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M. smegmatis MC2 155 MSMEG_2644 (-)

annotation: putative hydrolase
coordinates: 2724054 - 2725727
length: 557

PGIRRYTGKFAAKLLGLPPHSTDFTVHHGLRVPMRDGVELVADHYEPLTTRPAGTLLVRGPYGRRFPFSA
IFAEVYAARGYHVVLQSVRGTFGSGGEFTPMVHEMDDGADTVAWLRTQPWFTGSFATVGLSYLGFTQWAL
LADPPPEMKAAVITVGPHDFSQSAWGTGSFTLNDFLGWSAMVARQEEPGVVRALVRQLRSPAEVAKAAAG
VPVGPSGRRLLGAGAPWFESWLEHPDRDDPFWERLRFDQALERVEVPILLLSGWQDLFLDQTLEQYTQLH
RRGVPVAMTVGPWTHTQMMTKGASTVIGESLDWLGTHLAGASGSHSRDHVRIFVNHHGWIDLPEWPLADW
PTRRDRELFLQPAARLTDSAPPPTAAPSSFTYHPARPTPTIGGRLLSRDGGYRDDSELAARDDVVTFTSD
PLPADLYVVGNPFVELVHSCDNPHNDVFVRISEVDAKGRSRNVTDAFRRRTGQVGTPETVRLELDAVAHR
FAAGTRIRLLVAGGSHPRFARNLGTGEPQPSGSRLKQARHSVHHGDGGVSRLILPAGPTPPLGLRT*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_2644--100% (557)putative hydrolase
M. smegmatis MC2 155MSMEG_5283-1e-1623.64% (626) hydrolase, CocE/NonD family protein
M. smegmatis MC2 155MSMEG_1308-2e-1328.18% (181) peptidase S15

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2823-0.064.43% (551) hydrolase
M. gilvum PYR-GCKMflv_4032-0.060.29% (549) peptidase S15
M. tuberculosis H37RvRv2800-0.064.43% (551) hydrolase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0501c-1e-9135.28% (547) peptidase S15
M. marinum MMMAR_1910-0.061.02% (531) hydrolase
M. avium 104MAV_3687-0.060.36% (555) hydrolase CocE/NonD family protein
M. thermoresistible (build 8)TH_1432-2e-7755.07% (276) POSSIBLE HYDROLASE
M. ulcerans Agy99MUL_2134-0.061.21% (531) hydrolase
M. vanbaalenii PYR-1Mvan_2322-0.062.78% (540) peptidase S15

CLUSTAL 2.0.9 multiple sequence alignment


Mb2823|M.bovis_AF2122/97            MSTTSARPERPKLRALTGRVG----GQALGGLLGLPR-ATTRYTVGH-VR
Rv2800|M.tuberculosis_H37Rv         MSTTSARPERPKLRALTGRVG----GQALGGLLGLPR-ATTRYTVGH-VR
MMAR_1910|M.marinum_M               MSITSTDVGQPTLRALTKRVGGSAAGGALGGLLGLPR-ATTRYTVSR-VG
MUL_2134|M.ulcerans_Agy99           MSITSTHVGQPTLRALTKRVGGSAAGDALGGLLGLPR-ATTRYTVSR-VG
MAV_3687|M.avium_104                MSLTSLRPAQPALHTLR-HLG----GRAAGRLLGLPP-ATTDYTVRR-VA
MSMEG_2644|M.smegmatis_MC2_155      ---------MPGIRRYT--------GKFAAKLLGLPP-HSTDFTVHHGLR
Mflv_4032|M.gilvum_PYR-GCK          MSSELARRAR----------------RALSRVFDLPP-PVCDFVVHRELR
Mvan_2322|M.vanbaalenii_PYR-1       MSSELSRLAR----------------HALSRALHLPP-PVCDYAVNRHVR
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      MLEELALTWTGRLS-----------APVLEKLLDLPEPLTTDIQTQRDIT
                                                                                      

Mb2823|M.bovis_AF2122/97            VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFPFSLVFARIYAARGY
Rv2800|M.tuberculosis_H37Rv         VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFPFSLVFARIYAARGY
MMAR_1910|M.marinum_M               VPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRGFPFSLVFARLYAARGY
MUL_2134|M.ulcerans_Agy99           VPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRGFPFSLVFARLYAARGY
MAV_3687|M.avium_104                VPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFPFALVFGGLYAARGY
MSMEG_2644|M.smegmatis_MC2_155      VPMRDGVELVADHYEPLTTRPAGTLLVRGPYGRRFPFSAIFAEVYAARGY
Mflv_4032|M.gilvum_PYR-GCK          VPMRDRVELVADHYAPHTASPAGTLLVRGPYGRGLPFATMFASFYAARGY
Mvan_2322|M.vanbaalenii_PYR-1       VPMRDGVELVADHYTPRTADPAGTLLVRGPYGRGFPISVLFGSIYAARGY
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      VRMPDGVRLSTDHFRPPGQHPLPAVIFRTPYDKRGMVSQLWAMLLARQGF
                                                                                      

Mb2823|M.bovis_AF2122/97            HVVLQSVRGTFGSGGVFEPMVNEAADGADTVAWLREQPWFTGRFGTIGLP
Rv2800|M.tuberculosis_H37Rv         HVVLQSVRGTFGSGGVFEPMVNEAADGADTVAWLREQPWFTGRFGTIGLP
MMAR_1910|M.marinum_M               HVVLQSVRGTFGSAGQFEPMVNEAADGADTVEWLRRQPWFTGRFATIGVS
MUL_2134|M.ulcerans_Agy99           HVVLQSVRGTFGSAGQFEPMVNEAADGADTVEWLRRQPWFTGRFATIGVS
MAV_3687|M.avium_104                HVVLQSVRGTFGSGGVFEPMAHEVADGADTVAWLREQPWFTGRFATIGMS
MSMEG_2644|M.smegmatis_MC2_155      HVVLQSVRGTFGSGGEFTPMVHEMDDGADTVAWLRTQPWFTGSFATVGLS
Mflv_4032|M.gilvum_PYR-GCK          HVVFQSVRGTFGSGGEFDPFVNEVDDGADTAAWLRDQPWFTGTFATIGLS
Mvan_2322|M.vanbaalenii_PYR-1       HVVLQSVRGTFGSGGEFDPFVNEVADGADTAAWLRDQPWFTGTFATMGLS
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      QVIVQDTRGQYGSQGKFDAFRQERADGLATAAWVREQPWCDGTLATAGPS
                                                                                      

Mb2823|M.bovis_AF2122/97            YLGFTQWALLHDPPPELAAAVITVGPHDFRASVWGTGSFTVNDFLGWSDL
Rv2800|M.tuberculosis_H37Rv         YLGFTQWALLHDPPPELAAAVITVGPHDFRASVWGTGSFTVNDFLGWSDL
MMAR_1910|M.marinum_M               YLGFTQWALLQDPPPELAAAVITAGPHDLRSSVWGTGSFAINDFLGWSEL
MUL_2134|M.ulcerans_Agy99           YLGFTQWALLQDPPPELAAAVITAGPHDLRSSVWGTGSFAINDFLGWSEL
MAV_3687|M.avium_104                YLGFTQWALLQDPPPDMATAVIMVGPHDFNESTWGTGSFAVNDFLGWSDM
MSMEG_2644|M.smegmatis_MC2_155      YLGFTQWALLADPPPEMKAAVITVGPHDFSQSAWGTGSFTLNDFLGWSAM
Mflv_4032|M.gilvum_PYR-GCK          YLGFTQWALLTDPPPELAAAVITVGPDDVSGPRWGAGSFGLNDFLGWSDL
Mvan_2322|M.vanbaalenii_PYR-1       YLGFTQWALLTDPPPELKAAVITVGPDDVSGPRWGRGSFGLNDFLGWSHL
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      YLGHTQWAVAPYIEPPLAAMCPAITTSNFRELFYPGGSFNLHNLLTWSSS
                                                                                      

Mb2823|M.bovis_AF2122/97            VSHQEDPGRIRAGIRQLTAPRRVARTAATLPLGESARTLLGTGAPWFESW
Rv2800|M.tuberculosis_H37Rv         VSHQEDPGRIRAGIRQLTAPRRVARTAATLPLGESARTLLGTGAPWFESW
MMAR_1910|M.marinum_M               VARQEDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGTGAPWFESW
MUL_2134|M.ulcerans_Agy99           VARQEDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGTGAPWFESW
MAV_3687|M.avium_104                VSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWFESW
MSMEG_2644|M.smegmatis_MC2_155      VARQEEPGVVRALVRQLRSPAEVAKAAAGVPVGPSGRRLLGAGAPWFESW
Mflv_4032|M.gilvum_PYR-GCK          VGRQEDPNRVRTLLRQARAQRRVTSASLRLPLAAASRELLGDGALWFESW
Mvan_2322|M.vanbaalenii_PYR-1       VGGQEDPNRLRSLLRQAGAQRRVTEASLGLPLGPASRTLLGDGAPWFESW
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      IGSPE-TSQLTRLLRAGAIAKRVRRAMDHLPLGNADNIAIGKPEPFWRTV
                                                                                      

Mb2823|M.bovis_AF2122/97            VEHTDRDDPFWDRLRFPAALDRVQVPVLLVGGWQDIFLRQTLQQYRHLRD
Rv2800|M.tuberculosis_H37Rv         VEHTDRDDPFWDRLRFPAALDRVQVPVLLVGGWQDIFLRQTLQQYRHLRD
MMAR_1910|M.marinum_M               LEHTDHSDPFWDRMRSPDALDRVQVPVLLVGGWQDVFVQQTLQQYRHLRD
MUL_2134|M.ulcerans_Agy99           LEHTDHSDPFWDRMRSPDALDRVQVPVLLVGGWQDVFVQQTLQQYRHLRD
MAV_3687|M.avium_104                IEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRA
MSMEG_2644|M.smegmatis_MC2_155      LEHPDRDDPFWERLRFDQALERVEVPILLLSGWQDLFLDQTLEQYTQLHR
Mflv_4032|M.gilvum_PYR-GCK          LDHPDTDDPFWTRLRLRDGLERAEVPVLLLTGWQDLFVDQTVEHYRMLAG
Mvan_2322|M.vanbaalenii_PYR-1       LEHPETDDPFWSGLRLRDALADVDVPVLLLTGWQDLFVEQTLEHYRMLTS
TH_1432|M.thermoresistible__bu      --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199      IDHT--EDDHWDEINHTPALATLNTPVSMVTGWWDLLLVGQLRDYEELQK
                                                                                      

Mb2823|M.bovis_AF2122/97            RGVHVALTVGPWTHTQMLTKGLATGARESLDWLDAHLGRAPALR-PSPVR
Rv2800|M.tuberculosis_H37Rv         RGVHVALTVGPWTHTQMLTKGLATGARESLDWLDAHLGRAPALR-PSPVR
MMAR_1910|M.marinum_M               RGVDVALTIGPWTHSQLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVR
MUL_2134|M.ulcerans_Agy99           RGVDVALTIGPWTHSQLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVR
MAV_3687|M.avium_104                RGVDVALTVGPWTHTQLLTTGLGVCTRESLQWLETHLGDAPGRR-AGRVH
MSMEG_2644|M.smegmatis_MC2_155      RGVPVAMTVGPWTHTQMMTKGASTVIGESLDWLGTHLAGASGSHSRDHVR
Mflv_4032|M.gilvum_PYR-GCK          RGVPTGLTIGPWTHGDMMTKAAPTMLRESLDWLATHLKGEPPQR-RSPVR
Mvan_2322|M.vanbaalenii_PYR-1       RGVTAGLTVGPWTHGHMMTTAAPTVLGETLDWLATHLGGAAPLR-RSPVR
TH_1432|M.thermoresistible__bu      --VPVAMTIGPWTHGHILTRAAPRVLRESLAWLDTHLAGTRTAS-RPPVR
MAB_0501c|M.abscessus_ATCC_199      TDCPRRITIGPWDH----MKSLKAVIGDSFSWLAAHLHGDASATHRAQVR
                                          :*:*** *      .      ::: ** :**           *:

Mb2823|M.bovis_AF2122/97            VFVTGQG----WRHLPDWP----PATTERAWYLQPG------GRLGESAP
Rv2800|M.tuberculosis_H37Rv         VFVTGQG----WRHLPDWP----PATTERAWYLQPG------GRLGESAP
MMAR_1910|M.marinum_M               VYVTGEG----WRHLSDWP----PKTTDHELYLHPT------GRLSEIAP
MUL_2134|M.ulcerans_Agy99           VYVTGEG----WRHLSDWP----PKTTDHELYLHPT------GRLSEIAP
MAV_3687|M.avium_104                VYVTGVDRARAWRRLPDWP----PATTERALYLRPG------GYLGETAP
MSMEG_2644|M.smegmatis_MC2_155      IFVNHHG----WIDLPEWPLADWPTRRDRELFLQPA------ARLTDSAP
Mflv_4032|M.gilvum_PYR-GCK          IHLSRRG----WLNLPDWP----PAMPSLVLHPQPG------GGLAPGAP
Mvan_2322|M.vanbaalenii_PYR-1       IHLGGRG----WLNLPDWP----PAMPDVVLHPQPA------GRLGPAAP
TH_1432|M.thermoresistible__bu      VHVRRRG----WYDLPDWP----PELPAQSWYLRPGRHPRTEACLGTTAP
MAB_0501c|M.abscessus_ATCC_199      IYLQKAG---QWLDFDHWPP---RQSTSTALYLHAD------RALDWEAP
                                    :.:   .    *  : .**            . :.         *   **

Mb2823|M.bovis_AF2122/97            -ASGTPPAT-FRYHPADPTPTTGGPLLSS-NGGYRDDSRLATRADVLCFT
Rv2800|M.tuberculosis_H37Rv         -ASGTPPAT-FRYHPADPTPTTGGPLLSS-NGGYRDDSRLATRADVLCFT
MMAR_1910|M.marinum_M               -PDATTPAT-FRYDPTDPTPTIGGPLLSS-KAGYRNDSRLASRNDVLTFT
MUL_2134|M.ulcerans_Agy99           -PDATTPAT-FRYDPTDPTPTIGGPLLSS-KAGYRNDSRLASRNDVLTFT
MAV_3687|M.avium_104                SLKGLAPAT-FRYDPAHPTPTTGGPLLSP-NGGYRDDTRLASRDDVLAFT
MSMEG_2644|M.smegmatis_MC2_155      -PPTAAPSS-FTYHPARPTPTIGGRLLSR-DGGYRDDSELAARDDVVTFT
Mflv_4032|M.gilvum_PYR-GCK          --G-AADAT-FVYNPGDPTPTVGGRLLSP-VGGYRDDTALARRADVLTFT
Mvan_2322|M.vanbaalenii_PYR-1       --EPDGTAT-FVYNPADPTPTVGGRLLSP-AGGYRDDTALARRADVLTFT
TH_1432|M.thermoresistible__bu      DTGAAAPGWSFTFDPADPTPTVGGRLLSP-AGGRRRDDRLARRPDVLSFT
MAB_0501c|M.abscessus_ATCC_199      --QGDSSADNFTYDPKDPTPTVGGPLLDTRAAGQRDNSAIEKRPDVLVFT
                                           .  * :.*  **** ** **.   .* * :  :  * **: **

Mb2823|M.bovis_AF2122/97            GAPLTHDLCVHGNPVVELVHSSDNPYVDVFVRVSEVDAKGRSRNVSDGYR
Rv2800|M.tuberculosis_H37Rv         GAPLTHDLCVHGNPVVELVHSSDNPYVDVFVRVSEVDAKGRSRNVSDGYR
MMAR_1910|M.marinum_M               GSALTHDLWIHGHPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQ
MUL_2134|M.ulcerans_Agy99           GSALTHDLWIHGHPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQ
MAV_3687|M.avium_104                SATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
MSMEG_2644|M.smegmatis_MC2_155      SDPLPADLYVVGNPFVELVHSCDNPHNDVFVRISEVDAKGRSRNVTDAFR
Mflv_4032|M.gilvum_PYR-GCK          GTALASDLPVVGVPVLDVAHTCATPHNDLFVRISQVDAHGRSRNVSDGYV
Mvan_2322|M.vanbaalenii_PYR-1       GTPLPADLYVVGHPVLELAHTCANPHNDLFVRVSQVDEHGRSRNVSDGYL
TH_1432|M.thermoresistible__bu      SQPLPHALRLLGVPVAELVHSCDNPHHDLFVRISEVDRRGRSVNVSDGFR
MAB_0501c|M.abscessus_ATCC_199      SQPLTSDLDLIGPVSASIYATTDSGQGDLFVRLCDVDRKGRSHNVTDGII
                                    . .*.  : : *    .:         *:***:.:**  *** **::   

Mb2823|M.bovis_AF2122/97            RLGDAP-----ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTP
Rv2800|M.tuberculosis_H37Rv         RLGDAP-----ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTP
MMAR_1910|M.marinum_M               RLGDAP-----ETVRIELDPIAHRFKAGSRIRVLIAGSWFPRYARHLGTD
MUL_2134|M.ulcerans_Agy99           RLGDAP-----ETVRIELDPIAHRFKAGSRIRVLVAGSWFPRYARHLGTD
MAV_3687|M.avium_104                RLSAAAKPKADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSG
MSMEG_2644|M.smegmatis_MC2_155      RRTGQVG--TPETVRLELDAVAHRFAAGTRIRLLVAGGSHPRFARNLGTG
Mflv_4032|M.gilvum_PYR-GCK          ASAPDS-----GTVTVELDPVAWTFPAGSRIRVLIAGGSHPRFLRNLGTG
Mvan_2322|M.vanbaalenii_PYR-1       AAAPDS-----GTARIELDPVAWTFPAGSRIRLLIAGGSHPRFLRNLGTG
TH_1432|M.thermoresistible__bu      RCHREAG--SIGTVRLELDAVGHTFRAGHRIRVLIAGGSHPRFTRNLGTG
MAB_0501c|M.abscessus_ATCC_199      KLDGVTD----APIQVIMHPTGYRFARGHRLRLQVSGGGFPNHARNTGSG
                                                   : :.  .  *  . *:*: ::*.  *.. :: *: 

Mb2823|M.bovis_AF2122/97            EPILTGRQLKPATHAVHFGR---SRLLLPVG-----------------
Rv2800|M.tuberculosis_H37Rv         EPILTGRQLKPATHAVHFGR---SRLLLPVG-----------------
MMAR_1910|M.marinum_M               EPTLTGRQVQPATHSVYFGQ---SRLLLGVDQSANDITDAGSDESPE-
MUL_2134|M.ulcerans_Agy99           EPTLTGRQVQPATHSVYFGQ---SRLLLGVDQSANDITDAGSDESPE-
MAV_3687|M.avium_104                EPVLTARRLTPVTHSVRYGR---SRLLLPVGPAEPSADGVADPVGDGG
MSMEG_2644|M.smegmatis_MC2_155      EPQPSGSRLKQARHSVHHGDGGVSRLILPAGPTPPLGLRT--------
Mflv_4032|M.gilvum_PYR-GCK          EHAGTATDFATARHTVHLGEG--TRLTLPAGPPPPSAD----------
Mvan_2322|M.vanbaalenii_PYR-1       ETATTATTYKTARHTVHLGEQ--SRLVLPAGSHPPSTD----------
TH_1432|M.thermoresistible__bu      EPPVSGRRMTPATHTVHPGT----RVLLPADTEPPDPGSGFPSGH---
MAB_0501c|M.abscessus_ATCC_199      EPLATASRIVPIHFEVRHDKEHPSSVTLPVMHSS--------------
                                    *   :.       . *  .      : * .