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MNGRPWQRARSIKQITRGLGALDRELFEAIADTPTPLLDTVMPPLTRAADHSKLWFAMAAGLLASRSQSA QRGAVRGVVTLGAASLFTNQVAKRIRQRPRPLSDSVPLARRVRRRPTSNSLPSGHSASAAAFAIGVGLEN PPLGLGFSVLAALVGLSRVATGVHYPGDVLAGFGIGAGVAVLGGRLVPPIVETALPKTEPLWVQTPQRPD GSGVVLVVNPASGSGTGAQVIDEVRAGLPKARIVELAAGDDPQRVLREAAAQAEVLAVGGGDGTVAAAAA AAVDAGLPLAVFPAGTFNHFAKDIGCDSVAQTIDAIRRGSVARVDLVCLNESQMVINTASIGAYPKFVRY REKLEKRIGKPLASMYAMLHTLRKDQPVRIRYDNKTLQTSLLFIGNSVYLPAGFAPSRRTRMDDGLIDVR ILETGRRLATVRIPTALALGRLQRSPLYHELQVPEFSFSTVDAPTVLAHDGEVGEQYDQASFTAKYRVLA VFRPGPGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0569 | - | - | 100% (498) | hypothetical protein MMAR_0569 |
| M. marinum M | MMAR_5371 | - | 1e-11 | 33.71% (175) | transmembrane protein |
| M. marinum M | MMAR_3345 | - | 2e-07 | 24.51% (257) | hypothetical protein MMAR_3345 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2276 | - | 8e-09 | 23.40% (235) | diacylglycerol kinase |
| M. gilvum PYR-GCK | Mflv_0311 | - | 0.0 | 73.16% (488) | phosphoesterase, PA-phosphatase related |
| M. tuberculosis H37Rv | Rv2252 | - | 8e-09 | 23.40% (235) | diacylglycerol kinase |
| M. leprae Br4923 | MLBr_00094 | - | 2e-10 | 31.87% (160) | hypothetical protein MLBr_00094 |
| M. abscessus ATCC 19977 | MAB_0199 | - | 0.0 | 71.66% (487) | phosphoesterase, PA-phosphatase related protein |
| M. avium 104 | MAV_0210 | - | 2e-11 | 36.24% (149) | PAP2 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_0633 | - | 0.0 | 68.66% (485) | PAP2 superfamily protein |
| M. thermoresistible (build 8) | TH_1306 | - | 0.0 | 67.78% (509) | PAP2 superfamily protein |
| M. ulcerans Agy99 | MUL_4991 | - | 4e-11 | 33.33% (180) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_0430 | - | 0.0 | 73.16% (488) | phosphoesterase, PA-phosphatase related |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0633|M.smegmatis_MC2_155 ----------MDVPKIGRGLGTLDREVFEAVAESPSPLLDSLMPKLTRAA
TH_1306|M.thermoresistible__bu MYDGPLRRRQSPLGRIGEGLGTLDREVFEAIAESPTPLLDTVMPPLTRAA
Mflv_0311|M.gilvum_PYR-GCK MDLLPVGRRGRGIRQIGVGLGTLDREVFEAIAESPSPLLDAVMPRLTRAA
Mvan_0430|M.vanbaalenii_PYR-1 MDLLPGRRRGRGIRQIGEGLGTLDREVFEAVAESPSPLLDAVMPPLTKAA
MAB_0199|M.abscessus_ATCC_1997 MGLLPSRNSLKGLRQIGDGLGTLDREVFEAVAESPSPLLDAVMPRLTRAA
MMAR_0569|M.marinum_M MNGRP-WQRARSIKQITRGLGALDRELFEAIADTPTPLLDTVMPPLTRAA
MLBr_00094|M.leprae_Br4923 ------------MPEDKAPTGELAAIAAVQSVLVDRPGVLPTARGMSHFG
MUL_4991|M.ulcerans_Agy99 ------------MPEPAPPRGEAAAIVAVQSALADRPGVLGTARGLSHFG
MAV_0210|M.avium_104 --------------------------------------MLTVARALSHFG
Mb2276|M.bovis_AF2122/97 ----------------------------MSAGQLRRHEIGKVTALTNPLS
Rv2252|M.tuberculosis_H37Rv ----------------------------MSAGQLRRHEIGKVTALTNPLS
: . .
MSMEG_0633|M.smegmatis_MC2_155 DHSKLWFVIAAGLGAVGGNSARRGAVRGIASLAVTSLVTNQIAKRIWRRP
TH_1306|M.thermoresistible__bu DHSTLWLAIAAAMASVGGPSARRAAVRGVAGLAVTSLVTNQVAKRIWKRS
Mflv_0311|M.gilvum_PYR-GCK DHSKLWFGIAAGLMALGSPSVKRGAVRGVATLAVTSLVTNQGAKRVWKRE
Mvan_0430|M.vanbaalenii_PYR-1 DHSKLWFAIAAGLAALGSSSAKRGATRGVVSLALTSLLTNQVAKRVWKRE
MAB_0199|M.abscessus_ATCC_1997 DHSKLWIGIGVGLALFGKPAAARGATRGLLTLAVTSAVTNQVAKRLRRRE
MMAR_0569|M.marinum_M DHSKLWFAMAAGLLASRSQSAQRGAVRGVVTLGAASLFTNQVAKRIRQRP
MLBr_00094|M.leprae_Br4923 EHSIGWLAISLLGAILVPCRRRYWLVAGAG--VFAAHVAAVLIKRMVRRI
MUL_4991|M.ulcerans_Agy99 EHSVGWLLVSALGAMLFPSRRREWVVAGAG--TFVAHAAAVVIKRVVRRK
MAV_0210|M.avium_104 EHSIGWVAAAALGALCSPRRRADWLAAGAG--AFVAHAAAVVVKRIVRRE
Mb2276|M.bovis_AF2122/97 GHGAAVKAAHGAIARLKHRGVDVVEIVGGDAHDARHLLAAAVAKGTDAVM
Rv2252|M.tuberculosis_H37Rv GHGAAVKAAHGAIARLKHRGVDVVEIVGGDAHDARHLLAAAVAKGTDAVM
*. * : *
MSMEG_0633|M.smegmatis_MC2_155 RPDRSIIPLIRQTRRVPTSHSLPSGHSSSAAAFAVGVG-LESAPIGLPLA
TH_1306|M.thermoresistible__bu RPDYAIVPLIRRPRRMPTSHSLPSGHSASAAAFAVGVG-LESPPLGFGLA
Mflv_0311|M.gilvum_PYR-GCK RPNWSFVPLARQTRRHPTSNSLPSGHSASAAAFSIGVG-LENPPAGLGLA
Mvan_0430|M.vanbaalenii_PYR-1 RPSRLLVPLARQTRRHPTSNSLPSGHSASGAAFAVGVG-LENPPLGLGLA
MAB_0199|M.abscessus_ATCC_1997 RPNHLSVPLTRRSRRVPTSSSLPSGHSASAAAFAVGVG-LESPPLGFGLS
MMAR_0569|M.marinum_M RPLSDSVPLARRVRRRPTSNSLPSGHSASAAAFAIGVG-LENPPLGLGFS
MLBr_00094|M.leprae_Br4923 RPNHPAVTVNVG---TPSPLSFPSAHATSTAAAAILIGRASRLPKGIVAA
MUL_4991|M.ulcerans_Agy99 RPHDPAVTVNVG---TPSKLSFPSAHATSTAAAAILLSRAAGVSEAAGAA
MAV_0210|M.avium_104 RPHHPAVVVNVG---TPSRLSFPSAHATSTTAAAILLGRITGLP---LPA
Mb2276|M.bovis_AF2122/97 VTGGDGVVSNALQVLAGTDIPLGIIPAGTGNDHAREFGLPTKNPKAAADI
Rv2252|M.tuberculosis_H37Rv VTGGDGVVSNALQVLAGTDIPLGIIPAGTGNDHAREFGLPTKNPKAAADI
. : : .: : : : .. .
MSMEG_0633|M.smegmatis_MC2_155 LLAGLVGLSRVATGAHYPGDVFAGFGIGATIAILGARIVP-----TIPAA
TH_1306|M.thermoresistible__bu LLAGLVGLSRVVTGAHYPGDVLAGFGIGAGIAVLGGRAVPPVAPTRLPTA
Mflv_0311|M.gilvum_PYR-GCK LLAGLVGMSRVATGAHYPGDVLAGFGLGAGIAVLGARIVP-----PIVET
Mvan_0430|M.vanbaalenii_PYR-1 LLAGLVGMSRVATGAHYPGDVLAGFGIGAGIAVLGARVVP-----PIAEA
MAB_0199|M.abscessus_ATCC_1997 LLAGLVGLSRVATGVHYPGDVFAGFGIGAGLAVLGARVVP-----PIVTT
MMAR_0569|M.marinum_M VLAALVGLSRVATGVHYPGDVLAGFGIGAGVAVLGGRLVP-----PIVET
MLBr_00094|M.leprae_Br4923 VLVAPMALSRIVLGVHYPSDVAFGVVLGAAVAGTTARFDS----------
MUL_4991|M.ulcerans_Agy99 VLVPPMALSRILLGVHYPSDVAAGIAVGASVAAIAARLD-----------
MAV_0210|M.avium_104 VLVPPMALSRMVLGVHYPSDVACGIALGAGVAAVARRAP-----------
Mb2276|M.bovis_AF2122/97 VVDGWTETIDLGR-IQDDNGIEKWFGTVAATGFDSLVNDR----------
Rv2252|M.tuberculosis_H37Rv VVDGWTETIDLGR-IQDDNGIEKWFGTVAATGFDSLVNDR----------
:: : : ..: . * .
MSMEG_0633|M.smegmatis_MC2_155 S------------LPTSEPLRYKTAPRPEGSGVTLVINPASGSGTGARVV
TH_1306|M.thermoresistible__bu DPLRAVPPVAPTRLPTADPLRLETRPRPDGAGVVLVINPESGDGSGAETV
Mflv_0311|M.gilvum_PYR-GCK R------------LPVSDPLRVDTPERPEGEGLVLVINPASGSGTGARVV
Mvan_0430|M.vanbaalenii_PYR-1 R------------MPGAEPLRVDTPARPDGEGVTLVINPASGSGTGARVL
MAB_0199|M.abscessus_ATCC_1997 S------------VPTGEPLRVETPARPGGEGVVLVVNPASGDGTGQRIL
MMAR_0569|M.marinum_M A------------LPKTEPLWVQTPQRPDGSGVVLVVNPASGSGTGAQVI
MLBr_00094|M.leprae_Br4923 -------------------------------RLSRRWTVQHGLSSGSAVK
MUL_4991|M.ulcerans_Agy99 -------------------------------KVS-----TKGMSL-----
MAV_0210|M.avium_104 -------------------------------QLA------RGDQ------
Mb2276|M.bovis_AF2122/97 --------------------------------ANRMRWPHGRMRYYIAML
Rv2252|M.tuberculosis_H37Rv --------------------------------ANRMRWPHGRMRYYIAML
MSMEG_0633|M.smegmatis_MC2_155 EEVREALPQAEVVELDED--DDIEEVLREAASRCEVLAVGGGDGTVACAA
TH_1306|M.thermoresistible__bu DEVRAALPAAEIVELDPNSADDLVGTLRKAADRAEVLAVGGGDGTVACAA
Mflv_0311|M.gilvum_PYR-GCK DEVREALPKAEIVELDED--DDVASVLQSAADRAEVLGVGGGDGTVAAAA
Mvan_0430|M.vanbaalenii_PYR-1 DEVREALPRAEIVELGEN--DDVVEVLRSAAQRAEVLGVGGGDGTVATAA
MAB_0199|M.abscessus_ATCC_1997 EQVRKALPRTEIVELSKD--DDVIEVMRAAAGRAEVLAVGGGDGTVACAA
MMAR_0569|M.marinum_M DEVRAGLPKARIVELAAG--DDPQRVLREAAAQAEVLAVGGGDGTVAAAA
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 AELSRLRP------------------------------------------
Rv2252|M.tuberculosis_H37Rv AELSRLRP------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 GIAVEAGLPLAVFPGGTFNHFAKDIGCDTVARTVEAIRQGSAAYVDLVCL
TH_1306|M.thermoresistible__bu GIALEAGLPLAVFPCGTFNHFAKDIGCDTVDRTVEAIRTGSAGYVDLVCL
Mflv_0311|M.gilvum_PYR-GCK SIAVAAGLPLAVFPAGTFNHFAKDIGCDTTAKTVAAIRQGTVSCVDIVCM
Mvan_0430|M.vanbaalenii_PYR-1 AVAVDAGVPLAVFPAGTFNHFAKDIGCDTATKTVAAIKQGTVSCVDMVCL
MAB_0199|M.abscessus_ATCC_1997 GVAVETDRPLAVFPGGTFNHFAKDIGCESVAKTVDAIRRGSVSRVDLVYL
MMAR_0569|M.marinum_M AAAVDAGLPLAVFPAGTFNHFAKDIGCDSVAQTIDAIRRGSVARVDLVCL
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 -------LPFRLVLDG----------------------------------
Rv2252|M.tuberculosis_H37Rv -------LPFRLVLDG----------------------------------
MSMEG_0633|M.smegmatis_MC2_155 NDKHMVLNTASIGAYPKFVRIREKLEHRLGKRVAAAYALYLTLRRDEPVR
TH_1306|M.thermoresistible__bu NEDQMVINTASIGAYPDFVRRRERLERRIGKPLATVYAMAQTLRRDRSVR
Mflv_0311|M.gilvum_PYR-GCK NEKQMVVNTASIGAYPRFVQTREKLEHKIGKPLAGVYAMFHTLRRGEPVR
Mvan_0430|M.vanbaalenii_PYR-1 NEKQMVVNTASIGAYPMFVQTREKLEHRIGKPLAGIYAMFHTLRRDEPVR
MAB_0199|M.abscessus_ATCC_1997 NERQVVINTASIGSYPKFVQVREKLERRIGKPLAAVYAMLYVLRRDHPVR
MMAR_0569|M.marinum_M NESQMVINTASIGAYPKFVRYREKLEKRIGKPLASMYAMLHTLRKDQPVR
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 --------------------------------------------------
Rv2252|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_0633|M.smegmatis_MC2_155 ITYDDKTVETSLFFLGNSVYFPSGFAPSLRPRMDDGLIDVRILETGKRFG
TH_1306|M.thermoresistible__bu IRYDNKTLQTSLFFLGNSVYLPSGFAPTRRARIDDGLIDVRMLETGRPFA
Mflv_0311|M.gilvum_PYR-GCK IEYDNKTLQTSLFFLGNSGYLPTGFAPSRRTRMDDGLLDVRILETGRRLS
Mvan_0430|M.vanbaalenii_PYR-1 IAYDNKTLQTSLFFLGNSAYLPSGFAPSRRTRMDDGLLDVRILETGRRMS
MAB_0199|M.abscessus_ATCC_1997 IRFDNKTIQTSLFFLGNSVYLPAGFAPSLRSRLDDGLIDVRILETGRRFS
MMAR_0569|M.marinum_M IRYDNKTLQTSLLFIGNSVYLPAGFAPSRRTRMDDGLIDVRILETGRRLA
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 --TEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSDSRTK
Rv2252|M.tuberculosis_H37Rv --TEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSDSRTK
MSMEG_0633|M.smegmatis_MC2_155 RLRIATSMLLGRLERSPLYHEMQVPQFHFETVDGPTVLAHDGEVGEPYTE
TH_1306|M.thermoresistible__bu RLRIVGALLLGRLDRSPLYHEMRVPQFSFSTVDGPTVLAHDGEVGTEVDS
Mflv_0311|M.gilvum_PYR-GCK RLRILTALVLGRLTRSPLYHELKVPEFSFRSPDGPTVLALDGEVGTEIDE
Mvan_0430|M.vanbaalenii_PYR-1 RLRILTAVTLGRLERSPLYHELRVPEFAFRSVDGPTVLALDGEVGTEVEE
MAB_0199|M.abscessus_ATCC_1997 GVRILTALALGRLQRSPLYHELQVPEFTFTAVDGPTVLARDGEAGDRYTE
MMAR_0569|M.marinum_M TVRIPTALALGRLQRSPLYHELQVPEFSFSTVDAPTVLAHDGEVGEQYDQ
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 LLRLFPTIFKG---AHVELDEVSTTRAKTVHVECPGINVYADGDFACPLP
Rv2252|M.tuberculosis_H37Rv LLRLFPTIFKG---AHVELDEVSTTRAKTVHVECPGINVYADGDFACPLP
MSMEG_0633|M.smegmatis_MC2_155 ATFTSRYRALPVFRPLP--
TH_1306|M.thermoresistible__bu ATFRVRYRALPVFGPLP--
Mflv_0311|M.gilvum_PYR-GCK ASFSVQYRALPVFRPAV--
Mvan_0430|M.vanbaalenii_PYR-1 ASFSARYRALPVFRPAR--
MAB_0199|M.abscessus_ATCC_1997 AHFTVRYRALAVFRPLP--
MMAR_0569|M.marinum_M ASFTAKYRVLAVFRPGPGR
MLBr_00094|M.leprae_Br4923 -------------------
MUL_4991|M.ulcerans_Agy99 -------------------
MAV_0210|M.avium_104 -------------------
Mb2276|M.bovis_AF2122/97 AEISAVPAALQVLRPRHG-
Rv2252|M.tuberculosis_H37Rv AEISAVPAALQVLRPRHG-