For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSRAGARLRQFRRERGMSLTDVAAKAEVTKGFLSLAERGMTNVSVPVLMRICDALGIGIGDLFEYPAAPI VRSGAGAPLEMGGHGVREELLTPKTEHHVQVMRTVMRPGGGSGGAYRLDAATIVAYVLRGALSITVDGET VVLNVGDCLTFGAKQLHDWHNPTAGEAEVLWTIAPPVGAEDFCAAVRGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1139 | - | - | 100% (189) | transcription regulator |
| M. smegmatis MC2 155 | MSMEG_1151 | - | 3e-13 | 27.93% (179) | DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_4304 | - | 2e-07 | 25.27% (182) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0474c | - | 6e-05 | 35.85% (53) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0109 | - | 3e-05 | 37.74% (53) | hypothetical protein Mflv_0109 |
| M. tuberculosis H37Rv | Rv0465c | - | 4e-05 | 35.85% (53) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1049 | - | 3e-07 | 34.48% (87) | putative transcription regulator protein |
| M. marinum M | MMAR_2152 | - | 3e-11 | 27.68% (177) | transcriptional regulator |
| M. avium 104 | MAV_3453 | - | 1e-08 | 28.31% (166) | transcriptional regulator |
| M. thermoresistible (build 8) | TH_0145 | - | 5e-10 | 28.65% (178) | regulatory protein |
| M. ulcerans Agy99 | MUL_1737 | - | 8e-12 | 27.68% (177) | transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0450 | - | 7e-10 | 29.17% (168) | XRE family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2152|M.marinum_M -------------MTALLRAVRRQRGLTLEQLAQRAGLTKSYLSKIERGQ
MUL_1737|M.ulcerans_Agy99 -------------MTALLRAVRRQRGLTLEQLAQRAGLTKSYLSKIERGQ
MAV_3453|M.avium_104 -------------MTALLRPVRRQRGLTLEALAAQTGLTKSYLSKIERGQ
Mvan_0450|M.vanbaalenii_PYR-1 -------------MSGLLRAVRQERGMTLDDLAADTGLTKSYLSKVERGQ
MAB_1049|M.abscessus_ATCC_1997 -------------MASLVRALRRERGLTLEELGSRTGLTKSYLSKVEREH
Mb0474c|M.bovis_AF2122/97 --------MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLDQIEHDV
Rv0465c|M.tuberculosis_H37Rv --------MSKTYVGSRVRQLRNERGFSQAALAQMLEISPSYLNQIEHDV
Mflv_0109|M.gilvum_PYR-GCK --------MAKTFVGARVRQLRSERGFSQAALAQMLEISPSYLNQIEHDV
TH_0145|M.thermoresistible__bu MEANQREGRIEDRIRQRLRELRKQRGLTLEDVATRAQIDVSTLSRLESGK
MSMEG_1139|M.smegmatis_MC2_155 ----------MSRAGARLRQFRRERGMSLTDVAAKAEVTKGFLSLAERGM
:* .* :**:: :. : . *. *
MMAR_2152|M.marinum_M STPSIAVALKVARALDVDVGRLFSDE-----SAHETITVDRAHDRLGP--
MUL_1737|M.ulcerans_Agy99 STPSIAVALKVARALDVDVGRLFSDE-----SAHETITADRAHDRLGP--
MAV_3453|M.avium_104 STPSIAVALKVARALDVDVGRLFSDE-----AAREKIAVERAG---GP--
Mvan_0450|M.vanbaalenii_PYR-1 SVPSIAAALKISRALEVDVAQLFSDD-----PEVSTISVDRAAER-----
MAB_1049|M.abscessus_ATCC_1997 STPSVSVAMRIAGALDVDVSRLFTND-----AYESRVVVDRGADEWD---
Mb0474c|M.bovis_AF2122/97 RPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPH
Rv0465c|M.tuberculosis_H37Rv RPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDRDLDIAIDPH
Mflv_0109|M.gilvum_PYR-GCK RPLTVAVLLRITEVFGVDATFFASQDDTRLIAELREVTMDRDLDVEVDPA
TH_0145|M.thermoresistible__bu RRLAIDHLPRLAAALSVSTDDLLRAP-----DTEDPRVRGSAHTSHG---
MSMEG_1139|M.smegmatis_MC2_155 TNVSVPVLMRICDALGIGIGDLFEYP-------AAPIVRSGAGAP-----
:: :: .: :. :
MMAR_2152|M.marinum_M --------------------------------------------------
MUL_1737|M.ulcerans_Agy99 --------------------------------------------------
MAV_3453|M.avium_104 --------------------------------------------------
Mvan_0450|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1049|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0474c|M.bovis_AF2122/97 EVAEMVSAHPGLARAVVNLHRRYRITTAQLAAATEERFS--------DGS
Rv0465c|M.tuberculosis_H37Rv EVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFS--------DGS
Mflv_0109|M.gilvum_PYR-GCK EIAEVVASHPSLARAMVNLHRRYQLTTTQLAAATEDRFNTAGLSSAGGGS
TH_0145|M.thermoresistible__bu --------------------------------------------------
MSMEG_1139|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2152|M.marinum_M --------------------------------------------------
MUL_1737|M.ulcerans_Agy99 --------------------------------------------------
MAV_3453|M.avium_104 --------------------------------------------------
Mvan_0450|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1049|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0474c|M.bovis_AF2122/97 GRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELTR
Rv0465c|M.tuberculosis_H37Rv GRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELTR
Mflv_0109|M.gilvum_PYR-GCK GSGAISMPHEEVRDYFYQRQNYLHELDLAAENLTADMRVHRGELAGDLAD
TH_0145|M.thermoresistible__bu --------------------------------------------------
MSMEG_1139|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2152|M.marinum_M --------------------------------------------------
MUL_1737|M.ulcerans_Agy99 --------------------------------------------------
MAV_3453|M.avium_104 --------------------------------------------------
Mvan_0450|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1049|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0474c|M.bovis_AF2122/97 RLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAEL
Rv0465c|M.tuberculosis_H37Rv RLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAEL
Mflv_0109|M.gilvum_PYR-GCK RLRFVHGVTIIRRIDLGEVVMHRYDPDTRRLEMSAQLSAGQRVFRMAAEL
TH_0145|M.thermoresistible__bu --------------------------------------------------
MSMEG_1139|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2152|M.marinum_M -------------QSGRYHVLASTQLG-----------------------
MUL_1737|M.ulcerans_Agy99 -------------QSGRYHVLASTQLG-----------------------
MAV_3453|M.avium_104 -------------GGRRYRVLASSMLG-----------------------
Mvan_0450|M.vanbaalenii_PYR-1 -------------GADRHHAVAARMLG-----------------------
MAB_1049|M.abscessus_ATCC_1997 --------------DGKFHALSTEMLG-----------------------
Mb0474c|M.bovis_AF2122/97 AYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVA
Rv0465c|M.tuberculosis_H37Rv AYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDVA
Mflv_0109|M.gilvum_PYR-GCK AYLECGDLIEKLVAEGHFTSEESRKLARMGLANYFAAATVLPYGQFHEVA
TH_0145|M.thermoresistible__bu --------------VTYWPLTRQGPAG-----------------------
MSMEG_1139|M.smegmatis_MC2_155 ---------LEMGGHGVREELLTP--------------------------
MMAR_2152|M.marinum_M --------KTMSPFVVRPTAGQDCASDGPHPEHTGQEFVFVHTG------
MUL_1737|M.ulcerans_Agy99 --------KTMSPFVVRPTAGQDCASDGPHPEHTGQEFVFVHTG------
MAV_3453|M.avium_104 --------KTMSPFVIRPT---EQLADDPHPEHAGQEFLFVHAG------
Mvan_0450|M.vanbaalenii_PYR-1 --------KEMSPFVVRPG---RTFTTHPHPTHLGQEFIFVHSG------
MAB_1049|M.abscessus_ATCC_1997 --------KIMTPFLASPS---TEFAEH-KSSHEGQEFVFVHRG------
Mb0474c|M.bovis_AF2122/97 ENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVQVDRAGNMS
Rv0465c|M.tuberculosis_H37Rv ENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNMS
Mflv_0109|M.gilvum_PYR-GCK EKFRYDVERLSAYYSVSYETICHRLSTLQRPSMRGVPFSFVRVDRAGNMS
TH_0145|M.thermoresistible__bu ---------GLHAFKIRISAR-RRTPPAGLPVHEGHDWVYVLSG------
MSMEG_1139|M.smegmatis_MC2_155 -------KTEHHVQVMRTVMRPGGGSGGAYRLDAATIVAYVLRG------
. . :* .
MMAR_2152|M.marinum_M --------------------SVELDYG--DQTIT--LGTGDS-AYFDASV
MUL_1737|M.ulcerans_Agy99 --------------------SVELDYG--DQTIT--LGTGDS-AYFDASV
MAV_3453|M.avium_104 --------------------RVELDYG--DQTFT--LGPGDS-AYFDASV
Mvan_0450|M.vanbaalenii_PYR-1 --------------------RVELSHD--GRIIA--LEAGDC-AYFDASA
MAB_1049|M.abscessus_ATCC_1997 --------------------SIELQCGQDDEVVSYELDEGDS-AYLDATR
Mb0474c|M.bovis_AF2122/97 KRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVAR
Rv0465c|M.tuberculosis_H37Rv KRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVAR
Mflv_0109|M.gilvum_PYR-GCK KRQSATGFHFSSSGGTCPLWNVYETFANPGKIGVQIAEMPDGRAYMWVAR
TH_0145|M.thermoresistible__bu --------------------HMRLILDSRDFVIK-----PGEAVEFSTWT
MSMEG_1139|M.smegmatis_MC2_155 --------------------ALSITVDGETVVLN-----VGDCLTFGAKQ
: . : .
MMAR_2152|M.marinum_M GHKLRAVGTERAEVVVVAG--AELGGR-----------------------
MUL_1737|M.ulcerans_Agy99 GHKLRAVGTERAEVVVVAG--AELGGR-----------------------
MAV_3453|M.avium_104 SHKVRSVGPEPAEVVAVAH--AEPGSAAFAG-------------------
Mvan_0450|M.vanbaalenii_PYR-1 PHKLRQIGEDAAEVVVVAGNAPRPGAPRRRG-------------------
MAB_1049|M.abscessus_ATCC_1997 THRIRRTSETPALVVIVAAT------------------------------
Mb0474c|M.bovis_AF2122/97 TVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIG
Rv0465c|M.tuberculosis_H37Rv TVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPIG
Mflv_0109|M.gilvum_PYR-GCK TVERRAARYGQPGKTFAIGLGCELRHAQRLVYSEGLDLSGDPSVRATPIG
TH_0145|M.thermoresistible__bu PHWFGAVDGPVEAIMILGPHGERLHLHE----------------------
MSMEG_1139|M.smegmatis_MC2_155 LHDWHNPTAGEAEVLWTIAPPVGAEDFCAAVRGG----------------
MMAR_2152|M.marinum_M ----------------------------------------
MUL_1737|M.ulcerans_Agy99 ----------------------------------------
MAV_3453|M.avium_104 ----------------------------------------
Mvan_0450|M.vanbaalenii_PYR-1 ----------------------------------------
MAB_1049|M.abscessus_ATCC_1997 ----------------------------------------
Mb0474c|M.bovis_AF2122/97 AGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
Rv0465c|M.tuberculosis_H37Rv AGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
Mflv_0109|M.gilvum_PYR-GCK AGCRVCERDNCPQRAFPALGRALDIDEHRSTVSPYLVRQP
TH_0145|M.thermoresistible__bu ----------------------------------------
MSMEG_1139|M.smegmatis_MC2_155 ----------------------------------------