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DDEVIARRVFSAGVIGTALEWYDFILYGTASALVFATVFFPEEDPALATLAAFATFGVGFLARPLGALVF GQLGDRIGRKKVLILTLVIMGVASALMGVLPGYATVGASAPVFLVVLRLVQGFAAGAEYAGAGTMAVEFA PPKRKGIMGAAPGIGAAIGSVLSAVAFTIPAAVMPHDAFLLWGWRVPFILSVVMLGVAVYVRRRVLEVPG FESDRESGARQLPIVALMRQSPRNLVLGILASFGPNIGFYVPIVFGTSYAAQHGGVTAADLTTIHMVVYL IGIGITVFSGFLADRWTKRGTFILGALITAVSALPFFWLIESRSLPQIWAAFLLFSIGFYVMAGAQGALL ASLFTRRTRFTGVAVSREFSAAIVGGTAPFIAALLVAWGGPLPVSIYAIALLVLCALAAYGTVAQDDSEH NDSAVPTLTESKNKEATWLTS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1798 | - | - | 100% (442) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3398 | - | 1e-83 | 41.12% (411) | integral membrane transport protein |
| M. smegmatis MC2 155 | MSMEG_0483 | - | 2e-83 | 40.00% (435) | shikimate transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 1e-65 | 35.02% (414) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_4524 | - | 1e-79 | 39.28% (415) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 1e-65 | 35.02% (414) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 9e-09 | 23.46% (422) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2481 | - | 5e-69 | 37.92% (414) | putative integral membrane transporter |
| M. marinum M | MMAR_4238 | - | 6e-70 | 38.03% (426) | integral membrane transport protein |
| M. avium 104 | MAV_4627 | - | 8e-78 | 40.49% (410) | major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_2446 | - | 6e-79 | 40.10% (399) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0949 | - | 2e-69 | 37.79% (426) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_2899 | - | 4e-77 | 39.85% (389) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4627|M.avium_104 ----------MAATLPAPAPAGLADGHPLDESAEQQRR-------RLRIV
TH_2446|M.thermoresistible__bu ----------VQPYAHPPGSALLNAVTLLDAPVAPHHDDDSAVTPQARTA
MAB_2481|M.abscessus_ATCC_1997 ----------MTTTSAVP---AVHAGGPADGDAP-----------AARTV
Mflv_4524|M.gilvum_PYR-GCK ----------------------MTTATPSDPATL-------------RRV
Mvan_2899|M.vanbaalenii_PYR-1 ----------------------MNEASVADSALL-------------RRV
Mb1232|M.bovis_AF2122/97 ----------------------------------------------MKRV
Rv1200|M.tuberculosis_H37Rv ----------------------------------------------MKRV
MMAR_4238|M.marinum_M ----------------------------------------------MSRV
MUL_0949|M.ulcerans_Agy99 ----------------------------------------------MSRV
MSMEG_1798|M.smegmatis_MC2_155 ----------------------------MDDEVIA------------RRV
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_4627|M.avium_104 VAASLLGTTVEWYDFFLYATAAGLVFNKVFFPNESSLVGTLLAFATFAVG
TH_2446|M.thermoresistible__bu LWASLVGTTIEWYDFFLYATAAGLVFNHAFFPDQSTFVGTMLSFATFAVG
MAB_2481|M.abscessus_ATCC_1997 ALSCMVGTTIEWYDFYLYATAAALVLKPLFFPSVSPTAGTLASFATYAAG
Mflv_4524|M.gilvum_PYR-GCK ALSSLLGTAIEYYDFLVYGTMSALVFGRVFFPDSDPAVATIAAFGTLAAG
Mvan_2899|M.vanbaalenii_PYR-1 ALSSLLGTAIEYYDFLVYGTMSALVFGLVFFPDSDPAVATIAAFGTLAAG
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVA
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPGLSPALATIASMGTFATA
MSMEG_1798|M.smegmatis_MC2_155 FSAGVIGTALEWYDFILYGTASALVFATVFFPEEDPALATLAAFATFGVG
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
. .:.:.: .: : .* . * : . : . . ..
MAV_4627|M.avium_104 FVMRPIGGLVFG-HIGDRIGRKRSLALTMLIMGGATALIGVLPTAAQIGA
TH_2446|M.thermoresistible__bu FVVRPIGGVVFG-HVGDRIGRKRTLALTMVLMGGATALMGVLPTAAQIGA
MAB_2481|M.abscessus_ATCC_1997 FGARPVGAVIAG-HLGDRVGRKAVLVGALLLMGVATAVIGALPTYSEAGV
Mflv_4524|M.gilvum_PYR-GCK YVARPVGGILFG-HFGDRLGRKRMLVLTMGLMGAASFAIGLLPTFAAVGV
Mvan_2899|M.vanbaalenii_PYR-1 YVARPVGGIVFG-HFGDRIGRKSMLVLTMTLMGTASFLIGLLPSFAAVGV
Mb1232|M.bovis_AF2122/97 FLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGA
Rv1200|M.tuberculosis_H37Rv FLSRPFGAAVFG-YFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGA
MMAR_4238|M.marinum_M FLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIGV
MUL_0949|M.ulcerans_Agy99 FLSRPLGAAVFG-HFGDRLGRKKTLVATLLIMALSTVTVGVVPSTATIGV
MSMEG_1798|M.smegmatis_MC2_155 FLARPLGALVFG-QLGDRIGRKKVLILTLVIMGVASALMGVLPGYATVGA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVA--------
: * : * .** :*** : : :: :: .
MAV_4627|M.avium_104 WAPVLLLVLRVLQGFALG-GEWGGAVLLAVEHSPGDRR----GRYGAVPQ
TH_2446|M.thermoresistible__bu LAPILLLLLRIVQGFALG-GEWAGAVLLAVEHGPPRRR----GLCGSIPQ
MAB_2481|M.abscessus_ATCC_1997 LAPAALATLRVLQGLAAG-AEWGGAALLAVEHAPVGRR----GLFGSFTQ
Mflv_4524|M.gilvum_PYR-GCK TAPLLLVALRVIQGIAIG-GEWGGATLMVTEHAEPHRR----GFWNGVMQ
Mvan_2899|M.vanbaalenii_PYR-1 AAPILLVALRVIQGVAIG-GEWGGATLMVTEHAEAHRR----GFWNGVMQ
Mb1232|M.bovis_AF2122/97 AAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMFTV
Rv1200|M.tuberculosis_H37Rv AAPLILTTMRLLQGFAVG-GEWAGSALLSAEYAPASKR----GWYGMFTV
MMAR_4238|M.marinum_M SAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMFTV
MUL_0949|M.ulcerans_Agy99 SAPLILVALRLLQGFAVG-GEWAGSALLSIESAPAHKR----GYYGMFTV
MSMEG_1798|M.smegmatis_MC2_155 SAPVFLVVLRLVQGFAAG-AEYAGAGTMAVEFAPPKRK----GIMGAAPG
MLBr_01562|M.leprae_Br4923 WDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTA
* *::**.. . .. * : . : .
MAV_4627|M.avium_104 VGLALGLALGTGIFAF-------LQIVLG--PARFLSYGWRIGFLLSVLL
TH_2446|M.thermoresistible__bu IGLALGLALGTGVFAL-------LQIALP--DDAFLTYGWRIAFLLSIVL
MAB_2481|M.abscessus_ATCC_1997 LGSPAGMLLATGVFGL-------TRALTG--PEAFLAFGWRIPFLSSIVL
Mflv_4524|M.gilvum_PYR-GCK MGSPIGSLLSVTVVTA-------ITLLP---DEAFVSWGWRVPFLLSVVL
Mvan_2899|M.vanbaalenii_PYR-1 MGSPIGSLLSVAVVTV-------ITLLP---DESFLSWGWRIPFLVSLLL
Mb1232|M.bovis_AF2122/97 VGGGIALVLTSLTFLG-------VNYTIGESSPTFMQWGWRIPFLVSAAL
Rv1200|M.tuberculosis_H37Rv VGGGIALVLTSLTFLG-------VNYTIGESSPTFMQWGWRIPFLVSAAL
MMAR_4238|M.marinum_M LGGGVALVVSGLTFLG-------VNYTIGESSSAFLQWGWRVPFLLSALL
MUL_0949|M.ulcerans_Agy99 LGGGVALVVSGLTFLG-------VNYTIGESSSALLQWGWRVPFLLSALL
MSMEG_1798|M.smegmatis_MC2_155 IGAAIGSVLSAVAFTI-------PAAVMP--HDAFLLWGWRVPFILSVVM
MLBr_01562|M.leprae_Br4923 IGSVMGLVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKL
:* . : : . : . :
MAV_4627|M.avium_104 VAIGIVVRLRVEETPAFRE-------------LQD--LQAASTVPIRDIL
TH_2446|M.thermoresistible__bu VVFGVVVRLRATETPAFQR-------------VRD--TGDRAAVPLRDVF
MAB_2481|M.abscessus_ATCC_1997 VVVGLAIRLRLRDSVVFRK-------------VLE--RGEAARLPVVEVL
Mflv_4524|M.gilvum_PYR-GCK LAIGVYVRVSITESPVFEQ-------------AKPKVVE-SRRIPLIEVL
Mvan_2899|M.vanbaalenii_PYR-1 LAVGIYVRLSVTESPVFEA-------------ARKEAAGNAPRVPFVEIL
Mb1232|M.bovis_AF2122/97 IAVALYVRFNIDETPVFAR-----------ERADEKTRLGPAETPIAQVL
Rv1200|M.tuberculosis_H37Rv IAVALYVRFNIDETPVFAR-----------ERADEKTRLGPAETPIAQVL
MMAR_4238|M.marinum_M IAFALYVRLEINETPVFARAM---------AQADDQESTAAARAPLAAVL
MUL_0949|M.ulcerans_Agy99 IAFALYVRLEINETPVFARAM---------AQADDQESTAAARAPLAAVL
MSMEG_1798|M.smegmatis_MC2_155 LGVAVYVRRRVLEVPGFES----------------DRESGARQLPIVALM
MLBr_01562|M.leprae_Br4923 DAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVE
. : * .. :
MAV_4627|M.avium_104 RERR---------SRRNTVLGLLSRWAEGSAFNTWGVFAISYATGALGLN
TH_2446|M.thermoresistible__bu RPP----------VLRSTLLGLLSRWGEGAAFNTWGVFAIAYATTTLGLA
MAB_2481|M.abscessus_ATCC_1997 RTQ-----------SRNVLLTTGLRLSQIALFVLLTTFSLTYLQGSFGGD
Mflv_4524|M.gilvum_PYR-GCK RRP------------RNLVLACAVGIGPFALTALISTHMISYAT-SIGYH
Mvan_2899|M.vanbaalenii_PYR-1 RRP------------RTLVLACAVGIGPFALTALISTYMISYAT-AIGYH
Mb1232|M.bovis_AF2122/97 RRQ-----------RREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYS
Rv1200|M.tuberculosis_H37Rv RRQ-----------RREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYS
MMAR_4238|M.marinum_M CRQ-----------RREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYS
MUL_0949|M.ulcerans_Agy99 CRQ-----------RREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYS
MSMEG_1798|M.smegmatis_MC2_155 RQS-----------PRNLVLGILASFGPNIGFYVPIVFGTSYAAQHGGVT
MLBr_01562|M.leprae_Br4923 RTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYS
* :: . * *
MAV_4627|M.avium_104 RVSVLIAVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFPAF
TH_2446|M.thermoresistible__bu KVPVLVAVTAAALLMAVLLPVSGVLTDRFGAKRIYTIGITAYALAVFPVF
MAB_2481|M.abscessus_ATCC_1997 SQIGLTAVLISSALGILSTPVWSALSDRVGRRPLYLFGSAAGPLALGLFF
Mflv_4524|M.gilvum_PYR-GCK RTDVMTSLVFTSLSALIAIPVFSALSDRVGRRPVMLVGGVAIICYAWPFY
Mvan_2899|M.vanbaalenii_PYR-1 RTDVMTALIFTSLTGLIAIPFFSALSDHVGRRLVMVAGAIGIIGYAWPFY
Mb1232|M.bovis_AF2122/97 RGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVM
Rv1200|M.tuberculosis_H37Rv RGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVM
MMAR_4238|M.marinum_M RNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVM
MUL_0949|M.ulcerans_Agy99 RNLVLLIGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVM
MSMEG_1798|M.smegmatis_MC2_155 AADLTTIHMVVYLIGIGITVFSGFLADRWTKRGTFILGALITAVSALPFF
MLBr_01562|M.leprae_Br4923 ALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGW
. . * .: : *
MAV_4627|M.avium_104 ALFGTKK---LLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYTGL
TH_2446|M.thermoresistible__bu ALFGTGE---IVFYTLGMLLVFGVIHALFYGAQGTLYASLFPARIRYTGL
MAB_2481|M.abscessus_ATCC_1997 LAAGSGS---KVLVVLSIVFGINVVHDAMYGPQAAWFAELFDTRVRYSGA
Mflv_4524|M.gilvum_PYR-GCK WLVDMRA---MAWLVVAMMVAQ-IVQSLMYAPLGALYSEMFGTTVRYTGA
Mvan_2899|M.vanbaalenii_PYR-1 ALVDMRS---QAYLTAAMVIAQ-LIQSMMYAPLGALFSEMFGTTVRYTGA
Mb1232|M.bovis_AF2122/97 PLIDSGS---PSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYTGS
Rv1200|M.tuberculosis_H37Rv PLIDSGS---PSLFAVAVVGMY-AIGGFGFGPTASFIPELFATSYRYTGS
MMAR_4238|M.marinum_M PLIGSGD---TVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGT
MUL_0949|M.ulcerans_Agy99 PLIGSGD---TVGFTVALLGLY-AVAASGFGPAASLIPELFATRYRYTGT
MSMEG_1798|M.smegmatis_MC2_155 WLIESRS---LPQIWAAFLLFS-IGFYVMAGAQGALLASLFTRRTRFTGV
MLBr_01562|M.leprae_Br4923 AFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAI
.: . .: : :.
MAV_4627|M.avium_104 SFVYQFSG--VYASGVTPMILTALIAALGGAPWLACGYLVATAVISVLAT
TH_2446|M.thermoresistible__bu STVYQLSG--IFASGVTPMILTALIAAAGGAPWLACGYLVATALISVVAT
MAB_2481|M.abscessus_ATCC_1997 SLGYQIGA--VLSGGFAPLIAAALLAANHGDPRLIVCYYLALSVLTFGAA
Mflv_4524|M.gilvum_PYR-GCK SMGYQLAA--LVGAGFTPMIASSLLVDEVTSVPLVV-LAMGCGAVTVLAV
Mvan_2899|M.vanbaalenii_PYR-1 SMGYQLAA--LLGAGFTPLIASALHAQEVSRTPLVA-LAAGCGLVTVVAV
Mb1232|M.bovis_AF2122/97 ALAANLAG--VAGGALPPVIAGALVATYG--SWAIGVMLAILALISLVCT
Rv1200|M.tuberculosis_H37Rv ALAANLAG--VAGGALPPVIAGALVATYG--SWAIGVMLAILALISLVCT
MMAR_4238|M.marinum_M ALALNVAG--IVGGAAPPLIAGTLLASYG--SSAVGLMMTALVAASLLCT
MUL_0949|M.ulcerans_Agy99 ALALNVAG--IVGGAAPPLIAGTLLASYG--SSAVGLMMTALVAASLLCT
MSMEG_1798|M.smegmatis_MC2_155 AVSREFSA--AIVGGTAPFIAALLVAWGG--PLPVSIYAIALLVLCALAA
MLBr_01562|M.leprae_Br4923 ALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYT
: : . . ..* .
MAV_4627|M.avium_104 ALIRDRDLYL--------------------------------
TH_2446|M.thermoresistible__bu TALRPAPLHRL-------------------------------
MAB_2481|M.abscessus_ATCC_1997 CVARETYRDQIGDSL---------------------------
Mflv_4524|M.gilvum_PYR-GCK WRIRETQGVDLAGIDSGRNAVRTP------------------
Mvan_2899|M.vanbaalenii_PYR-1 WRISETRGTDLTTV----------------------------
Mb1232|M.bovis_AF2122/97 YRLPETAGSALVSR----------------------------
Rv1200|M.tuberculosis_H37Rv YRLPETAGSALVSR----------------------------
MMAR_4238|M.marinum_M YLLPETAGAPLTAA----------------------------
MUL_0949|M.ulcerans_Agy99 YLLPETAGAPLTAA----------------------------
MSMEG_1798|M.smegmatis_MC2_155 YGTVAQDDSEHNDSAVPTLTESKNKEATWLTS----------
MLBr_01562|M.leprae_Br4923 YGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL