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VPTRNPIYDRPWRRAGVVRYAAARVRAILRPPVTVSAAPPDLVVDRDVSVRMRDGVVLRVNVYRPPGSGP FPVILAAHPYGKDRLPKRRWWGWGINPQFRILRQPGQVEISSETSWEAPDPVWWLAHGYAVVNADIRGAG TSDGAGALMSDQEAEDVYDLIEWAGAAPWSSGSVGMAGVSYLAMAQFKAAALRPPSLKAICPWEGFTDAY RDMFNPGGVAEKGFSRVWQTGTKHVMRVTEDIGAQRRVHPLRDQWWQSLVPDLGRIEVPMLVCASFSDNN LHGRGSFRAFEKVGAEDKFAYTHRGGKWTTFYSPEARQAQLAFFDRYLKHLDVPKPPRVRLEVRERGDVI AETRAERQWPLENTDWRDLYLADDGVLDHEPPAAEGSVTFHTRRRAAAFTLPVVADLELTGPMSLALWVS VEGTDDVALFAGVEKWVGNKWVSFEGSYGYGRDRITTGWQRVSLRELDVEQSTPYEPVHTFAHSQPLSPG EVVPVELALGPSATAFHHGDRIRLVIAGRQLAPRNPLYGSFPALYAPSPPARCTLHWGADRPARLRVPVI GSGDNAPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1269 | - | - | 100% (568) | Acyl esterase |
| M. marinum M | MMAR_5521 | - | 3e-41 | 27.52% (556) | peptidase S15 |
| M. marinum M | MMAR_1910 | - | 2e-10 | 24.19% (525) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1247c | - | 0.0 | 56.12% (556) | hypothetical protein Mb1247c |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv1215c | - | 0.0 | 56.12% (556) | hypothetical protein Rv1215c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2222c | - | 5e-28 | 24.49% (641) | peptidase |
| M. avium 104 | MAV_1359 | - | 0.0 | 55.95% (563) | hydrolase CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_5283 | - | 0.0 | 57.19% (556) | hydrolase, CocE/NonD family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3980 | - | 4e-39 | 26.98% (556) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 7e-10 | 27.69% (242) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1247c|M.bovis_AF2122/97 MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDP-PADVVIERDV
Rv1215c|M.tuberculosis_H37Rv MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDP-PADVVIERDV
MAV_1359|M.avium_104 MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDP-PADLHVERDV
MSMEG_5283|M.smegmatis_MC2_155 -----MAALDRPWRRPGAARYALSRLRGFVRTPVEVYEPEPGSVTVRHDV
MMAR_1269|M.marinum_M -MPTRNPIYDRPWRRAGVVRYAAARVRAILRPPVTVSAA-PPDLVVDRDV
MUL_3980|M.ulcerans_Agy99 MAVQSSARRLEKTSGLGKGERQLNGPQTTGREYANLSEP-QYNTMRENNA
MAB_2222c|M.abscessus_ATCC_199 -------------------------------------------------M
Mvan_2322|M.vanbaalenii_PYR-1 ------------------MSSELSRLARHALSRALHLPPPVCDYAVNRHV
Mb1247c|M.bovis_AF2122/97 EVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRR--RGNRWTFS
Rv1215c|M.tuberculosis_H37Rv EVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRR--RGNRWTFS
MAV_1359|M.avium_104 AVPTRDATVLRINVFRKADAEPRPVILSIHPYGKDSLPKR--RGNRWTFS
MSMEG_5283|M.smegmatis_MC2_155 PVTTRDGTVLRVNVHLPAGENPVPVLLCAHPYGKDKVPVRKKRGRGYALP
MMAR_1269|M.marinum_M SVRMRDGVVLRVNVYRPPGSGPFPVILAAHPYGKDRLPKR--RWWGWGIN
MUL_3980|M.ulcerans_Agy99 AIPVRDGTVLLADVHRPDAQGRFPALIAASPYPRQIQDLG----------
MAB_2222c|M.abscessus_ATCC_199 PATMRDGTILRADIYRPKLKDPVPVILMRTQYGKDTAQIQ----------
Mvan_2322|M.vanbaalenii_PYR-1 RVPMRDGVELVADHYTPRTADPAGTLLVRGPYGRGFPIS-----------
**.. * : . .: * :
Mb1247c|M.bovis_AF2122/97 PQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTG
Rv1215c|M.tuberculosis_H37Rv PQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTG
MAV_1359|M.avium_104 AQYRILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTG
MSMEG_5283|M.smegmatis_MC2_155 FQYRVLRQPARVRFSSLTTWEAPDPAWWTKQGFAVVNCDLRGAGTSGGVG
MMAR_1269|M.marinum_M PQFRILRQPGQVEISSETSWEAPDPVWWLAHGYAVVNADIRGAGTSDGAG
MUL_3980|M.ulcerans_Agy99 --------------APMGFIEAGVTDFWVPRGYVHVIANVRGTGGSGGTF
MAB_2222c|M.abscessus_ATCC_199 ------------------PSRFRTPDWFASHCYLVVVQDVRGQGTSDGIF
Mvan_2322|M.vanbaalenii_PYR-1 ---------------------VLFGSIYAARGYHVVLQSVRGTFGSGGEF
: : : * . ** * *
Mb1247c|M.bovis_AF2122/97 DLLSHQEAEDTYDLVGWLADQSWSDGRVVMLGVSYLAISQYAVAALQPPA
Rv1215c|M.tuberculosis_H37Rv DLLSHQEAEDTYDLVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPA
MAV_1359|M.avium_104 NLLSHREAEDTYDLVQWVAGQPWSDGNVVMLGVSYLAISQYAVAALQPPA
MSMEG_5283|M.smegmatis_MC2_155 SPLSDQEGEDVYDLVEWAAAQPWSTGAVGMIGVSYLAISQWKSAALRPPH
MMAR_1269|M.marinum_M ALMSDQEAEDVYDLIEWAGAAPWSSGSVGMAGVSYLAMAQFKAAALRPPS
MUL_3980|M.ulcerans_Agy99 GFFDATERRDMHDLVEWAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPH
MAB_2222c|M.abscessus_ATCC_199 TEFGN-DGDDGYDTVEWAAGLPGATGKVGMYGSSYVGATQWLAATTTPPH
Mvan_2322|M.vanbaalenii_PYR-1 DPFVN-EVADGADTAAWLRDQPWFTGTFATMGLSYLGFTQWALLTDPPPE
: : * * * . * . * **.. :* . **
Mb1247c|M.bovis_AF2122/97 LRAICPWEGFTDAYRDLAFPG--------------GIRESGFTRLWS---
Rv1215c|M.tuberculosis_H37Rv LRAICPWEGFTDAYRDLAFPG--------------GIRESGFTRLWS---
MAV_1359|M.avium_104 LRAICPWEGFTDAYRDLMFPG--------------GVRELGFIRMWS---
MSMEG_5283|M.smegmatis_MC2_155 LRAIVPWEGMTDPYRDLLHPG--------------GIAETGFIKLWS---
MMAR_1269|M.marinum_M LKAICPWEGFTDAYRDMFNPG--------------GVAEKGFSRVWQ---
MUL_3980|M.ulcerans_Agy99 LKAIFPVAATTDLYEAAVHHGLFSSSFVSPFLTMVGITSERSDALWRG--
MAB_2222c|M.abscessus_ATCC_199 LTTIVPSNTASDYYDGWTYEG--------------GAFRLGFVQPWAMGT
Mvan_2322|M.vanbaalenii_PYR-1 LKAAVITVGPDDVSGPRWGRG---------------SFGLNDFLGWS---
* : * * *
Mb1247c|M.bovis_AF2122/97 --------RGVRRRTRQTYDMEQMQ-------------------------
Rv1215c|M.tuberculosis_H37Rv --------RGVRRRTRQTYDMEQMQ-------------------------
MAV_1359|M.avium_104 --------RNVRRDTRQAYDLQDMQ-------------------------
MSMEG_5283|M.smegmatis_MC2_155 --------RSLR-DTRLKYDLGKEN-------------------------
MMAR_1269|M.marinum_M --------TGTKHVMRVTEDIGAQR-------------------------
MUL_3980|M.ulcerans_Agy99 --KLVGLVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRPWDQLW
MAB_2222c|M.abscessus_ATCC_199 IATTAAKNRADLAALEQLRAAAAERGRWLNHLPYQDLPPMQPGDPRVAPW
Mvan_2322|M.vanbaalenii_PYR-1 --HLVGGQEDPNRLRSLLRQAGAQRRVTEASLGLPLGPASRTLLGDGAPW
.
Mb1247c|M.bovis_AF2122/97 ----EAHPLRDD-FWRS--RVPDLSAIKVPMLVCGSFSDNNLHS-RGSIR
Rv1215c|M.tuberculosis_H37Rv ----EAHPLRDD-FWRS--RVPDLSAIKVPMLVCGSFSDNNLHS-RGSIR
MAV_1359|M.avium_104 ----DRHPLRDE-FWRS--LVPDLSAIAVPMLVCGSFSDNNLHS-RGSLR
MSMEG_5283|M.smegmatis_MC2_155 ----SSRPRYDD-WWRS--LVPALDRIEVPALICGSFSDNNLHT-RGSVR
MMAR_1269|M.marinum_M ----RVHPLRDQ-WWQS--LVPDLGRIEVPMLVCASFSDNNLHG-RGSFR
MUL_3980|M.ulcerans_Agy99 LSAAVEHPTRDE-WWDERDINPLLDRIDVPVYLGCDWQNVPLNL-PSTFA
MAB_2222c|M.abscessus_ATCC_199 YFDWIRHSTRDD-YWKRWSIRDRYQNVTVPVLHFEGWYDAFLRGGLENFA
Mvan_2322|M.vanbaalenii_PYR-1 FESWLEHPETDDPFWSGLRLRDALADVDVPVLLLTGWQDLFVEQTLEHYR
:. *: :* : ** .: : :.
Mb1247c|M.bovis_AF2122/97 AFTRSGC--GHARLYTHRGGKWETFYS-------------------ATAL
Rv1215c|M.tuberculosis_H37Rv AFTRSGC--GHARLYTHRGGKWETFYS-------------------ATAL
MAV_1359|M.avium_104 AFTHSSS--THARLYTHRGGKWATFYA-------------------EEAL
MSMEG_5283|M.smegmatis_MC2_155 GFEQIGS--AERHLYTHRGGKWAAFYS-------------------DDAL
MMAR_1269|M.marinum_M AFEKVGA--EDKFAYTHRGGKWTTFYS-------------------PEAR
MUL_3980|M.ulcerans_Agy99 AWKALAD--GPSTRMGMLGEFGLTWPW-------------------ESLH
MAB_2222c|M.abscessus_ATCC_199 GMTARGGSPGARRYQRMVIGPWDHLAWGRESSSPSPLLKGLGPGANSPVN
Mvan_2322|M.vanbaalenii_PYR-1 MLTSRGVTAGLTVGPWTHGHMMTTAAP--------------------TVL
.
Mb1247c|M.bovis_AF2122/97 SEQLKFLRDALAGSSGSRS--VRLEVREDRDTITAVREETQWPLAGTRWR
Rv1215c|M.tuberculosis_H37Rv SEQLKFLRDALAGSSGSRS--VRLEVREDRDTITAVREETQWPLAGTRWR
MAV_1359|M.avium_104 AEQLSFFRGVLDGAPAARS--VRLEVREDRDTVTAVREESEWPLARTRWR
MSMEG_5283|M.smegmatis_MC2_155 RTQLAFLVRHLRGGTAQELPRVRLEVRESRDRVVAVRDEAQWPLPSTRWT
MMAR_1269|M.marinum_M QAQLAFFDRYLKHLDVPKPPRVRLEVRERGDVIAETRAERQWPLENTDWR
MUL_3980|M.ulcerans_Agy99 LEALAWFDHWLKSRDTGIL--AGPAIRYVLPGAEGWRTTETWPPPGVVYR
MAB_2222c|M.abscessus_ATCC_199 EMQLAWFDHFLKGSDNGVAT-ESPRLDYYLMGANRWKHASAWPLPQTNWT
Mvan_2322|M.vanbaalenii_PYR-1 GETLDWLATHLGGAAPLRRSPVRIHLG-----GRGWLNLPDWP-PAMPDV
* :: * : **
Mb1247c|M.bovis_AF2122/97 PMYLAGPGLLATEPPPTAGSIRFQTRSRAAAFNWTIPEDIELTGPMAARL
Rv1215c|M.tuberculosis_H37Rv PMYLAGPGLLATEPPPTAGSIRFQTRSRAAAFNWTIPEDIELTGPMAARL
MAV_1359|M.avium_104 ALHLGDAGVLRTDPAAQPGRVAFGTRSRAACFTWTVPDDVELTGPMAARL
MSMEG_5283|M.smegmatis_MC2_155 PLYLHDAG-LRAAPPDAAGSISFDTRRAAARFGWTLPEDTELTGPMALRL
MMAR_1269|M.marinum_M DLYLADDGVLDHEPPAAEGSVTFHTRRRAAAFTLPVVADLELTGPMSLAL
MUL_3980|M.ulcerans_Agy99 KFALRADGQLGDDEGEPGAREYLVLGGGLNRAAASAIDPPSMLTWTSAPL
MAB_2222c|M.abscessus_ATCC_199 VYHLGGRGTQHNGTLRDSAAAHDAPDVYLYDPANPVPSAGGHSCCAAESA
Mvan_2322|M.vanbaalenii_PYR-1 VLHPQPAGRLGPAAPEPDGTATFVYN---------PADPTPTVGGRLLSP
* .
Mb1247c|M.bovis_AF2122/97 WVQLDGCDDANLFVGVEKWRDG---------QFVAFEGSYGWG--RDRVT
Rv1215c|M.tuberculosis_H37Rv WVQLDGCDDANLFVGVEKWRDG---------QFVAFEGSYGWG--RDRVT
MAV_1359|M.avium_104 WVELHGCDDANLFVGVEKWRPGRFRD-----RFVAFEGSYGYG--RDRVS
MSMEG_5283|M.smegmatis_MC2_155 YLSAD-TDDVDLFVGVEKWDGA---------RYVPFEGSYGFG--RDRVT
MMAR_1269|M.marinum_M WVSVEGTDDVALFAGVEKWVGN---------KWVSFEGSYGYG--RDRIT
MUL_3980|M.ulcerans_Agy99 TRDLDVVGDIELRLVAAATAMDT--------AWIATLHEVARDGTVSDVT
MAB_2222c|M.abscessus_ATCC_199 PQGRYDQRAVEQRPDVLTYTTEPLSTNTEITGPISVDLWASSSAPDTDFT
Mvan_2322|M.vanbaalenii_PYR-1 AGGYRDDTALARRADVLTFTGTPLPADLYVVGHPVLELAHTCANPHNDLF
. .
Mb1247c|M.bovis_AF2122/97 TGWQRVSLRELDPELSQ---PWEPVPACARPRPVTAGEVVAVDVALGPSA
Rv1215c|M.tuberculosis_H37Rv TGWQRVSLRELDPELSQ---PWEPVPACARPRPVTAGEVVAVDVALGPSA
MAV_1359|M.avium_104 TGWQRVSLRALDSRLSR---PGQPVAACTDPQPVAAGEVVAVDVALGPSA
MSMEG_5283|M.smegmatis_MC2_155 TGWLRASMRALDESRSR---PFEPVPTFTDPRPLRPGEVVPVDIPLGPSS
MMAR_1269|M.marinum_M TGWQRVSLRELDVEQST---PYEPVHTFAHSQPLSPGEVVPVELALGPSA
MUL_3980|M.ulcerans_Agy99 AGWLRASMRRVDEKASR---RGAPILPCRGMEAVPIGEDVVYRIPLVANA
MAB_2222c|M.abscessus_ATCC_199 AKLVAVQADGTAANLNNGIVRTSLAQSLSERRLMPIGQPHKYHIDIWPVS
Mvan_2322|M.vanbaalenii_PYR-1 VRVSQVDEHGRSRNVSDG-------------YLAAAPDSGTARIELDPVA
. .. . : : : . :
Mb1247c|M.bovis_AF2122/97 TLFRAGEQLRLVVGGRWL--SPRNPLTGQFPAAYPRPPRGRVTLHWGPRY
Rv1215c|M.tuberculosis_H37Rv TLFRAGEQLRLVVGGRWL--SPRNPLTGQFPAAYPRPPRGRVTLHWGPRY
MAV_1359|M.avium_104 TLFRAGEHLRLVVAGRWL--CPTNPLTGQIPAAYQNSPRGRVSLHWGPRR
MSMEG_5283|M.smegmatis_MC2_155 TLFRAGEQLRLVVAGRWL--WPRNPLTGQFPAAYERRSRGTATLHWGPDR
MMAR_1269|M.marinum_M TAFHHGDRIRLVIAGRQL--APRNPLYGSFPALYAPSPPARCTLHWGADR
MUL_3980|M.ulcerans_Agy99 RRFKAGCRIRLIFTSDDQ--DPATPAIMSFRHASVGTS-SRNTIRSSSRL
MAB_2222c|M.abscessus_ATCC_199 YQFRTGERIRLEISSSDFPQYAPNPNTAAPFGRNAELRTATQIILHDAAH
Mvan_2322|M.vanbaalenii_PYR-1 WTFPAGSRIRLLIAGGSHPRFLRNLGTGETATTATTYKTARHTVHLGEQS
* * ::** . . . . : .
Mb1247c|M.bovis_AF2122/97 DAHLLIPEVPG--------------------
Rv1215c|M.tuberculosis_H37Rv DAHLLIPEVPG--------------------
MAV_1359|M.avium_104 DAHLLIPEIP---------------------
MSMEG_5283|M.smegmatis_MC2_155 QARLLVPVVGDAHR-----------------
MMAR_1269|M.marinum_M PARLRVPVIGSGDNAPA--------------
MUL_3980|M.ulcerans_Agy99 HLRVLPAQSSELQS-----------------
MAB_2222c|M.abscessus_ATCC_199 PSTLTLPVIPAGDPGTETFPMPRRPDDPPGN
Mvan_2322|M.vanbaalenii_PYR-1 RLVLPAGSHPPSTD-----------------
: