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TAAQVTVTGGRIEGHNSPDGKVRWFLGIPYAAPPVGDLRWRPPQPVKPWTGVRLTLRYGPSAPQPHVAAN SLYHGGEREFSEDCLYLNVWTGPRGEQPRPVLVWLHFGAFQFGSASNPLYDGTVLARDGATVVSVNFRLS RLGFFAHPALSAESDHGVSGNYGMLDQLAALRWVQDNVEAFGGDPTRVTVAGVSAGGHSVHNLRASDLAA GLIHRAIAQSGPGVAPVLDGPSHAANPQSLSAAEQAGTEIADLLGARTAAQLRAVPPETLAAVSLPRAKG AWCSDSRPGPSTSTHVVDAAYPVVDGHVLRESPLTAYQSGRALDVPMIVGNVGNERSGSRYLACLRDYHD HVRRTYGVHAARLLELYPASSDAEVPAASRALESDRIFVWSSWTAARLQARRGNSPLWHYNFLRRPPIPP DSDLIEKSYAAAFHGADVPYLFGTYGVRDWPWTDADRTLGRQLRAAWLSFLATGDPSVQGPVSWPQFSEH TPSTLVWDLPSPHIADVPYRDRMAAFDEFNQLAAMPEPLSHVE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0470 | - | - | 100% (534) | para-nitrobenzyl esterase |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 8e-60 | 35.71% (504) | acetylcholinesterase |
| M. smegmatis MC2 155 | MSMEG_3848 | - | 3e-51 | 31.82% (528) | para-nitrobenzyl esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 1e-47 | 32.44% (524) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_5051 | - | 6e-60 | 35.34% (515) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 1e-47 | 32.44% (524) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3803c | - | 2e-59 | 35.97% (506) | carboxylesterase |
| M. marinum M | MMAR_4363 | - | 3e-52 | 31.71% (492) | carboxylesterase |
| M. avium 104 | MAV_0492 | - | 2e-62 | 34.44% (514) | para-nitrobenzyl esterase |
| M. thermoresistible (build 8) | TH_3456 | - | 7e-61 | 35.91% (479) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 4e-47 | 31.84% (534) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_1303 | - | 3e-60 | 36.51% (493) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2071c|M.bovis_AF2122/97 ----------------------MALESATVGSMHERTVRARTATGIVEGF
Rv2045c|M.tuberculosis_H37Rv ----------------------MALESATVGSMHERTVRARTATGIVEGF
MUL_2261|M.ulcerans_Agy99 --------------------------------MHERTVRARTATGVVEGF
MMAR_4363|M.marinum_M -------------------------MTSDIRRMASDGYVVETAYGPVRGA
MAV_0492|M.avium_104 -----------------------------------MSPTVRLAQGVVSGA
Mflv_5051|M.gilvum_PYR-GCK --------MLVALVVAVACGSQAS------PQPAPDPAVVQTSTGPVRGT
Mvan_1303|M.vanbaalenii_PYR-1 MPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRGT
TH_3456|M.thermoresistible__bu --------------------------------------VVQTDAGAVRGT
MAB_3803c|M.abscessus_ATCC_199 -----MTRLLVAVLVVLAAAVSCS------PTKAADPTVVTTRAGAVRGH
MSMEG_0470|M.smegmatis_MC2_155 ----------------------------------MTAAQVTVTGGRIEGH
. * : *
Mb2071c|M.bovis_AF2122/97 TR------DGVHR--WRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
Rv2045c|M.tuberculosis_H37Rv TR------DGVHR--WRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFA
MUL_2261|M.ulcerans_Agy99 TR------DGVHR--WRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFT
MMAR_4363|M.marinum_M EDGIAAAGSGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFG
MAV_0492|M.avium_104 ED------GGVYR--FLGMPYAAPPVGDLRWAPPAPPASWAGVRDATRYG
Mflv_5051|M.gilvum_PYR-GCK VADD--------HRLFAGIPYAAPPVGALRWQGPRPAPKWDGVRDATAYG
Mvan_1303|M.vanbaalenii_PYR-1 VEPD--------HRLFAGIPYAAPPIGPLRWRDPEPAPRWDGVRDATAFG
TH_3456|M.thermoresistible__bu VTDR--------YRFFGGIPYAAAPVGDLRWRAPEPPRSWPQVRDATIPG
MAB_3803c|M.abscessus_ATCC_199 IDDQ--------VRVFAAIPYAAPPVGPRRFAEPGPVTPWPDTRDATGPG
MSMEG_0470|M.smegmatis_MC2_155 NSPDG------KVRWFLGIPYAAPPVGDLRWRPPQPVKPWTGVRLTLRYG
: .: *. .*:* *: * * *
Mb2071c|M.bovis_AF2122/97 NCAPQQRRYTVMGIGRYQTR-SEDCLTLNVVTPE-EPAT-QPLPVMVFIH
Rv2045c|M.tuberculosis_H37Rv NCAPQQRRYTVMGIGRYQTR-SEDCLTLNVVTPE-EPAT-QPLPVMVFIH
MUL_2261|M.ulcerans_Agy99 HCSPQQRRYTMLGLGKYQPM-SEDCLTLNVVAPE-APTH-RPLPVMVFIH
MMAR_4363|M.marinum_M PVCPQP-VLANMPIDLGAPQ-DEDCLRLNIWAPA-NTAPGAAKPVMVWLH
MAV_0492|M.avium_104 NAAIQT---VDTGFDPGAPQ-SEDCLYLNVWTST-LDVG-ARRPVMVWIH
Mflv_5051|M.gilvum_PYR-GCK PRCMQDLDGDLELGRQTD----EDCLNLNVWTPPVAGDRPEPKPVMVWIH
Mvan_1303|M.vanbaalenii_PYR-1 SRCLQDLAGDLELGRQTD----EDCLNLNVWTPAAEPGRP--RAVMVWIH
TH_3456|M.thermoresistible__bu PRCIQNPAGDPEGGRNSD----EDCLTLNVWTPPPDGVLR---PVLVWIH
MAB_3803c|M.abscessus_ATCC_199 VECPQ--PGQ-ESNLPQT----EDCLLLTVTMPRHTQGKV---PVLVWIH
MSMEG_0470|M.smegmatis_MC2_155 PSAPQPHVAANSLYHGGEREFSEDCLYLNVWTGPRGEQPR---PVLVWLH
. * **** *.: .*:*::*
Mb2071c|M.bovis_AF2122/97 GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTP-Q
Rv2045c|M.tuberculosis_H37Rv GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTP-Q
MUL_2261|M.ulcerans_Agy99 GGGYILGSSATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTP-D
MMAR_4363|M.marinum_M GGAYMLGSASQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHA-G
MAV_0492|M.avium_104 GGGFLNGASSMDLWQGQHLARRG-VTVVSLNYRLGAFGFLAHPQAG----
Mflv_5051|M.gilvum_PYR-GCK GGSFVAGSSG--VYDSRRLVARGDIIVVTVNYRLGALGFLAHPALGPP--
Mvan_1303|M.vanbaalenii_PYR-1 GGSFVAGSGG--IYDARRLAARGDIVVVTLNYRLGAPGFLAHPSLGPP--
TH_3456|M.thermoresistible__bu GGGFVNGGGA--MFNSEWFVERGDIVVVTINYRLGTLGFLAHPELGPP--
MAB_3803c|M.abscessus_ATCC_199 GGAFIAGNGV--DYNARKLAAQGGIAVVTFNYRLGTLGFLAAPGLS----
MSMEG_0470|M.smegmatis_MC2_155 FGAFQFGSASN-PLYDGTVLARDGATVVSVNFRLSRLGFFAHPALSAESD
*.: * . . . *:.*:**. * : . .
Mb2071c|M.bovis_AF2122/97 ITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLA
Rv2045c|M.tuberculosis_H37Rv ITLDSNVYLRDLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLA
MUL_2261|M.ulcerans_Agy99 IAIDGNLYLRDLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLA
MMAR_4363|M.marinum_M RSFDSNVGLRDVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLV
MAV_0492|M.avium_104 ----GNFGLLDWVAALSWVAENIATFGGDPANVTIFGQSAGGAATRALLH
Mflv_5051|M.gilvum_PYR-GCK -GAVGNYGLADQQAALRWVRDNIANFGGDPARVTVAGESAGAMSVCDHLV
Mvan_1303|M.vanbaalenii_PYR-1 -GEVGNYGLADQQAALRWVRDNIAAFGGDPGKVTVAGESAGAMSVCDHLV
TH_3456|M.thermoresistible__bu -GAVGNYGFLDQQAALRWVRANIAGFGGDPDRVTIAGESAGGMAVCDHLA
MAB_3803c|M.abscessus_ATCC_199 -GGIGNYGLLDQEAALRWVRDNIAEFGGDPARVTIAGQSAGGVSVCDLMV
MSMEG_0470|M.smegmatis_MC2_155 HGVSGNYGMLDQLAALRWVQDNVEAFGGDPTRVTVAGVSAGGHSVHNLRA
.* : * ** *: *: ***** .:*: * ***. .
Mb2071c|M.bovis_AF2122/97 VPAAKGLFARAISESP-------AAGMVRSREVAAEFAARFANLIGARTQ
Rv2045c|M.tuberculosis_H37Rv VPAAKGLFARAISESP-------AAGMVRSREVAAEFAARFANLIGARTQ
MUL_2261|M.ulcerans_Agy99 VPAAKGLFARAISESP-------AAGMVRPREIAAEFATRFARLLGARKH
MMAR_4363|M.marinum_M TPAARGLFSRAIAQSS-------PATSVYDRERAQRVAVHLLDKLGVAAS
MAV_0492|M.avium_104 TPSARGLFHRAVIQSAGYED--YAVVGSPSYQRVTDASERLFEQLGSADI
Mflv_5051|M.gilvum_PYR-GCK APGSDGLFDAAIVMSGL-------CQSQADLPTAEKRSLDYAAQAGCGG-
Mvan_1303|M.vanbaalenii_PYR-1 APASQGLFDAAIIMSGP-------CQAQAPLPVAEQRSIEYAAALGCADK
TH_3456|M.thermoresistible__bu APGSAGLFHAAIIMSAP-------CQGQVDVDTAEQVSLRYAAEVGCGDP
MAB_3803c|M.abscessus_ATCC_199 SPQASGLFRSAIMESAP-------CQAQAPVSSAVRDSTAYAAEVGCPAG
MSMEG_0470|M.smegmatis_MC2_155 SDLAAGLIHRAIAQSGPGVAPVLDGPSHAANPQSLSAAEQAGTEIADLLG
: **: *: * : .
Mb2071c|M.bovis_AF2122/97 DAANALMQASPAQLVEAQHHLIR----------QGMRKRLGAFPIGPVFG
Rv2045c|M.tuberculosis_H37Rv DAANALMQASPAQLVEAQHHLIR----------QGMRKRLGAFPIGPVFG
MUL_2261|M.ulcerans_Agy99 DAASALMRATAAQLVQTQHRLID----------QGMQKRLGAFPIGPTFG
MMAR_4363|M.marinum_M DVD-KLTQLPTAAIVAASTEVFN----------EVPVRNPGTLAFVPIVD
MAV_0492|M.avium_104 DELRRLPAEQVRQASFDQCGVNPP---------PGQVHTPANLVWYPTVD
Mflv_5051|M.gilvum_PYR-GCK PVPAECLRGLDANALRTPVW---------------YYDIGDDRLSGPVTG
Mvan_1303|M.vanbaalenii_PYR-1 ATAAECLRALPGNKLRTPVW---------------FYEIGDDRLSGPATG
TH_3456|M.thermoresistible__bu GAAAACLRGLPPEAVAAPVS---------------YFEFGTEKLSGPVTG
MAB_3803c|M.abscessus_ATCC_199 PDMARCLRALSVDALRDSPQ---------------FTGIG--LPVSPVIG
MSMEG_0470|M.smegmatis_MC2_155 ARTAAQLRAVPPETLAAVSLPRAKGAWCSDSRPGPSTSTHVVDAAYPVVD
* .
Mb2071c|M.bovis_AF2122/97 DDYLPMDPVEAMRSGRVHA-VPLIVGTNAEEGRLFTR----FLG-MLPTN
Rv2045c|M.tuberculosis_H37Rv DDYLPMDPVEAMRSGRVHA-VPLIVGTNAEEGRLFTR----FLG-MLPTN
MUL_2261|M.ulcerans_Agy99 DDCLPLDPVEAMRAGQSHK-VPLIVGTNADEGRLFTR----FLK-MLPTN
MMAR_4363|M.marinum_M GDVLTDYPVKVAQEGRSHP-VPLLIGTNKHEAALFRL----MRSPLMPIT
MAV_0492|M.avium_104 GRVMEED-----FSGWPAD-VPVMIGCTEHEGRFFVQPTMLYAHPELDPA
Mflv_5051|M.gilvum_PYR-GCK SAVLPTAPPVAFGDGKAAR-VPVLMGTTRDEWTLFVA-----LQHLRDGK
Mvan_1303|M.vanbaalenii_PYR-1 SAELPADPVTAFGAGRAAR-VPVLIGTTRDEWTLFVA-----LQHLRDGR
TH_3456|M.thermoresistible__bu TEALPVDPVDAIAEGRVAR-VPVLIGTNRDEFTLFAG-----LRYLREGE
MAB_3803c|M.abscessus_ATCC_199 TPELPAAPLDAFTSGLAASPVPVLIGSNANEATVFEA-----KQYQHRPV
MSMEG_0470|M.smegmatis_MC2_155 GHVLRESPLTAYQSGRALD-VPMIVGNVGNERSGSRY-----LACLR---
: * **:::* .*
Mb2071c|M.bovis_AF2122/97 EPMVEELLSGMKP-------ADRERITAAYPNYPAPSACIQLGGDFAFSS
Rv2045c|M.tuberculosis_H37Rv EPMVEELLSGMKP-------ADRERITAAYPNYPAPSACIQLGGDFAFSS
MUL_2261|M.ulcerans_Agy99 KAMIDELLADTEP-------ATRERITAAYPNYPESAACIQLGGDFAFNA
MMAR_4363|M.marinum_M PRAITSMFTQIAAEQPDLQLPTEEEIGLAYSRLRRRARPLSIATDVGFRM
MAV_0492|M.avium_104 QVYTQDTLEHMARALGGERAGDILAHYAASGLSAYEALAELITIGVWHEP
Mflv_5051|M.gilvum_PYR-GCK DYAPQEYPRLLADTFGADAPAVEAHYPLTAFSSVAL-AYAATVTDGVFAC
Mvan_1303|M.vanbaalenii_PYR-1 DYTPEEYPRLLADTFGADARAVAGRYPLSAFPDVAL-AYAATVTDGILAC
TH_3456|M.thermoresistible__bu RFAAEDHPRLLAEIFGDDAAAVAARYPLEDYPSPAL-AYSAAVTDSLFAC
MAB_3803c|M.abscessus_ATCC_199 PRTAEEYQSVLESKYGTRATELGRRYPLADFDGNVLGALAAIDTDNSYAC
MSMEG_0470|M.smegmatis_MC2_155 -----DYHDHVRRTYGVHAARLLELYPASSDAEVPA-ASRALESDRIFVW
. .
Mb2071c|M.bovis_AF2122/97 AAWQIAEAHGAN--APTYLYRYDYAPRTLR------WSGFGATHATELFA
Rv2045c|M.tuberculosis_H37Rv AAWQIAEAHGAN--APTYLYRYDYAPRTLR------WSGFGATHATELFA
MUL_2261|M.ulcerans_Agy99 AAWQIAEAQGVH--APTYLYRYDYAPRTLR------WSGFGATHATELFA
MMAR_4363|M.marinum_M PSVWLAEGHSRV--APVYLYRFDYSTPLLK------LLLVRAAHATELPY
MAV_0492|M.avium_104 ALASVERFAALG--RRAYHYRFARVSPGAR------TSGLLAKHSAEIPY
Mflv_5051|M.gilvum_PYR-GCK AGRRWAGDLAET--APVYFYEFNDRDAPAPDPLRTVPFPVGASHSLELRY
Mvan_1303|M.vanbaalenii_PYR-1 PAERWARQLSRD--ASVYFYEFNDRNAPAPDPLRTLPFPVGASHSLELRY
TH_3456|M.thermoresistible__bu LSERLADQLARH--QPVYSYEFADRDAPAPEPLRTLPFPVGAGHSLELRY
MAB_3803c|M.abscessus_ATCC_199 PTFAMAEALARR--APVYAYEFADPVAPVEQQYRDAPLPLGASHGSELGY
MSMEG_0470|M.smegmatis_MC2_155 SSWTAARLQARRGNSPLWHYNFLRRPPIPPDSDLIEKSYAAAFHGADVPY
. : *.: * *. ::
Mb2071c|M.bovis_AF2122/97 VFDIYRTRFGALLTAAADRRAALRVSNEVQRRWRCFSQIGVPG-------
Rv2045c|M.tuberculosis_H37Rv VFDIYRTRFGALLTAAADRRAALRVSNEVQRRWRCFSQIGVPG-------
MUL_2261|M.ulcerans_Agy99 VFDIYRTRFGALLTAAADRRHALRVSDEVIRRWRSFSQTGTPG-------
MMAR_4363|M.marinum_M VWGNLGGPQDPTLRLGG-AKTAKAVSKRMRTRWINFATQDNPAGPAGE--
MAV_0492|M.avium_104 LFGGLTP-------AGSYDEVDAAVSDAVQHAWVEFARTGVPRTPDG---
Mflv_5051|M.gilvum_PYR-GCK LFDTGGA--------PPPSPAQVRLGEQMIDYWASFVKTGDP--------
Mvan_1303|M.vanbaalenii_PYR-1 LFDVGGA--------PPPDPAQVRLGEQMVDHWAAFVRAGDP--------
TH_3456|M.thermoresistible__bu LFDVGGA--------PALTAAQRALSEQMIDYWSAFVATGVPATDGHPDW
MAB_3803c|M.abscessus_ATCC_199 LFDLS----------RTMNPESAALSTQMTRYWAQFVKTGNPNVEGQP--
MSMEG_0470|M.smegmatis_MC2_155 LFGTYGVR------DWPWTDADRTLGRQLRAAWLSFLATGDPSVQG----
::. :. : * * . *
Mb2071c|M.bovis_AF2122/97 -----------------------DDWPAYTQDDRAVLVFDRRCRIEFDPH
Rv2045c|M.tuberculosis_H37Rv -----------------------DDWPAYTQDDRAVLVFDRRCRIEFDPH
MUL_2261|M.ulcerans_Agy99 -----------------------EDWPAYTHTRRAVMVIDRKSRVEIDPH
MMAR_4363|M.marinum_M -----------------------PDWPAYQDGDRACLVIDKSDRVARDID
MAV_0492|M.avium_104 -----------------------TDFPSYDTTSRQVVVFDDTTEVRPLDA
Mflv_5051|M.gilvum_PYR-GCK ------------------------GFPGIDSG--VMSLQPDGSRMIEDFD
Mvan_1303|M.vanbaalenii_PYR-1 ------------------------GWPGVDAG--VMSLQPDGSRMVETFG
TH_3456|M.thermoresistible__bu PAHRAAADSGAGPDESPTDRDPGDGGPGAGPA--RMSLRPGGSTVVDDFA
MAB_3803c|M.abscessus_ATCC_199 ------------------------EWPAYISGGAFQRLAPPAPRSEGGFA
MSMEG_0470|M.smegmatis_MC2_155 ----------------------PVSWPQFSEHTPSTLVWDLPSPHIADVP
* :
Mb2071c|M.bovis_AF2122/97 QHRRIAWDGFSLAN-----------
Rv2045c|M.tuberculosis_H37Rv QHRRIAWDGFSLAN-----------
MUL_2261|M.ulcerans_Agy99 RHRRLAWDGFSLAR-----------
MMAR_4363|M.marinum_M APIRAAWGREVVGFR----------
MAV_0492|M.avium_104 NPVTDMIHTLRAAPTRR--------
Mflv_5051|M.gilvum_PYR-GCK RVHQCVFWDGLG-------------
Mvan_1303|M.vanbaalenii_PYR-1 EVHQCSFWAGLQ-------------
TH_3456|M.thermoresistible__bu TEHRCVFWAELAG------------
MAB_3803c|M.abscessus_ATCC_199 SRHQCGYWR----------------
MSMEG_0470|M.smegmatis_MC2_155 YRDRMAAFDEFNQLAAMPEPLSHVE