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SNTRWRMFALLLLLVTVNYVDRGSLSVALPAIKEDFHISAEVTGLLLSAFFWAYAAMQIPAGWLIDRFGP RKLITAACTGWGTATALSGMAPNIGTMAVARGLIGVTEAPIMPAGGKLNAVFLTEKERGRGATILDAGAP LGSAVGGIAFAALIGATGSWRWAFIIAGAVTVLLGIWAWRAIRDTPEEHPKVDEAEREYLVSAHREESAR HQSTGERAGLVYYMKYRSFWAMCAGWLGFNGVFYGLLTWGPLFLSESKGFELEAIGWSTFAIFGSGFVGE IIGGQLADRLKEKGYGTNRVMRSLLGFAGMCVVAGLVGVVLMPSPLAAVLLLSTVLFFLRWVGLFWSVPS ILGGREDAGVLGGAMNLAGNISGFVTPMAVGFIVGATGAYTWALLYFVGAGVIMTAAVLILDYSKRLAPK AAPLSTTKGASV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1320 | - | - | 100% (433) | major facilitator superfamily protein MFS_1 |
| M. smegmatis MC2 155 | MSMEG_6178 | - | 9e-48 | 29.14% (429) | D-galactonate transporter |
| M. smegmatis MC2 155 | MSMEG_2549 | - | 7e-43 | 28.84% (423) | major facilitator superfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1699c | - | 2e-23 | 25.12% (422) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3439 | - | 5e-18 | 26.07% (349) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1672c | - | 2e-23 | 25.12% (422) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 1e-08 | 25.29% (170) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1396 | - | 4e-12 | 28.49% (172) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_0596 | - | 1e-31 | 26.98% (430) | integral membrane transport protein |
| M. avium 104 | MAV_1387 | - | 3e-11 | 26.86% (175) | drug transporter |
| M. thermoresistible (build 8) | TH_0390 | - | 1e-12 | 22.33% (421) | major facilitator superfamily protein permease |
| M. ulcerans Agy99 | MUL_3155 | - | 3e-16 | 24.02% (408) | hypothetical protein MUL_3155 |
| M. vanbaalenii PYR-1 | Mvan_3193 | - | 1e-17 | 26.04% (288) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1699c|M.bovis_AF2122/97 -----------------------------------MATIAA---SPTHNA
Rv1672c|M.tuberculosis_H37Rv -----------------------------------MATIAA---SPTHNA
MMAR_0596|M.marinum_M -----------------------------------MAVLDTGERSLEART
Mflv_3439|M.gilvum_PYR-GCK -----------------------------------MSAPAAAETTSDTHG
Mvan_3193|M.vanbaalenii_PYR-1 -----------------------------------MSAPTAPATTTETHG
MAB_1396|M.abscessus_ATCC_1997 -----------------------------------------------MRP
MAV_1387|M.avium_104 --------------------------------------------------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MSMEG_1320|M.smegmatis_MC2_155 --------------------------------------------------
TH_0390|M.thermoresistible__bu ---------------------------------MNPGRRARTAAGDDDER
MUL_3155|M.ulcerans_Agy99 ----------------------------------MTTNGRAIRGGLADAV
Mb1699c|M.bovis_AF2122/97 LGKAARRLLPLLFVLYVINFVDRANISVAALAMNADLRLSATAYGTAAGV
Rv1672c|M.tuberculosis_H37Rv LGKAARRLLPLLFVLYVINFVDRANISVAALAMNADLRLSATAYGTAAGV
MMAR_0596|M.marinum_M IRKLGIRIVPFLMALYFVNYLDRTNLGIARADISAHLQLTATMFGLASGI
Mflv_3439|M.gilvum_PYR-GCK P-TRAWSAVCVLAVVGTLNYADRFLPAVLAEPIREDLSLSDTAIGVINGF
Mvan_3193|M.vanbaalenii_PYR-1 P-RRAWAAVSVLAVVGTLNYADRFLPAVLAEPIREELALTDTALGVINGF
MAB_1396|M.abscessus_ATCC_1997 EYPRPWITLWVVLFGLFMILLDSTIVSVANPAIKAGFGADYSSTVWVTSA
MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MSMEG_1320|M.smegmatis_MC2_155 MSNTRWRMFALLLLLVTVNYVDRGSLSVALPAIKEDFHISAEVTGLLLSA
TH_0390|M.thermoresistible__bu LAVRPWIVWATGLLAYIVAVLDRTTLGVSGLAAADRFNAAPAALSTFVVL
MUL_3155|M.ulcerans_Agy99 GGPARMRVIVLLALVVGLEGASNGTIGALAVVLKQAFGITNLQVGLLVTA
: . :
Mb1699c|M.bovis_AF2122/97 -FFLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALVTSAHTLY
Rv1672c|M.tuberculosis_H37Rv -FFLGYVLFQVPANAALARFGAGRTLTAVVLAWGVCSAATALVTSAHTLY
MMAR_0596|M.marinum_M -FFIGYVLVEVPSNLALDRYGARRWLARIAVSWGIVVVATGFAPNATTLL
Mflv_3439|M.gilvum_PYR-GCK GFLAVYALIGIPIARISDRGAYGLVISGCLSLWGVMTMLGGAVQSGFQLA
Mvan_3193|M.vanbaalenii_PYR-1 GFLVVYALVGIPIARISDRGAYGLVISGCLSLWGVMTMLGGAVQSGFQLA
MAB_1396|M.abscessus_ATCC_1997 -YLLGYAVPLLITGRLGDQFGPRSMYLSGLAVFTAASLWCGLAGSIGWLI
MAV_1387|M.avium_104 -YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLI
MLBr_01562|M.leprae_Br4923 -YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLV
MSMEG_1320|M.smegmatis_MC2_155 -FFWAYAAMQIPAGWLIDRFGPRKLITAACTGWGTATALSGMAPNIGTMA
TH_0390|M.thermoresistible__bu -QVIVYALAQVPAGLLLDRFGSKALIVAGAAVMATGQLILAFTESLTLAI
MUL_3155|M.ulcerans_Agy99 STAIG-IVVMLVSGTLADRVNRTRVLWITVLIWSVAMALGGISAGYGWLL
: . .
Mb1699c|M.bovis_AF2122/97 LARFALGVAEGGFFPGVIAYLTVWFPC-AQRARAVATFLLAIPVANTVGL
Rv1672c|M.tuberculosis_H37Rv LARFALGVAEGGFFPGVIAYLTVWFPC-AQRARAVATFLLAIPVANTVGL
MMAR_0596|M.marinum_M VLRFLLGVAEAGLFPGVIYYLSRWFPR-DYRARVVALFMMASPIAAALGT
Mflv_3439|M.gilvum_PYR-GCK MTRVGVAIGEAGSTPAAHAYVARNFAP-ERRAAPLAVITLAIPLASAASL
Mvan_3193|M.vanbaalenii_PYR-1 LTRVGVAIGEAGSTPAAHAYVARNFAP-ERRAAPLAVITLAIPLASAASL
MAB_1396|M.abscessus_ATCC_1997 AARVVQGIGAAMLTPQTLTVVQRVFPP-ERRGTAMGVWGAVAGIATLVGP
MAV_1387|M.avium_104 AARVVQGVGAGVMTPQTLSTITRIFPA-ERRGVAVSVWSATAGAASLAGP
MLBr_01562|M.leprae_Br4923 IARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGL
MSMEG_1320|M.smegmatis_MC2_155 VARGLIGVTEAPIMPAGGKLNAVFLTE-KERGRGATILDAGAPLGSAVGG
TH_0390|M.thermoresistible__bu LARAIVGLGDAVTFISVLRLVPHWFRP-RQVPLVTQLTGICGQLGQVLSA
MUL_3155|M.ulcerans_Agy99 ASRVALGAVVAVGGPVVASLMGDFFAQ-HERGRIYGFVLAGEGICTALGV
* . . : .
Mb1699c|M.bovis_AF2122/97 PLSGLIVGHVH-MAGLPGWRAMFVI---EALPALLLAPLLRRLLPDNPQR
Rv1672c|M.tuberculosis_H37Rv PLSGLIVGHVH-MAGLPGWRAMFVI---EALPALLLAPLLRRLLPDNPQR
MMAR_0596|M.marinum_M PLAAWLIHLGNGVFGLAGWQFMMIA---VGVPAIVLGFACWYYLVDRPGD
Mflv_3439|M.gilvum_PYR-GCK IGGGLLAQALG-------WRTAFVV---MGAISVLFVPVVLAVVGRR---
Mvan_3193|M.vanbaalenii_PYR-1 IGGGLLAQALG-------WRTAFLV---MGALSVVFVPVVLAVVGRR---
MAB_1396|M.abscessus_ATCC_1997 VAGGLLVDGWG-------WQWIFYVNVPVGVLGIILGAIYIPRMPTHRHR
MAV_1387|M.avium_104 LAGGVLVDGLG-------WQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR
MLBr_01562|M.leprae_Br4923 VVGGALT-EVS-------WRLAFLVNVPIGLVMIYLARTALHETHKERMK
MSMEG_1320|M.smegmatis_MC2_155 IAFAALIGATG------SWRWAFIIAGAVTVLLGIWAWRAIRDTPEEHPK
TH_0390|M.thermoresistible__bu VLFLALLTARG-------WTPAYLSVVALGVLTIALTLALVQNTPDGR--
MUL_3155|M.ulcerans_Agy99 LVSGWLAAIT--------WRLSFLW---LAVTGLLLTLALARTVPEPAR-
: *
Mb1699c|M.bovis_AF2122/97 ASWL------------------------TPEERAELSARLTEDTPAPTG-
Rv1672c|M.tuberculosis_H37Rv ASWL------------------------TPEERAELSARLTEDTPAPTG-
MMAR_0596|M.marinum_M AAWL------------------------EPDERQWLVDTLAEEQRQVAGD
Mflv_3439|M.gilvum_PYR-GCK --------------------------------QKPLVESVAVQQVPVKW-
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------QRPVIESVAAEQVSANW-
MAB_1396|M.abscessus_ATCC_1997 LDLLGMALSAVGMFAFVFALQEGESFQWAPGVWAMMAAGLVVLGVFVWWQ
MAV_1387|M.avium_104 FDLVGVGLSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQ
MLBr_01562|M.leprae_Br4923 LDAAGAILATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVV
MSMEG_1320|M.smegmatis_MC2_155 VD--------------------------EAEREYLVSAHREESARHQSTG
TH_0390|M.thermoresistible__bu -------------------------------AAPATMGTVREIAASLKT-
MUL_3155|M.ulcerans_Agy99 -------------------------------GGDTFGASAGSDRRDCSND
Mb1699c|M.bovis_AF2122/97 -----RSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVA----SLAHGT
Rv1672c|M.tuberculosis_H37Rv -----RSSGAGWDLVLFAVVYGGLYFALYALQFFLPQLVA----SLAHGT
MMAR_0596|M.marinum_M FHFPLRRALTSPRIWALALVYFGIAYGLYALTFFLPSIISGFKKSFGIDF
Mflv_3439|M.gilvum_PYR-GCK -----WDILRKPSYLAIVAGAASISVAGYALTTFAPAFLMR-ARGMTLGD
Mvan_3193|M.vanbaalenii_PYR-1 -----WDILRKPSYLAIVAGAASISVAGYALTTFAPAFLMR-ARGMSLGE
MAB_1396|M.abscessus_ATCC_1997 SANRGEPLIPLRLFADRNFSLAGVGIASMSFCVISTGLPMMFYTQLALGF
MAV_1387|M.avium_104 SVNVREPLIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGL
MLBr_01562|M.leprae_Br4923 ERTAENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGY
MSMEG_1320|M.smegmatis_MC2_155 ERAGLVYYMKYRSFWAMCAGWLGFNGVFYGLLTWGPLFLSE-SKGFELEA
TH_0390|M.thermoresistible__bu -----VWLRAGTRLGFFTHMGTQFSVTVFALMWGVPYLTVG------QGL
MUL_3155|M.ulcerans_Agy99 TLAAAVIAQRVSAHPHLILQESPEGRSLRWAVGYVLKIRTN---------
.
Mb1699c|M.bovis_AF2122/97 ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAAL
Rv1672c|M.tuberculosis_H37Rv ATLTAATLAALPYGVAALAMLAWSHRSIDRSGAQAGHITLPTTAAGSAAL
MMAR_0596|M.marinum_M SIVQVGLIAAIPYTCAAVAMYLWS-RHADATGEQVWHVAVPMLLGG-LAI
Mflv_3439|M.gilvum_PYR-GCK VGLQYGIASGVTGILGLLVVGKVADRLSARDPRWLLWLVALMTAALIPFS
Mvan_3193|M.vanbaalenii_PYR-1 VGLQYGIASGVTGILGLIVVGKVADRLSAADPRWLLWLVAAMTATLIPFS
MAB_1396|M.abscessus_ATCC_1997 SPTKAALTQAPTAIVSGILAPLAGWLVDRVRPSILIGGGIALMIASTLWW
MAV_1387|M.avium_104 SPTRSALLIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWL
MLBr_01562|M.leprae_Br4923 SALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYG
MSMEG_1320|M.smegmatis_MC2_155 IGWSTFAIFGSGFVGEIIGGQLADRLKEKGYGTNRVMRSLLGFAGMCVVA
TH_0390|M.thermoresistible__bu STQMAGAMLTLSVAVAIVAGVLIGIFTGR-HPHRRSRLVLAIIASNAAAW
MUL_3155|M.ulcerans_Agy99 VALMVASSFGYFFYTGLGTFAVALLRSRFRISQTLAISLIAIIGVGAPIG
Mb1699c|M.bovis_AF2122/97 GAALSPMSPIVT-LSWLTIAVAGILAAMP-AFWSRCTAALAGPRVAVAIA
Rv1672c|M.tuberculosis_H37Rv GAALSPMSPIVT-LSWLTIAVAGILAAMP-AFWSRCTAALAGPRVAVAIA
MMAR_0596|M.marinum_M PVALHLHTPVLV-MVAVAITAMGVFAAIP-SFWALPSNFLTGTAAAGAIG
Mflv_3439|M.gilvum_PYR-GCK TLGLLVASPGLA-VLFISLSYVVGTAYMA-PSIAAIQRLVPAEQRATASA
Mvan_3193|M.vanbaalenii_PYR-1 TLGFLVDSSTLA-VCFIALSYVVGTAYMA-PSIAAIQRLVPAEQRATASA
MAB_1396|M.abscessus_ATCC_1997 TLLMRPETQMWQ-LMLPAAGIGAAMACIWGPLATTATRNLPPSVAGAGSG
MAV_1387|M.avium_104 TFEMSPATPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSA
MLBr_01562|M.leprae_Br4923 WAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSA
MSMEG_1320|M.smegmatis_MC2_155 GLVGVVLMPSPLAAVLLLSTVLFFLRWVG-LFWSVPSILGGREDAGVLGG
TH_0390|M.thermoresistible__bu TAVLALPDRAPLWLLITLIVVISVGGPGSMVGFDFARTFNPSATLGTAQG
MUL_3155|M.ulcerans_Agy99 TLCAGRLADWLIGRGYLGARLGVAGAAFLVAGGFFVPALLTDNVVIAVVA
.
Mb1699c|M.bovis_AF2122/97 TVNAVASLASFAG-PYATGHLKDATGTYHLALLTVAAVLAAAAACSLLLR
Rv1672c|M.tuberculosis_H37Rv TVNAVASLASFAG-PYATGHLKDATGTYHLALLTVAAVLAAAAACSLLLR
MMAR_0596|M.marinum_M LINSVGNLGGFAA-PYLTGALEQVTGTDKAGMWAVGAMMLMSAFVVVLLR
Mflv_3439|M.gilvum_PYR-GCK IFLFFSAILGSAG-PFVAGLISDAMKAELGSGSLGRALLCVVPVMHLVAI
Mvan_3193|M.vanbaalenii_PYR-1 IFLFFSAILGSVG-PLVTGLISDTLKADLGTMSLGRALLCVVPLMHLVAI
MAB_1396|M.abscessus_ATCC_1997 VYNTLRQVGGVVGSSAMGALMTARLTATMPAMPPGSG-STPEAALPPGLR
MAV_1387|M.avium_104 VYNSVRQLGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLR
MLBr_01562|M.leprae_Br4923 IALMLQSLGGPLVLAVIQAVITSRT-LYLGGTTGPVKFMNDAQLRALDHG
MSMEG_1320|M.smegmatis_MC2_155 AMNLAGNISGFVT-PMAVGFIVGATGAYTWALLYFVGAGVIMTAAVLILD
TH_0390|M.thermoresistible__bu MVNMGGFLASLLVMQAMGQILDAAGGYSFDSFRLAWTVQYVVWVVAAVGI
MUL_3155|M.ulcerans_Agy99 AFLAAIGLGGVNPPLDAARLDIMHSRLWGRAEAIRTTLRSGFTAAAPLVF
: .
Mb1699c|M.bovis_AF2122/97 HAGRTVCANDSEIMLHPSPATPFV--------------------------
Rv1672c|M.tuberculosis_H37Rv HAGRTVCANDSEIMLHPSPATPFV--------------------------
MMAR_0596|M.marinum_M AVPGSPTAAE-----RPN--------------------------------
Mflv_3439|M.gilvum_PYR-GCK GCYLLASRRYLRELVN----------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 GCYLLASRRYVREIVD----------------------------------
MAB_1396|M.abscessus_ATCC_1997 APFSAAMAQSMLLGIAALALGLVAALFMR---------------------
MAV_1387|M.avium_104 GPFAAAMSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYG
MLBr_01562|M.leprae_Br4923 YTYGLLWVAGAVVIVGVAALFIGYT-------------------------
MSMEG_1320|M.smegmatis_MC2_155 YSKRLAPKAAPLSTTKGASV------------------------------
TH_0390|M.thermoresistible__bu LITRKKARRQMALEQERMLLESFE--------------------------
MUL_3155|M.ulcerans_Agy99 AWYPCSWRRSGARPVGWQPHRPG---------------------------
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1396|M.abscessus_ATCC_1997 --------------------------------PGGSQVGAVPLDDVVS--
MAV_1387|M.avium_104 GDYHDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRD
MLBr_01562|M.leprae_Br4923 --------------------------------PEQVAYAQEVKEAVDAGE
MSMEG_1320|M.smegmatis_MC2_155 --------------------------------------------------
TH_0390|M.thermoresistible__bu --------------------------------PGPRRHTGPDRTNRPHG-
MUL_3155|M.ulcerans_Agy99 --------------------------------------------------
Mb1699c|M.bovis_AF2122/97 --------------------------------------------------
Rv1672c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0596|M.marinum_M --------------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1396|M.abscessus_ATCC_1997 -VED----------------------------------------------
MAV_1387|M.avium_104 PVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPAD
MLBr_01562|M.leprae_Br4923 L-------------------------------------------------
MSMEG_1320|M.smegmatis_MC2_155 --------------------------------------------------
TH_0390|M.thermoresistible__bu --------------------------------------------------
MUL_3155|M.ulcerans_Agy99 --------------------------------------------------
Mb1699c|M.bovis_AF2122/97 -----------------------------------------------
Rv1672c|M.tuberculosis_H37Rv -----------------------------------------------
MMAR_0596|M.marinum_M -----------------------------------------------
Mflv_3439|M.gilvum_PYR-GCK -----------------------------------------------
Mvan_3193|M.vanbaalenii_PYR-1 -----------------------------------------------
MAB_1396|M.abscessus_ATCC_1997 -----------------------------------------------
MAV_1387|M.avium_104 RFTRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN
MLBr_01562|M.leprae_Br4923 -----------------------------------------------
MSMEG_1320|M.smegmatis_MC2_155 -----------------------------------------------
TH_0390|M.thermoresistible__bu -----------------------------------------------
MUL_3155|M.ulcerans_Agy99 -----------------------------------------------