For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. vanbaalenii PYR-1 Mvan_0837 (-)

annotation: pyrroline-5-carboxylate reductase
coordinates: 872490 - 873410
length: 306

LSRQVCAHRERAMLCGMARIAIIGGGSIGEALLAGLLRAGRQVKDLVVAEKNPGRAKYLAEKYSVLVTAV
SDAVDAATYVVVAVKPSDVQYVIGDIADTAARAESNAAEQVFVTVAAGVSTAYYENKLPAGSPVVRVMPN
APMLVGGGVSALAPGRFATQEHLKEVSLLFDAVGGVLTVAESQIDAVTAVSGSGPAYFFLMVEALVDAAV
DAGLARSVATDLVVQTMAGSAAMLLERLDESAPSNDSAAGAFMDTSAAQLRATVTSPGGTTAAGLRELER
GGLRAAVANAVEAAKTRSEQLGITPE
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. vanbaalenii PYR-1Mvan_0837--100% (306)pyrroline-5-carboxylate reductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0511proC1e-11272.20% (295) pyrroline-5-carboxylate reductase
M. gilvum PYR-GCKMflv_0075-1e-13787.76% (294) pyrroline-5-carboxylate reductase
M. tuberculosis H37RvRv0500proC1e-11271.86% (295) pyrroline-5-carboxylate reductase
M. leprae Br4923MLBr_02430proC1e-10670.51% (295) pyrroline-5-carboxylate reductase
M. abscessus ATCC 19977MAB_4005c-1e-10165.35% (303) pyrroline-5-carboxylate reductase
M. marinum MMMAR_0826proC1e-10771.09% (294) pyrroline-5-carboxylate reductase ProC
M. avium 104MAV_4652proC1e-10971.53% (295) pyrroline-5-carboxylate reductase
M. smegmatis MC2 155MSMEG_0943proC1e-12278.97% (290) pyrroline-5-carboxylate reductase
M. thermoresistible (build 8)TH_0955proC1e-12279.31% (290) PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C
M. ulcerans Agy99MUL_4570proC1e-10871.09% (294) pyrroline-5-carboxylate reductase

CLUSTAL 2.0.9 multiple sequence alignment


Mvan_0837|M.vanbaalenii_PYR-1       MSRQVCAHRERAMLCGMARIAIIGGGSIGEALLAGLLRAGRQVKDLVVAE
Mflv_0075|M.gilvum_PYR-GCK          ------------MLARMARIAIIGGGSIGEALLAGLLRAGRQVKDLVVAE
MSMEG_0943|M.smegmatis_MC2_155      ----------------MSRIAIIGGGSMGEALLSGLLRAGRQVKDMVVAE
TH_0955|M.thermoresistible__bu      ----------------VARIAIIGGGNIGEALLSGLLRAGRQVKDLVVAE
MMAR_0826|M.marinum_M               ------------MLSGMPRIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MUL_4570|M.ulcerans_Agy99           ------------MLSGMPRIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MAV_4652|M.avium_104                ------------MLSGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVVE
Mb0511|M.bovis_AF2122/97            ------------MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
Rv0500|M.tuberculosis_H37Rv         ------------MLFGMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MLBr_02430|M.leprae_Br4923          ------------MLSSMARIAIIGGGSIGEALLSGLLRAGRQVKDLVVAE
MAB_4005c|M.abscessus_ATCC_199      ------------MLVAMSRIAIIGGGNIGEALISGLLRAGRQAKDIVVSE
                                                    :.********.:****::********.**:** *

Mvan_0837|M.vanbaalenii_PYR-1       KNPGRAKYLAEKYSVLVTAVSDAVDAATYVVVAVKPSDVQYVIGDIADTA
Mflv_0075|M.gilvum_PYR-GCK          KSPDRGKYLAEKYSVLVTTVADAVDAATYVIVAVKPADVQHVIGDIADTA
MSMEG_0943|M.smegmatis_MC2_155      KFPERAKYLADKYSVRVTSVADAAENAHYVVVAVKPADVEKVIGEIAEAA
TH_0955|M.thermoresistible__bu      KDPNRAKYLAEKYGVLVTSVGDAAESATFIVIAVKPGDVEKVIDDIAEAA
MMAR_0826|M.marinum_M               RVPERAKYLASTYSVLVTSAKDAAESASLVVVAVKPGDVDSVMGDLSAVV
MUL_4570|M.ulcerans_Agy99           RVPERAKYLASTYSVLVTSAKDAAESASLVVVAVKPGDVDSVMGDLSAVV
MAV_4652|M.avium_104                RVPERAKYLADTYSVLMTSVADAVENASFVVVAVKPADVESVMSEIARAA
Mb0511|M.bovis_AF2122/97            RMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANAT
Rv0500|M.tuberculosis_H37Rv         RMPDRANYLAQTYSVLVTSAADAVENATFVVVAVKPADVEPVIADLANAT
MLBr_02430|M.leprae_Br4923          RMPDRARYLADTYSVLVTSVTDAVENAMFVVVAVKPTDVESVMGDLVQAA
MAB_4005c|M.abscessus_ATCC_199      KVPARARALADAYSIRISEVADAVEGADFIVVAVKPSDVESATTEIAAAL
                                    : * *.. **. *.: :: . **.: *  :::**** **: .  ::  . 

Mvan_0837|M.vanbaalenii_PYR-1       ARAESNAAE----QVFVTVAAGVSTAYYENKLPAGSPVVRVMPNAPMLVG
Mflv_0075|M.gilvum_PYR-GCK          ARADSDAAE----QVFVSVAAGVSTSFYESKLPAGSPVIRVMPNAPMLVG
MSMEG_0943|M.smegmatis_MC2_155      ANAETDTAE----QVFVTIAAGVGTAYYEAKLPAGSPVIRVMPNAPVIVG
TH_0955|M.thermoresistible__bu      ARADSGTDE----QVFVSVAAGVGTGYYEAKLPAGAPVVRVMPNAPMVVG
MMAR_0826|M.marinum_M               AAAESYSGE----QVFVTVAAGVTTSYFESKLPAGTPVVRAMPNAAALVS
MUL_4570|M.ulcerans_Agy99           AAAESYSGE----QVFVTVAAGVTTSYFESKLPAGTPVVRAMPNAAALVS
MAV_4652|M.avium_104                GQAESDTAE----QVFVTVAAGVTIGYFESRLPAGTPVVRAMPNAAALVG
Mb0511|M.bovis_AF2122/97            AAAENDSAE----QVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVG
Rv0500|M.tuberculosis_H37Rv         AAAENDSAE----QVFVTVVAGITIAYFESKLPAGTPVVRAMPNAAALVG
MLBr_02430|M.leprae_Br4923          AVA-NDSAE----QVLVTVAAGVTITYLESKLPAGTPVVRAMPNAAALVG
MAB_4005c|M.abscessus_ATCC_199      AKLDAEGSERETEQVLVSVAAGVSTGFFESKLAAGAPVVRVMPNAPMLVG
                                    .       *    **:*::.**:   : * :*.**:**:*.****. :*.

Mvan_0837|M.vanbaalenii_PYR-1       GGVSALAPGRFATQEHLKEVSLLFDAVGGVLTVAESQIDAVTAVSGSGPA
Mflv_0075|M.gilvum_PYR-GCK          GGVSALAPGRFASPEQLKEVSLLFDAVGGVLTVAESQIDAVTAVSGSGPA
MSMEG_0943|M.smegmatis_MC2_155      GGVSALAPGRFATPEQLKEVSTLFDAVGGVITVSESQLDAVTALSGSGPA
TH_0955|M.thermoresistible__bu      GGVSALAPGRFATPEQLKEVAGIFDAVGGVLTVTEAQMDAVTAVSGSGPA
MMAR_0826|M.marinum_M               AGVTALAKGRFVTPEQLEEVSALFDSVGVVLTVPEQQLDAVTALSGSGPA
MUL_4570|M.ulcerans_Agy99           AGVTALAKGRFVTPEQLEEVSALFDSVGVVLTVPEQQLDAVTALSGSGPA
MAV_4652|M.avium_104                AGVTALAKGRFVTAPQLEGVSALFDSVGGVLSVPESQMDAVTALSGSGPA
Mb0511|M.bovis_AF2122/97            AGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPA
Rv0500|M.tuberculosis_H37Rv         AGVTALAKGRFVTPQQLEEVSALFDAVGGVLTVPESQLDAVTAVSGSGPA
MLBr_02430|M.leprae_Br4923          AGVTVLAKGRFVTGQQFEDVLAMFDAVGGVLTVPESQMDAVTAVSGSGPA
MAB_4005c|M.abscessus_ATCC_199      AGVSALAKGRFANDEQLSAVAELLESVGTVITVAESQMDTVTAISGSGPA
                                    .**:.** ***..  ::. *  ::::** *::*.* *:*:***:******

Mvan_0837|M.vanbaalenii_PYR-1       YFFLMVEALVDAAVDAGLARSVATDLVVQTMAGSAAMLLERLDESAP-SN
Mflv_0075|M.gilvum_PYR-GCK          YFFLMVEALVDAGVDAGLPRAVATDLAVQTMAGSAAMLLERLDQNAA-G-
MSMEG_0943|M.smegmatis_MC2_155      YFFLMAEAMVDAGVAVGLSRAVATDLVAQTMAGSAAMLLDRLDQVN----
TH_0955|M.thermoresistible__bu      YFFLMAEAMVDAGVAVGLSRAVATGLVAQTMAGSAAMLLDRLDDAAK---
MMAR_0826|M.marinum_M               YFLLMVEALVDAGVAAGLSRQVATDLTAQTMAGSAAMLLERMDQDRR-GA
MUL_4570|M.ulcerans_Agy99           YFLLMVEALVDAGVAAGLSRQVATDLTAQTMAGSAAMLLERMDQDRR-GA
MAV_4652|M.avium_104                YFFLLVEALVDAGVAAGLSREVAADLTAQTMAGSAAMLLERMDADRRLGE
Mb0511|M.bovis_AF2122/97            YFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMDQDQGGAN
Rv0500|M.tuberculosis_H37Rv         YFFLLVEALVDAGVGVGLSRQVATDLAAQTMAGSAAMLLERMEQDQGGAN
MLBr_02430|M.leprae_Br4923          YFFLLVEALVDAGVAVGLTRQVATELAAQTMAGSAAMLLERMDQDRHSAE
MAB_4005c|M.abscessus_ATCC_199      YFFLLVEALVDAGVASGLTRPVATDLVIQTMAGSAAMLLERAESDENRAP
                                    **:*:.**:***.*  **.* **: *. ***********:* :       

Mvan_0837|M.vanbaalenii_PYR-1       DSAAGAFMDTSAAQLRATVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
Mflv_0075|M.gilvum_PYR-GCK          SASAGPSMDTSAAQLRATVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
MSMEG_0943|M.smegmatis_MC2_155      -AAGGAALDTTPAQLRATVTSPAGTTAAGLRELERGGLRAAVANAVEAAK
TH_0955|M.thermoresistible__bu      -SAAGAAMDTSPAELRAMVTSPGGTTAAGLRELERGGLRAAVANAVEAAK
MMAR_0826|M.marinum_M               AEPLGLRVDTSPAQLRASVTSPGGTTAAALRELEREGFRGAVDAAVQAAK
MUL_4570|M.ulcerans_Agy99           AEPLGLRLDTSPAQLRASVTSPGGTTAAALRELEREGFRGAVDAAVQAAK
MAV_4652|M.avium_104                AETPGMRVDATATQLRATVTSPGGTTAAGLRELERGGLRAAVDAAVQAAK
Mb0511|M.bovis_AF2122/97            GELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAK
Rv0500|M.tuberculosis_H37Rv         GELMGLRVDLTASRLRAAVTSPGGTTAAALRELERGGFRMAVDAAVQAAK
MLBr_02430|M.leprae_Br4923          VAPLGAQVDVPAAQLRATITSPGGTTAAALRELERGGLRMVVDAAVQAAK
MAB_4005c|M.abscessus_ATCC_199      GLQTRTEVDTTAAELRATITSPGGTTAAALRELERGGLRASVYAAVDAAK
                                           :* ..:.*** :***.*****.****** *:*  *  **:***

Mvan_0837|M.vanbaalenii_PYR-1       TRSEQLGITPE
Mflv_0075|M.gilvum_PYR-GCK          KRSEQLGITTE
MSMEG_0943|M.smegmatis_MC2_155      TRSEQLGITSE
TH_0955|M.thermoresistible__bu      MRSEQLGITSE
MMAR_0826|M.marinum_M               SRSEQLRITSE
MUL_4570|M.ulcerans_Agy99           SRSEQLRITSE
MAV_4652|M.avium_104                IRSEQLRITSE
Mb0511|M.bovis_AF2122/97            SRSEQLRITPE
Rv0500|M.tuberculosis_H37Rv         SRSEQLRITPE
MLBr_02430|M.leprae_Br4923          IRSEQLRITSE
MAB_4005c|M.abscessus_ATCC_199      TRSEQLGITSE
                                     ***** **.*