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TTALAHTAKQLGVLATVGFSLVACQTQTPVPDGGPEVDVLGSMLARESEIRTIMGVDVRPKTAYRTPTKN ETFEPISHQECMVVAGNAMDWVYRDSGYRQFRENQLSDDADDLEVDQAVARFDTPAAAQALVDTTVAIWH RCAGEVLTFSFDGGETTEIQTLAAPRVIDGVDVTNDQPTGPDERITRRAILAEGDVVVDIRITGFGVGDR ETVQLAKTIEGRNAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1201 | - | - | 100% (226) | hypothetical protein MSMEG_1201 |
| M. smegmatis MC2 155 | MSMEG_4597 | lppH | 3e-06 | 25.20% (127) | putative lipoprotein lpph |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1297c | pknH | 2e-08 | 25.13% (187) | transmembrane serine/threonine-protein kinase H |
| M. gilvum PYR-GCK | Mflv_2235 | - | 4e-06 | 25.64% (195) | putative lipoprotein LppH |
| M. tuberculosis H37Rv | Rv1266c | pknH | 2e-08 | 24.30% (214) | transmembrane serine/threonine-protein kinase H |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4171 | - | 2e-09 | 26.67% (195) | transmembrane serine/threonine-protein kinase |
| M. avium 104 | MAV_4097 | - | 4e-10 | 25.00% (220) | PknJ protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4150 | lppH | 3e-08 | 24.03% (233) | lipoprotein LppH |
| M. vanbaalenii PYR-1 | Mvan_3880 | - | 5e-05 | 24.05% (158) | hypothetical protein Mvan_3880 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
Rv1266c|M.tuberculosis_H37Rv MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAE
MMAR_4171|M.marinum_M MSDAQGSRVGSTFGPYRLTRLLGRGGMGEVYEAEHTVKEWTVAVKLMSET
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
Rv1266c|M.tuberculosis_H37Rv FSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTD
MMAR_4171|M.marinum_M FSKDPVFRERMKREARITGRLQEPHVVPIHDYGEIDGQMYLEMRLIEGTD
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
Rv1266c|M.tuberculosis_H37Rv LDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRD
MMAR_4171|M.marinum_M LDNLLKRFGPLTPPRAVAIITQVASALDAAHAAGVMHRDVKPQNILVTRE
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Rv1266c|M.tuberculosis_H37Rv DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
MMAR_4171|M.marinum_M DFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYA
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
Rv1266c|M.tuberculosis_H37Rv LACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVV
MMAR_4171|M.marinum_M LACVLHECLTGSPPYRADSASMLVTAHMMDPIPQPSTVRAGIPKAFDTVI
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 -----------MTNQQDPYWRNPLSYDPLGRVPPPEPEPVGPPPTQPATL
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPG--
Rv1266c|M.tuberculosis_H37Rv ARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPP
MMAR_4171|M.marinum_M ARGMAKQPGDRYASAGDLALAAHEALSNPDQDHAADILRRSQEATLPGPP
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 APPYRPGVNTLATLSLVFAFLFAPAGAVLGHLGLAQIRRTGELG------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ---------TAAVTAQPPTMPTVTPPPIQAAP------------------
Rv1266c|M.tuberculosis_H37Rv KPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAG----
MMAR_4171|M.marinum_M DPAAPPTMPATAAAPPARPGPAATPPRPAPTPQQPPYYPAAAAPAAGSPP
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------------------------
MUL_4150|M.ulcerans_Agy99 --------------------------------------------------
Mb1297c|M.bovis_AF2122/97 ------------------------------TGQPSWAPNSGPMPASGPTP
Rv1266c|M.tuberculosis_H37Rv -------------------------QRPGPTGQPSWAPNSGPMPASGPTP
MMAR_4171|M.marinum_M SGPSAVAGPPRGVAPSGPAGPSGPIPRPPAAGQPGWQQASGPIPASQPTP
Mvan_3880|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1201|M.smegmatis_MC2_155 --------------------------------------------------
MAV_4097|M.avium_104 --------------------------------------------------
Mflv_2235|M.gilvum_PYR-GCK --------------------------------MRR-----AVAIAGIAIM
MUL_4150|M.ulcerans_Agy99 --------------------------------MRQRVAALAALVGGAGML
Mb1297c|M.bovis_AF2122/97 TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
Rv1266c|M.tuberculosis_H37Rv TPQYYQGGGWG-APPSG---GPSPWAQTP-----RKTNPWPLVAGAAAVV
MMAR_4171|M.marinum_M SPPYYQGAGWGGAPPPGQPAGPSTWNQGPQGPGPRGRNPWPIVA-AVAIV
Mvan_3880|M.vanbaalenii_PYR-1 ---------------------------------------MALAGLAVSLW
MSMEG_1201|M.smegmatis_MC2_155 ----------------------------------------MTTALAHTAK
MAV_4097|M.avium_104 ------------------------RDRALVGVTLSYVFILLAVVALAGWA
Mflv_2235|M.gilvum_PYR-GCK VTGCASTSSAESAEPPTR-TMIPRPLVEREIGEVLLSPEEIAALMGVPA-
MUL_4150|M.ulcerans_Agy99 VTGCTNIVDGNAVAADMSGPLNQTPIAVSALDDLLLDVSQIDSALGATS-
Mb1297c|M.bovis_AF2122/97 LVLVLGAIGIWIANRP-KPVQPPQPVAEERLSALLLNSSEVNAVMGSSS-
Rv1266c|M.tuberculosis_H37Rv LVLVLGAIGIWIAIRP-KPVQPPQPVAEERLSALLLNSSEVNAVMGSSS-
MMAR_4171|M.marinum_M LVLIVGGIGVWMITQPPKPSPPPKPIAEDRLSSLLLSPAEVNSVMGASN-
Mvan_3880|M.vanbaalenii_PYR-1 ATACTSTVDGTAVRPDAAPSAVAGVLTERDLDAVLLDSAEIAALLNSPD-
MSMEG_1201|M.smegmatis_MC2_155 QLGVLATVGFSLVACQTQTPVPDGGPEVDVLGSMLARESEIRTIMGVDVR
MAV_4097|M.avium_104 TLGGSTAAHRAAHEATTSAGPPPPTVPPDTITTLLPGLDALRNITADANL
: :* :
Mflv_2235|M.gilvum_PYR-GCK -MTVIEAQTSLSDHSDIMAPIECLAIDGAGELQVYANSDYRASR----DQ
MUL_4150|M.ulcerans_Agy99 -MKVWFNAKAMWDWSKNISDKNCLAVDGPAQDEVYAGTGWTAMRGQRMDD
Mb1297c|M.bovis_AF2122/97 -MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LI
Rv1266c|M.tuberculosis_H37Rv -MQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAING---LI
MMAR_4171|M.marinum_M -IQPGKPITSMDASPVTLSLPECQGALYTSQDPVYSGTGYTAISG---LV
Mvan_3880|M.vanbaalenii_PYR-1 -IEVTDEIDEMTDTSADVSNPECLGALYTAEDPVYESTGYTAVLT---RL
MSMEG_1201|M.smegmatis_MC2_155 -PKTAYRTPTKNETFEPISHQECMVVAGNAMDWVYRDSGYRQFRE-----
MAV_4097|M.avium_104 DVGPTWNSPGRSAQDGSIDRPECWGSIAAGSPDAYTPGAFTGYHAG--EF
: :* . .* :
Mflv_2235|M.gilvum_PYR-GCK SLNDGEGWKTYVKQAVVLFPYLEKAGEFFDASVAQWPACR-----EYTHT
MUL_4150|M.ulcerans_Agy99 SVDDSKRRKHYAIQAVVAFPSAHDASAFYNSSVRSWGNCSNRRFTDVSTD
Mb1297c|M.bovis_AF2122/97 SSEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNK
Rv1266c|M.tuberculosis_H37Rv SSEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAG-KTVTVTNK
MMAR_4171|M.marinum_M ASEPGDNNDHWVNQAVVSFPSAAKASSFVETMAGKWKNCAG-KTVTVTNK
Mvan_3880|M.vanbaalenii_PYR-1 ASEPGDDNEHWVEESAVLVPTAEDAEQFVERSAREWDDCAG-RQVSISDG
MSMEG_1201|M.smegmatis_MC2_155 NQLSDDADDLEVDQAVARFDTPAAAQALVDTTVAIWHRCAGEVLTFSFDG
MAV_4097|M.avium_104 TDTRSMLKSIQVIQGVAAFRDAPGAQAQLDALLAGWRQCGGSTVTVTAPG
. . . :... . * : * *
Mflv_2235|M.gilvum_PYR-GCK QSGSVWNPGEITSADRTLSTVAMQRDAAAPGWGCGRALVHRNNVIVDVNT
MUL_4150|M.ulcerans_Agy99 QPDTIWTVSDVVNDNGMLSTSQVQ--EAGDGWTCQRALTVRNNVAIDVVT
Mb1297c|M.bovis_AF2122/97 AKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVNA
Rv1266c|M.tuberculosis_H37Rv AKTYRWTFADVKGSPPTITVIDTQ--EGAEGWECQRAMSVANNVVVDVNA
MMAR_4171|M.marinum_M SKTYRWTFAQVVGSPPRITMLETQ--EGAEGWECQRAMSVANNVIVDINS
Mvan_3880|M.vanbaalenii_PYR-1 EEWFDWELDAVVRDGGMVSQQSTI--LDSIDWQCQHTVVSVSNLIIEASV
MSMEG_1201|M.smegmatis_MC2_155 GETTEIQTLAAPRVIDGVDVTNDQP-TGPDERITRRAILAEGDVVVDIRI
MAV_4097|M.avium_104 GQPIAMALSTPADAGNGITTLDLT--PKGIQVRSARAVAAKANVVVDLNV
: ::: :: ::
Mflv_2235|M.gilvum_PYR-GCK CSAAP-GDSAVRIAHQIADKVDAQW---
MUL_4150|M.ulcerans_Agy99 CAYSQSGSVAADVAQQIAAKAAKQ----
Mb1297c|M.bovis_AF2122/97 CGYQI-TNQAGQIAAKIVDKVNKE----
Rv1266c|M.tuberculosis_H37Rv CGYRI-TNQAGQIAAKIVDKVNKE----
MMAR_4171|M.marinum_M CGYHI-TDQGGALADKIVDKIHKETKY-
Mvan_3880|M.vanbaalenii_PYR-1 CAERIHDEATTVVAEMIAKASARTR---
MSMEG_1201|M.smegmatis_MC2_155 TGFGVGDRETVQLAKTIEGRNAL-----
MAV_4097|M.avium_104 SASGTTDSERPRLAAVSIANYILGKIPG
. :*