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MSRIAIIGGGSMGEALLSGLLRAGRQVKDMVVAEKFPERAKYLADKYSVRVTSVADAAENAHYVVVAVKP ADVEKVIGEIAEAAANAETDTAEQVFVTIAAGVGTAYYEAKLPAGSPVIRVMPNAPVIVGGGVSALAPGR FATPEQLKEVSTLFDAVGGVITVSESQLDAVTALSGSGPAYFFLMAEAMVDAGVAVGLSRAVATDLVAQT MAGSAAMLLDRLDQVNAAGGAALDTTPAQLRATVTSPAGTTAAGLRELERGGLRAAVANAVEAAKTRSEQ LGITSE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0943 | proC | - | 100% (286) | pyrroline-5-carboxylate reductase |
| M. smegmatis MC2 155 | MSMEG_5884 | - | 3e-08 | 26.54% (211) | 3-hydroxyisobutyrate dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_5477 | - | 4e-05 | 26.99% (226) | 2-hydroxy-3-oxopropionate reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0511 | proC | 1e-111 | 71.82% (291) | pyrroline-5-carboxylate reductase |
| M. gilvum PYR-GCK | Mflv_0075 | - | 1e-124 | 79.66% (290) | pyrroline-5-carboxylate reductase |
| M. tuberculosis H37Rv | Rv0500 | proC | 1e-110 | 72.51% (291) | pyrroline-5-carboxylate reductase |
| M. leprae Br4923 | MLBr_02430 | proC | 1e-107 | 70.10% (291) | pyrroline-5-carboxylate reductase |
| M. abscessus ATCC 19977 | MAB_4005c | - | 1e-102 | 66.78% (295) | pyrroline-5-carboxylate reductase |
| M. marinum M | MMAR_0826 | proC | 1e-108 | 71.38% (290) | pyrroline-5-carboxylate reductase ProC |
| M. avium 104 | MAV_4652 | proC | 1e-112 | 73.54% (291) | pyrroline-5-carboxylate reductase |
| M. thermoresistible (build 8) | TH_0955 | proC | 1e-128 | 81.88% (287) | PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C |
| M. ulcerans Agy99 | MUL_4570 | proC | 1e-109 | 71.72% (290) | pyrroline-5-carboxylate reductase |
| M. vanbaalenii PYR-1 | Mvan_0837 | - | 1e-122 | 78.97% (290) | pyrroline-5-carboxylate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0943|M.smegmatis_MC2_155 ----------------MSRIAIIGGGSMGEALLSGLLRAGRQVKDMVVAE
TH_0955|M.thermoresistible__bu ----------------VARIAIIGGGNIGEALLSGLLRAGRQVKDLVVAE
Mflv_0075|M.gilvum_PYR-GCK ------------MLARMARIAIIGGGSIGEALLAGLLRAGRQVKDLVVAE
Mvan_0837|M.vanbaalenii_PYR-1 MSRQVCAHRERAMLCGMARIAIIGGGSIGEALLAGLLRAGRQVKDLVVAE
MMAR_0826|M.marinum_M ------------MLSGMPRIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MUL_4570|M.ulcerans_Agy99 ------------MLSGMPRIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MAV_4652|M.avium_104 ------------MLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVE
Mb0511|M.bovis_AF2122/97 ------------MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
Rv0500|M.tuberculosis_H37Rv ------------MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MLBr_02430|M.leprae_Br4923 ------------MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MAB_4005c|M.abscessus_ATCC_199 ------------MLVAMSRIAIIGGGNIGEALISGLLRAGRQAKDIVVSE
:.********.:****::********.**:** *
MSMEG_0943|M.smegmatis_MC2_155 KFPERAKYLADKYSVRVTSVADAAENAHYVVVAVKPADVEKVIGEIAEAA
TH_0955|M.thermoresistible__bu KDPNRAKYLAEKYGVLVTSVGDAAESATFIVIAVKPGDVEKVIDDIAEAA
Mflv_0075|M.gilvum_PYR-GCK KSPDRGKYLAEKYSVLVTTVADAVDAATYVIVAVKPADVQHVIGDIADTA
Mvan_0837|M.vanbaalenii_PYR-1 KNPGRAKYLAEKYSVLVTAVSDAVDAATYVVVAVKPSDVQYVIGDIADTA
MMAR_0826|M.marinum_M RVPERAKYLASTYSVLVTSAKDAAESASLVVVAVKPGDVDSVMGDLSAVV
MUL_4570|M.ulcerans_Agy99 RVPERAKYLASTYSVLVTSAKDAAESASLVVVAVKPGDVDSVMGDLSAVV
MAV_4652|M.avium_104 RVPERAKYLADTYSVLMTSVADAVENASFVVVAVKPADVESVMSEIARAA
Mb0511|M.bovis_AF2122/97 RMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANAT
Rv0500|M.tuberculosis_H37Rv RMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANAT
MLBr_02430|M.leprae_Br4923 RMPDRARYLADTYSVLVTSVTDAVENAMFVVVAVKPTDVESVMGDLVQAA
MAB_4005c|M.abscessus_ATCC_199 KVPARARALADAYSIRISEVADAVEGADFIVVAVKPSDVESATTEIAAAL
: * *.. **. *.: :: . **.: * :::**** **: . :: .
MSMEG_0943|M.smegmatis_MC2_155 ANAETDTAE----QVFVTIAAGVGTAYYEAKLPAGSPVIRVMPNAPVIVG
TH_0955|M.thermoresistible__bu ARADSGTDE----QVFVSVAAGVGTGYYEAKLPAGAPVVRVMPNAPMVVG
Mflv_0075|M.gilvum_PYR-GCK ARADSDAAE----QVFVSVAAGVSTSFYESKLPAGSPVIRVMPNAPMLVG
Mvan_0837|M.vanbaalenii_PYR-1 ARAESNAAE----QVFVTVAAGVSTAYYENKLPAGSPVVRVMPNAPMLVG
MMAR_0826|M.marinum_M AAAESYSGE----QVFVTVAAGVTTSYFESKLPAGTPVVRAMPNAAALVS
MUL_4570|M.ulcerans_Agy99 AAAESYSGE----QVFVTVAAGVTTSYFESKLPAGTPVVRAMPNAAALVS
MAV_4652|M.avium_104 GQAESDTAE----QVFVTVAAGVTIGYFESRLPAGTPVVRAMPNAAALVG
Mb0511|M.bovis_AF2122/97 AAAENDSAE----QVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVG
Rv0500|M.tuberculosis_H37Rv AAAENDSAE----QVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVG
MLBr_02430|M.leprae_Br4923 AVA-NDSAE----QVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVG
MAB_4005c|M.abscessus_ATCC_199 AKLDAEGSERETEQVLVSVAAGVSTGFFESKLAAGAPVVRVMPNAPMLVG
. * **:*::.**: : * :*.**:**:*.****. :*.
MSMEG_0943|M.smegmatis_MC2_155 GGVSALAPGRFATPEQLKEVSTLFDAVGGVITVSESQLDAVTALSGSGPA
TH_0955|M.thermoresistible__bu GGVSALAPGRFATPEQLKEVAGIFDAVGGVLTVTEAQMDAVTAVSGSGPA
Mflv_0075|M.gilvum_PYR-GCK GGVSALAPGRFASPEQLKEVSLLFDAVGGVLTVAESQIDAVTAVSGSGPA
Mvan_0837|M.vanbaalenii_PYR-1 GGVSALAPGRFATQEHLKEVSLLFDAVGGVLTVAESQIDAVTAVSGSGPA
MMAR_0826|M.marinum_M AGVTALAKGRFVTPEQLEEVSALFDSVGVVLTVPEQQLDAVTALSGSGPA
MUL_4570|M.ulcerans_Agy99 AGVTALAKGRFVTPEQLEEVSALFDSVGVVLTVPEQQLDAVTALSGSGPA
MAV_4652|M.avium_104 AGVTALAKGRFVTAPQLEGVSALFDSVGGVLSVPESQMDAVTALSGSGPA
Mb0511|M.bovis_AF2122/97 AGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPA
Rv0500|M.tuberculosis_H37Rv AGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPA
MLBr_02430|M.leprae_Br4923 AGVTVLAKGRFVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPA
MAB_4005c|M.abscessus_ATCC_199 AGVSALAKGRFANDEQLSAVAELLESVGTVITVAESQMDTVTAISGSGPA
.**:.** ***.. ::. * ::::** *::*.* *:*:***:******
MSMEG_0943|M.smegmatis_MC2_155 YFFLMAEAMVDAGVAVGLSRAVATDLVAQTMAGSAAMLLDRLDQVN----
TH_0955|M.thermoresistible__bu YFFLMAEAMVDAGVAVGLSRAVATGLVAQTMAGSAAMLLDRLDDAAK---
Mflv_0075|M.gilvum_PYR-GCK YFFLMVEALVDAGVDAGLPRAVATDLAVQTMAGSAAMLLERLDQNAA-G-
Mvan_0837|M.vanbaalenii_PYR-1 YFFLMVEALVDAAVDAGLARSVATDLVVQTMAGSAAMLLERLDESAP-SN
MMAR_0826|M.marinum_M YFLLMVEALVDAGVAAGLSRQVATDLTAQTMAGSAAMLLERMDQDRR-GA
MUL_4570|M.ulcerans_Agy99 YFLLMVEALVDAGVAAGLSRQVATDLTAQTMAGSAAMLLERMDQDRR-GA
MAV_4652|M.avium_104 YFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGE
Mb0511|M.bovis_AF2122/97 YFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGAN
Rv0500|M.tuberculosis_H37Rv YFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGAN
MLBr_02430|M.leprae_Br4923 YFFLLVEALVDAGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAE
MAB_4005c|M.abscessus_ATCC_199 YFFLLVEALVDAGVASGLTRPVATDLVIQTMAGSAAMLLERAESDENRAP
**:*:.**:***.* **.* **: *. ***********:* :
MSMEG_0943|M.smegmatis_MC2_155 -AAGGAALDTTPAQLRATVTSPAGTTAAGLRELERGGLRAAVANAVEAAK
TH_0955|M.thermoresistible__bu -SAAGAAMDTSPAELRAMVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
Mflv_0075|M.gilvum_PYR-GCK SASAGPSMDTSAAQLRATVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
Mvan_0837|M.vanbaalenii_PYR-1 DSAAGAFMDTSAAQLRATVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
MMAR_0826|M.marinum_M AEPLGLRVDTSPAQLRASVTSPGGTTAAALRELEREGFRGAVDAAVQAAK
MUL_4570|M.ulcerans_Agy99 AEPLGLRLDTSPAQLRASVTSPGGTTAAALRELEREGFRGAVDAAVQAAK
MAV_4652|M.avium_104 AETPGMRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAK
Mb0511|M.bovis_AF2122/97 GELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAK
Rv0500|M.tuberculosis_H37Rv GELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAK
MLBr_02430|M.leprae_Br4923 VAPLGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAK
MAB_4005c|M.abscessus_ATCC_199 GLQTRTEVDTTAAELRATITSPGGTTAAALRELERGGLRASVYAAVDAAK
:* ..:.*** :***.*****.****** *:* * **:***
MSMEG_0943|M.smegmatis_MC2_155 TRSEQLGITSE
TH_0955|M.thermoresistible__bu MRSEQLGITSE
Mflv_0075|M.gilvum_PYR-GCK KRSEQLGITTE
Mvan_0837|M.vanbaalenii_PYR-1 TRSEQLGITPE
MMAR_0826|M.marinum_M SRSEQLRITSE
MUL_4570|M.ulcerans_Agy99 SRSEQLRITSE
MAV_4652|M.avium_104 IRSEQLRITSE
Mb0511|M.bovis_AF2122/97 SRSEQLRITPE
Rv0500|M.tuberculosis_H37Rv SRSEQLRITPE
MLBr_02430|M.leprae_Br4923 IRSEQLRITSE
MAB_4005c|M.abscessus_ATCC_199 TRSEQLGITSE
***** **.*