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VLIVGAGSAGSVLAERLSADPSCQVTVVEAGPAPSDPRVAAQITDGVRLPIGAASSVVRHYGSTLTEDPP RRTEIIRGSVVGGSGAVNGGYFCRGLPTDFTAWAVPGWSWDDVLPHFRAIETDLDFATALHGSEGPIKVR RVHEFDGCTAAFVDAVSAAGYGWIDDLNGSDADAALPPGVGAVPLNIDGGTRLGPGGAYLQPALDRPNLH LRADTRVRRVLVEHDAAVGVECVDGEILYADRIVLSAGAIGSAHLLLLSGIGPAGDLAAHGIAVAANLPV GTATVDHPEWVLPVAWTPTHDLPPLEAVLTTADGIEIRPYTAGFSALVHGPEHDPAELPHLGVALMRPHS RGRVRLASADPAVPPIIEHRYDTVAGDVDALRAGAELARELVSHAVKVGEASWSTSQHLAGTAPLSADGQ GVLDPTCRVLGVERLWVVDGSIMPAITSRGPHATIAMIGHRAAEFIAT
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_1428 | - | - | 100% (468) | glucose-methanol-choline oxidoreductase |
M. smegmatis MC2 155 | MSMEG_3444 | - | 1e-56 | 33.86% (505) | choline dehydrogenase |
M. smegmatis MC2 155 | MSMEG_5305 | - | 1e-41 | 29.92% (508) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0716 | - | 1e-149 | 56.69% (471) | dehydrogenase |
M. gilvum PYR-GCK | Mflv_5056 | - | 1e-176 | 65.61% (471) | glucose-methanol-choline oxidoreductase |
M. tuberculosis H37Rv | Rv0697 | - | 1e-149 | 56.69% (471) | dehydrogenase |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_3830c | - | 1e-120 | 52.64% (473) | dehydrogenase (glucose-methanol-choline oxidoreductase) |
M. marinum M | MMAR_1025 | - | 1e-155 | 61.57% (471) | dehydrogenase |
M. avium 104 | MAV_4474 | - | 1e-153 | 59.45% (471) | FAD dependent oxidoreductase, putative |
M. thermoresistible (build 8) | TH_4588 | - | 1e-108 | 71.33% (279) | PUTATIVE glucose-methanol-choline oxidoreductase |
M. ulcerans Agy99 | MUL_0777 | - | 1e-156 | 61.57% (471) | dehydrogenase |
M. vanbaalenii PYR-1 | Mvan_1300 | - | 1e-179 | 66.17% (470) | glucose-methanol-choline oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment Mb0716|M.bovis_AF2122/97 ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP Rv0697|M.tuberculosis_H37Rv ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP MAV_4474|M.avium_104 ----MNDAVSHSDVLIVGAGSAGSVVAERLSADPGCTVTVVEAGPSLDDP MMAR_1025|M.marinum_M ----MTAALRHSDVLIVGAGSAGSVLAARLSADPSCAVTLVEAGPGLADP MUL_0777|M.ulcerans_Agy99 ----MTAALRHSDVLVVGAGSAGSVLAARLSTDPSCAVTLVEAGPGLADP MAB_3830c|M.abscessus_ATCC_199 ----------------MGAGSAGSILAGRLSEDPSFRVVLVEAGP--VSS MSMEG_1428|M.smegmatis_MC2_155 -------------MLIVGAGSAGSVLAERLSADPSCQVTVVEAGPAPSDP Mflv_5056|M.gilvum_PYR-GCK -----------MSVLIVGAGSAGSVLAERLSADPGCEVTVVEAGPGLSDS Mvan_1300|M.vanbaalenii_PYR-1 ---------MRSDVLIVGAGSAGSVLAERLSADDGCQVTVVEAGPGPFDP TH_4588|M.thermoresistible__bu VTGRPGAERCHSDVLIVGAGSAGSVLAERLSADSGCRVTVVEAGPGPSDP :*******::* *** * . *.::**** .. Mb0716|M.bovis_AF2122/97 GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI Rv0697|M.tuberculosis_H37Rv GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI MAV_4474|M.avium_104 ALLARTANGLQLPIGVGSPLVRRYQTQLTERPARRHPLVRGATIGGSGAI MMAR_1025|M.marinum_M RLLAQTANGLQLPISADSPLVQRYQSQLTDHPVRRIPILRGATLGGSGAV MUL_0777|M.ulcerans_Agy99 RLLAQTANGLQLPISADSPLVQCYQSQLTDHPVRRTPILRGATLGGSGAV MAB_3830c|M.abscessus_ATCC_199 ADEAGVRNGYRLPIGPGSQIATYYWATLTS-TGDQAELVRGSVVGGSGAI MSMEG_1428|M.smegmatis_MC2_155 RVAAQITDGVRLPIGAASSVVRHYGSTLTEDPPRRTEIIRGSVVGGSGAV Mflv_5056|M.gilvum_PYR-GCK RVRDQISDGLRLPIGAASSVVRRYDTALTEEPRRHARIMRGVVVGGSGAV Mvan_1300|M.vanbaalenii_PYR-1 RVGTQITDGLRLPIGVASSVVRRYPTALTDEPRRHAQIMRGAVVGGSGAV TH_4588|M.thermoresistible__bu RVAHQITDGLRLPIGDASSVVRRYPTTLTDHPRRPAQLMRGAVVGGSGAV :* :***. * :. * : **. . ::** .:*****: Mb0716|M.bovis_AF2122/97 NGGYFCRGLPSDFDRASIPGWAWSDVLEHFRAIETDLDF-ETPVHGRSGP Rv0697|M.tuberculosis_H37Rv NGGYFCRGLPSDFDRASIPGWAWSDVLEHFRAIETDLDF-ETPVHGRSGP MAV_4474|M.avium_104 NGGYFCRGLRRDFDRLGLPGWAWSDVLDSFRAIETDLDF-DGPAHGRSGP MMAR_1025|M.marinum_M NGGYFCRGLARDFDGAAIPGWSWSQVLPHFRAIETDLDF-DTPVHGRTGP MUL_0777|M.ulcerans_Agy99 NGGYFCRGLARDFDGAAIPGWSWSQVLPHFRAIETDLDF-DTPVHGRTGP MAB_3830c|M.abscessus_ATCC_199 NGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDFRDDPLHGSQGP MSMEG_1428|M.smegmatis_MC2_155 NGGYFCRGLPTDFTAWAVPGWSWDDVLPHFRAIETDLDF-ATALHGSEGP Mflv_5056|M.gilvum_PYR-GCK NGGYFCRALPADVDGWGMDGWSWDDVLPHFRAIETDLDF-ATPVHGDTGP Mvan_1300|M.vanbaalenii_PYR-1 NGGYFCRALPSDFDGWGIAGWSWDEVLPHYTAIETDLDF-TGPLHGSAGP TH_4588|M.thermoresistible__bu NGGYFCRGLPADFDRWGLGDWTWDRVLPHFRAIETDLDF-DGPLHGADGP ***** *. *. .: .*:* * : ***** ** . ** ** Mb0716|M.bovis_AF2122/97 IPVRRTHEMTGITESFMAAAEDAGFAWIADLN--DVGPEMPSGVGAVPLN Rv0697|M.tuberculosis_H37Rv IPVRRTHEMTGITESFMAAAEDAGFAWIADLN--DVGPEMPSGVGAVPLN MAV_4474|M.avium_104 ILVRRTREMTGTTERFIDAAWRAGFGWIDDLN--DAAAQPVSGIGAVPLN MMAR_1025|M.marinum_M IPVRRTRDQTGVTQRFVTAAQRAGFGWIADLN--DVGPDIAAGVGAVPLN MUL_0777|M.ulcerans_Agy99 IPVRRIRDQTGVTQRFVTAAQRAGFGWIADLN--DVGPDIAAGVGAVPLN MAB_3830c|M.abscessus_ATCC_199 IPVGRRHEQSSAGTELMDLAVNRGYPVVADLN--GSAG---AGVGLVPLN MSMEG_1428|M.smegmatis_MC2_155 IKVRRVHEFDGCTAAFVDAVSAAGYGWIDDLNGSDADAALPPGVGAVPLN Mflv_5056|M.gilvum_PYR-GCK ITVRRVAEFDGATASFVDAARTAGFGWVEDLNGATAEHAVPAGIGAVPLN Mvan_1300|M.vanbaalenii_PYR-1 ISVRRVSEFDGCTASFVESAREAGFGWIEDLNGSTPERPLPAGVGAVPLN TH_4588|M.thermoresistible__bu IPVRRSTEFDGCTAKFIEAVEDAGYPWIPDLNGATPDQPLPPGVGQVPLN * * * : . :: . *: : *** .*:* **** Mb0716|M.bovis_AF2122/97 IVNGVRTSSAVGYLMPALGRPNLTLLARTRAVRLRFSATTAVGVDAIGPG Rv0697|M.tuberculosis_H37Rv IVNGVRTSSAVGYLMPALGRPNLTLLARTRAVRLRFSATTAVGVDAIGPG MAV_4474|M.avium_104 IVDGVRKGSGAGYLIPALSRPNLRVQAHTRVARLRFAGTVARGADVVGPH MMAR_1025|M.marinum_M IVDGVRTGSGAAYLLPALGRPNLTLLEETRAQQVRFSAATAVGVDAVGPR MUL_0777|M.ulcerans_Agy99 IVDGVRTGSGAAYLLPALGRPNLTLLEETRAQQVRFSAATAVGVDAVGPR MAB_3830c|M.abscessus_ATCC_199 IDSGIRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGN MSMEG_1428|M.smegmatis_MC2_155 IDGGTRLGPGGAYLQPALDRPNLHLRADTRVRRVLVEHDAAVGVECVDG- Mflv_5056|M.gilvum_PYR-GCK IDRGTRVGPGGAFLQPALGRANLTVLTDTRVLRLTFAAGRVTGVLCVGPD Mvan_1300|M.vanbaalenii_PYR-1 INGGTRVGPGGAFLQPALQRANLTLVTDTRVGGLRFSAGRVVGVDCLGPG TH_4588|M.thermoresistible__bu INGGTRVGPGAAYLQPALARPNLTVLTETRVRRVRIADGRADGVECLGPD * * * ... .:* .*: *.** : **. : . *. Mb0716|M.bovis_AF2122/97 GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAGVKVLMALP-VGM Rv0697|M.tuberculosis_H37Rv GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAGVKVLMALP-VGM MAV_4474|M.avium_104 GRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALP-VGT MMAR_1025|M.marinum_M GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHAMLRSAGVPVVQALP-VGM MUL_0777|M.ulcerans_Agy99 GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHAMLRAAGVPVVQALP-VGM MAB_3830c|M.abscessus_ATCC_199 SVRTLTADRIILSAGAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGT MSMEG_1428|M.smegmatis_MC2_155 --EILYADRIVLSAGAIGSAHLLLLSGIGPAGDLAAHGIAVAANLP-VGT Mflv_5056|M.gilvum_PYR-GCK GPVTVGADRIVLCAGAIATAQLLMVSGVGPPPVLRAAGVPVEIDLP-VGV Mvan_1300|M.vanbaalenii_PYR-1 GPTTLVADRVVLCAGAIASAQLLMVSGVGPQQVLRAAGVAVQIDLP-VGV TH_4588|M.thermoresistible__bu GATVLTADRIVLSAGAIGSAHLLMLSGIGPQRLLGALGIPVVAAXXXXGV : ***::*.**** :*:**::**:* * : *: * Mb0716|M.bovis_AF2122/97 GCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD--GIEIRPYTGGFVAMTGD Rv0697|M.tuberculosis_H37Rv GCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD--GIEIRPYTGGFVAMTGD MAV_4474|M.avium_104 SFSDHAEWVLPTDWPVAPGRPVLEVVLSTAD--DLEIRPYTGGFVAMTGD MMAR_1025|M.marinum_M NCSDHPEWALPTTWTVAAGRPVLEAVLNTAD--GIEIRPYTTGFAAMAGA MUL_0777|M.ulcerans_Agy99 NCSDHPEWALPTTWTVVAGRPVLEAVLNTAD--GIEIRPYTTGFEAMAGA MAB_3830c|M.abscessus_ATCC_199 RVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHPMCLEIRPYTTGFAAMAGV MSMEG_1428|M.smegmatis_MC2_155 ATVDHPEWVLPVAWTPTHDLPPLEAVLTTAD--GIEIRPYTAGFSALVHG Mflv_5056|M.gilvum_PYR-GCK DTIDHPEWVLPVSWAPTHGVPPLEAVLTTDD--GVEIRPYTVGFEAMMTG Mvan_1300|M.vanbaalenii_PYR-1 DTVDHPEWVLPVTWPPTHGVPPLEAVLTTGD--GLEIRPYTAGFGAMMTG TH_4588|M.thermoresistible__bu GEPDPAHLAGQVDGGQGVDRDARRVTLHREHR-GPRIG---GGQHVEHRR * .. . . . . * . .* * . Mb0716|M.bovis_AF2122/97 GTAGHRDWPHIGVALMQPRARG--RITLVSSDPQIPVRIEHRYDSEPA-D Rv0697|M.tuberculosis_H37Rv GTAGHRDWPHIGVALMQPRARG--RITLVSSDPQIPVRIEHRYDSEPA-D MAV_4474|M.avium_104 GTAGHADWPHLGVALMQPRARG--CLTLMSADPAVPPRIEHRYDSEPG-D MMAR_1025|M.marinum_M AAKGHRDWPHLGVALMRPRSRA--RVTLASPDPSVPPRIGHHYDSEPA-D MUL_0777|M.ulcerans_Agy99 AAKGHRDWPHLGVALMRPRSRA--RVTLASPDPSVPPRIGHHYDSEPA-D MAB_3830c|M.abscessus_ATCC_199 VADG-ADARQIGVALMTPQCRG--RLELRSTDPAAPVYIDLRYDSETA-D MSMEG_1428|M.smegmatis_MC2_155 PEHDPAELPHLGVALMRPHSRG--RVRLASADPAVPPIIEHRYDTVAG-D Mflv_5056|M.gilvum_PYR-GCK RRDDPTDQPHLGVTLMRPLSRG--RVTICSADPDADPVIEHRYDSAPA-D Mvan_1300|M.vanbaalenii_PYR-1 RRDDPTDQPHLGVTLMQPLSRG--RVTITSADPDADPVIEHRYDSEPA-D TH_4588|M.thermoresistible__bu GRRVEHERLLAGEPPLVARAAGGGRRHVGDQRRGRALGIGHGGDELPGGD : * . : . . . : . * * .. * Mb0716|M.bovis_AF2122/97 VAALRQGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDP Rv0697|M.tuberculosis_H37Rv VAALRQGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDP MAV_4474|M.avium_104 VAALARGAELARELAGGTTDAAAAIWSTSQHLCGTAPMGVDGDPRAVVDP MMAR_1025|M.marinum_M VAALQRGTELARELAGSAVAGEPG-WSTSQHLCGSAPMGVDADPTAVVDP MUL_0777|M.ulcerans_Agy99 VAALQRGTELARELAGSAVAGEPG-WSTSQHLCGSAPMGVDADPTAVVDP MAB_3830c|M.abscessus_ATCC_199 MDRLRDGVHLVSELYG--RRFGGPRWSTSQHLCGTAPLGNDRDKHAVVDK MSMEG_1428|M.smegmatis_MC2_155 VDALRAGAELARELVSHAVKVGEASWSTSQHLAGTAPLSADG--QGVLDP Mflv_5056|M.gilvum_PYR-GCK VALLREGAQLASELAGATVQSEPS-WATSQHLCGTAKMG------AVVDE Mvan_1300|M.vanbaalenii_PYR-1 VELLRAGTRLAHELAGATVQSEAS-WATSQHLCGTARMG------AVVDA TH_4588|M.thermoresistible__bu PRQHRRPFVTGAELVEQVRHHDRAGQIRPAQQRAAHLLGDDAQLDRSRAR ** . : .: :. Mb0716|M.bovis_AF2122/97 RCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEFVQ---- Rv0697|M.tuberculosis_H37Rv RCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEFVQ---- MAV_4474|M.avium_104 RCRVRG-IDNLWVIDGSVLP---AITSRGPHATIVMIGHRAAEFVR---- MMAR_1025|M.marinum_M ECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEFIG---- MUL_0777|M.ulcerans_Agy99 ECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEFIG---- MAB_3830c|M.abscessus_ATCC_199 YCRVRG-IDGLFVIDGSILP---TIPSRGPAATIAMIGHRAAQFVAWS-- MSMEG_1428|M.smegmatis_MC2_155 TCRVLG-VERLWVVDGSIMP---AITSRGPHATIAMIGHRAAEFIAT--- Mflv_5056|M.gilvum_PYR-GCK RCRVYG-VDNLWVVDGSILP---DIPSRGPHATIVMAGHRAAEFVSSS-- Mvan_1300|M.vanbaalenii_PYR-1 RCRVYG-VSNLWVVDGSILP---AIPSRGPHATIVMAGHRAAEFVSATST TH_4588|M.thermoresistible__bu SAEVLGNHQAEQTHPGQLLPQRRIVAGVGRHQRPHLLLRRALLHEVGDSF ..* * . . *.::* :.. * : :** . Mb0716|M.bovis_AF2122/97 ----- Rv0697|M.tuberculosis_H37Rv ----- MAV_4474|M.avium_104 ----- MMAR_1025|M.marinum_M ----- MUL_0777|M.ulcerans_Agy99 ----- MAB_3830c|M.abscessus_ATCC_199 ----- MSMEG_1428|M.smegmatis_MC2_155 ----- Mflv_5056|M.gilvum_PYR-GCK --AGA Mvan_1300|M.vanbaalenii_PYR-1 ERAGA TH_4588|M.thermoresistible__bu A----