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ARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVVIERDVEVPTRDGTLLRINVFRSAEGGA RPVIASIHPYGKDALPRRRGNRWTFSPQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCG RSDGTGDLLSHQEAEDTYDLVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAY RDLAFPGGIRESGFTRLWSRGVRRRTRQTYDMEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGSFSDNN LHSRGSIRAFTRSGCGHARLYTHRGGKWETFYSATALSEQLKFLRDALAGSSGSRSVRLEVREDRDTITA VREETQWPLAGTRWRPMYLAGPGLLATEPPPTAGSIRFQTRSRAAAFNWTIPEDIELTGPMAARLWVQLD GCDDANLFVGVEKWRDGQFVAFEGSYGWGRDRVTTGWQRVSLRELDPELSQPWEPVPACARPRPVTAGEV VAVDVALGPSATLFRAGEQLRLVVGGRWLSPRNPLTGQFPAAYPRPPRGRVTLHWGPRYDAHLLIPEVPG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1215c | - | - | 100% (561) | hypothetical protein Rv1215c |
| M. tuberculosis H37Rv | Rv1835c | - | 1e-14 | 33.33% (183) | hypothetical protein Rv1835c |
| M. tuberculosis H37Rv | Rv2800 | - | 3e-09 | 26.03% (388) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1247c | - | 0.0 | 99.82% (561) | hypothetical protein Mb1247c |
| M. gilvum PYR-GCK | Mflv_4032 | - | 8e-08 | 27.07% (181) | peptidase S15 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2222c | - | 1e-15 | 25.91% (301) | peptidase |
| M. marinum M | MMAR_1269 | - | 0.0 | 56.12% (556) | Acyl esterase |
| M. avium 104 | MAV_1359 | - | 0.0 | 78.10% (557) | hydrolase CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_5283 | - | 0.0 | 60.86% (557) | hydrolase, CocE/NonD family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3980 | - | 2e-28 | 25.48% (569) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 1e-08 | 24.80% (367) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1215c|M.tuberculosis_H37Rv MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDP-PADVVIERDV
Mb1247c|M.bovis_AF2122/97 MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDP-PADVVIERDV
MAV_1359|M.avium_104 MPPTRMTALDRPWRRPGALRYALNRIRGVAKPPVTVTDP-PADLHVERDV
MSMEG_5283|M.smegmatis_MC2_155 -----MAALDRPWRRPGAARYALSRLRGFVRTPVEVYEPEPGSVTVRHDV
MMAR_1269|M.marinum_M -MPTRNPIYDRPWRRAGVVRYAAARVRAILRPPVTVSAA-PPDLVVDRDV
Mflv_4032|M.gilvum_PYR-GCK ----------MSSELARRARRALSRVFDLPPP--------VCDFVVHREL
Mvan_2322|M.vanbaalenii_PYR-1 ----------MSSELSRLARHALSRALHLPPP--------VCDYAVNRHV
MAB_2222c|M.abscessus_ATCC_199 -------------------------------------------------M
MUL_3980|M.ulcerans_Agy99 MAVQSSARRLEKTSGLGKGERQLNGPQTTGREYANLSEP-QYNTMRENNA
Rv1215c|M.tuberculosis_H37Rv EVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRR--RGNRWTFS
Mb1247c|M.bovis_AF2122/97 EVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRR--RGNRWTFS
MAV_1359|M.avium_104 AVPTRDATVLRINVFRKADAEPRPVILSIHPYGKDSLPKR--RGNRWTFS
MSMEG_5283|M.smegmatis_MC2_155 PVTTRDGTVLRVNVHLPAGENPVPVLLCAHPYGKDKVPVRKKRGRGYALP
MMAR_1269|M.marinum_M SVRMRDGVVLRVNVYRPPGSGPFPVILAAHPYGKDRLPKR--RWWGWGIN
Mflv_4032|M.gilvum_PYR-GCK RVPMRDRVELVADHYAPHTASPAGTLLVRGPYGRG---------------
Mvan_2322|M.vanbaalenii_PYR-1 RVPMRDGVELVADHYTPRTADPAGTLLVRGPYGRG---------------
MAB_2222c|M.abscessus_ATCC_199 PATMRDGTILRADIYRPKLKDPVPVILMRTQYGKDTAQIQ----------
MUL_3980|M.ulcerans_Agy99 AIPVRDGTVLLADVHRPDAQGRFPALIAASPYPRQIQDLG----------
** . * : . .: * :
Rv1215c|M.tuberculosis_H37Rv PQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTG
Mb1247c|M.bovis_AF2122/97 PQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTG
MAV_1359|M.avium_104 AQYRILRQPRPVTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSEGTG
MSMEG_5283|M.smegmatis_MC2_155 FQYRVLRQPARVRFSSLTTWEAPDPAWWTKQGFAVVNCDLRGAGTSGGVG
MMAR_1269|M.marinum_M PQFRILRQPGQVEISSETSWEAPDPVWWLAHGYAVVNADIRGAGTSDGAG
Mflv_4032|M.gilvum_PYR-GCK -----------------LPFATMFASFYAARGYHVVFQSVRGTFGSGGEF
Mvan_2322|M.vanbaalenii_PYR-1 -----------------FPISVLFGSIYAARGYHVVLQSVRGTFGSGGEF
MAB_2222c|M.abscessus_ATCC_199 ------------------PSRFRTPDWFASHCYLVVVQDVRGQGTSDGIF
MUL_3980|M.ulcerans_Agy99 --------------APMGFIEAGVTDFWVPRGYVHVIANVRGTGGSGGTF
: : : * . ** * *
Rv1215c|M.tuberculosis_H37Rv DLLSHQEAEDTYDLVGWLADQAWSDGRVVMLGVSYLAISQYAVAALQPPA
Mb1247c|M.bovis_AF2122/97 DLLSHQEAEDTYDLVGWLADQSWSDGRVVMLGVSYLAISQYAVAALQPPA
MAV_1359|M.avium_104 NLLSHREAEDTYDLVQWVAGQPWSDGNVVMLGVSYLAISQYAVAALQPPA
MSMEG_5283|M.smegmatis_MC2_155 SPLSDQEGEDVYDLVEWAAAQPWSTGAVGMIGVSYLAISQWKSAALRPPH
MMAR_1269|M.marinum_M ALMSDQEAEDVYDLIEWAGAAPWSSGSVGMAGVSYLAMAQFKAAALRPPS
Mflv_4032|M.gilvum_PYR-GCK DPFVN-EVDDGADTAAWLRDQPWFTGTFATIGLSYLGFTQWALLTDPPPE
Mvan_2322|M.vanbaalenii_PYR-1 DPFVN-EVADGADTAAWLRDQPWFTGTFATMGLSYLGFTQWALLTDPPPE
MAB_2222c|M.abscessus_ATCC_199 TEFGN-DGDDGYDTVEWAAGLPGATGKVGMYGSSYVGATQWLAATTTPPH
MUL_3980|M.ulcerans_Agy99 GFFDATERRDMHDLVEWAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPH
: : * * * . * . * **.. :* . **
Rv1215c|M.tuberculosis_H37Rv LRAICPWEGFTDAYRDLAFPGGIRESGFTRLWSRGVRRRTRQT-----YD
Mb1247c|M.bovis_AF2122/97 LRAICPWEGFTDAYRDLAFPGGIRESGFTRLWSRGVRRRTRQT-----YD
MAV_1359|M.avium_104 LRAICPWEGFTDAYRDLMFPGGVRELGFIRMWSRNVRRDTRQA-----YD
MSMEG_5283|M.smegmatis_MC2_155 LRAIVPWEGMTDPYRDLLHPGGIAETGFIKLWSRSLR-DTRLK-----YD
MMAR_1269|M.marinum_M LKAICPWEGFTDAYRDMFNPGGVAEKGFSRVWQTGTKHVMRVT-----ED
Mflv_4032|M.gilvum_PYR-GCK LAAAVITVGPDDVSGPRWGAGSFGLNDFLG-WSDLVGRQEDPN-----RV
Mvan_2322|M.vanbaalenii_PYR-1 LKAAVITVGPDDVSGPRWGRGSFGLNDFLG-WSHLVGGQEDPN-----RL
MAB_2222c|M.abscessus_ATCC_199 LTTIVPSNTASDYYDGWTYEGGAFRLGFVQPWAMGTIATTAAKNRADLAA
MUL_3980|M.ulcerans_Agy99 LKAIFPVAATTDLYEAAVHHG-LFSSSFVSPFLTMVGITSERS-------
* : * * .* :
Rv1215c|M.tuberculosis_H37Rv MEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGS--FSDNNLHSRGSIRA
Mb1247c|M.bovis_AF2122/97 MEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGS--FSDNNLHSRGSIRA
MAV_1359|M.avium_104 LQDMQDRHPLRDEFWRSLVPDLSAIAVPMLVCGS--FSDNNLHSRGSLRA
MSMEG_5283|M.smegmatis_MC2_155 LGKENSSRPRYDDWWRSLVPALDRIEVPALICGS--FSDNNLHTRGSVRG
MMAR_1269|M.marinum_M IGAQRRVHPLRDQWWQSLVPDLGRIEVPMLVCAS--FSDNNLHGRGSFRA
Mflv_4032|M.gilvum_PYR-GCK RTLLRQARAQRRVTSASLRLPLAAASRELLGDGALWFESWLDHPDTDDPF
Mvan_2322|M.vanbaalenii_PYR-1 RSLLRQAGAQRRVTEASLGLPLGPASRTLLGDGAPWFESWLEHPETDDPF
MAB_2222c|M.abscessus_ATCC_199 LEQLRAAAAERGRWLNHLPYQDLPPMQPGDPRVAPWYFDWIRHS-TRDDY
MUL_3980|M.ulcerans_Agy99 -DALWRGKLVGLVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRP
: :
Rv1215c|M.tuberculosis_H37Rv FTRSGCGHARLYTHRGGKWETFYSATALS-----EQLKFLRDALAGSSGS
Mb1247c|M.bovis_AF2122/97 FTRSGCGHARLYTHRGGKWETFYSATALS-----EQLKFLRDALAGSSGS
MAV_1359|M.avium_104 FTHSSSTHARLYTHRGGKWATFYAEEALA-----EQLSFFRGVLDGAPAA
MSMEG_5283|M.smegmatis_MC2_155 FEQIGSAERHLYTHRGGKWAAFYSDDALR-----TQLAFLVRHLRGGTAQ
MMAR_1269|M.marinum_M FEKVGAEDKFAYTHRGGKWTTFYSPEARQ-----AQLAFFDRYLKHLDVP
Mflv_4032|M.gilvum_PYR-GCK WTRLRLRDGLERAEVPVLLLTGWQDLFVD-----QTVEHYRMLAGRGVPT
Mvan_2322|M.vanbaalenii_PYR-1 WSGLRLRDALADVDVPVLLLTGWQDLFVE-----QTLEHYRMLTSRGVTA
MAB_2222c|M.abscessus_ATCC_199 WKRWSIRDRYQNVTVPVLHFEGWYDAFLR-----GGLENFAGMTARGGSP
MUL_3980|M.ulcerans_Agy99 WDQLWLSAAVEHPTRDEWWDERDINPLLDRIDVPVYLGCDWQNVPLNLPS
: :
Rv1215c|M.tuberculosis_H37Rv RS---VRLEVREDRDTITAVREETQWPLAG--------------TRWRPM
Mb1247c|M.bovis_AF2122/97 RS---VRLEVREDRDTITAVREETQWPLAG--------------TRWRPM
MAV_1359|M.avium_104 RS---VRLEVREDRDTVTAVREESEWPLAR--------------TRWRAL
MSMEG_5283|M.smegmatis_MC2_155 ELP-RVRLEVRESRDRVVAVRDEAQWPLPS--------------TRWTPL
MMAR_1269|M.marinum_M KPP-RVRLEVRERGDVIAETRAERQWPLEN--------------TDWRDL
Mflv_4032|M.gilvum_PYR-GCK G------LTIGPWTHGDMMTKAAPTMLRES--------------LDWLAT
Mvan_2322|M.vanbaalenii_PYR-1 G------LTVGPWTHGHMMTTAAPTVLGET--------------LDWLAT
MAB_2222c|M.abscessus_ATCC_199 GARRYQRMVIGPWDHLAWGRESSSPSPLLKGLGPGANSPVNEMQLAWFDH
MUL_3980|M.ulcerans_Agy99 TFAAWKALADGPSTRMGMLGEFGLTWPWES---------LHLEALAWFDH
: *
Rv1215c|M.tuberculosis_H37Rv YLAGPGLLATEPP----PTAGSIRFQTRSRAAAFNWTIPED---------
Mb1247c|M.bovis_AF2122/97 YLAGPGLLATEPP----PTAGSIRFQTRSRAAAFNWTIPED---------
MAV_1359|M.avium_104 HLGDAGVLRTDPA----AQPGRVAFGTRSRAACFTWTVPDD---------
MSMEG_5283|M.smegmatis_MC2_155 YLHDAG-LRAAPP----DAAGSISFDTRRAAARFGWTLPED---------
MMAR_1269|M.marinum_M YLADDGVLDHEPP----AAEGSVTFHTRRRAAAFTLPVVAD---------
Mflv_4032|M.gilvum_PYR-GCK HLKGEPPQRRSPVRIHLSRRGWLNLPDWPPAMPSLVLHPQP---------
Mvan_2322|M.vanbaalenii_PYR-1 HLGGAAPLRRSPVRIHLGGRGWLNLPDWPPAMPDVVLHPQP---------
MAB_2222c|M.abscessus_ATCC_199 FLKGSDNGVATES----PRLDYYLMGANRWKHASAWPLPQTNWTVYHLGG
MUL_3980|M.ulcerans_Agy99 WLKSRDTGILAGP-----AIRYVLPGAEGWRTTETWPPPGV---------
* .
Rv1215c|M.tuberculosis_H37Rv -----IELTGPMAAR-------LWVQLDGCDDAN--LFVGVEKWRDG---
Mb1247c|M.bovis_AF2122/97 -----IELTGPMAAR-------LWVQLDGCDDAN--LFVGVEKWRDG---
MAV_1359|M.avium_104 -----VELTGPMAAR-------LWVELHGCDDAN--LFVGVEKWRPGRFR
MSMEG_5283|M.smegmatis_MC2_155 -----TELTGPMALR-------LYLSAD-TDDVD--LFVGVEKWDGA---
MMAR_1269|M.marinum_M -----LELTGPMSLA-------LWVSVEGTDDVA--LFAGVEKWVGN---
Mflv_4032|M.gilvum_PYR-GCK -----GGGLAPGAPG-AADATFVYNPGDPTPTVGGRLLSPVGGYRDDT--
Mvan_2322|M.vanbaalenii_PYR-1 -----AGRLGPAAPEPDGTATFVYNPADPTPTVGGRLLSPAGGYRDDT--
MAB_2222c|M.abscessus_ATCC_199 RGTQHNGTLRDSAAAHDAPDVYLYDPANPVPSAGGHSCCAAESAPQGRYD
MUL_3980|M.ulcerans_Agy99 ----VYRKFALRADG-------QLGDDEGEPGAREYLVLGGGLNRAAA--
: . .
Rv1215c|M.tuberculosis_H37Rv --QFVAFEGSYGWGRDRVTTGWQRVSLRELDPELSQP---------WEPV
Mb1247c|M.bovis_AF2122/97 --QFVAFEGSYGWGRDRVTTGWQRVSLRELDPELSQP---------WEPV
MAV_1359|M.avium_104 D-RFVAFEGSYGYGRDRVSTGWQRVSLRALDSRLSRP---------GQPV
MSMEG_5283|M.smegmatis_MC2_155 --RYVPFEGSYGFGRDRVTTGWLRASMRALDESRSRP---------FEPV
MMAR_1269|M.marinum_M --KWVSFEGSYGYGRDRITTGWQRVSLRELDVEQSTP---------YEPV
Mflv_4032|M.gilvum_PYR-GCK --ALARRADVLTFTGTALASDLPVVGVPVLDVAHTCATPHNDLFVRISQV
Mvan_2322|M.vanbaalenii_PYR-1 --ALARRADVLTFTGTPLPADLYVVGHPVLELAHTCANPHNDLFVRVSQV
MAB_2222c|M.abscessus_ATCC_199 QRAVEQRPDVLTYTTEPLSTNTEITGPISVDLWASSSAPDTDFTAKLVAV
MUL_3980|M.ulcerans_Agy99 --SAIDPPSMLTWTSAPLTRDLDVVGDIELRLVAAATAMDTAWIATLHEV
. : :. . .. : : . *
Rv1215c|M.tuberculosis_H37Rv PACARPRPVTAGEVVAVD--------------------------------
Mb1247c|M.bovis_AF2122/97 PACARPRPVTAGEVVAVD--------------------------------
MAV_1359|M.avium_104 AACTDPQPVAAGEVVAVD--------------------------------
MSMEG_5283|M.smegmatis_MC2_155 PTFTDPRPLRPGEVVPVD--------------------------------
MMAR_1269|M.marinum_M HTFAHSQPLSPGEVVPVE--------------------------------
Mflv_4032|M.gilvum_PYR-GCK DAHGRSRNVSDGYVASAPDSGTV--------------------------T
Mvan_2322|M.vanbaalenii_PYR-1 DEHGRSRNVSDGYLAAAPDSGTA--------------------------R
MAB_2222c|M.abscessus_ATCC_199 QADGTAANLNNGIVRTSLAQSLSER-------------RLMPIGQPHKYH
MUL_3980|M.ulcerans_Agy99 ARDGTVSDVTAGWLRASMRRVDEKASRRGAPILPCRGMEAVPIGEDVVYR
: * : .
Rv1215c|M.tuberculosis_H37Rv VALGPSATLFRAGEQLRLVVGG--RWLSPRNPLTGQFPAAYPRPPRGRVT
Mb1247c|M.bovis_AF2122/97 VALGPSATLFRAGEQLRLVVGG--RWLSPRNPLTGQFPAAYPRPPRGRVT
MAV_1359|M.avium_104 VALGPSATLFRAGEHLRLVVAG--RWLCPTNPLTGQIPAAYQNSPRGRVS
MSMEG_5283|M.smegmatis_MC2_155 IPLGPSSTLFRAGEQLRLVVAG--RWLWPRNPLTGQFPAAYERRSRGTAT
MMAR_1269|M.marinum_M LALGPSATAFHHGDRIRLVIAG--RQLAPRNPLYGSFPALYAPSPPARCT
Mflv_4032|M.gilvum_PYR-GCK VELDPVAWTFPAGSRIRVLIAGGSHPRFLRNLGTGEHAGTATDFATARHT
Mvan_2322|M.vanbaalenii_PYR-1 IELDPVAWTFPAGSRIRLLIAGGSHPRFLRNLGTGETATTATTYKTARHT
MAB_2222c|M.abscessus_ATCC_199 IDIWPVSYQFRTGERIRLEISSSDFPQYAPNPNTAAPFGRNAELRTATQI
MUL_3980|M.ulcerans_Agy99 IPLVANARRFKAGCRIRLIFTS--DDQDPATPAIMSFRHASVG-TSSRNT
: : . : * * ::*: . . . .
Rv1215c|M.tuberculosis_H37Rv LHWGPRYDAHLLIPEVPG--------------------
Mb1247c|M.bovis_AF2122/97 LHWGPRYDAHLLIPEVPG--------------------
MAV_1359|M.avium_104 LHWGPRRDAHLLIPEIP---------------------
MSMEG_5283|M.smegmatis_MC2_155 LHWGPDRQARLLVPVVGDAHR-----------------
MMAR_1269|M.marinum_M LHWGADRPARLRVPVIGSGDNAPA--------------
Mflv_4032|M.gilvum_PYR-GCK VHLGEGTRLTLPAGPPPPSAD-----------------
Mvan_2322|M.vanbaalenii_PYR-1 VHLGEQSRLVLPAGSHPPSTD-----------------
MAB_2222c|M.abscessus_ATCC_199 ILHDAAHPSTLTLPVIPAGDPGTETFPMPRRPDDPPGN
MUL_3980|M.ulcerans_Agy99 IRSSSRLHLRVLPAQSSELQS-----------------
: . :