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IIERDVAVPCDDGLILRADVFRPDDGEPAPVIMTLGPYGKGVEYSDGYAPQWNWLITTYPEVLPGSSRSY MAWETVDPEIWVPWGYAVVRVDSRGAGRSPGVLDMLSPREVRDYHDAIEWAARQPWSTGKVGLNGISYYA INQWLLAAQQPPSLAAMIPWEGAGDFYRDWARHGGIVSNGFLEAWYPRQVVSVQHGNPDGRMDRWQGERA TGPEDLSADELALNRNDPLPEILKRPLDDEFYRDRSPDWSKVTVPFLSAANWAGFGLHPRGNFEAFTQAA SAQKWLEAHPGRHEEWFYLTQGMALQKEFLDHFLKGEDNGWDTRPPVLLHIRRPFTDEVEVRTHSAWPLE NTQWTEVHLDAADMALNFAPVDTEHSVTFDAAGEPLTFLTGPLTAETELTGPLSARLFVSSSTVDADLFV TVQAFAPDGREVEFQGTIDPHTPLAQGWLRASHRKLDVARSLPYRPYHSHDELQPLDPGTIYQLDIEIWP TCIVLPAEYRIALQISGHDFEREEPKDGNEAWVSRGSGPWLHTHPEDRPASIYTGRTTIHTGGSTPSTLL LPVIPS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1308 | - | - | 100% (567) | peptidase S15 |
| M. smegmatis MC2 155 | MSMEG_5283 | - | 7e-77 | 34.21% (573) | hydrolase, CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_2644 | - | 2e-13 | 28.18% (181) | putative hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1247c | - | 6e-72 | 32.87% (575) | hypothetical protein Mb1247c |
| M. gilvum PYR-GCK | Mflv_4032 | - | 2e-13 | 29.09% (165) | peptidase S15 |
| M. tuberculosis H37Rv | Rv1215c | - | 6e-72 | 32.87% (575) | hypothetical protein Rv1215c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2222c | - | 7e-43 | 27.89% (631) | peptidase |
| M. marinum M | MMAR_1269 | - | 2e-79 | 34.20% (576) | Acyl esterase |
| M. avium 104 | MAV_1359 | - | 2e-71 | 32.64% (573) | hydrolase CocE/NonD family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3980 | - | 2e-31 | 25.52% (529) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 4e-14 | 32.04% (181) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1247c|M.bovis_AF2122/97 MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVVIERDVE
Rv1215c|M.tuberculosis_H37Rv MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVVIERDVE
MAV_1359|M.avium_104 MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDPPADLHVERDVA
MMAR_1269|M.marinum_M -MPTRNPIYDRPWRRAGVVRYAAARVRAILRPPVTVSAAPPDLVVDRDVS
MSMEG_1308|M.smegmatis_MC2_155 ------------------------------------------MIIERDVA
Mflv_4032|M.gilvum_PYR-GCK -----------------MSSELARRARRALSRVFDLPPPVCDFVVHRELR
Mvan_2322|M.vanbaalenii_PYR-1 -----------------MSSELSRLARHALSRALHLPPPVCDYAVNRHVR
MAB_2222c|M.abscessus_ATCC_199 ------------------------------------------------MP
MUL_3980|M.ulcerans_Agy99 MAVQSSARRLEKTSGLGKGERQLNGPQTTGREYANLSEPQYNTMRENNAA
Mb1247c|M.bovis_AF2122/97 VPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRRRGNRWTFSPQY
Rv1215c|M.tuberculosis_H37Rv VPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRRRGNRWTFSPQY
MAV_1359|M.avium_104 VPTRDATVLRINVFRKADAEPRPVILSIHPYGKDSLPKRRGNRWTFSAQY
MMAR_1269|M.marinum_M VRMRDGVVLRVNVYRPPGSGPFPVILAAHPYGKDRLPKRRWWGWGINPQF
MSMEG_1308|M.smegmatis_MC2_155 VPCDDGLILRADVFRPDDGEPAPVIMTLGPYGKG-VEYSDGYAPQWNWLI
Mflv_4032|M.gilvum_PYR-GCK VPMRDRVELVADHYAPHTASPAGTLLVRGPYGRG----------------
Mvan_2322|M.vanbaalenii_PYR-1 VPMRDGVELVADHYTPRTADPAGTLLVRGPYGRG----------------
MAB_2222c|M.abscessus_ATCC_199 ATMRDGTILRADIYRPKLKDPVPVILMRTQYGKD----------------
MUL_3980|M.ulcerans_Agy99 IPVRDGTVLLADVHRPDAQGRFPALIAASPYPRQIQDLG-----------
* * : . .: * :
Mb1247c|M.bovis_AF2122/97 RMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTGDLL
Rv1215c|M.tuberculosis_H37Rv RMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTGDLL
MAV_1359|M.avium_104 RILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTGNLL
MMAR_1269|M.marinum_M RILRQPGQVEISSETSWEAPDPVWWLAHGYAVVNADIRGAGTSDGAGALM
MSMEG_1308|M.smegmatis_MC2_155 TTYPEVLPGSSRSYMAWETVDPEIWVPWGYAVVRVDSRGAGRSPGVLDML
Mflv_4032|M.gilvum_PYR-GCK --------------LPFATMFASFYAARGYHVVFQSVRGTFGSGGEFDPF
Mvan_2322|M.vanbaalenii_PYR-1 --------------FPISVLFGSIYAARGYHVVLQSVRGTFGSGGEFDPF
MAB_2222c|M.abscessus_ATCC_199 ----------TAQIQPSRFRTPDWFASHCYLVVVQDVRGQGTSDGIFTEF
MUL_3980|M.ulcerans_Agy99 -----------APMGFIEAGVTDFWVPRGYVHVIANVRGTGGSGGTFGFF
: . : * . ** * * :
Mb1247c|M.bovis_AF2122/97 SHQEAEDTYDLVGWLADQSWSDGRVVMLGVSYLAISQYAVAALQPPALRA
Rv1215c|M.tuberculosis_H37Rv SHQEAEDTYDLVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPALRA
MAV_1359|M.avium_104 SHREAEDTYDLVQWVAGQPWSDGNVVMLGVSYLAISQYAVAALQPPALRA
MMAR_1269|M.marinum_M SDQEAEDVYDLIEWAGAAPWSSGSVGMAGVSYLAMAQFKAAALRPPSLKA
MSMEG_1308|M.smegmatis_MC2_155 SPREVRDYHDAIEWAARQPWSTGKVGLNGISYYAINQWLLAAQQPPSLAA
Mflv_4032|M.gilvum_PYR-GCK VN-EVDDGADTAAWLRDQPWFTGTFATIGLSYLGFTQWALLTDPPPELAA
Mvan_2322|M.vanbaalenii_PYR-1 VN-EVADGADTAAWLRDQPWFTGTFATMGLSYLGFTQWALLTDPPPELKA
MAB_2222c|M.abscessus_ATCC_199 GN-DGDDGYDTVEWAAGLPGATGKVGMYGSSYVGATQWLAATTTPPHLTT
MUL_3980|M.ulcerans_Agy99 DATERRDMHDLVEWAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPHLKA
: * * * . * . * ** . * . ** * :
Mb1247c|M.bovis_AF2122/97 ICPWEGFTDAYRDLAFPGGIRESGFT--------RLWSRG----------
Rv1215c|M.tuberculosis_H37Rv ICPWEGFTDAYRDLAFPGGIRESGFT--------RLWSRG----------
MAV_1359|M.avium_104 ICPWEGFTDAYRDLMFPGGVRELGFI--------RMWSRN----------
MMAR_1269|M.marinum_M ICPWEGFTDAYRDMFNPGGVAEKGFS--------RVWQTG----------
MSMEG_1308|M.smegmatis_MC2_155 MIPWEGAGDFYRDWARHGGIVSNGFL--------EAWYPR----------
Mflv_4032|M.gilvum_PYR-GCK AVITVGPDDVSGPRWGAGSFGLNDFLGWSDLVGRQEDPNR----------
Mvan_2322|M.vanbaalenii_PYR-1 AVITVGPDDVSGPRWGRGSFGLNDFLGWSHLVGGQEDPNR----------
MAB_2222c|M.abscessus_ATCC_199 IVPSNTASDYYDGWTYEGGAFRLGFVQPWAMGTIATTAAK----------
MUL_3980|M.ulcerans_Agy99 IFPVAATTDLYEAAVHHG-LFSSSFVSPFLTMVGITSERSDALWRGKLVG
* * .*
Mb1247c|M.bovis_AF2122/97 -VRRRTRQTYDMEQMQEAH-------------------------------
Rv1215c|M.tuberculosis_H37Rv -VRRRTRQTYDMEQMQEAH-------------------------------
MAV_1359|M.avium_104 -VRRDTRQAYDLQDMQDRH-------------------------------
MMAR_1269|M.marinum_M -TKHVMRVTEDIGAQRRVH-------------------------------
MSMEG_1308|M.smegmatis_MC2_155 -QVVSVQHGNPDGRMDRWQGERATGPEDLSADELALN---RNDPLPEILK
Mflv_4032|M.gilvum_PYR-GCK -VRTLLRQARAQRRVTSASLRLPLAAASRELLGDG-----ALWFESWLDH
Mvan_2322|M.vanbaalenii_PYR-1 -LRSLLRQAGAQRRVTEASLGLPLGPASRTLLGDG-----APWFESWLEH
MAB_2222c|M.abscessus_ATCC_199 -NRADLAALEQLRAAAAERGRWLNHLPYQDLPPMQPGDPRVAPWYFDWIR
MUL_3980|M.ulcerans_Agy99 LVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRPWDQLWLSAAVE
Mb1247c|M.bovis_AF2122/97 -PLRDDFWR--SRVPDLSAIKVPMLVCGSFSDNNLHSRGSIRAFTRSGCG
Rv1215c|M.tuberculosis_H37Rv -PLRDDFWR--SRVPDLSAIKVPMLVCGSFSDNNLHSRGSIRAFTRSGCG
MAV_1359|M.avium_104 -PLRDEFWR--SLVPDLSAIAVPMLVCGSFSDNNLHSRGSLRAFTHSSST
MMAR_1269|M.marinum_M -PLRDQWWQ--SLVPDLGRIEVPMLVCASFSDNNLHGRGSFRAFEKVGAE
MSMEG_1308|M.smegmatis_MC2_155 RPLDDEFYR--DRSPDWSKVTVPFLSAANWAGFGLHPRGNFEAFTQAASA
Mflv_4032|M.gilvum_PYR-GCK PDTDDPFWTRLRLRDGLERAEVPVLLLTGWQDLFVDQTVEHYRMLAGRGV
Mvan_2322|M.vanbaalenii_PYR-1 PETDDPFWSGLRLRDALADVDVPVLLLTGWQDLFVEQTLEHYRMLTSRGV
MAB_2222c|M.abscessus_ATCC_199 HSTRDDYWKRWSIRDRYQNVTVPVLHFEGWYDAFLRGGLENFAGMTARGG
MUL_3980|M.ulcerans_Agy99 HPTRDEWWDERDINPLLDRIDVPVYLGCDWQNVPLNLPSTFAAWKALADG
* :: **. .: . :
Mb1247c|M.bovis_AF2122/97 HARLYT----------HRGGKWETFYSATALS------------EQLKFL
Rv1215c|M.tuberculosis_H37Rv HARLYT----------HRGGKWETFYSATALS------------EQLKFL
MAV_1359|M.avium_104 HARLYT----------HRGGKWATFYAEEALA------------EQLSFF
MMAR_1269|M.marinum_M DKFAYT----------HRGGKWTTFYSPEARQ------------AQLAFF
MSMEG_1308|M.smegmatis_MC2_155 QKWLEA----------HPGRHEEWFYLTQGMA------------LQKEFL
Mflv_4032|M.gilvum_PYR-GCK PTGLTIGP--------WTHGDMMTKAAPTMLR------------ESLDWL
Mvan_2322|M.vanbaalenii_PYR-1 TAGLTVGP--------WTHGHMMTTAAPTVLG------------ETLDWL
MAB_2222c|M.abscessus_ATCC_199 SPGARRYQRMVIGPWDHLAWGRESSSPSPLLKGLGPGANSPVNEMQLAWF
MUL_3980|M.ulcerans_Agy99 PSTRMG-----------MLGEFGLTWPWESLH-----------LEALAWF
::
Mb1247c|M.bovis_AF2122/97 RDALAGSSGSRS----VRLEVREDRDTITAVREETQWPLAGTRWRPMYLA
Rv1215c|M.tuberculosis_H37Rv RDALAGSSGSRS----VRLEVREDRDTITAVREETQWPLAGTRWRPMYLA
MAV_1359|M.avium_104 RGVLDGAPAARS----VRLEVREDRDTVTAVREESEWPLARTRWRALHLG
MMAR_1269|M.marinum_M DRYLKHLDVPKPPR--VRLEVRERGDVIAETRAERQWPLENTDWRDLYLA
MSMEG_1308|M.smegmatis_MC2_155 DHFLKGEDNGWDTRPPVLLHIRRPFTDEVEVRTHSAWPLENTQWTEVHLD
Mflv_4032|M.gilvum_PYR-GCK ATHLKGEPPQRRSP--VRIHLSRR-----GWLNLPDWPPAMPSLVLHPQP
Mvan_2322|M.vanbaalenii_PYR-1 ATHLGGAAPLRRSP--VRIHLGGR-----GWLNLPDWPPAMPDVVLHPQP
MAB_2222c|M.abscessus_ATCC_199 DHFLKGSDNGVATE---SPRLDYYLMGANRWKHASAWPLPQTNWTVYHLG
MUL_3980|M.ulcerans_Agy99 DHWLKSRDTGILAG----PAIRYVLPGAEGWRTTETWPPPGVVYRKFALR
* : **
Mb1247c|M.bovis_AF2122/97 ------GPG-LLATEPPPTAGSIRFQTR-SRAAAFNWTIPEDIELT----
Rv1215c|M.tuberculosis_H37Rv ------GPG-LLATEPPPTAGSIRFQTR-SRAAAFNWTIPEDIELT----
MAV_1359|M.avium_104 ------DAG-VLRTDPAAQPGRVAFGTR-SRAACFTWTVPDDVELT----
MMAR_1269|M.marinum_M ------DDG-VLDHEPPAAEGSVTFHTR-RRAAAFTLPVVADLELT----
MSMEG_1308|M.smegmatis_MC2_155 ------AADMALNFAPVDTEHSVTFDAAGEPLTFLTGPLTAETELT----
Mflv_4032|M.gilvum_PYR-GCK ------GGGLAPGAPG-AADATFVYNPGDPTPTVGGRLLSPVGGYR----
Mvan_2322|M.vanbaalenii_PYR-1 ------AGRLGPAAPEPDGTATFVYNPADPTPTVGGRLLSPAGGYR----
MAB_2222c|M.abscessus_ATCC_199 GRGTQHNGTLRDSAAAHDAPDVYLYDPANPVPSAGGHSCCAAESAPQGRY
MUL_3980|M.ulcerans_Agy99 -----ADGQLGDDEGEPGAREYLVLGGGLNRAAASAIDPPSMLTWT----
:
Mb1247c|M.bovis_AF2122/97 GPMAARLWVQLDGCDDANLFVGVEKWRDG----QFVAFEGSYGWGRDRVT
Rv1215c|M.tuberculosis_H37Rv GPMAARLWVQLDGCDDANLFVGVEKWRDG----QFVAFEGSYGWGRDRVT
MAV_1359|M.avium_104 GPMAARLWVELHGCDDANLFVGVEKWRPGRFRDRFVAFEGSYGYGRDRVS
MMAR_1269|M.marinum_M GPMSLALWVSVEGTDDVALFAGVEKWVGN----KWVSFEGSYGYGRDRIT
MSMEG_1308|M.smegmatis_MC2_155 GPLSARLFVSSS-TVDADLFVTVQAFAPD---GREVEFQGTIDP-HTPLA
Mflv_4032|M.gilvum_PYR-GCK DDTALARRADVLTFTGTALASDLPVVGVP-----VLDVAHTCATPHNDLF
Mvan_2322|M.vanbaalenii_PYR-1 DDTALARRADVLTFTGTPLPADLYVVGHP-----VLELAHTCANPHNDLF
MAB_2222c|M.abscessus_ATCC_199 DQRAVEQRPDVLTYTTEPLSTNTEITGPIS-----VDLWASSSAPDTDFT
MUL_3980|M.ulcerans_Agy99 -SAPLTRDLDVVGDIELRLVAAATAMDTAW---IATLHEVARDGTVSDVT
. . * : .
Mb1247c|M.bovis_AF2122/97 TGWQRVSLRELDPELSQPWE---PVPACARPRPVTAGEVVAVDVALGPSA
Rv1215c|M.tuberculosis_H37Rv TGWQRVSLRELDPELSQPWE---PVPACARPRPVTAGEVVAVDVALGPSA
MAV_1359|M.avium_104 TGWQRVSLRALDSRLSRPGQ---PVAACTDPQPVAAGEVVAVDVALGPSA
MMAR_1269|M.marinum_M TGWQRVSLRELDVEQSTPYE---PVHTFAHSQPLSPGEVVPVELALGPSA
MSMEG_1308|M.smegmatis_MC2_155 QGWLRASHRKLDVARSLPYR---PYHSHDELQPLDPGTIYQLDIEIWPTC
Mflv_4032|M.gilvum_PYR-GCK VRISQVDAHGRSRNVSDGYV---ASAPDSG----------TVTVELDPVA
Mvan_2322|M.vanbaalenii_PYR-1 VRVSQVDEHGRSRNVSDGYL---AAAPDSG----------TARIELDPVA
MAB_2222c|M.abscessus_ATCC_199 AKLVAVQADGTAANLNNGIVRTSLAQSLSERRLMPIGQPHKYHIDIWPVS
MUL_3980|M.ulcerans_Agy99 AGWLRASMRRVDEKASRRGA---PILPCRGMEAVPIGEDVVYRIPLVANA
.. . . : : . .
Mb1247c|M.bovis_AF2122/97 TLFRAGEQLRLVVGGRWLSPRNPLTG--------QFPAAYPRPP------
Rv1215c|M.tuberculosis_H37Rv TLFRAGEQLRLVVGGRWLSPRNPLTG--------QFPAAYPRPP------
MAV_1359|M.avium_104 TLFRAGEHLRLVVAGRWLCPTNPLTG--------QIPAAYQNSP------
MMAR_1269|M.marinum_M TAFHHGDRIRLVIAGRQLAPRNPLYG--------SFPALYAPSP------
MSMEG_1308|M.smegmatis_MC2_155 IVLPAEYRIALQISGHDFEREEPKDGNEAWVSRGSGPWLHTHPEDRPASI
Mflv_4032|M.gilvum_PYR-GCK WTFPAGSRIRVLIAGGSHPRFLRNLG--------TGEHAGTATD-----F
Mvan_2322|M.vanbaalenii_PYR-1 WTFPAGSRIRLLIAGGSHPRFLRNLG--------TGETATTATT-----Y
MAB_2222c|M.abscessus_ATCC_199 YQFRTGERIRLEISSSDFPQYAPNPN--------TAAPFGRNAELR----
MUL_3980|M.ulcerans_Agy99 RRFKAGCRIRLIFTSDDQDPATPAIM--------SFRHASVGTS------
: :: : . . .
Mb1247c|M.bovis_AF2122/97 -RGRVTLHWGPRYDAHLLIPEVPG--------------------
Rv1215c|M.tuberculosis_H37Rv -RGRVTLHWGPRYDAHLLIPEVPG--------------------
MAV_1359|M.avium_104 -RGRVSLHWGPRRDAHLLIPEIP---------------------
MMAR_1269|M.marinum_M -PARCTLHWGADRPARLRVPVIGSGDNAPA--------------
MSMEG_1308|M.smegmatis_MC2_155 YTGRTTIHTGGSTPSTLLLPVIPS--------------------
Mflv_4032|M.gilvum_PYR-GCK ATARHTVHLGEGTRLTLPAGPPPPSAD-----------------
Mvan_2322|M.vanbaalenii_PYR-1 KTARHTVHLGEQSRLVLPAGSHPPSTD-----------------
MAB_2222c|M.abscessus_ATCC_199 -TATQIILHDAAHPSTLTLPVIPAGDPGTETFPMPRRPDDPPGN
MUL_3980|M.ulcerans_Agy99 --SRNTIRSSSRLHLRVLPAQSSELQS-----------------
. : . :