For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_1428 (-)

annotation: glucose-methanol-choline oxidoreductase
coordinates: 1528038 - 1529444
length: 468

VLIVGAGSAGSVLAERLSADPSCQVTVVEAGPAPSDPRVAAQITDGVRLPIGAASSVVRHYGSTLTEDPP
RRTEIIRGSVVGGSGAVNGGYFCRGLPTDFTAWAVPGWSWDDVLPHFRAIETDLDFATALHGSEGPIKVR
RVHEFDGCTAAFVDAVSAAGYGWIDDLNGSDADAALPPGVGAVPLNIDGGTRLGPGGAYLQPALDRPNLH
LRADTRVRRVLVEHDAAVGVECVDGEILYADRIVLSAGAIGSAHLLLLSGIGPAGDLAAHGIAVAANLPV
GTATVDHPEWVLPVAWTPTHDLPPLEAVLTTADGIEIRPYTAGFSALVHGPEHDPAELPHLGVALMRPHS
RGRVRLASADPAVPPIIEHRYDTVAGDVDALRAGAELARELVSHAVKVGEASWSTSQHLAGTAPLSADGQ
GVLDPTCRVLGVERLWVVDGSIMPAITSRGPHATIAMIGHRAAEFIAT
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_1428--100% (468)glucose-methanol-choline oxidoreductase
M. smegmatis MC2 155MSMEG_3444-1e-5633.86% (505) choline dehydrogenase
M. smegmatis MC2 155MSMEG_5305-1e-4129.92% (508) choline dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0716-1e-14956.69% (471) dehydrogenase
M. gilvum PYR-GCKMflv_5056-1e-17665.61% (471) glucose-methanol-choline oxidoreductase
M. tuberculosis H37RvRv0697-1e-14956.69% (471) dehydrogenase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3830c-1e-12052.64% (473) dehydrogenase (glucose-methanol-choline oxidoreductase)
M. marinum MMMAR_1025-1e-15561.57% (471) dehydrogenase
M. avium 104MAV_4474-1e-15359.45% (471) FAD dependent oxidoreductase, putative
M. thermoresistible (build 8)TH_4588-1e-10871.33% (279) PUTATIVE glucose-methanol-choline oxidoreductase
M. ulcerans Agy99MUL_0777-1e-15661.57% (471) dehydrogenase
M. vanbaalenii PYR-1Mvan_1300-1e-17966.17% (470) glucose-methanol-choline oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0716|M.bovis_AF2122/97            ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP
Rv0697|M.tuberculosis_H37Rv         ----MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADP
MAV_4474|M.avium_104                ----MNDAVSHSDVLIVGAGSAGSVVAERLSADPGCTVTVVEAGPSLDDP
MMAR_1025|M.marinum_M               ----MTAALRHSDVLIVGAGSAGSVLAARLSADPSCAVTLVEAGPGLADP
MUL_0777|M.ulcerans_Agy99           ----MTAALRHSDVLVVGAGSAGSVLAARLSTDPSCAVTLVEAGPGLADP
MAB_3830c|M.abscessus_ATCC_199      ----------------MGAGSAGSILAGRLSEDPSFRVVLVEAGP--VSS
MSMEG_1428|M.smegmatis_MC2_155      -------------MLIVGAGSAGSVLAERLSADPSCQVTVVEAGPAPSDP
Mflv_5056|M.gilvum_PYR-GCK          -----------MSVLIVGAGSAGSVLAERLSADPGCEVTVVEAGPGLSDS
Mvan_1300|M.vanbaalenii_PYR-1       ---------MRSDVLIVGAGSAGSVLAERLSADDGCQVTVVEAGPGPFDP
TH_4588|M.thermoresistible__bu      VTGRPGAERCHSDVLIVGAGSAGSVLAERLSADSGCRVTVVEAGPGPSDP
                                                    :*******::* *** * .  *.::****   ..

Mb0716|M.bovis_AF2122/97            GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI
Rv0697|M.tuberculosis_H37Rv         GLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAI
MAV_4474|M.avium_104                ALLARTANGLQLPIGVGSPLVRRYQTQLTERPARRHPLVRGATIGGSGAI
MMAR_1025|M.marinum_M               RLLAQTANGLQLPISADSPLVQRYQSQLTDHPVRRIPILRGATLGGSGAV
MUL_0777|M.ulcerans_Agy99           RLLAQTANGLQLPISADSPLVQCYQSQLTDHPVRRTPILRGATLGGSGAV
MAB_3830c|M.abscessus_ATCC_199      ADEAGVRNGYRLPIGPGSQIATYYWATLTS-TGDQAELVRGSVVGGSGAI
MSMEG_1428|M.smegmatis_MC2_155      RVAAQITDGVRLPIGAASSVVRHYGSTLTEDPPRRTEIIRGSVVGGSGAV
Mflv_5056|M.gilvum_PYR-GCK          RVRDQISDGLRLPIGAASSVVRRYDTALTEEPRRHARIMRGVVVGGSGAV
Mvan_1300|M.vanbaalenii_PYR-1       RVGTQITDGLRLPIGVASSVVRRYPTALTDEPRRHAQIMRGAVVGGSGAV
TH_4588|M.thermoresistible__bu      RVAHQITDGLRLPIGDASSVVRRYPTTLTDHPRRPAQLMRGAVVGGSGAV
                                           :* :***.  * :.  * : **. .     ::** .:*****:

Mb0716|M.bovis_AF2122/97            NGGYFCRGLPSDFDRASIPGWAWSDVLEHFRAIETDLDF-ETPVHGRSGP
Rv0697|M.tuberculosis_H37Rv         NGGYFCRGLPSDFDRASIPGWAWSDVLEHFRAIETDLDF-ETPVHGRSGP
MAV_4474|M.avium_104                NGGYFCRGLRRDFDRLGLPGWAWSDVLDSFRAIETDLDF-DGPAHGRSGP
MMAR_1025|M.marinum_M               NGGYFCRGLARDFDGAAIPGWSWSQVLPHFRAIETDLDF-DTPVHGRTGP
MUL_0777|M.ulcerans_Agy99           NGGYFCRGLARDFDGAAIPGWSWSQVLPHFRAIETDLDF-DTPVHGRTGP
MAB_3830c|M.abscessus_ATCC_199      NGGYFVRGRPADFDGWAVSGWSWAEVRDHFRAIETDHDFRDDPLHGSQGP
MSMEG_1428|M.smegmatis_MC2_155      NGGYFCRGLPTDFTAWAVPGWSWDDVLPHFRAIETDLDF-ATALHGSEGP
Mflv_5056|M.gilvum_PYR-GCK          NGGYFCRALPADVDGWGMDGWSWDDVLPHFRAIETDLDF-ATPVHGDTGP
Mvan_1300|M.vanbaalenii_PYR-1       NGGYFCRALPSDFDGWGIAGWSWDEVLPHYTAIETDLDF-TGPLHGSAGP
TH_4588|M.thermoresistible__bu      NGGYFCRGLPADFDRWGLGDWTWDRVLPHFRAIETDLDF-DGPLHGADGP
                                    ***** *.   *.   .: .*:*  *   : ***** **   . **  **

Mb0716|M.bovis_AF2122/97            IPVRRTHEMTGITESFMAAAEDAGFAWIADLN--DVGPEMPSGVGAVPLN
Rv0697|M.tuberculosis_H37Rv         IPVRRTHEMTGITESFMAAAEDAGFAWIADLN--DVGPEMPSGVGAVPLN
MAV_4474|M.avium_104                ILVRRTREMTGTTERFIDAAWRAGFGWIDDLN--DAAAQPVSGIGAVPLN
MMAR_1025|M.marinum_M               IPVRRTRDQTGVTQRFVTAAQRAGFGWIADLN--DVGPDIAAGVGAVPLN
MUL_0777|M.ulcerans_Agy99           IPVRRIRDQTGVTQRFVTAAQRAGFGWIADLN--DVGPDIAAGVGAVPLN
MAB_3830c|M.abscessus_ATCC_199      IPVGRRHEQSSAGTELMDLAVNRGYPVVADLN--GSAG---AGVGLVPLN
MSMEG_1428|M.smegmatis_MC2_155      IKVRRVHEFDGCTAAFVDAVSAAGYGWIDDLNGSDADAALPPGVGAVPLN
Mflv_5056|M.gilvum_PYR-GCK          ITVRRVAEFDGATASFVDAARTAGFGWVEDLNGATAEHAVPAGIGAVPLN
Mvan_1300|M.vanbaalenii_PYR-1       ISVRRVSEFDGCTASFVESAREAGFGWIEDLNGSTPERPLPAGVGAVPLN
TH_4588|M.thermoresistible__bu      IPVRRSTEFDGCTAKFIEAVEDAGYPWIPDLNGATPDQPLPPGVGQVPLN
                                    * * *  :  .    ::  .   *:  : ***         .*:* ****

Mb0716|M.bovis_AF2122/97            IVNGVRTSSAVGYLMPALGRPNLTLLARTRAVRLRFSATTAVGVDAIGPG
Rv0697|M.tuberculosis_H37Rv         IVNGVRTSSAVGYLMPALGRPNLTLLARTRAVRLRFSATTAVGVDAIGPG
MAV_4474|M.avium_104                IVDGVRKGSGAGYLIPALSRPNLRVQAHTRVARLRFAGTVARGADVVGPH
MMAR_1025|M.marinum_M               IVDGVRTGSGAAYLLPALGRPNLTLLEETRAQQVRFSAATAVGVDAVGPR
MUL_0777|M.ulcerans_Agy99           IVDGVRTGSGAAYLLPALGRPNLTLLEETRAQQVRFSAATAVGVDAVGPR
MAB_3830c|M.abscessus_ATCC_199      IDSGIRVGPARAYLESAVWRPNLAVYSGTRVLRVLCSGGKATGVQVAVGN
MSMEG_1428|M.smegmatis_MC2_155      IDGGTRLGPGGAYLQPALDRPNLHLRADTRVRRVLVEHDAAVGVECVDG-
Mflv_5056|M.gilvum_PYR-GCK          IDRGTRVGPGGAFLQPALGRANLTVLTDTRVLRLTFAAGRVTGVLCVGPD
Mvan_1300|M.vanbaalenii_PYR-1       INGGTRVGPGGAFLQPALQRANLTLVTDTRVGGLRFSAGRVVGVDCLGPG
TH_4588|M.thermoresistible__bu      INGGTRVGPGAAYLQPALARPNLTVLTETRVRRVRIADGRADGVECLGPD
                                    *  * * ... .:* .*: *.** :   **.  :      . *.      

Mb0716|M.bovis_AF2122/97            GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAGVKVLMALP-VGM
Rv0697|M.tuberculosis_H37Rv         GPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAGVKVLMALP-VGM
MAV_4474|M.avium_104                GRATLTADRIVLCAGAIETAHLLMLSGIGEPGMLRAAGVPVRVALP-VGT
MMAR_1025|M.marinum_M               GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHAMLRSAGVPVVQALP-VGM
MUL_0777|M.ulcerans_Agy99           GPMTLWADRIVLCAGAIGSAHLLMLSGIGDHAMLRAAGVPVVQALP-VGM
MAB_3830c|M.abscessus_ATCC_199      SVRTLTADRIILSAGAIESAKLLLLSGLGPADELRAVGVQPVVDLPGVGT
MSMEG_1428|M.smegmatis_MC2_155      --EILYADRIVLSAGAIGSAHLLLLSGIGPAGDLAAHGIAVAANLP-VGT
Mflv_5056|M.gilvum_PYR-GCK          GPVTVGADRIVLCAGAIATAQLLMVSGVGPPPVLRAAGVPVEIDLP-VGV
Mvan_1300|M.vanbaalenii_PYR-1       GPTTLVADRVVLCAGAIASAQLLMVSGVGPQQVLRAAGVAVQIDLP-VGV
TH_4588|M.thermoresistible__bu      GATVLTADRIVLSAGAIGSAHLLMLSGIGPQRLLGALGIPVVAAXXXXGV
                                        : ***::*.**** :*:**::**:*    * : *:         * 

Mb0716|M.bovis_AF2122/97            GCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD--GIEIRPYTGGFVAMTGD
Rv0697|M.tuberculosis_H37Rv         GCSDHPEWVMPTNWAVAVDRPVLEVLLSTHD--GIEIRPYTGGFVAMTGD
MAV_4474|M.avium_104                SFSDHAEWVLPTDWPVAPGRPVLEVVLSTAD--DLEIRPYTGGFVAMTGD
MMAR_1025|M.marinum_M               NCSDHPEWALPTTWTVAAGRPVLEAVLNTAD--GIEIRPYTTGFAAMAGA
MUL_0777|M.ulcerans_Agy99           NCSDHPEWALPTTWTVVAGRPVLEAVLNTAD--GIEIRPYTTGFEAMAGA
MAB_3830c|M.abscessus_ATCC_199      RVMDHAEWVLDTGEQGQQGHPVLDTVLHTDHPMCLEIRPYTTGFAAMAGV
MSMEG_1428|M.smegmatis_MC2_155      ATVDHPEWVLPVAWTPTHDLPPLEAVLTTAD--GIEIRPYTAGFSALVHG
Mflv_5056|M.gilvum_PYR-GCK          DTIDHPEWVLPVSWAPTHGVPPLEAVLTTDD--GVEIRPYTVGFEAMMTG
Mvan_1300|M.vanbaalenii_PYR-1       DTVDHPEWVLPVTWPPTHGVPPLEAVLTTGD--GLEIRPYTAGFGAMMTG
TH_4588|M.thermoresistible__bu      GEPDPAHLAGQVDGGQGVDRDARRVTLHREHR-GPRIG---GGQHVEHRR
                                       * .. .  .      .     . *   .    .*     *  .    

Mb0716|M.bovis_AF2122/97            GTAGHRDWPHIGVALMQPRARG--RITLVSSDPQIPVRIEHRYDSEPA-D
Rv0697|M.tuberculosis_H37Rv         GTAGHRDWPHIGVALMQPRARG--RITLVSSDPQIPVRIEHRYDSEPA-D
MAV_4474|M.avium_104                GTAGHADWPHLGVALMQPRARG--CLTLMSADPAVPPRIEHRYDSEPG-D
MMAR_1025|M.marinum_M               AAKGHRDWPHLGVALMRPRSRA--RVTLASPDPSVPPRIGHHYDSEPA-D
MUL_0777|M.ulcerans_Agy99           AAKGHRDWPHLGVALMRPRSRA--RVTLASPDPSVPPRIGHHYDSEPA-D
MAB_3830c|M.abscessus_ATCC_199      VADG-ADARQIGVALMTPQCRG--RLELRSTDPAAPVYIDLRYDSETA-D
MSMEG_1428|M.smegmatis_MC2_155      PEHDPAELPHLGVALMRPHSRG--RVRLASADPAVPPIIEHRYDTVAG-D
Mflv_5056|M.gilvum_PYR-GCK          RRDDPTDQPHLGVTLMRPLSRG--RVTICSADPDADPVIEHRYDSAPA-D
Mvan_1300|M.vanbaalenii_PYR-1       RRDDPTDQPHLGVTLMQPLSRG--RVTITSADPDADPVIEHRYDSEPA-D
TH_4588|M.thermoresistible__bu      GRRVEHERLLAGEPPLVARAAGGGRRHVGDQRRGRALGIGHGGDELPGGD
                                          :    * . : . . .     : .        *    *  .. *

Mb0716|M.bovis_AF2122/97            VAALRQGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDP
Rv0697|M.tuberculosis_H37Rv         VAALRQGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDP
MAV_4474|M.avium_104                VAALARGAELARELAGGTTDAAAAIWSTSQHLCGTAPMGVDGDPRAVVDP
MMAR_1025|M.marinum_M               VAALQRGTELARELAGSAVAGEPG-WSTSQHLCGSAPMGVDADPTAVVDP
MUL_0777|M.ulcerans_Agy99           VAALQRGTELARELAGSAVAGEPG-WSTSQHLCGSAPMGVDADPTAVVDP
MAB_3830c|M.abscessus_ATCC_199      MDRLRDGVHLVSELYG--RRFGGPRWSTSQHLCGTAPLGNDRDKHAVVDK
MSMEG_1428|M.smegmatis_MC2_155      VDALRAGAELARELVSHAVKVGEASWSTSQHLAGTAPLSADG--QGVLDP
Mflv_5056|M.gilvum_PYR-GCK          VALLREGAQLASELAGATVQSEPS-WATSQHLCGTAKMG------AVVDE
Mvan_1300|M.vanbaalenii_PYR-1       VELLRAGTRLAHELAGATVQSEAS-WATSQHLCGTARMG------AVVDA
TH_4588|M.thermoresistible__bu      PRQHRRPFVTGAELVEQVRHHDRAGQIRPAQQRAAHLLGDDAQLDRSRAR
                                                **              . :  .:  :.           

Mb0716|M.bovis_AF2122/97            RCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEFVQ----
Rv0697|M.tuberculosis_H37Rv         RCRVRG-IENLWVIDGSVLP---SITSRGPHATIVMLGHRAAEFVQ----
MAV_4474|M.avium_104                RCRVRG-IDNLWVIDGSVLP---AITSRGPHATIVMIGHRAAEFVR----
MMAR_1025|M.marinum_M               ECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEFIG----
MUL_0777|M.ulcerans_Agy99           ECRVRG-IENLWVVDGSILP---LIPSRGPHATIVMLGHRAAEFIG----
MAB_3830c|M.abscessus_ATCC_199      YCRVRG-IDGLFVIDGSILP---TIPSRGPAATIAMIGHRAAQFVAWS--
MSMEG_1428|M.smegmatis_MC2_155      TCRVLG-VERLWVVDGSIMP---AITSRGPHATIAMIGHRAAEFIAT---
Mflv_5056|M.gilvum_PYR-GCK          RCRVYG-VDNLWVVDGSILP---DIPSRGPHATIVMAGHRAAEFVSSS--
Mvan_1300|M.vanbaalenii_PYR-1       RCRVYG-VSNLWVVDGSILP---AIPSRGPHATIVMAGHRAAEFVSATST
TH_4588|M.thermoresistible__bu      SAEVLGNHQAEQTHPGQLLPQRRIVAGVGRHQRPHLLLRRALLHEVGDSF
                                     ..* *  .   .  *.::*    :.. *      :  :**  .      

Mb0716|M.bovis_AF2122/97            -----
Rv0697|M.tuberculosis_H37Rv         -----
MAV_4474|M.avium_104                -----
MMAR_1025|M.marinum_M               -----
MUL_0777|M.ulcerans_Agy99           -----
MAB_3830c|M.abscessus_ATCC_199      -----
MSMEG_1428|M.smegmatis_MC2_155      -----
Mflv_5056|M.gilvum_PYR-GCK          --AGA
Mvan_1300|M.vanbaalenii_PYR-1       ERAGA
TH_4588|M.thermoresistible__bu      A----