASPTGTHAVPLTETPEQARRRQRRMALAAVVGTAVEWYDFYLYAAMASIVFATVFFPEGDSKF AALQSLATFAVGFLARPVGGVVFGALGDRIGRKRTLVVTFILMGVSTGVIGFLPDFATIGMWAPIALVLL RILQGLGAGAEFASAAVASYEHADVAKRGSMGSWPTLGMNLGLVLSAATVFVISLLGDDFLTTVGWRIPF VASFALVAVGLWIRASVPETPDFAQESEQRRTKAFPLIALLRQDWRGLAVVIGIALGCTSISYIFKTFSL AYLTQFKGVSAADSALGVTLAGIAAVLVIPLLGRLCDRWSSKRVLIVGGVLSGVWATFFLALLNTGETWA IWTALIVGTGVLVPTMMAAQGSFYSRQFPVATRASGVGTAREFGTSVAGGAAPLGALALVTASPTHSTVG VGVVLVGAAVLAVVPAMFDQGTKHSAYKN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1983 | - | - | 100% (450) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_0483 | - | 2e-80 | 38.85% (399) | shikimate transporter |
| M. smegmatis MC2 155 | MSMEG_1798 | - | 3e-75 | 38.92% (406) | major facilitator superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 4e-67 | 34.71% (412) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1471 | - | 2e-73 | 37.71% (419) | general substrate transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 4e-67 | 34.71% (412) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-08 | 23.68% (397) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2481 | - | 6e-68 | 37.47% (411) | putative integral membrane transporter |
| M. marinum M | MMAR_4238 | - | 5e-62 | 36.65% (412) | integral membrane transport protein |
| M. avium 104 | MAV_4627 | - | 2e-74 | 37.68% (422) | major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_3714 | - | 2e-70 | 35.12% (410) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0949 | - | 2e-62 | 36.25% (411) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5300 | - | 4e-72 | 35.75% (442) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4627|M.avium_104 --------------MAATLPAPAPAGLADGHPLDESAEQQRRRLR---IV
TH_3714|M.thermoresistible__bu --------------MSAEAATPT------------SRVTPRR-------V
Mflv_1471|M.gilvum_PYR-GCK --------------MSSTGSS----------------TGLKR-------V
Mvan_5300|M.vanbaalenii_PYR-1 --------------MSTQHDARPDGP-------PSITTGLKR-------V
MAB_2481|M.abscessus_ATCC_1997 --------------MTTTSAVPAVHAGG---PADGDAPAART-------V
Mb1232|M.bovis_AF2122/97 ---------------------------------------MKR-------V
Rv1200|M.tuberculosis_H37Rv ---------------------------------------MKR-------V
MMAR_4238|M.marinum_M ---------------------------------------MSR-------V
MUL_0949|M.ulcerans_Agy99 ---------------------------------------MSR-------V
MSMEG_1983|M.smegmatis_MC2_155 --------------MSTPALNDASPTGTHAVPLTETPEQARRRQR---RM
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
.
MAV_4627|M.avium_104 VAASLLGTTVEWYDFFLYATAAGLVFNKVFFPN-ESSLVGTLLAFATFAV
TH_3714|M.thermoresistible__bu AVASFIGTTVEFYDFLIYGTAAALVFPKLFFPT-ASPASGVLLSFATFGV
Mflv_1471|M.gilvum_PYR-GCK VVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTYAV
Mvan_5300|M.vanbaalenii_PYR-1 VVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTYAV
MAB_2481|M.abscessus_ATCC_1997 ALSCMVGTTIEWYDFYLYATAAALVLKPLFFPS-VSPTAGTLASFATYAA
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
MSMEG_1983|M.smegmatis_MC2_155 ALAAVVGTAVEWYDFYLYAAMASIVFATVFFPE-GDSKFAALQSLATFAV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVA-IVALPK-IQNELSLSDAGRSWGI
. . .:.: : : .: * : . . . : ::.
MAV_4627|M.avium_104 GFVMRPIGGLVFG--HIGDRIGRKRSLALTMLIMGGATALIGVLPTAAQI
TH_3714|M.thermoresistible__bu GFFARPLGGIVFG--HFGDRLGRKRMLVYSLVGMGVATVLIGLLPTYAQI
Mflv_1471|M.gilvum_PYR-GCK GFVARPLGGVVFG--HFGDKYGRKKLLQFAILLVGVVTFLMGCLPTYNQI
Mvan_5300|M.vanbaalenii_PYR-1 GFVARPLGGVVFG--HFGDKYGRKKLLQFAILLVGAVTFLMGCLPTYAQI
MAB_2481|M.abscessus_ATCC_1997 GFGARPVGAVIAG--HLGDRVGRKAVLVGALLLMGVATAVIGALPTYSEA
Mb1232|M.bovis_AF2122/97 AFLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAI
Rv1200|M.tuberculosis_H37Rv AFLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAI
MMAR_4238|M.marinum_M AFLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATI
MUL_0949|M.ulcerans_Agy99 AFLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATI
MSMEG_1983|M.smegmatis_MC2_155 GFLARPVGGVVFG--ALGDRIGRKRTLVVTFILMGVSTGVIGFLPDFATI
MLBr_01562|M.leprae_Br4923 TAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVA------
..*. : :** *** : . . : .
MAV_4627|M.avium_104 GAWAPVLLLVLRVLQGFALG-GEWGGAVLLAVEHSPGDRR----GRYGAV
TH_3714|M.thermoresistible__bu GMAAPALLTLLRLAQGFAMG-GEWGGATLMAVEHASADRK----GFYGAF
Mflv_1471|M.gilvum_PYR-GCK GVWAPILLVVLRFVQGFAVG-GEWGGAVLLVAEHSPAKER----GFWASW
Mvan_5300|M.vanbaalenii_PYR-1 GVWAPILLVVLRFMQGFAVG-GEWGGAVLLVAEHSPNKER----GFWASW
MAB_2481|M.abscessus_ATCC_1997 GVLAPAALATLRVLQGLAAG-AEWGGAALLAVEHAPVGRR----GLFGSF
Mb1232|M.bovis_AF2122/97 GAAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMF
Rv1200|M.tuberculosis_H37Rv GAAAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMF
MMAR_4238|M.marinum_M GVSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMF
MUL_0949|M.ulcerans_Agy99 GVSAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMF
MSMEG_1983|M.smegmatis_MC2_155 GMWAPIALVLLRILQGLGAG-AEFASAAVASYEHADVAKR----GSMGSW
MLBr_01562|M.leprae_Br4923 --WDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAM
* *. **:. . .. . .: : : . .
MAV_4627|M.avium_104 PQVGLALGLALGTGI-------FAFLQIVLGP--ARFLSYGWRIGFLLSV
TH_3714|M.thermoresistible__bu PQMGAPAGTATAT---------LAFFAVSRLPD-GQFLSWGWRLPFLLSA
Mflv_1471|M.gilvum_PYR-GCK PQAAVPVGNMLATVV-------LLVLTGVLPE--AAFMSWGWRIAFWLSA
Mvan_5300|M.vanbaalenii_PYR-1 PQAAVPVGNMLATVV-------LLVLTGTLSN--DAFLSWGWRVAFWLSA
MAB_2481|M.abscessus_ATCC_1997 TQLGSPAGMLLATGV-------FGLTRALTGP--EAFLAFGWRIPFLSSI
Mb1232|M.bovis_AF2122/97 TVVGGGIALVLTSLT-------FLGVNYTIGESSPTFMQWGWRIPFLVSA
Rv1200|M.tuberculosis_H37Rv TVVGGGIALVLTSLT-------FLGVNYTIGESSPTFMQWGWRIPFLVSA
MMAR_4238|M.marinum_M TVLGGGVALVVSGLT-------FLGVNYTIGESSSAFLQWGWRVPFLLSA
MUL_0949|M.ulcerans_Agy99 TVLGGGVALVVSGLT-------FLGVNYTIGESSSALLQWGWRVPFLLSA
MSMEG_1983|M.smegmatis_MC2_155 PTLGMNLGLVLSAAT-------VFVISLLGDD---FLTTVGWRIPFVASF
MLBr_01562|M.leprae_Br4923 TAIGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERM
. . . : . : .
MAV_4627|M.avium_104 LLVAIGIVVRLRVEETP---AFRELQD---LQAASTVPIRDILRER----
TH_3714|M.thermoresistible__bu VLIGIGLAVRLTLTESP---DFAAVQA---RSAVHRMPIAEAFR------
Mflv_1471|M.gilvum_PYR-GCK VVVLIGYYIRTKVTDAPIFVAAQEEVE---RTKAVSYGVVEVLK------
Mvan_5300|M.vanbaalenii_PYR-1 VVVLVGYYIRTKVTDAPIFVAAQEEVE---RVKSVSYGVVEVLK------
MAB_2481|M.abscessus_ATCC_1997 VLVVVGLAIRLRLRDS---VVFRKVLE---RGEAARLPVVEVLR------
Mb1232|M.bovis_AF2122/97 ALIAVALYVRFNIDETPVFAR--ERADEKTRLGPAETPIAQVLR------
Rv1200|M.tuberculosis_H37Rv ALIAVALYVRFNIDETPVFAR--ERADEKTRLGPAETPIAQVLR------
MMAR_4238|M.marinum_M LLIAFALYVRLEINETPVFARAMAQADDQESTAAARAPLAAVLC------
MUL_0949|M.ulcerans_Agy99 LLIAFALYVRLEINETPVFARAMAQADDQESTAAARAPLAAVLC------
MSMEG_1983|M.smegmatis_MC2_155 ALVAVGLWIRASVPETPDFAQESEQRR------TKAFPLIALLR------
MLBr_01562|M.leprae_Br4923 KLDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAV
: . : : : .
MAV_4627|M.avium_104 --------------RSRRNTVLGLLSRWAEGSAFNTWGVFAISYATGALG
TH_3714|M.thermoresistible__bu --------------RHRRQILLVAGAYLSQGVFAYICVAYLVSYGTSVAG
Mflv_1471|M.gilvum_PYR-GCK --------------RYPRGVFTAMGLRFAENIMYYLVVTFSIVYLKNHVG
Mvan_5300|M.vanbaalenii_PYR-1 --------------RYPRGVFTAMGLRFAENIMYYLVVTFSIVYLKTHVG
MAB_2481|M.abscessus_ATCC_1997 --------------TQSRNVLLTTGLRLSQIALFVLLTTFSLTYLQGSFG
Mb1232|M.bovis_AF2122/97 --------------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLG
Rv1200|M.tuberculosis_H37Rv --------------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLG
MMAR_4238|M.marinum_M --------------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLG
MUL_0949|M.ulcerans_Agy99 --------------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLG
MSMEG_1983|M.smegmatis_MC2_155 --------------QDWRGLAVVIGIALGCTSISYIFKTFSLAYLTQFKG
MLBr_01562|M.leprae_Br4923 VERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILG
* . * *
MAV_4627|M.avium_104 LNRVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFP
TH_3714|M.thermoresistible__bu IDRTATLFGVSVAAVLAVVMYPLFGSLSDTFGRKPLFLAGVIAMGVSIGP
Mflv_1471|M.gilvum_PYR-GCK ADTSDILWWLLAAHAVHFLVVPQVGRLSDRFGRRPVYIVGAILAATWGFF
Mvan_5300|M.vanbaalenii_PYR-1 ADTSDILWWLLAAHAVHFLVVPQVGRLADRFGRRPVYIAGAMLAATWGFF
MAB_2481|M.abscessus_ATCC_1997 GDSQIGLTAVLISSALGILSTPVWSALSDRVGRRPLYLFGSAAGPLALGL
Mb1232|M.bovis_AF2122/97 YSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLL
Rv1200|M.tuberculosis_H37Rv YSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLL
MMAR_4238|M.marinum_M YSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPL
MUL_0949|M.ulcerans_Agy99 YSRNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPL
MSMEG_1983|M.smegmatis_MC2_155 VSAADSALGVTLAGIAAVLVIPLLGRLCDRWSSKRVLIVGGVLSGVWATF
MLBr_01562|M.leprae_Br4923 YSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLY
. . * . . : : : *
MAV_4627|M.avium_104 AFALFGTKK---LLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYT
TH_3714|M.thermoresistible__bu AFALIDTGR---PALFLVALVLVFGLAMAPAAGVTGALFAMTFDADVRYS
Mflv_1471|M.gilvum_PYR-GCK AFPMMNTGS---YLLIMGAVILGL-MIHALMYAPQPAIMAEMFPTRMRYS
Mvan_5300|M.vanbaalenii_PYR-1 AFPMMNSGD---YLLILGAVILGL-MIHALMYAPQPAIMAEMFPTRMRYS
MAB_2481|M.abscessus_ATCC_1997 FFLAAGSGS---KVLVVLSIVFGINVVHDAMYGPQAAWFAELFDTRVRYS
Mb1232|M.bovis_AF2122/97 VMPLIDSGS---PSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYT
Rv1200|M.tuberculosis_H37Rv VMPLIDSGS---PSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYT
MMAR_4238|M.marinum_M VMPLIGSGD---TVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYT
MUL_0949|M.ulcerans_Agy99 VMPLIGSGD---TVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYT
MSMEG_1983|M.smegmatis_MC2_155 FLALLNTGE---TWAIWTALIVGTGVLVPTMMAAQGSFYSRQFPVATRAS
MLBr_01562|M.leprae_Br4923 GWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVS
. . :: : : :
MAV_4627|M.avium_104 GLSFVYQFSG-----------------VYASGVTPMILTALIAAL-GGAP
TH_3714|M.thermoresistible__bu GVSIGYTLSQ-----------------VLGSAFAPTIAAALYAAT-ESSG
Mflv_1471|M.gilvum_PYR-GCK GVSLGYQVTS-----------------IVAGSLAPAIATWLLDK--FGTW
Mvan_5300|M.vanbaalenii_PYR-1 GVSLGYQVTS-----------------IVAGSLAPAIATWLLDR--FGTW
MAB_2481|M.abscessus_ATCC_1997 GASLGYQIGA-----------------VLSGGFAPLIAAALLAAN-HGDP
Mb1232|M.bovis_AF2122/97 GSALAANLAG-----------------VAGGALPPVIAGALVAT---YGS
Rv1200|M.tuberculosis_H37Rv GSALAANLAG-----------------VAGGALPPVIAGALVAT---YGS
MMAR_4238|M.marinum_M GTALALNVAG-----------------IVGGAAPPLIAGTLLAS---YGS
MUL_0949|M.ulcerans_Agy99 GTALALNVAG-----------------IVGGAAPPLIAGTLLAS---YGS
MSMEG_1983|M.smegmatis_MC2_155 GVGTAREFGT-----------------SVAGGAAPLGALALVTASPTHST
MLBr_01562|M.leprae_Br4923 AIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHG
. . .. *
MAV_4627|M.avium_104 WLACGYLVATAVISVLATALIRD-----------------RDLYL----
TH_3714|M.thermoresistible__bu SIVA-YLIGVSVISAVSVCLLPGGWGRTGDQPATEVPASVRPMVSGPD-
Mflv_1471|M.gilvum_PYR-GCK VPIALYLAGAAVITLVAAWFTRETKGIDLHALDVADREQLEKAGIV---
Mvan_5300|M.vanbaalenii_PYR-1 VPIAVYLAGAAVITLVAAWFTRETNGIDLHSLDVADREQLAKAGIV---
MAB_2481|M.abscessus_ATCC_1997 RLIVCYYLALSVLTFGAACVARETY-----------RDQIGDSL-----
Mb1232|M.bovis_AF2122/97 WAIGVMLAILALISLVCTYRLPETAG--------------SALVSR---
Rv1200|M.tuberculosis_H37Rv WAIGVMLAILALISLVCTYRLPETAG--------------SALVSR---
MMAR_4238|M.marinum_M SAVGLMMTALVAASLLCTYLLPETAG--------------APLTAA---
MUL_0949|M.ulcerans_Agy99 SAVGLMMTALVAASLLCTYLLPETAG--------------APLTAA---
MSMEG_1983|M.smegmatis_MC2_155 VGVGVVLVGAAVLAVVPAMFDQGTKH--------------SAYKN----
MLBr_01562|M.leprae_Br4923 YTYGLLWVAGAVVIVGVAALFIGYTP-----EQVAYAQEVKEAVDAGEL
.