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MDLLPVGRRGRGIRQIGVGLGTLDREVFEAIAESPSPLLDAVMPRLTRAADHSKLWFGIAAGLMALGSPS VKRGAVRGVATLAVTSLVTNQGAKRVWKRERPNWSFVPLARQTRRHPTSNSLPSGHSASAAAFSIGVGLE NPPAGLGLALLAGLVGMSRVATGAHYPGDVLAGFGLGAGIAVLGARIVPPIVETRLPVSDPLRVDTPERP EGEGLVLVINPASGSGTGARVVDEVREALPKAEIVELDEDDDVASVLQSAADRAEVLGVGGGDGTVAAAA SIAVAAGLPLAVFPAGTFNHFAKDIGCDTTAKTVAAIRQGTVSCVDIVCMNEKQMVVNTASIGAYPRFVQ TREKLEHKIGKPLAGVYAMFHTLRRGEPVRIEYDNKTLQTSLFFLGNSGYLPTGFAPSRRTRMDDGLLDV RILETGRRLSRLRILTALVLGRLTRSPLYHELKVPEFSFRSPDGPTVLALDGEVGTEIDEASFSVQYRAL PVFRPAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0311 | - | - | 100% (497) | phosphoesterase, PA-phosphatase related |
| M. gilvum PYR-GCK | Mflv_2771 | - | 6e-09 | 24.42% (303) | diacylglycerol kinase |
| M. gilvum PYR-GCK | Mflv_1161 | - | 6e-09 | 34.31% (137) | phosphoesterase, PA-phosphatase related |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2276 | - | 5e-08 | 23.21% (237) | diacylglycerol kinase |
| M. tuberculosis H37Rv | Rv2252 | - | 5e-08 | 23.21% (237) | diacylglycerol kinase |
| M. leprae Br4923 | MLBr_00094 | - | 2e-10 | 34.34% (166) | hypothetical protein MLBr_00094 |
| M. abscessus ATCC 19977 | MAB_0199 | - | 0.0 | 72.12% (495) | phosphoesterase, PA-phosphatase related protein |
| M. marinum M | MMAR_0569 | - | 0.0 | 73.16% (488) | hypothetical protein MMAR_0569 |
| M. avium 104 | MAV_0210 | - | 9e-10 | 35.21% (142) | PAP2 superfamily protein |
| M. smegmatis MC2 155 | MSMEG_0633 | - | 0.0 | 73.50% (483) | PAP2 superfamily protein |
| M. thermoresistible (build 8) | TH_1306 | - | 0.0 | 70.20% (510) | PAP2 superfamily protein |
| M. ulcerans Agy99 | MUL_4991 | - | 4e-11 | 34.34% (166) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_0430 | - | 0.0 | 85.48% (496) | phosphoesterase, PA-phosphatase related |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0311|M.gilvum_PYR-GCK MDLLPVGRRGRGIRQIGVGLGTLDREVFEAIAESPSPLLDAVMPRLTRAA
Mvan_0430|M.vanbaalenii_PYR-1 MDLLPGRRRGRGIRQIGEGLGTLDREVFEAVAESPSPLLDAVMPPLTKAA
MSMEG_0633|M.smegmatis_MC2_155 ----------MDVPKIGRGLGTLDREVFEAVAESPSPLLDSLMPKLTRAA
TH_1306|M.thermoresistible__bu MYDGPLRRRQSPLGRIGEGLGTLDREVFEAIAESPTPLLDTVMPPLTRAA
MAB_0199|M.abscessus_ATCC_1997 MGLLPSRNSLKGLRQIGDGLGTLDREVFEAVAESPSPLLDAVMPRLTRAA
MMAR_0569|M.marinum_M MNGRP-WQRARSIKQITRGLGALDRELFEAIADTPTPLLDTVMPPLTRAA
MLBr_00094|M.leprae_Br4923 ------------MPEDKAPTGELAAIAAVQSVLVDRPGVLPTARGMSHFG
MUL_4991|M.ulcerans_Agy99 ------------MPEPAPPRGEAAAIVAVQSALADRPGVLGTARGLSHFG
MAV_0210|M.avium_104 --------------------------------------MLTVARALSHFG
Mb2276|M.bovis_AF2122/97 -----------------MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHG
Rv2252|M.tuberculosis_H37Rv -----------------MSAGQLRRHEIGKVTALTNPLSGHGAAVKAAHG
: .
Mflv_0311|M.gilvum_PYR-GCK DHSKLWFGIAAGLMALGSPSVKRGAVRGVATLAVTSLVTNQGAKRVWKRE
Mvan_0430|M.vanbaalenii_PYR-1 DHSKLWFAIAAGLAALGSSSAKRGATRGVVSLALTSLLTNQVAKRVWKRE
MSMEG_0633|M.smegmatis_MC2_155 DHSKLWFVIAAGLGAVGGNSARRGAVRGIASLAVTSLVTNQIAKRIWRRP
TH_1306|M.thermoresistible__bu DHSTLWLAIAAAMASVGGPSARRAAVRGVAGLAVTSLVTNQVAKRIWKRS
MAB_0199|M.abscessus_ATCC_1997 DHSKLWIGIGVGLALFGKPAAARGATRGLLTLAVTSAVTNQVAKRLRRRE
MMAR_0569|M.marinum_M DHSKLWFAMAAGLLASRSQSAQRGAVRGVVTLGAASLFTNQVAKRIRQRP
MLBr_00094|M.leprae_Br4923 EHSIGWLAISLLGAILVPCRRRYWLVAGAG--VFAAHVAAVLIKRMVRRI
MUL_4991|M.ulcerans_Agy99 EHSVGWLLVSALGAMLFPSRRREWVVAGAG--TFVAHAAAVVIKRVVRRK
MAV_0210|M.avium_104 EHSIGWVAAAALGALCSPRRRADWLAAGAG--AFVAHAAAVVVKRIVRRE
Mb2276|M.bovis_AF2122/97 AIARLKHRGVDVVEIVGGDAHDARHLLAAAVAKGTDAVMVTGGDGVVSNA
Rv2252|M.tuberculosis_H37Rv AIARLKHRGVDVVEIVGGDAHDARHLLAAAVAKGTDAVMVTGGDGVVSNA
: . . . : .
Mflv_0311|M.gilvum_PYR-GCK RPNWSFVPLARQTRRHPTSNSLPSGHSASAAAFSIGVG-LENPPAGLGLA
Mvan_0430|M.vanbaalenii_PYR-1 RPSRLLVPLARQTRRHPTSNSLPSGHSASGAAFAVGVG-LENPPLGLGLA
MSMEG_0633|M.smegmatis_MC2_155 RPDRSIIPLIRQTRRVPTSHSLPSGHSSSAAAFAVGVG-LESAPIGLPLA
TH_1306|M.thermoresistible__bu RPDYAIVPLIRRPRRMPTSHSLPSGHSASAAAFAVGVG-LESPPLGFGLA
MAB_0199|M.abscessus_ATCC_1997 RPNHLSVPLTRRSRRVPTSSSLPSGHSASAAAFAVGVG-LESPPLGFGLS
MMAR_0569|M.marinum_M RPLSDSVPLARRVRRRPTSNSLPSGHSASAAAFAIGVG-LENPPLGLGFS
MLBr_00094|M.leprae_Br4923 RPNHPAVTVNVG---TPSPLSFPSAHATSTAAAAILIGRASRLPKGIVAA
MUL_4991|M.ulcerans_Agy99 RPHDPAVTVNVG---TPSKLSFPSAHATSTAAAAILLSRAAGVSEAAGAA
MAV_0210|M.avium_104 RPHHPAVVVNVG---TPSRLSFPSAHATSTTAAAILLGRITGLP---LPA
Mb2276|M.bovis_AF2122/97 LQVLAGTDIPLG--------IIPAGTGNDHAREFGLPTKNPKAAADIVVD
Rv2252|M.tuberculosis_H37Rv LQVLAGTDIPLG--------IIPAGTGNDHAREFGLPTKNPKAAADIVVD
: :*:. . . : .
Mflv_0311|M.gilvum_PYR-GCK LLAGLVGMSRVAT--GAHYPGDVLAGFGLGAGIAVLGARIVPP-----IV
Mvan_0430|M.vanbaalenii_PYR-1 LLAGLVGMSRVAT--GAHYPGDVLAGFGIGAGIAVLGARVVPP-----IA
MSMEG_0633|M.smegmatis_MC2_155 LLAGLVGLSRVAT--GAHYPGDVFAGFGIGATIAILGARIVP-----TIP
TH_1306|M.thermoresistible__bu LLAGLVGLSRVVT--GAHYPGDVLAGFGIGAGIAVLGGRAVPPVAPTRLP
MAB_0199|M.abscessus_ATCC_1997 LLAGLVGLSRVAT--GVHYPGDVFAGFGIGAGLAVLGARVVPP-----IV
MMAR_0569|M.marinum_M VLAALVGLSRVAT--GVHYPGDVLAGFGIGAGVAVLGGRLVPP-----IV
MLBr_00094|M.leprae_Br4923 VLVAPMALSRIVL--GVHYPSDVAFGVVLGAAVAGTTARFDS--------
MUL_4991|M.ulcerans_Agy99 VLVPPMALSRILL--GVHYPSDVAAGIAVGASVAAIAARLD---------
MAV_0210|M.avium_104 VLVPPMALSRMVL--GVHYPSDVACGIALGAGVAAVARRAP---------
Mb2276|M.bovis_AF2122/97 GWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVNDRANRMRWP-------
Rv2252|M.tuberculosis_H37Rv GWTETIDLGRIQDDNGIEKWFGTVAATGFDSLVNDRANRMRWP-------
. : :.*: * . .. . ..: : *
Mflv_0311|M.gilvum_PYR-GCK ETR------------LPVSDPLRVDTPERPEGEGLVLVINPASGSGTGAR
Mvan_0430|M.vanbaalenii_PYR-1 EAR------------MPGAEPLRVDTPARPDGEGVTLVINPASGSGTGAR
MSMEG_0633|M.smegmatis_MC2_155 AAS------------LPTSEPLRYKTAPRPEGSGVTLVINPASGSGTGAR
TH_1306|M.thermoresistible__bu TADPLRAVPPVAPTRLPTADPLRLETRPRPDGAGVVLVINPESGDGSGAE
MAB_0199|M.abscessus_ATCC_1997 TTS------------VPTGEPLRVETPARPGGEGVVLVVNPASGDGTGQR
MMAR_0569|M.marinum_M ETA------------LPKTEPLWVQTPQRPDGSGVVLVVNPASGSGTGAQ
MLBr_00094|M.leprae_Br4923 ---------------------------------RLSRRWTVQHGLSSGSA
MUL_4991|M.ulcerans_Agy99 ---------------------------------KVS-----TKGMSL---
MAV_0210|M.avium_104 ---------------------------------QLA------RGDQ----
Mb2276|M.bovis_AF2122/97 -----------------------------------------HGRMRYYIA
Rv2252|M.tuberculosis_H37Rv -----------------------------------------HGRMRYYIA
Mflv_0311|M.gilvum_PYR-GCK VVDEVREALPKAEIVELDED--DDVASVLQSAADRAEVLGVGGGDGTVAA
Mvan_0430|M.vanbaalenii_PYR-1 VLDEVREALPRAEIVELGEN--DDVVEVLRSAAQRAEVLGVGGGDGTVAT
MSMEG_0633|M.smegmatis_MC2_155 VVEEVREALPQAEVVELDED--DDIEEVLREAASRCEVLAVGGGDGTVAC
TH_1306|M.thermoresistible__bu TVDEVRAALPAAEIVELDPNSADDLVGTLRKAADRAEVLAVGGGDGTVAC
MAB_0199|M.abscessus_ATCC_1997 ILEQVRKALPRTEIVELSKD--DDVIEVMRAAAGRAEVLAVGGGDGTVAC
MMAR_0569|M.marinum_M VIDEVRAGLPKARIVELAAG--DDPQRVLREAAAQAEVLAVGGGDGTVAA
MLBr_00094|M.leprae_Br4923 VK------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 MLAELSRLRP----------------------------------------
Rv2252|M.tuberculosis_H37Rv MLAELSRLRP----------------------------------------
Mflv_0311|M.gilvum_PYR-GCK AASIAVAAGLPLAVFPAGTFNHFAKDIGCDTTAKTVAAIRQGTVSCVDIV
Mvan_0430|M.vanbaalenii_PYR-1 AAAVAVDAGVPLAVFPAGTFNHFAKDIGCDTATKTVAAIKQGTVSCVDMV
MSMEG_0633|M.smegmatis_MC2_155 AAGIAVEAGLPLAVFPGGTFNHFAKDIGCDTVARTVEAIRQGSAAYVDLV
TH_1306|M.thermoresistible__bu AAGIALEAGLPLAVFPCGTFNHFAKDIGCDTVDRTVEAIRTGSAGYVDLV
MAB_0199|M.abscessus_ATCC_1997 AAGVAVETDRPLAVFPGGTFNHFAKDIGCESVAKTVDAIRRGSVSRVDLV
MMAR_0569|M.marinum_M AAAAAVDAGLPLAVFPAGTFNHFAKDIGCDSVAQTIDAIRRGSVARVDLV
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 ---------LPFRLVLDG--------------------------------
Rv2252|M.tuberculosis_H37Rv ---------LPFRLVLDG--------------------------------
Mflv_0311|M.gilvum_PYR-GCK CMNEKQMVVNTASIGAYPRFVQTREKLEHKIGKPLAGVYAMFHTLRRGEP
Mvan_0430|M.vanbaalenii_PYR-1 CLNEKQMVVNTASIGAYPMFVQTREKLEHRIGKPLAGIYAMFHTLRRDEP
MSMEG_0633|M.smegmatis_MC2_155 CLNDKHMVLNTASIGAYPKFVRIREKLEHRLGKRVAAAYALYLTLRRDEP
TH_1306|M.thermoresistible__bu CLNEDQMVINTASIGAYPDFVRRRERLERRIGKPLATVYAMAQTLRRDRS
MAB_0199|M.abscessus_ATCC_1997 YLNERQVVINTASIGSYPKFVQVREKLERRIGKPLAAVYAMLYVLRRDHP
MMAR_0569|M.marinum_M CLNESQMVINTASIGAYPKFVRYREKLEKRIGKPLASMYAMLHTLRKDQP
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 --------------------------------------------------
Rv2252|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0311|M.gilvum_PYR-GCK VRIEYDNKTLQTSLFFLGNSGYLPTGFAPSRRTRMDDGLLDVRILETGRR
Mvan_0430|M.vanbaalenii_PYR-1 VRIAYDNKTLQTSLFFLGNSAYLPSGFAPSRRTRMDDGLLDVRILETGRR
MSMEG_0633|M.smegmatis_MC2_155 VRITYDDKTVETSLFFLGNSVYFPSGFAPSLRPRMDDGLIDVRILETGKR
TH_1306|M.thermoresistible__bu VRIRYDNKTLQTSLFFLGNSVYLPSGFAPTRRARIDDGLIDVRMLETGRP
MAB_0199|M.abscessus_ATCC_1997 VRIRFDNKTIQTSLFFLGNSVYLPAGFAPSLRSRLDDGLIDVRILETGRR
MMAR_0569|M.marinum_M VRIRYDNKTLQTSLLFIGNSVYLPAGFAPSRRTRMDDGLIDVRILETGRR
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 ----TEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSDSR
Rv2252|M.tuberculosis_H37Rv ----TEEIVADLTLADFGNTRSYGGGLLICPNADHSDGLLDITMAQSDSR
Mflv_0311|M.gilvum_PYR-GCK LSRLRILTALVLGRLTRSPLYHELKVPEFSFRSPDGPTVLALDGEVGTEI
Mvan_0430|M.vanbaalenii_PYR-1 MSRLRILTAVTLGRLERSPLYHELRVPEFAFRSVDGPTVLALDGEVGTEV
MSMEG_0633|M.smegmatis_MC2_155 FGRLRIATSMLLGRLERSPLYHEMQVPQFHFETVDGPTVLAHDGEVGEPY
TH_1306|M.thermoresistible__bu FARLRIVGALLLGRLDRSPLYHEMRVPQFSFSTVDGPTVLAHDGEVGTEV
MAB_0199|M.abscessus_ATCC_1997 FSGVRILTALALGRLQRSPLYHELQVPEFTFTAVDGPTVLARDGEAGDRY
MMAR_0569|M.marinum_M LATVRIPTALALGRLQRSPLYHELQVPEFSFSTVDAPTVLAHDGEVGEQY
MLBr_00094|M.leprae_Br4923 --------------------------------------------------
MUL_4991|M.ulcerans_Agy99 --------------------------------------------------
MAV_0210|M.avium_104 --------------------------------------------------
Mb2276|M.bovis_AF2122/97 TKLLRLFPTIFKG---AHVELDEVSTTRAKTVHVECPGINVYADGDFACP
Rv2252|M.tuberculosis_H37Rv TKLLRLFPTIFKG---AHVELDEVSTTRAKTVHVECPGINVYADGDFACP
Mflv_0311|M.gilvum_PYR-GCK DEASFSVQYRALPVFRPAV--
Mvan_0430|M.vanbaalenii_PYR-1 EEASFSARYRALPVFRPAR--
MSMEG_0633|M.smegmatis_MC2_155 TEATFTSRYRALPVFRPLP--
TH_1306|M.thermoresistible__bu DSATFRVRYRALPVFGPLP--
MAB_0199|M.abscessus_ATCC_1997 TEAHFTVRYRALAVFRPLP--
MMAR_0569|M.marinum_M DQASFTAKYRVLAVFRPGPGR
MLBr_00094|M.leprae_Br4923 ---------------------
MUL_4991|M.ulcerans_Agy99 ---------------------
MAV_0210|M.avium_104 ---------------------
Mb2276|M.bovis_AF2122/97 LPAEISAVPAALQVLRPRHG-
Rv2252|M.tuberculosis_H37Rv LPAEISAVPAALQVLRPRHG-