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DVPKIGRGLGTLDREVFEAVAESPSPLLDSLMPKLTRAADHSKLWFVIAAGLGAVGGNSARRGAVRGIAS LAVTSLVTNQIAKRIWRRPRPDRSIIPLIRQTRRVPTSHSLPSGHSSSAAAFAVGVGLESAPIGLPLALL AGLVGLSRVATGAHYPGDVFAGFGIGATIAILGARIVPTIPAASLPTSEPLRYKTAPRPEGSGVTLVINP ASGSGTGARVVEEVREALPQAEVVELDEDDDIEEVLREAASRCEVLAVGGGDGTVACAAGIAVEAGLPLA VFPGGTFNHFAKDIGCDTVARTVEAIRQGSAAYVDLVCLNDKHMVLNTASIGAYPKFVRIREKLEHRLGK RVAAAYALYLTLRRDEPVRITYDDKTVETSLFFLGNSVYFPSGFAPSLRPRMDDGLIDVRILETGKRFGR LRIATSMLLGRLERSPLYHEMQVPQFHFETVDGPTVLAHDGEVGEPYTEATFTSRYRALPVFRPLP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0633 | - | - | 100% (487) | PAP2 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6402 | - | 6e-10 | 36.96% (138) | PAP2 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_4335 | - | 2e-06 | 23.97% (242) | diacylglycerol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3837c | - | 4e-11 | 33.57% (140) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_0311 | - | 0.0 | 73.50% (483) | phosphoesterase, PA-phosphatase related |
| M. tuberculosis H37Rv | Rv3807c | - | 4e-11 | 33.57% (140) | transmembrane protein |
| M. leprae Br4923 | MLBr_00094 | - | 2e-11 | 34.15% (164) | hypothetical protein MLBr_00094 |
| M. abscessus ATCC 19977 | MAB_0199 | - | 0.0 | 71.64% (483) | phosphoesterase, PA-phosphatase related protein |
| M. marinum M | MMAR_0569 | - | 0.0 | 68.66% (485) | hypothetical protein MMAR_0569 |
| M. avium 104 | MAV_0210 | - | 6e-11 | 35.21% (142) | PAP2 superfamily protein |
| M. thermoresistible (build 8) | TH_1306 | - | 0.0 | 72.31% (502) | PAP2 superfamily protein |
| M. ulcerans Agy99 | MUL_4991 | - | 2e-12 | 33.15% (181) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_0430 | - | 0.0 | 73.91% (483) | phosphoesterase, PA-phosphatase related |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0633|M.smegmatis_MC2_155 ----------MDVPKIGRGLGTLDREVFEAVAESPSPLLDSLMPKLTRAA
TH_1306|M.thermoresistible__bu MYDGPLRRRQSPLGRIGEGLGTLDREVFEAIAESPTPLLDTVMPPLTRAA
Mflv_0311|M.gilvum_PYR-GCK MDLLPVGRRGRGIRQIGVGLGTLDREVFEAIAESPSPLLDAVMPRLTRAA
Mvan_0430|M.vanbaalenii_PYR-1 MDLLPGRRRGRGIRQIGEGLGTLDREVFEAVAESPSPLLDAVMPPLTKAA
MAB_0199|M.abscessus_ATCC_1997 MGLLPSRNSLKGLRQIGDGLGTLDREVFEAVAESPSPLLDAVMPRLTRAA
MMAR_0569|M.marinum_M MNGRP-WQRARSIKQITRGLGALDRELFEAIADTPTPLLDTVMPPLTRAA
Mb3837c|M.bovis_AF2122/97 -------------------------MVAVQSALVDRPGMLATARGLSHFG
Rv3807c|M.tuberculosis_H37Rv -------------------------MVAVQSALVDRPGMLATARGLSHFG
MLBr_00094|M.leprae_Br4923 ------------MPEDKAPTGELAAIAAVQSVLVDRPGVLPTARGMSHFG
MUL_4991|M.ulcerans_Agy99 ------------MPEPAPPRGEAAAIVAVQSALADRPGVLGTARGLSHFG
MAV_0210|M.avium_104 --------------------------------------MLTVARALSHFG
: ::: .
MSMEG_0633|M.smegmatis_MC2_155 DHSKLWFVIAAGLGAVGGNSARRGAVRGIASLAVTSLVTNQIAKRIWRRP
TH_1306|M.thermoresistible__bu DHSTLWLAIAAAMASVGGPSARRAAVRGVAGLAVTSLVTNQVAKRIWKRS
Mflv_0311|M.gilvum_PYR-GCK DHSKLWFGIAAGLMALGSPSVKRGAVRGVATLAVTSLVTNQGAKRVWKRE
Mvan_0430|M.vanbaalenii_PYR-1 DHSKLWFAIAAGLAALGSSSAKRGATRGVVSLALTSLLTNQVAKRVWKRE
MAB_0199|M.abscessus_ATCC_1997 DHSKLWIGIGVGLALFGKPAAARGATRGLLTLAVTSAVTNQVAKRLRRRE
MMAR_0569|M.marinum_M DHSKLWFAMAAGLLASRSQSAQRGAVRGVVTLGAASLFTNQVAKRIRQRP
Mb3837c|M.bovis_AF2122/97 EHCIGWLILALLGAIALPRRRREWLVAGAG--AFVAHAIAVLIKRLVRRQ
Rv3807c|M.tuberculosis_H37Rv EHCIGWLILALLGAIALPRRRREWLVAGAG--AFVAHAIAVLIKRLVRRQ
MLBr_00094|M.leprae_Br4923 EHSIGWLAISLLGAILVPCRRRYWLVAGAG--VFAAHVAAVLIKRMVRRI
MUL_4991|M.ulcerans_Agy99 EHSVGWLLVSALGAMLFPSRRREWVVAGAG--TFVAHAAAVVIKRVVRRK
MAV_0210|M.avium_104 EHSIGWVAAAALGALCSPRRRADWLAAGAG--AFVAHAAAVVVKRIVRRE
:*. *. . . * .: **: :*
MSMEG_0633|M.smegmatis_MC2_155 RPDRSIIPLIRQTRRVPTSHSLPSGHSSSAAAFAVGVG-LESAPIGLPLA
TH_1306|M.thermoresistible__bu RPDYAIVPLIRRPRRMPTSHSLPSGHSASAAAFAVGVG-LESPPLGFGLA
Mflv_0311|M.gilvum_PYR-GCK RPNWSFVPLARQTRRHPTSNSLPSGHSASAAAFSIGVG-LENPPAGLGLA
Mvan_0430|M.vanbaalenii_PYR-1 RPSRLLVPLARQTRRHPTSNSLPSGHSASGAAFAVGVG-LENPPLGLGLA
MAB_0199|M.abscessus_ATCC_1997 RPNHLSVPLTRRSRRVPTSSSLPSGHSASAAAFAVGVG-LESPPLGFGLS
MMAR_0569|M.marinum_M RPLSDSVPLARRVRRRPTSNSLPSGHSASAAAFAIGVG-LENPPLGLGFS
Mb3837c|M.bovis_AF2122/97 RPDHPAIAVN---VDTPSQLSFPSAHATSTTAAALLMGRATGLP---LPV
Rv3807c|M.tuberculosis_H37Rv RPDHPAIAVN---VDTPSQLSFPSAHATSTTAAALLMGRATGLP---LPV
MLBr_00094|M.leprae_Br4923 RPNHPAVTVN---VGTPSPLSFPSAHATSTAAAAILIGRASRLPKGIVAA
MUL_4991|M.ulcerans_Agy99 RPHDPAVTVN---VGTPSKLSFPSAHATSTAAAAILLSRAAGVSEAAGAA
MAV_0210|M.avium_104 RPHHPAVVVN---VGTPSRLSFPSAHATSTTAAAILLGRITGLP---LPA
** : : *: *:**.*::* :* :: :. .
MSMEG_0633|M.smegmatis_MC2_155 LLAGLVGLSRVATGAHYPGDVFAGFGIGATIAILGARIVP-----TIPAA
TH_1306|M.thermoresistible__bu LLAGLVGLSRVVTGAHYPGDVLAGFGIGAGIAVLGGRAVPPVAPTRLPTA
Mflv_0311|M.gilvum_PYR-GCK LLAGLVGMSRVATGAHYPGDVLAGFGLGAGIAVLGARIVP-----PIVET
Mvan_0430|M.vanbaalenii_PYR-1 LLAGLVGMSRVATGAHYPGDVLAGFGIGAGIAVLGARVVP-----PIAEA
MAB_0199|M.abscessus_ATCC_1997 LLAGLVGLSRVATGVHYPGDVFAGFGIGAGLAVLGARVVP-----PIVTT
MMAR_0569|M.marinum_M VLAALVGLSRVATGVHYPGDVLAGFGIGAGVAVLGGRLVP-----PIVET
Mb3837c|M.bovis_AF2122/97 VLVPPMALSRILLGVHYPSDVAVGVALGATVG---AIVDS----------
Rv3807c|M.tuberculosis_H37Rv VLVPPMALSRILLGVHYPSDVAVGVALGATVG---AIVDS----------
MLBr_00094|M.leprae_Br4923 VLVAPMALSRIVLGVHYPSDVAFGVVLGAAVAGTTARFDS----------
MUL_4991|M.ulcerans_Agy99 VLVPPMALSRILLGVHYPSDVAAGIAVGASVAAIAARLDK----------
MAV_0210|M.avium_104 VLVPPMALSRMVLGVHYPSDVACGIALGAGVAAVARRAPQ----------
:*. :.:**: *.***.** *. :** :.
MSMEG_0633|M.smegmatis_MC2_155 S------------LPTSEPLRYKTAPRPEGSGVTLVINPASGSGTGARVV
TH_1306|M.thermoresistible__bu DPLRAVPPVAPTRLPTADPLRLETRPRPDGAGVVLVINPESGDGSGAETV
Mflv_0311|M.gilvum_PYR-GCK R------------LPVSDPLRVDTPERPEGEGLVLVINPASGSGTGARVV
Mvan_0430|M.vanbaalenii_PYR-1 R------------MPGAEPLRVDTPARPDGEGVTLVINPASGSGTGARVL
MAB_0199|M.abscessus_ATCC_1997 S------------VPTGEPLRVETPARPGGEGVVLVVNPASGDGTGQRIL
MMAR_0569|M.marinum_M A------------LPKTEPLWVQTPQRPDGSGVVLVVNPASGSGTGAQVI
Mb3837c|M.bovis_AF2122/97 --------------VGGGRQRARKR-------------------------
Rv3807c|M.tuberculosis_H37Rv --------------VGGGRQRARKR-------------------------
MLBr_00094|M.leprae_Br4923 --------------RLSRRWTVQHGLSSGSAVK-----------------
MUL_4991|M.ulcerans_Agy99 --------------VSTKGMSL----------------------------
MAV_0210|M.avium_104 --------------LARGDQ------------------------------
MSMEG_0633|M.smegmatis_MC2_155 EEVREALPQAEVVELDED--DDIEEVLREAASRCEVLAVGGGDGTVACAA
TH_1306|M.thermoresistible__bu DEVRAALPAAEIVELDPNSADDLVGTLRKAADRAEVLAVGGGDGTVACAA
Mflv_0311|M.gilvum_PYR-GCK DEVREALPKAEIVELDED--DDVASVLQSAADRAEVLGVGGGDGTVAAAA
Mvan_0430|M.vanbaalenii_PYR-1 DEVREALPRAEIVELGEN--DDVVEVLRSAAQRAEVLGVGGGDGTVATAA
MAB_0199|M.abscessus_ATCC_1997 EQVRKALPRTEIVELSKD--DDVIEVMRAAAGRAEVLAVGGGDGTVACAA
MMAR_0569|M.marinum_M DEVRAGLPKARIVELAAG--DDPQRVLREAAAQAEVLAVGGGDGTVAAAA
Mb3837c|M.bovis_AF2122/97 --------------------------------------------------
Rv3807c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 GIAVEAGLPLAVFPGGTFNHFAKDIGCDTVARTVEAIRQGSAAYVDLVCL
TH_1306|M.thermoresistible__bu GIALEAGLPLAVFPCGTFNHFAKDIGCDTVDRTVEAIRTGSAGYVDLVCL
Mflv_0311|M.gilvum_PYR-GCK SIAVAAGLPLAVFPAGTFNHFAKDIGCDTTAKTVAAIRQGTVSCVDIVCM
Mvan_0430|M.vanbaalenii_PYR-1 AVAVDAGVPLAVFPAGTFNHFAKDIGCDTATKTVAAIKQGTVSCVDMVCL
MAB_0199|M.abscessus_ATCC_1997 GVAVETDRPLAVFPGGTFNHFAKDIGCESVAKTVDAIRRGSVSRVDLVYL
MMAR_0569|M.marinum_M AAAVDAGLPLAVFPAGTFNHFAKDIGCDSVAQTIDAIRRGSVARVDLVCL
Mb3837c|M.bovis_AF2122/97 --------------------------------------------------
Rv3807c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 NDKHMVLNTASIGAYPKFVRIREKLEHRLGKRVAAAYALYLTLRRDEPVR
TH_1306|M.thermoresistible__bu NEDQMVINTASIGAYPDFVRRRERLERRIGKPLATVYAMAQTLRRDRSVR
Mflv_0311|M.gilvum_PYR-GCK NEKQMVVNTASIGAYPRFVQTREKLEHKIGKPLAGVYAMFHTLRRGEPVR
Mvan_0430|M.vanbaalenii_PYR-1 NEKQMVVNTASIGAYPMFVQTREKLEHRIGKPLAGIYAMFHTLRRDEPVR
MAB_0199|M.abscessus_ATCC_1997 NERQVVINTASIGSYPKFVQVREKLERRIGKPLAAVYAMLYVLRRDHPVR
MMAR_0569|M.marinum_M NESQMVINTASIGAYPKFVRYREKLEKRIGKPLASMYAMLHTLRKDQPVR
Mb3837c|M.bovis_AF2122/97 --------------------------------------------------
Rv3807c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 ITYDDKTVETSLFFLGNSVYFPSGFAPSLRPRMDDGLIDVRILETGKRFG
TH_1306|M.thermoresistible__bu IRYDNKTLQTSLFFLGNSVYLPSGFAPTRRARIDDGLIDVRMLETGRPFA
Mflv_0311|M.gilvum_PYR-GCK IEYDNKTLQTSLFFLGNSGYLPTGFAPSRRTRMDDGLLDVRILETGRRLS
Mvan_0430|M.vanbaalenii_PYR-1 IAYDNKTLQTSLFFLGNSAYLPSGFAPSRRTRMDDGLLDVRILETGRRMS
MAB_0199|M.abscessus_ATCC_1997 IRFDNKTIQTSLFFLGNSVYLPAGFAPSLRSRLDDGLIDVRILETGRRFS
MMAR_0569|M.marinum_M IRYDNKTLQTSLLFIGNSVYLPAGFAPSRRTRMDDGLIDVRILETGRRLA
Mb3837c|M.bovis_AF2122/97 --------------------------------------------------
Rv3807c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 RLRIATSMLLGRLERSPLYHEMQVPQFHFETVDGPTVLAHDGEVGEPYTE
TH_1306|M.thermoresistible__bu RLRIVGALLLGRLDRSPLYHEMRVPQFSFSTVDGPTVLAHDGEVGTEVDS
Mflv_0311|M.gilvum_PYR-GCK RLRILTALVLGRLTRSPLYHELKVPEFSFRSPDGPTVLALDGEVGTEIDE
Mvan_0430|M.vanbaalenii_PYR-1 RLRILTAVTLGRLERSPLYHELRVPEFAFRSVDGPTVLALDGEVGTEVEE
MAB_0199|M.abscessus_ATCC_1997 GVRILTALALGRLQRSPLYHELQVPEFTFTAVDGPTVLARDGEAGDRYTE
MMAR_0569|M.marinum_M TVRIPTALALGRLQRSPLYHELQVPEFSFSTVDAPTVLAHDGEVGEQYDQ
Mb3837c|M.bovis_AF2122/97 --------------------------------------------------
Rv3807c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 ATFTSRYRALPVFRPLP--
TH_1306|M.thermoresistible__bu ATFRVRYRALPVFGPLP--
Mflv_0311|M.gilvum_PYR-GCK ASFSVQYRALPVFRPAV--
Mvan_0430|M.vanbaalenii_PYR-1 ASFSARYRALPVFRPAR--
MAB_0199|M.abscessus_ATCC_1997 AHFTVRYRALAVFRPLP--
MMAR_0569|M.marinum_M ASFTAKYRVLAVFRPGPGR
Mb3837c|M.bovis_AF2122/97 -------------------
Rv3807c|M.tuberculosis_H37Rv -------------------
MLBr_00094|M.leprae_Br4923 -------------------
MUL_4991|M.ulcerans_Agy99 -------------------
MAV_0210|M.avium_104 -------------------