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PGIRRYTGKFAAKLLGLPPHSTDFTVHHGLRVPMRDGVELVADHYEPLTTRPAGTLLVRGPYGRRFPFSA IFAEVYAARGYHVVLQSVRGTFGSGGEFTPMVHEMDDGADTVAWLRTQPWFTGSFATVGLSYLGFTQWAL LADPPPEMKAAVITVGPHDFSQSAWGTGSFTLNDFLGWSAMVARQEEPGVVRALVRQLRSPAEVAKAAAG VPVGPSGRRLLGAGAPWFESWLEHPDRDDPFWERLRFDQALERVEVPILLLSGWQDLFLDQTLEQYTQLH RRGVPVAMTVGPWTHTQMMTKGASTVIGESLDWLGTHLAGASGSHSRDHVRIFVNHHGWIDLPEWPLADW PTRRDRELFLQPAARLTDSAPPPTAAPSSFTYHPARPTPTIGGRLLSRDGGYRDDSELAARDDVVTFTSD PLPADLYVVGNPFVELVHSCDNPHNDVFVRISEVDAKGRSRNVTDAFRRRTGQVGTPETVRLELDAVAHR FAAGTRIRLLVAGGSHPRFARNLGTGEPQPSGSRLKQARHSVHHGDGGVSRLILPAGPTPPLGLRT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2644 | - | - | 100% (557) | putative hydrolase |
| M. smegmatis MC2 155 | MSMEG_5283 | - | 1e-16 | 23.64% (626) | hydrolase, CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_1308 | - | 2e-13 | 28.18% (181) | peptidase S15 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2823 | - | 0.0 | 64.43% (551) | hydrolase |
| M. gilvum PYR-GCK | Mflv_4032 | - | 0.0 | 60.29% (549) | peptidase S15 |
| M. tuberculosis H37Rv | Rv2800 | - | 0.0 | 64.43% (551) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0501c | - | 1e-91 | 35.28% (547) | peptidase S15 |
| M. marinum M | MMAR_1910 | - | 0.0 | 61.02% (531) | hydrolase |
| M. avium 104 | MAV_3687 | - | 0.0 | 60.36% (555) | hydrolase CocE/NonD family protein |
| M. thermoresistible (build 8) | TH_1432 | - | 2e-77 | 55.07% (276) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_2134 | - | 0.0 | 61.21% (531) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 0.0 | 62.78% (540) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2823|M.bovis_AF2122/97 MSTTSARPERPKLRALTGRVG----GQALGGLLGLPR-ATTRYTVGH-VR
Rv2800|M.tuberculosis_H37Rv MSTTSARPERPKLRALTGRVG----GQALGGLLGLPR-ATTRYTVGH-VR
MMAR_1910|M.marinum_M MSITSTDVGQPTLRALTKRVGGSAAGGALGGLLGLPR-ATTRYTVSR-VG
MUL_2134|M.ulcerans_Agy99 MSITSTHVGQPTLRALTKRVGGSAAGDALGGLLGLPR-ATTRYTVSR-VG
MAV_3687|M.avium_104 MSLTSLRPAQPALHTLR-HLG----GRAAGRLLGLPP-ATTDYTVRR-VA
MSMEG_2644|M.smegmatis_MC2_155 ---------MPGIRRYT--------GKFAAKLLGLPP-HSTDFTVHHGLR
Mflv_4032|M.gilvum_PYR-GCK MSSELARRAR----------------RALSRVFDLPP-PVCDFVVHRELR
Mvan_2322|M.vanbaalenii_PYR-1 MSSELSRLAR----------------HALSRALHLPP-PVCDYAVNRHVR
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 MLEELALTWTGRLS-----------APVLEKLLDLPEPLTTDIQTQRDIT
Mb2823|M.bovis_AF2122/97 VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFPFSLVFARIYAARGY
Rv2800|M.tuberculosis_H37Rv VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFPFSLVFARIYAARGY
MMAR_1910|M.marinum_M VPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRGFPFSLVFARLYAARGY
MUL_2134|M.ulcerans_Agy99 VPMRDGVHLVADHYCPTTSRPAGTVLVRGPYGRGFPFSLVFARLYAARGY
MAV_3687|M.avium_104 VPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFPFALVFGGLYAARGY
MSMEG_2644|M.smegmatis_MC2_155 VPMRDGVELVADHYEPLTTRPAGTLLVRGPYGRRFPFSAIFAEVYAARGY
Mflv_4032|M.gilvum_PYR-GCK VPMRDRVELVADHYAPHTASPAGTLLVRGPYGRGLPFATMFASFYAARGY
Mvan_2322|M.vanbaalenii_PYR-1 VPMRDGVELVADHYTPRTADPAGTLLVRGPYGRGFPISVLFGSIYAARGY
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 VRMPDGVRLSTDHFRPPGQHPLPAVIFRTPYDKRGMVSQLWAMLLARQGF
Mb2823|M.bovis_AF2122/97 HVVLQSVRGTFGSGGVFEPMVNEAADGADTVAWLREQPWFTGRFGTIGLP
Rv2800|M.tuberculosis_H37Rv HVVLQSVRGTFGSGGVFEPMVNEAADGADTVAWLREQPWFTGRFGTIGLP
MMAR_1910|M.marinum_M HVVLQSVRGTFGSAGQFEPMVNEAADGADTVEWLRRQPWFTGRFATIGVS
MUL_2134|M.ulcerans_Agy99 HVVLQSVRGTFGSAGQFEPMVNEAADGADTVEWLRRQPWFTGRFATIGVS
MAV_3687|M.avium_104 HVVLQSVRGTFGSGGVFEPMAHEVADGADTVAWLREQPWFTGRFATIGMS
MSMEG_2644|M.smegmatis_MC2_155 HVVLQSVRGTFGSGGEFTPMVHEMDDGADTVAWLRTQPWFTGSFATVGLS
Mflv_4032|M.gilvum_PYR-GCK HVVFQSVRGTFGSGGEFDPFVNEVDDGADTAAWLRDQPWFTGTFATIGLS
Mvan_2322|M.vanbaalenii_PYR-1 HVVLQSVRGTFGSGGEFDPFVNEVADGADTAAWLRDQPWFTGTFATMGLS
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 QVIVQDTRGQYGSQGKFDAFRQERADGLATAAWVREQPWCDGTLATAGPS
Mb2823|M.bovis_AF2122/97 YLGFTQWALLHDPPPELAAAVITVGPHDFRASVWGTGSFTVNDFLGWSDL
Rv2800|M.tuberculosis_H37Rv YLGFTQWALLHDPPPELAAAVITVGPHDFRASVWGTGSFTVNDFLGWSDL
MMAR_1910|M.marinum_M YLGFTQWALLQDPPPELAAAVITAGPHDLRSSVWGTGSFAINDFLGWSEL
MUL_2134|M.ulcerans_Agy99 YLGFTQWALLQDPPPELAAAVITAGPHDLRSSVWGTGSFAINDFLGWSEL
MAV_3687|M.avium_104 YLGFTQWALLQDPPPDMATAVIMVGPHDFNESTWGTGSFAVNDFLGWSDM
MSMEG_2644|M.smegmatis_MC2_155 YLGFTQWALLADPPPEMKAAVITVGPHDFSQSAWGTGSFTLNDFLGWSAM
Mflv_4032|M.gilvum_PYR-GCK YLGFTQWALLTDPPPELAAAVITVGPDDVSGPRWGAGSFGLNDFLGWSDL
Mvan_2322|M.vanbaalenii_PYR-1 YLGFTQWALLTDPPPELKAAVITVGPDDVSGPRWGRGSFGLNDFLGWSHL
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 YLGHTQWAVAPYIEPPLAAMCPAITTSNFRELFYPGGSFNLHNLLTWSSS
Mb2823|M.bovis_AF2122/97 VSHQEDPGRIRAGIRQLTAPRRVARTAATLPLGESARTLLGTGAPWFESW
Rv2800|M.tuberculosis_H37Rv VSHQEDPGRIRAGIRQLTAPRRVARTAATLPLGESARTLLGTGAPWFESW
MMAR_1910|M.marinum_M VARQEDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGTGAPWFESW
MUL_2134|M.ulcerans_Agy99 VARQEDPVRIRTGIRQLTAPRRVARAAAELPMGESARTLLGTGAPWFESW
MAV_3687|M.avium_104 VSHQEDPVRARAALHQLRARRKVAEAAAGVPLGEAARALLGTGAPWFESW
MSMEG_2644|M.smegmatis_MC2_155 VARQEEPGVVRALVRQLRSPAEVAKAAAGVPVGPSGRRLLGAGAPWFESW
Mflv_4032|M.gilvum_PYR-GCK VGRQEDPNRVRTLLRQARAQRRVTSASLRLPLAAASRELLGDGALWFESW
Mvan_2322|M.vanbaalenii_PYR-1 VGGQEDPNRLRSLLRQAGAQRRVTEASLGLPLGPASRTLLGDGAPWFESW
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 IGSPE-TSQLTRLLRAGAIAKRVRRAMDHLPLGNADNIAIGKPEPFWRTV
Mb2823|M.bovis_AF2122/97 VEHTDRDDPFWDRLRFPAALDRVQVPVLLVGGWQDIFLRQTLQQYRHLRD
Rv2800|M.tuberculosis_H37Rv VEHTDRDDPFWDRLRFPAALDRVQVPVLLVGGWQDIFLRQTLQQYRHLRD
MMAR_1910|M.marinum_M LEHTDHSDPFWDRMRSPDALDRVQVPVLLVGGWQDVFVQQTLQQYRHLRD
MUL_2134|M.ulcerans_Agy99 LEHTDHSDPFWDRMRSPDALDRVQVPVLLVGGWQDVFVQQTLQQYRHLRD
MAV_3687|M.avium_104 IEHADPSDPFWNSLRCNEALDRVRVPVLLVGGWQDLFIRQTLQQYAHLRA
MSMEG_2644|M.smegmatis_MC2_155 LEHPDRDDPFWERLRFDQALERVEVPILLLSGWQDLFLDQTLEQYTQLHR
Mflv_4032|M.gilvum_PYR-GCK LDHPDTDDPFWTRLRLRDGLERAEVPVLLLTGWQDLFVDQTVEHYRMLAG
Mvan_2322|M.vanbaalenii_PYR-1 LEHPETDDPFWSGLRLRDALADVDVPVLLLTGWQDLFVEQTLEHYRMLTS
TH_1432|M.thermoresistible__bu --------------------------------------------------
MAB_0501c|M.abscessus_ATCC_199 IDHT--EDDHWDEINHTPALATLNTPVSMVTGWWDLLLVGQLRDYEELQK
Mb2823|M.bovis_AF2122/97 RGVHVALTVGPWTHTQMLTKGLATGARESLDWLDAHLGRAPALR-PSPVR
Rv2800|M.tuberculosis_H37Rv RGVHVALTVGPWTHTQMLTKGLATGARESLDWLDAHLGRAPALR-PSPVR
MMAR_1910|M.marinum_M RGVDVALTIGPWTHSQLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVR
MUL_2134|M.ulcerans_Agy99 RGVDVALTIGPWTHSQLLSKGLAVSAQETLDWLDTHLGGTAELRRPDAVR
MAV_3687|M.avium_104 RGVDVALTVGPWTHTQLLTTGLGVCTRESLQWLETHLGDAPGRR-AGRVH
MSMEG_2644|M.smegmatis_MC2_155 RGVPVAMTVGPWTHTQMMTKGASTVIGESLDWLGTHLAGASGSHSRDHVR
Mflv_4032|M.gilvum_PYR-GCK RGVPTGLTIGPWTHGDMMTKAAPTMLRESLDWLATHLKGEPPQR-RSPVR
Mvan_2322|M.vanbaalenii_PYR-1 RGVTAGLTVGPWTHGHMMTTAAPTVLGETLDWLATHLGGAAPLR-RSPVR
TH_1432|M.thermoresistible__bu --VPVAMTIGPWTHGHILTRAAPRVLRESLAWLDTHLAGTRTAS-RPPVR
MAB_0501c|M.abscessus_ATCC_199 TDCPRRITIGPWDH----MKSLKAVIGDSFSWLAAHLHGDASATHRAQVR
:*:*** * . ::: ** :** *:
Mb2823|M.bovis_AF2122/97 VFVTGQG----WRHLPDWP----PATTERAWYLQPG------GRLGESAP
Rv2800|M.tuberculosis_H37Rv VFVTGQG----WRHLPDWP----PATTERAWYLQPG------GRLGESAP
MMAR_1910|M.marinum_M VYVTGEG----WRHLSDWP----PKTTDHELYLHPT------GRLSEIAP
MUL_2134|M.ulcerans_Agy99 VYVTGEG----WRHLSDWP----PKTTDHELYLHPT------GRLSEIAP
MAV_3687|M.avium_104 VYVTGVDRARAWRRLPDWP----PATTERALYLRPG------GYLGETAP
MSMEG_2644|M.smegmatis_MC2_155 IFVNHHG----WIDLPEWPLADWPTRRDRELFLQPA------ARLTDSAP
Mflv_4032|M.gilvum_PYR-GCK IHLSRRG----WLNLPDWP----PAMPSLVLHPQPG------GGLAPGAP
Mvan_2322|M.vanbaalenii_PYR-1 IHLGGRG----WLNLPDWP----PAMPDVVLHPQPA------GRLGPAAP
TH_1432|M.thermoresistible__bu VHVRRRG----WYDLPDWP----PELPAQSWYLRPGRHPRTEACLGTTAP
MAB_0501c|M.abscessus_ATCC_199 IYLQKAG---QWLDFDHWPP---RQSTSTALYLHAD------RALDWEAP
:.: . * : .** . :. * **
Mb2823|M.bovis_AF2122/97 -ASGTPPAT-FRYHPADPTPTTGGPLLSS-NGGYRDDSRLATRADVLCFT
Rv2800|M.tuberculosis_H37Rv -ASGTPPAT-FRYHPADPTPTTGGPLLSS-NGGYRDDSRLATRADVLCFT
MMAR_1910|M.marinum_M -PDATTPAT-FRYDPTDPTPTIGGPLLSS-KAGYRNDSRLASRNDVLTFT
MUL_2134|M.ulcerans_Agy99 -PDATTPAT-FRYDPTDPTPTIGGPLLSS-KAGYRNDSRLASRNDVLTFT
MAV_3687|M.avium_104 SLKGLAPAT-FRYDPAHPTPTTGGPLLSP-NGGYRDDTRLASRDDVLAFT
MSMEG_2644|M.smegmatis_MC2_155 -PPTAAPSS-FTYHPARPTPTIGGRLLSR-DGGYRDDSELAARDDVVTFT
Mflv_4032|M.gilvum_PYR-GCK --G-AADAT-FVYNPGDPTPTVGGRLLSP-VGGYRDDTALARRADVLTFT
Mvan_2322|M.vanbaalenii_PYR-1 --EPDGTAT-FVYNPADPTPTVGGRLLSP-AGGYRDDTALARRADVLTFT
TH_1432|M.thermoresistible__bu DTGAAAPGWSFTFDPADPTPTVGGRLLSP-AGGRRRDDRLARRPDVLSFT
MAB_0501c|M.abscessus_ATCC_199 --QGDSSADNFTYDPKDPTPTVGGPLLDTRAAGQRDNSAIEKRPDVLVFT
. * :.* **** ** **. .* * : : * **: **
Mb2823|M.bovis_AF2122/97 GAPLTHDLCVHGNPVVELVHSSDNPYVDVFVRVSEVDAKGRSRNVSDGYR
Rv2800|M.tuberculosis_H37Rv GAPLTHDLCVHGNPVVELVHSSDNPYVDVFVRVSEVDAKGRSRNVSDGYR
MMAR_1910|M.marinum_M GSALTHDLWIHGHPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQ
MUL_2134|M.ulcerans_Agy99 GSALTHDLWIHGHPVIELTHSSDNPNVDVFVRISEVDSNGRSRNVSDGYQ
MAV_3687|M.avium_104 SATLTEDVYVYGNPVVELAHGADHPHADLFVRVSEVDAAGRSRNVTETYR
MSMEG_2644|M.smegmatis_MC2_155 SDPLPADLYVVGNPFVELVHSCDNPHNDVFVRISEVDAKGRSRNVTDAFR
Mflv_4032|M.gilvum_PYR-GCK GTALASDLPVVGVPVLDVAHTCATPHNDLFVRISQVDAHGRSRNVSDGYV
Mvan_2322|M.vanbaalenii_PYR-1 GTPLPADLYVVGHPVLELAHTCANPHNDLFVRVSQVDEHGRSRNVSDGYL
TH_1432|M.thermoresistible__bu SQPLPHALRLLGVPVAELVHSCDNPHHDLFVRISEVDRRGRSVNVSDGFR
MAB_0501c|M.abscessus_ATCC_199 SQPLTSDLDLIGPVSASIYATTDSGQGDLFVRLCDVDRKGRSHNVTDGII
. .*. : : * .: *:***:.:** *** **::
Mb2823|M.bovis_AF2122/97 RLGDAP-----ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTP
Rv2800|M.tuberculosis_H37Rv RLGDAP-----ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTP
MMAR_1910|M.marinum_M RLGDAP-----ETVRIELDPIAHRFKAGSRIRVLIAGSWFPRYARHLGTD
MUL_2134|M.ulcerans_Agy99 RLGDAP-----ETVRIELDPIAHRFKAGSRIRVLVAGSWFPRYARHLGTD
MAV_3687|M.avium_104 RLSAAAKPKADKVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSG
MSMEG_2644|M.smegmatis_MC2_155 RRTGQVG--TPETVRLELDAVAHRFAAGTRIRLLVAGGSHPRFARNLGTG
Mflv_4032|M.gilvum_PYR-GCK ASAPDS-----GTVTVELDPVAWTFPAGSRIRVLIAGGSHPRFLRNLGTG
Mvan_2322|M.vanbaalenii_PYR-1 AAAPDS-----GTARIELDPVAWTFPAGSRIRLLIAGGSHPRFLRNLGTG
TH_1432|M.thermoresistible__bu RCHREAG--SIGTVRLELDAVGHTFRAGHRIRVLIAGGSHPRFTRNLGTG
MAB_0501c|M.abscessus_ATCC_199 KLDGVTD----APIQVIMHPTGYRFARGHRLRLQVSGGGFPNHARNTGSG
: :. . * . *:*: ::*. *.. :: *:
Mb2823|M.bovis_AF2122/97 EPILTGRQLKPATHAVHFGR---SRLLLPVG-----------------
Rv2800|M.tuberculosis_H37Rv EPILTGRQLKPATHAVHFGR---SRLLLPVG-----------------
MMAR_1910|M.marinum_M EPTLTGRQVQPATHSVYFGQ---SRLLLGVDQSANDITDAGSDESPE-
MUL_2134|M.ulcerans_Agy99 EPTLTGRQVQPATHSVYFGQ---SRLLLGVDQSANDITDAGSDESPE-
MAV_3687|M.avium_104 EPVLTARRLTPVTHSVRYGR---SRLLLPVGPAEPSADGVADPVGDGG
MSMEG_2644|M.smegmatis_MC2_155 EPQPSGSRLKQARHSVHHGDGGVSRLILPAGPTPPLGLRT--------
Mflv_4032|M.gilvum_PYR-GCK EHAGTATDFATARHTVHLGEG--TRLTLPAGPPPPSAD----------
Mvan_2322|M.vanbaalenii_PYR-1 ETATTATTYKTARHTVHLGEQ--SRLVLPAGSHPPSTD----------
TH_1432|M.thermoresistible__bu EPPVSGRRMTPATHTVHPGT----RVLLPADTEPPDPGSGFPSGH---
MAB_0501c|M.abscessus_ATCC_199 EPLATASRIVPIHFEVRHDKEHPSSVTLPVMHSS--------------
* :. . * . : * .