For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTGPEHQPRKPVILTVDDDPAVSRAVARDLRRHYGEKYRIMRAESGPDALETLNELKLRGETVAVFVADY RMPQMSGIEFLEAAMDIFPLARRVLLTAYADTHAAIDAINVVDLDHYLLKPWDPPQEKLYPVIDALLDAW RSTGDRAIPHTKIIGHPWNARSSEVREFLARNRLYYTWFRSDEPKGAALLEAAGQDGMTLPVIITEQGET LVDPTDAELGSTLGLTTTPSGDFYDLVVIGGGPAGLAAAVYGASEGLRTVLIERTATGGQAGQSSRIENY LGFPDGLSGAQLAERARRQAEKFEAELITAAEVTRLEVDGNARTVHLSDGRTIGTRAVILAMGVEYRQLP ADGCADLTGAGVYYGATASVAADCDDDEVYVIGGANSAGQAAMHLARTAKTVTIVSRRTLEDSMSHYLIQ QIRAQDNIRELPHTVVHAVKGDGHLEGICLENTQTGQRDEVTCGRMFIFIGAEPRTEWLDGVVVRDDHGF IPAGPDLRDVSGWTLDRPPHHLESSVPGVFVAGDVRADSAKRVAAAVGEGSMAVMLVHRYLAET
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5003 | - | - | 100% (554) | response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0839 | - | 1e-43 | 34.44% (331) | thioredoxin reductase |
| M. gilvum PYR-GCK | Mflv_2894 | - | 2e-13 | 26.15% (325) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3944 | trxB2 | 8e-42 | 35.49% (324) | thioredoxin reductase TRXB2 |
| M. tuberculosis H37Rv | Rv3913 | trxB2 | 8e-42 | 35.49% (324) | thioredoxin reductase TRXB2 |
| M. leprae Br4923 | MLBr_02703 | trx | 5e-43 | 35.12% (336) | bifunctional thioredoxin reductase/thioredoxin |
| M. abscessus ATCC 19977 | MAB_4940 | - | 1e-44 | 36.23% (334) | thioredoxin reductase (TrxB) |
| M. marinum M | MMAR_5477 | trxB2 | 1e-43 | 36.01% (336) | thioredoxin reductase TrxB2 |
| M. avium 104 | MAV_5301 | trxB | 7e-45 | 35.38% (325) | thioredoxin-disulfide reductase |
| M. smegmatis MC2 155 | MSMEG_1516 | - | 0.0 | 73.01% (552) | thioredoxin reductase |
| M. thermoresistible (build 8) | TH_2413 | trxB2 | 2e-44 | 35.08% (325) | PROBABLE THIOREDOXIN REDUCTASE TRXB2 (TRXR) (TR) |
| M. ulcerans Agy99 | MUL_5066 | trxB2 | 9e-44 | 36.01% (336) | thioredoxin reductase TrxB2 |
| M. vanbaalenii PYR-1 | Mvan_1371 | - | 0.0 | 94.40% (554) | response regulator receiver modulated FAD-dependent pyridine |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5477|M.marinum_M --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5003|M.gilvum_PYR-GCK ----------------------------MTGPEHQPRKPVILTVDDDPAV
Mvan_1371|M.vanbaalenii_PYR-1 MPDPPVGSYVHPAARTGFPLDSGGILNAMTGPEHQPRKPVILTVDDDPAV
MSMEG_1516|M.smegmatis_MC2_155 ---------------------------------------MILSVDDDPAV
MMAR_5477|M.marinum_M --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5003|M.gilvum_PYR-GCK SRAVARDLRRHYGEKYRIMRAESGPDALETLNELKLRGETVAVFVADYRM
Mvan_1371|M.vanbaalenii_PYR-1 SRAVARDLRRHYGEKFRIVRAESGPDALETLNELKLRGETVAVFVADYRM
MSMEG_1516|M.smegmatis_MC2_155 SRAVARDLRRHYGERYRIVRAESGPDALETLHELKLRGDTVAVFVADYRM
MMAR_5477|M.marinum_M --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5003|M.gilvum_PYR-GCK PQMSGIEFLEAAMDIFPLARRVLLTAYADTHAAIDAINVVDLDHYLLKPW
Mvan_1371|M.vanbaalenii_PYR-1 PQMSGIEFLEAAMDIFPMARRVLLTAYADTHAAIDAINVVDLDHYLLKPW
MSMEG_1516|M.smegmatis_MC2_155 PQMSGIEFLESAMDLYPMARRVLLTAYADTNAAIAAINVVDLDHYLLKPW
MMAR_5477|M.marinum_M --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02703|M.leprae_Br4923 --------------------------------------------------
MAV_5301|M.avium_104 --------------------------------------------------
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5003|M.gilvum_PYR-GCK DPPQEKLYPVIDALLDAWRSTGDRAIPHTKIIGHPWNARSSEVREFLARN
Mvan_1371|M.vanbaalenii_PYR-1 DPPEEKLYPVIDALVDAWRSTGDRAIPHTKIIGHPWSARSSEVREFLARN
MSMEG_1516|M.smegmatis_MC2_155 DPPEEKLYPVIDGLLEAWHAAGDRAIPYTKVIGHQWSPRSWEVRQFLARN
MMAR_5477|M.marinum_M ------------------------------------------MTTDSS--
MUL_5066|M.ulcerans_Agy99 ------------------------------------------MTTDSS--
Mb3944|M.bovis_AF2122/97 ------------------------------------------MTAPPVHD
Rv3913|M.tuberculosis_H37Rv ------------------------------------------MTAPPVHD
MLBr_02703|M.leprae_Br4923 ------------------------------------------MNTTPS--
MAV_5301|M.avium_104 -------------------------MPAVLFATAGNSHPYPGVYTDPETI
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 ------------------------------------------MSQAPSTG
Mflv_5003|M.gilvum_PYR-GCK RLYYTWFRSDEPKGAALLEAAGQDGMTLPVIITEQGETLVDPTDAELGST
Mvan_1371|M.vanbaalenii_PYR-1 RLYYTWFRSDEPRGAQLLEAAGEDGMTLPVVITEQGETLVDPTDSELAAT
MSMEG_1516|M.smegmatis_MC2_155 QHTYRAFNADEPKGRQLLEAAGLDGMQLPVVITEGGTTLVEPTDAELADM
MMAR_5477|M.marinum_M ------ADATIHDVIVIGSGPAGYTAALYTARAQLAPLVFEGTSFGGALM
MUL_5066|M.ulcerans_Agy99 ------ADATIHDVIVIGSGPAGYTAALYTARAQLAPLVFEGTSFGGALM
Mb3944|M.bovis_AF2122/97 R-----AHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALM
Rv3913|M.tuberculosis_H37Rv R-----AHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALM
MLBr_02703|M.leprae_Br4923 ------AHETIHEVIVIGSGPAGYTAALYAARAQLTPLVFEGTSFGGALM
MAV_5301|M.avium_104 ARKVFMTADTVHDVIIIGSGPAGYTAALYTARAQLAPVVFEGTSFGGALM
TH_2413|M.thermoresistible__bu -----MSDQTIHDVIIIGSGPAGYTAAIYTARAQLKPLVFEGTQFGGALM
MAB_4940|M.abscessus_ATCC_1997 ------TESDVHELIIIGSGPAGYTAAVYAARAQLKPIVFEGTQFGGALM
Mflv_5003|M.gilvum_PYR-GCK LGLTTTPSGDFYDLVVIGGGPAGLAAAVYGASEGLRTVLIERTATGGQAG
Mvan_1371|M.vanbaalenii_PYR-1 LGLTTTPSDDFYDLVVIGGGPAGLAAAVYGASEGLKTVLIERTATGGQAG
MSMEG_1516|M.smegmatis_MC2_155 LGLSTAPSLTMYDLAVIGGGPAGLAAAVYGASEGLKTVLIEGTTTGGQAS
. . :: :**.**** :**:* * * .:::* * **
MMAR_5477|M.marinum_M TTTEVENYPGFREGITGPELMDEMREQALRFGADLR-MEDVESVSLDGPI
MUL_5066|M.ulcerans_Agy99 TTTEVENYPGFREGITGPELMDEMREQALRFGADLR-MEDVQSVSLDGPI
Mb3944|M.bovis_AF2122/97 TTTGVENYPGFRNGITGPELMDEMREQALRFGADLR-MEDVESVSLHGPL
Rv3913|M.tuberculosis_H37Rv TTTDVENYPGFRNGITGPELMDEMREQALRFGADLR-MEDVESVSLHGPL
MLBr_02703|M.leprae_Br4923 TTTEVENYPGFRNGITGPELMDDMREQALRFGAELR-TEDVESVSLRGPI
MAV_5301|M.avium_104 TTTEVENYPGFRDGITGPELMDQMREQALRFGADLR-MEDVESVSLAGPV
TH_2413|M.thermoresistible__bu TTTEVENYPGFRDGIMGPELMDQMREQALRFGADLR-MEDVEAVSLQGPV
MAB_4940|M.abscessus_ATCC_1997 TTTEVENYPGFREGIMGPDLMDQMREQAIRFGADLR-TEDVDEVSLRGPV
Mflv_5003|M.gilvum_PYR-GCK QSSRIENYLGFPDGLSGAQLAERARRQAEKFEAELITAAEVTRLEVDGNA
Mvan_1371|M.vanbaalenii_PYR-1 QSSRIENYLGFPDGLSGAQLAERARRQAEKFEAELITAAEVVRLEVDGNA
MSMEG_1516|M.smegmatis_MC2_155 RSSRIENYLGFPTGISGAELATSARRQAERFGAEVITTREAVKLEVAGSA
:: :*** ** *: *.:* *.** :* *:: :. :.: *
MMAR_5477|M.marinum_M KSVVTSEGETHRARAVILAMGAAARYLHVPGEQE-------LLGRGVSS-
MUL_5066|M.ulcerans_Agy99 KSVVTSDGETHRARAVILAMGAAARYLHVPGEQE-------LLGRGVSS-
Mb3944|M.bovis_AF2122/97 KSVVTADGQTHRARAVILAMGAAARYLQVPGEQE-------LLGRGVSS-
Rv3913|M.tuberculosis_H37Rv KSVVTADGQTHRARAVILAMGAAARYLQVPGEQE-------LLGRGVSS-
MLBr_02703|M.leprae_Br4923 KSVVTAEGQTYQARAVILAMGTSVRYLQIPGEQE-------LLGRGVSA-
MAV_5301|M.avium_104 KSVTTAEGETVRARAVILAMGAAARYLGVPGEQD-------LLGRGVSS-
TH_2413|M.thermoresistible__bu KTVTVGD-ETHRARAVILAMGAAARHLGVPGEEE-------LIGMGVST-
MAB_4940|M.abscessus_ATCC_1997 KTVTVGD-EVYRARAVILAMGAAPRYLGVPGEDT-------LLGRGVSS-
Mflv_5003|M.gilvum_PYR-GCK RTVHLSDGRTIGTRAVILAMGVEYRQLPADGCAD-------LTGAGVYYG
Mvan_1371|M.vanbaalenii_PYR-1 RTVHLSDGRTIGTRAVILAMGVEYRQLPAEGCAD-------LTGAGVYYG
MSMEG_1516|M.smegmatis_MC2_155 RTITFADGDTIGARAVILATGVDYRQLPVPGCWDDPDNPVNFIGRGVYYG
::: .: . :****** *. * * * : * **
MMAR_5477|M.marinum_M CATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRR--DEFRA
MUL_5066|M.ulcerans_Agy99 CATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRR--DEFRA
Mb3944|M.bovis_AF2122/97 CATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRR--DEFRA
Rv3913|M.tuberculosis_H37Rv CATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRR--DEFRA
MLBr_02703|M.leprae_Br4923 CATCDGSFFRGQDIAVIGGGDSAMEEALFLTRFARSVTLVHRR--DEFRA
MAV_5301|M.avium_104 CATCDGFFFKDQDIAVIGGGDSAMEEATFLTRFARSVTLLHRR--EEFRA
TH_2413|M.thermoresistible__bu CATCDGFFFRDQDIIVVGGGDSAMEEALFLTKFARKVTLIHRR--DEFRA
MAB_4940|M.abscessus_ATCC_1997 CATCDGFFFKDQDIAVIGGGDSAMEEATFLTRFARSVTLIHRR--DEFRA
Mflv_5003|M.gilvum_PYR-GCK ATASVAADCDDDEVYVIGGANSAGQAAMHLARTAKTVTIVSRR-TLEDSM
Mvan_1371|M.vanbaalenii_PYR-1 ATASVAADCDDDEVYVIGGANSAGQAAMFLSRTAKSVTIVSRR-TLEDSM
MSMEG_1516|M.smegmatis_MC2_155 ASVSDAAECCDEDVYIVGGANSAGQAAMFMARTARSVTLLVRGPSLEASM
.:.. . .::: ::**.:** : * .::: *:.**:: * *
MMAR_5477|M.marinum_M SKIMINRAQANDKIRILTNK-IVLAVDGETTVTGLQLRDTVTGEETTLPV
MUL_5066|M.ulcerans_Agy99 SKIMTNRAQANDKIRILTNK-IVLAVDGETTVTGLQLRDTVTGEETTLPV
Mb3944|M.bovis_AF2122/97 SKIMLDRARNNDKIRFLTNH-TVVAVDGDTTVTGLRVRDTNTGAETTLPV
Rv3913|M.tuberculosis_H37Rv SKIMLDRARNNDKIRFLTNH-TVVAVDGDTTVTGLRVRDTNTGAETTLPV
MLBr_02703|M.leprae_Br4923 SKIMLGRARNNDKIKFITNH-TVVAVNGYTTVTGLRLRNTTTGEETTLVV
MAV_5301|M.avium_104 SRIMLERARANDKITIVTNK-AVEAVEGSETVTGLRLRDTVTGETSTLAV
TH_2413|M.thermoresistible__bu SRIMLERARANEKITFVTNT-QVTAIEGDPKVTGVRLRNTVTGEESHMAV
MAB_4940|M.abscessus_ATCC_1997 SKIMLERAYADPKITVLTNT-KIVGVEGTDSVTGLKLENTVTGQASELPV
Mflv_5003|M.gilvum_PYR-GCK SHYLIQQIRAQDNIRELPHT-VVHAVKGDGHLEGICLENTQTGQRDEVTC
Mvan_1371|M.vanbaalenii_PYR-1 SHYLIQQIRAQDNITEMPNT-VVHAVKGDGHLEGVCLENTRTGEREEFRC
MSMEG_1516|M.smegmatis_MC2_155 SYYLIQQIEDTPNIHVRTCTEVVKAIGEDDHLVGLVLENKRTGEQEEVRS
* : : :* . : .: : *: :.:. ** .
MMAR_5477|M.marinum_M TGVFVAIGHEPRSSLVRDAVDVDPDGYVLVN--------------GRTTG
MUL_5066|M.ulcerans_Agy99 TGVFVAIGHEPRSSLVRDAVDVDPDGYVLVN--------------GRTTG
Mb3944|M.bovis_AF2122/97 TGVFVAIGHEPRSGLVREAIDVDPDGYVLVQ--------------GRTTS
Rv3913|M.tuberculosis_H37Rv TGVFVAIGHEPRSGLVREAIDVDPDGYVLVQ--------------GRTTS
MLBr_02703|M.leprae_Br4923 TGVFVAIGHEPRSSLVSDVVDIDPDGYVLVK--------------GRTTS
MAV_5301|M.avium_104 TGVFVAIGHDPRSELVRDVLDTDPDGYVLVQ--------------GRTTA
TH_2413|M.thermoresistible__bu TGVFVAIGHDPRSELVRGQLDLDDDGYVLVK--------------GRTTA
MAB_4940|M.abscessus_ATCC_1997 TGMFVAVGHDPRSELVKDVVDVDPDGYVLVR--------------DRSTY
Mflv_5003|M.gilvum_PYR-GCK GRMFIFIGAEPRTEWLDGVVVRDDHGFIPAGPDLRDVSGWTLDRPPHHLE
Mvan_1371|M.vanbaalenii_PYR-1 GRMFIFIGAEPRTEWLDGVVVRDDHGFILAGPDLRDVSGWTLDRPPHHLE
MSMEG_1516|M.smegmatis_MC2_155 SRLCCFIGATPRTEWLDGVVARDEHGFILAGPDLRDVCGWTLERPPHHLE
: :* **: : : * .*:: . :
MMAR_5477|M.marinum_M TSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHE--------
MUL_5066|M.ulcerans_Agy99 TSLEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHE--------
Mb3944|M.bovis_AF2122/97 TSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA--------
Rv3913|M.tuberculosis_H37Rv TSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHA--------
MLBr_02703|M.leprae_Br4923 TSMDGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEHAGSKANETT
MAV_5301|M.avium_104 TSIPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAES------
TH_2413|M.thermoresistible__bu TSVEGVFAAGDLVDRTYRQAITAAGSGCAAAIDAERWLAEQP--------
MAB_4940|M.abscessus_ATCC_1997 TSVEGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAETA--------
Mflv_5003|M.gilvum_PYR-GCK SSVPGVFVAGDVRADSAKRVAAAVGEGSMAVMLVHRYLAET---------
Mvan_1371|M.vanbaalenii_PYR-1 SSVPGVFVAGDVRAESAKRVAAAVGEGSMAVMLVHRYLAET---------
MSMEG_1516|M.smegmatis_MC2_155 TSVPGVFVAGDVRAESAKRVAAAVGEGSMAVMFVHRYLAES---------
:*: ***.***: : ::. :*.*.*. *.: ..*:***
MMAR_5477|M.marinum_M -ATGDADSTD------TLIGAQQ---------------------------
MUL_5066|M.ulcerans_Agy99 -ATGDADSTD------TLIGAQQ---------------------------
Mb3944|M.bovis_AF2122/97 -ATGEADSTD------ALIGAQR---------------------------
Rv3913|M.tuberculosis_H37Rv -ATGEADSTD------ALIGAQR---------------------------
MLBr_02703|M.leprae_Br4923 EETGDVDSTDTTDWSTAMTDAKNAGVTIEVTDASFFADVLSSNKPVLVDF
MAV_5301|M.avium_104 SAAAQGDATEFPGSTDTLIGAPQ---------------------------
TH_2413|M.thermoresistible__bu -RTPSTEDTD-------LIGAPR---------------------------
MAB_4940|M.abscessus_ATCC_1997 -----HSQT--------LIEA-----------------------------
Mflv_5003|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1371|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1516|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5477|M.marinum_M --------------------------------------------------
MUL_5066|M.ulcerans_Agy99 --------------------------------------------------
Mb3944|M.bovis_AF2122/97 --------------------------------------------------
Rv3913|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02703|M.leprae_Br4923 WATWCGPCKMVAPVLEEIASEQRNQLTVAKLDVDTNPEMAREFQVVSIPT
MAV_5301|M.avium_104 --------------------------------------------------
TH_2413|M.thermoresistible__bu --------------------------------------------------
MAB_4940|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_5003|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1371|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1516|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5477|M.marinum_M ----------------------------------
MUL_5066|M.ulcerans_Agy99 ----------------------------------
Mb3944|M.bovis_AF2122/97 ----------------------------------
Rv3913|M.tuberculosis_H37Rv ----------------------------------
MLBr_02703|M.leprae_Br4923 MILFQGGQPVKRIVGAKGKAALLRDLSDVVPNLN
MAV_5301|M.avium_104 ----------------------------------
TH_2413|M.thermoresistible__bu ----------------------------------
MAB_4940|M.abscessus_ATCC_1997 ----------------------------------
Mflv_5003|M.gilvum_PYR-GCK ----------------------------------
Mvan_1371|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_1516|M.smegmatis_MC2_155 ----------------------------------