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MITLTATAPESLSRSTASQRPPLRVGLVQHRWRPDAGELVKVLREGIDRAAGEGAKAVFLPEITLLRYPA DTPAGPNPGDVAEDLTGGPTFELAAEAARANGIFVHASLYEKAPAADGLGYNTAILVSPEGELVGRTRKM HIPISAGYYEDTYFRPGPARPSDGDPYPVYSPEGLGARIGLPTCWDEWFPEVARCYSLGGAEIVVYPTAI GSEPVFPAFDTQPLWQQVIVANGISSGLFMVVPNRTGDEGSLSFYGSSFISDPFGRVLVSAPRDEEAVLV ADLDLDQRRDWLELFPFLLTRRPESYGALTEPVDPDHPYGAGHAATAVVK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0443 | - | - | 100% (330) | hydrolase, carbon-nitrogen family protein |
| M. smegmatis MC2 155 | MSMEG_3555 | - | 3e-23 | 29.19% (298) | hydrolase |
| M. smegmatis MC2 155 | MSMEG_2988 | - | 4e-20 | 30.26% (304) | carbon-nitrogen hydrolase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0490c | - | 3e-11 | 25.72% (276) | hypothetical protein Mb0490c |
| M. gilvum PYR-GCK | Mflv_0095 | - | 4e-14 | 29.71% (276) | Nitrilase/cyanide hydratase and apolipoprotein |
| M. tuberculosis H37Rv | Rv0480c | - | 3e-11 | 25.72% (276) | amidohydrolase |
| M. leprae Br4923 | MLBr_02449 | - | 1e-10 | 25.00% (276) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2545c | - | 1e-127 | 68.32% (322) | nitrilase/cyanide hydratase and apolipoprotein |
| M. marinum M | MMAR_0805 | - | 5e-13 | 26.55% (275) | amidohydrolase |
| M. avium 104 | MAV_4670 | - | 3e-15 | 26.94% (271) | carbon-nitrogen hydrolase |
| M. thermoresistible (build 8) | TH_0873 | - | 7e-16 | 29.41% (272) | POSSIBLE AMIDOHYDROLASE |
| M. ulcerans Agy99 | MUL_4548 | - | 6e-13 | 26.55% (275) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_0813 | - | 3e-14 | 28.21% (273) | Nitrilase/cyanide hydratase and apolipoprotein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0805|M.marinum_M -------------------------------MRIALAQILSGTDPTANLE
MUL_4548|M.ulcerans_Agy99 -------------------------------MRIALAQILSGTDPTANLE
MLBr_02449|M.leprae_Br4923 -------------------------------MRIALAQILSGTDPVANLR
Mb0490c|M.bovis_AF2122/97 MRRARRRAQAGLPGSCARRCGALVAGPRLARMRIALAQIRSGTDPAANLQ
Rv0480c|M.tuberculosis_H37Rv -------------------------------MRIALAQIRSGTDPAANLQ
MAV_4670|M.avium_104 -------------------------------MRIALAQILSGTDPAANLA
Mflv_0095|M.gilvum_PYR-GCK ---------------------------MRSGMRIALAQIQSSTDPAANLT
Mvan_0813|M.vanbaalenii_PYR-1 -------------------------------MRIALAQIRGSTDPAENLD
TH_0873|M.thermoresistible__bu -------------------------------MRIALAQIRSGTDPSANLN
MSMEG_0443|M.smegmatis_MC2_155 --------MITLTATAPES-LSRSTASQRPPLRVGLVQHRWRPDAGELVK
MAB_2545c|M.abscessus_ATCC_199 ---MPTSGFVVATAFTPMSSPARVSAPLRTPVRVGLVQHRWLADPDQLRD
:*:.*.* .*.
MMAR_0805|M.marinum_M LVRDYAERAADAGARLVVFPEATMCRFGVPLGPVAQP-------LDGPWA
MUL_4548|M.ulcerans_Agy99 LVRDYAERAADAGARLVVFPEATMCRFGVPLGPVAQP-------LDGPWA
MLBr_02449|M.leprae_Br4923 LVREYTGQATDAGATLVVFPEATMCRFGVPLGPVAEP-------IDGPWA
Mb0490c|M.bovis_AF2122/97 LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEP-------VDGPWA
Rv0480c|M.tuberculosis_H37Rv LVGKYAGEAATAGAQLVVFPEATMCRLGVPLRQVAEP-------VDGPWA
MAV_4670|M.avium_104 LVGEYTRRAAGAGARLVVFPEATMCRFGVPLAPIAEP-------VDGPWA
Mflv_0095|M.gilvum_PYR-GCK LVEEYTRRAVDAGASLVLFPEATMVRFGVPLGGVAEP-------FDGPWA
Mvan_0813|M.vanbaalenii_PYR-1 LVEEYTGRAAEAGASLVLFPEATICRFGVPPAEIAEP-------FDGPWA
TH_0873|M.thermoresistible__bu LVEEYTRRAAATGAGLVLFPEATMCRFGVSLKPVAEP-------LDGPWA
MSMEG_0443|M.smegmatis_MC2_155 VLREGIDRAAGEGAKAVFLPEITLLRYPADTPAGPNPGDVAEDLTGGPTF
MAB_2545c|M.abscessus_ATCC_199 QLLEGVRLAVAQGARAVFLPELTLSRYPADVRAGTNPGDRAEDLLTGPTF
: . *. ** *.:** *: * . .:* **
MMAR_0805|M.marinum_M NGVRRIAAQTGITVVAGMFTPADAG--RVSNTLFAAGPGAPNQPDDHYHK
MUL_4548|M.ulcerans_Agy99 NGVRRIAAQTGITVVAGMFTPADAG--RVSNTLFAAGPGAPNQPDDHYHK
MLBr_02449|M.leprae_Br4923 NGVRQIATEAGITIIAGIFTPADDG--RVMNTLIAAGPGTPNQPDTHYHK
Mb0490c|M.bovis_AF2122/97 NGVRRIATEAGITVIAGMFTPTGDG--RVTNTLIAAGPGTPNQPDAHYHK
Rv0480c|M.tuberculosis_H37Rv NGVRRIATEAGITVIAGMFTPTGDG--RVTNTLIAAGPGTPNQPDAHYHK
MAV_4670|M.avium_104 DGVRRIATEANVTVIAGMFTPSGDG--RVKNTLLVAN--SDDQAVTHYDK
Mflv_0095|M.gilvum_PYR-GCK NAVRDIAARAGIVVVAGMFVPSDDG--RSFNTLLATGPGVEAR----YDK
Mvan_0813|M.vanbaalenii_PYR-1 SAVRGIAARAGVVVVAGMYVPSDDDD-RVTNTLIATGPGVDAR----YDK
TH_0873|M.thermoresistible__bu TAVREIAAGAGVVVVAGMFTPSGDG--RVTNTLLATGPGVAAH----YHK
MSMEG_0443|M.smegmatis_MC2_155 ELAAEAARANGIFVHASLYEKAPAADGLGYNTAILVSPEGELVG--RTRK
MAB_2545c|M.abscessus_ATCC_199 CFAAHAATENGVLVHASLYERADAADGLGYNTAILVSPSGELVG--RTRK
. * .: : *.:: : ** : .. *
MMAR_0805|M.marinum_M IHLYDAFGFAESRTVAPG------HEPVVITVDD----VQVGLTVCYDIR
MUL_4548|M.ulcerans_Agy99 IHLYDAFGFAESRTVAPG------HEPVVITVDD----FQVGLTVCYDIR
MLBr_02449|M.leprae_Br4923 IHLYDAFGFTESRTVTAG------HEPVVITVDD----VQVGLTICYDIR
Mb0490c|M.bovis_AF2122/97 IHLYDAFGFTESRTVAPG------REPVVVVVDG----VRVGLTVCYDIR
Rv0480c|M.tuberculosis_H37Rv IHLYDAFGFTESRTVAPG------REPVVVVVDG----VRVGLTVCYDIR
MAV_4670|M.avium_104 IHLYDAFGFTESRTVAPG------REPVVVGVDG----VRVGLSVCYDIR
Mflv_0095|M.gilvum_PYR-GCK IHLYDAFGFLESKTVAPG------REPVVISVDTESGPVTVGLTLCYDIR
Mvan_0813|M.vanbaalenii_PYR-1 IHLYDAFGFSESKTVAPG------RDPVVITVESESGPVKVGLTLCYDIR
TH_0873|M.thermoresistible__bu IHLYDAYGFTESRTVAPG------SEPVTIDV----GGVRVGLTTCYDIR
MSMEG_0443|M.smegmatis_MC2_155 MHIPISAGYYEDTYFRPGPARPSDGDPYPVYSPEGLG-ARIGLPTCWDEW
MAB_2545c|M.abscessus_ATCC_199 LHIPVTAGYYEDTYFRPGPAEN----AYPVYRPAELDGAAVGMPTCWDEW
:*: : *: *. . .* . : :*:. *:*
MMAR_0805|M.marinum_M FPALYTELARRGAELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAA
MUL_4548|M.ulcerans_Agy99 FPALYTELARRGAELIVVSASWGSGPGKLDQWTLLARARALDSASYVAAA
MLBr_02449|M.leprae_Br4923 FPALYTELARRGAQLIVVCASWGSGAGKLEQWTLLARARALDSMSYVAAV
Mb0490c|M.bovis_AF2122/97 FPALYTELARRGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAA
Rv0480c|M.tuberculosis_H37Rv FPALYTELARRGAQLIAVCASWGSGPGKLEQWTLLARARALDSMSYVAAA
MAV_4670|M.avium_104 FPELYTELARRGAQLIAVCASWGAGPGKLDQWTLLARARALDSMSYIAAA
Mflv_0095|M.gilvum_PYR-GCK FPELYVELADRGAEIITAHASWGTGPGKLEQWTLLARARAIDTSSVVAAV
Mvan_0813|M.vanbaalenii_PYR-1 FPELYVELAERGAEIITAHASWGNGPGKIDQWTLLARARAIDTSTVVAAV
TH_0873|M.thermoresistible__bu FPELYVELARRGAELLTVHASWGSGPGKLEQWTLLARARALDTTCVVAAV
MSMEG_0443|M.smegmatis_MC2_155 FPEVARCYSLGGAEIVVYPTAIGSEPVFPAFDTQPLWQQVIVANGISSGL
MAB_2545c|M.abscessus_ATCC_199 FPEVSRMYSLAGAEILVYPTAIGSEPAFPSFDTQPLWQHVIVGNGITAGT
** : : **:::. :: * . * :.: :.
MMAR_0805|M.marinum_M GQADPGDTASDPGGGSGAPRGVGGSLVASPLGEVVASAGSD-PQLVVADI
MUL_4548|M.ulcerans_Agy99 GQADPGDTASDPGGGSGAPRGVGGSLVTSPLGEVVASAGSD-PQLVVADI
MLBr_02449|M.leprae_Br4923 GQADPGGALTDSGPSSAAPTGVGGSLVASPLGEVVASAGTE-SKLVVADI
Mb0490c|M.bovis_AF2122/97 GQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQ-PQLLVADI
Rv0480c|M.tuberculosis_H37Rv GQADPGDARTGVGASSAAPTGVGGSLVASPLGEVVVSAGTQ-PQLLVADI
MAV_4670|M.avium_104 GQADPGGSLS----ASGAPTGVGGSLVASPLGEVVASAGAQ-PQLVLADI
Mflv_0095|M.gilvum_PYR-GCK GQAYPGDEIAALG-----PTGVGGSLVASALGEVLASAGDD-PELLVCDV
Mvan_0813|M.vanbaalenii_PYR-1 GQAYPGDEIAALG-----PTGVGHSVVASALGEVLASAGAD-PQLLMCDI
TH_0873|M.thermoresistible__bu GQAYPGDEIAAQG-----PTGVGGSLVASATGEVLAAAGPE-PELLVADL
MSMEG_0443|M.smegmatis_MC2_155 FMVVPNRTGDEGS-----LSFYGSSFISDPFGRVLVSAPRDEEAVLVADL
MAB_2545c|M.abscessus_ATCC_199 FMVVPNRFGDEGT-----VNFYGSSFISDPYGRILAQAPRDAPAVLVADL
. *. * *.::.. *.::. * : :::.*:
MMAR_0805|M.marinum_M DLAKVGAARDNIGVLRNQSRFTQTDKAQSRR-------------------
MUL_4548|M.ulcerans_Agy99 DLAKVGAARDNIGMLRNQSRFTQTDKAQSRR-------------------
MLBr_02449|M.leprae_Br4923 DVDNVTTARENIAVLRNRSHFA----------------------------
Mb0490c|M.bovis_AF2122/97 DVDNVAAARDRIAVLRNQTDFVQIDKAQSRG-------------------
Rv0480c|M.tuberculosis_H37Rv DVDNVAAARDRIAVLRNQTDFVQIDKAQSRG-------------------
MAV_4670|M.avium_104 DVDRVAQARKTIAALSNRSDFAQVGRAESVG-------------------
Mflv_0095|M.gilvum_PYR-GCK DLEAARKARQTVAVMQNRSGFAHRGKAESRG-------------------
Mvan_0813|M.vanbaalenii_PYR-1 DLEAARAARQTVAVMHNRSEAVRSSRERSSPAVRSSRERSSPAVRSSRER
TH_0873|M.thermoresistible__bu DLDAARRARDTIAVLRNRSDVAQWGKAESVG-------------------
MSMEG_0443|M.smegmatis_MC2_155 DLDQRRDWLELFPFLLTRRPESYGALTEPVDPDHPYGAGHAATAVVK---
MAB_2545c|M.abscessus_ATCC_199 DLEQRKDWLDLFPFNTTRRPDTYARLAAPVDTSHPHGSEAS---------
*: . . .: