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MEILVTGGAGFQGSHLTESLLANGHWVTVLDKSSRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDH HVVFHLAAHVNVDQSLGDPESFLETNVMGTYRVLEAVRRYRNRLIYVSTCEVYGDGHNLKEGERLDEHAE LKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIFGVRQKAGRFGALIPRLVRQGINGEGLTIFGAG SATRDYLYVSDIVGAYNLVLRTPTLRGQAINFASGKDTRVRDIVEYVADKFGARIEHRDARPGEVQRFPA DISLAKSIGFQPQVEIWDGIDRYINWAKDQPQYPYEQDGFSGSSVL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3813 | rfbB | - | 100% (326) | dTDP-glucose 4,6-dehydratase RfbB |
| M. bovis AF2122 / 97 | Mb3493 | rmlB1 | 7e-37 | 34.06% (320) | dTDP-glucose 4,6-dehydratase RmlB1 |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 5e-36 | 31.83% (311) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3296 | - | 9e-37 | 34.52% (310) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3784 | - | 0.0 | 100.00% (326) | dTDP-glucose 4,6-dehydratase |
| M. leprae Br4923 | MLBr_01964 | rmlB | 1e-35 | 39.01% (223) | dTDP-glucose 4,6-dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 2e-37 | 31.61% (310) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5346 | rmlB_1 | 1e-160 | 82.41% (324) | dTDP-glucose-4,6-dehydratase, RmlB_1 |
| M. avium 104 | MAV_4406 | rfbB | 1e-36 | 33.53% (340) | dTDP-glucose 4,6-dehydratase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 8e-37 | 34.19% (313) | dTDP-glucose 4,6-dehydratase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 5e-35 | 35.42% (271) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 8e-36 | 31.51% (311) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 5e-34 | 31.79% (324) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3813|M.bovis_AF2122/97 ---------MEILVTG---GAGFQGSHLTESLLANGH-----WVTVLDKS
Rv3784|M.tuberculosis_H37Rv ---------MEILVTG---GAGFQGSHLTESLLANGH-----WVTVLDKS
MMAR_5346|M.marinum_M ---------MEILVIG---GAGFQGSHLTESLLADGH-----WVTVLNTP
MLBr_01964|M.leprae_Br4923 -------MTMRLLVTG---GAGFIGANFVHNAVRDHP---DDTVTVLDAM
MAV_4406|M.avium_104 ---------MRLLVTG---GAGFIGANFVHSTVREHP---EDSVTVLDAL
MSMEG_1512|M.smegmatis_MC2_155 ---------MRLLVTG---GAGFIGANFVHLALREAR---TSSITVLDAL
Mvan_1365|M.vanbaalenii_PYR-1 ---------MRLLVTG---GAGFIGANFVRTTVQQRP---DVQVTVLDSL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
Mflv_3296|M.gilvum_PYR-GCK --------MARLLVTG---GAGFIGSNFVHHVLAHTD----HHVTVLDKL
MAB_0503|M.abscessus_ATCC_1997 ---------MRAMVTG---AAGFIGSTLVDRLLADGH-----EVTGLDNL
MUL_4210|M.ulcerans_Agy99 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
* . ..* . . . *:
Mb3813|M.bovis_AF2122/97 SRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDH-HVVFHLAAHVNV
Rv3784|M.tuberculosis_H37Rv SRNAVRNMQGFRSHDRAAFISGSVTDGQTIDRAVRDH-HVVFHLAAHVNV
MMAR_5346|M.marinum_M SKNTTRNMQGFQSHERVSFISGSVTDGETVYRAVRDH-HVVFHLAARTNV
MLBr_01964|M.leprae_Br4923 TYAGRHESLADVDHA-VRLVQGNITDTKLVFRLVAES-DVVVHFAAETHV
MAV_4406|M.avium_104 TYAGRRESLAGVEDS-IRLVVGDITDAELVSRLVAES-DAVVHFAAESHV
MSMEG_1512|M.smegmatis_MC2_155 TYAGSRESLAPVADR-IRLVQGDITDAALVGDLVAES-DAVVHFAAETHV
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDSQ-IRLVEGDITDAELVGKLVADS-DAVVHFAAETHV
TH_0330|M.thermoresistible__bu TYAGSRESLAPVADR-IRVVEGDVTDSDLVDKLVAES-DAVVHFAAESHV
Mflv_3296|M.gilvum_PYR-GCK TYAGNRASLDGLPERRLDFVHGDVADADLVDELVAGT-DAVVHYAAESHN
MAB_0503|M.abscessus_ATCC_1997 ATGKVANLEAAEANAKFTFVKDDIVEADLDAVVAEYSPEVIFHLAAQIDV
MUL_4210|M.ulcerans_Agy99 ATGRATNLEHLVDNLAHVFVEADIVDADLQAIFEQHRPEVIFHLAAQIDV
: .: .:.: ..:.* **. .
Mb3813|M.bovis_AF2122/97 DQSLGDPESFLETNVMGTYRVLEAVRRYR----NRLIYVSTCEVYGDGHN
Rv3784|M.tuberculosis_H37Rv DQSLGDPESFLETNVMGTYRVLEAVRRYR----NRLIYVSTCEVYGDGHN
MMAR_5346|M.marinum_M DESLSDPKSFLETNVMGTYRALEAVRRYR----NRLIYVSTCEVYGDGHN
MLBr_01964|M.leprae_Br4923 DNALDDPEPFLRTNVIGTFTILEAVRHHS----VRLHHISTDEVYGD-LE
MAV_4406|M.avium_104 DNALAGPEPFLHTNVVGTFTILEAVRRHG----VRLHHISTDEVYGD-LE
MSMEG_1512|M.smegmatis_MC2_155 DNALADPEPFLHSNVVGTYTILEAVRRHN----VRLHHVSTDEVYGD-LE
Mvan_1365|M.vanbaalenii_PYR-1 DNALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVYGD-LE
TH_0330|M.thermoresistible__bu DNALAEPEPFLRTNVVGTFTVLEAVRRHR----VRLHHISTDEVYGD-LP
Mflv_3296|M.gilvum_PYR-GCK DNSLDRPEPFLHSNVIGTFTVLEAVRRHG----RRLHHVSTDEVYGD-LE
MAB_0503|M.abscessus_ATCC_1997 RHSVADPQFDSSVNVVGTVRLAEAARKAG------VRKIVHTSSGGSIYG
MUL_4210|M.ulcerans_Agy99 RHSVADPQFDASVNVIGTLRLAEAARLTG------VRKVVHTSSGGSIYG
.:: *: **:** **.* : : . *.
Mb3813|M.bovis_AF2122/97 LKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF
Rv3784|M.tuberculosis_H37Rv LKEGERLDEHAELKPNSPYGASKAAADRLCYSYFRSYGLDVTIVRPFNIF
MMAR_5346|M.marinum_M LEEGQRLDEHAELKPNSPYAASKAAADRLCYSYFRSFGIDVTIVRPFNIF
MLBr_01964|M.leprae_Br4923 LDEPTRFTESTPYNPSSPYSATKAAGDMLVRAWVRSYGVRATISNCSNNY
MAV_4406|M.avium_104 LDDPNRFTESTPYNPSSPYSATKAAADMLVRAWVRSYGVRATISNCSNNY
MSMEG_1512|M.smegmatis_MC2_155 LDNPARFNETTPYNPSSPYSSTKAAADLLVRAWVRSYGVRATISNCSNNY
Mvan_1365|M.vanbaalenii_PYR-1 LDDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNCSNNY
TH_0330|M.thermoresistible__bu LHDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATISNCSNNY
Mflv_3296|M.gilvum_PYR-GCK LDDPARFTESSPYNPSSPYSSTKAGSDLLVRAWTRSFGVAATISNCSNNY
MAB_0503|M.abscessus_ATCC_1997 TPKQIPTSETVPTDPHSPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVY
MUL_4210|M.ulcerans_Agy99 TPPQYPTSERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSHIAPANVY
: .* ***.: *...: :: : : : : * :
Mb3813|M.bovis_AF2122/97 GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNL
Rv3784|M.tuberculosis_H37Rv GVRQKAGRFGALIPRLVRQGINGEGLTIFGAGSATRDYLYVSDIVGAYNL
MMAR_5346|M.marinum_M GIRQKTGRFGALIPRLVRQAINGKNLTIFGAGTSSRDYLYISDIVNAYNL
MLBr_01964|M.leprae_Br4923 GPYQHVEKF---IPRQITNVLTGRRPKLYGTGVNVRDWIHVDDHNSAVWQ
MAV_4406|M.avium_104 GPYQHVEKF---IPRQITNVLTGRRPKLYGTGANVRDWIHVDDHNSAVRR
MSMEG_1512|M.smegmatis_MC2_155 GPYQHVEKF---IPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVWR
Mvan_1365|M.vanbaalenii_PYR-1 GPYQHVEKF---IPRQITNVLTGRRPELYGTGANVRDWIHVDDHNSAVWR
TH_0330|M.thermoresistible__bu GPYQHVEKF---IPRQITNVLTGRRPKLYGTGANVRDWIHVEDHNDAVWR
Mflv_3296|M.gilvum_PYR-GCK GPYQHVEKF---IPRQITNVLWGIRPRLYGEGRNVRDWIHADDHSSAVLL
MAB_0503|M.abscessus_ATCC_1997 GPRQDPHGEAGVVAIFAQALLSGRSTKVFGDGGNTRDYVFVDDVVEAFVR
MUL_4210|M.ulcerans_Agy99 GPRQDPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVDAFVK
* *. :. : * ::* * **::. .* *
Mb3813|M.bovis_AF2122/97 VLRTPTLRGQAINFASGK--DTRVRDIVEYVADKFGARIEHRDARPGEVQ
Rv3784|M.tuberculosis_H37Rv VLRTPTLRGQAINFASGK--DTRVRDIVEYVADKFGARIEHRDARPGEVQ
MMAR_5346|M.marinum_M ILQTPSLRGQTINFASGK--DTCVKDIVEYVAGKFDATIEHRDARPGEVQ
MLBr_01964|M.leprae_Br4923 ILEKGQIGRTYLIGAENGHNNLTVLRTLLQMMGRDPNDFDHVTDRVGHDL
MAV_4406|M.avium_104 ILESGEIGRTYLISSEGERDNLTVLRTLLQMMGRDPDDFDHVTDRVGHDL
MSMEG_1512|M.smegmatis_MC2_155 ILTDGTIGRTYLIGAECERNNLTVMRTILKLMGRDPDDFDHVTDRAGHDL
Mvan_1365|M.vanbaalenii_PYR-1 ILHDGTVGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDRVGHDL
TH_0330|M.thermoresistible__bu ILTAGQIGRTYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDRAGHDL
Mflv_3296|M.gilvum_PYR-GCK ILEKGRIGETYLIGANGEKDNKTVVELILTLMGEDADAYDRVPDRLGHDL
MAB_0503|M.abscessus_ATCC_1997 ASGPDGGGQRFNVGTGVETSDRQLHSLVAAAAGA-PDDPEFHPPRLGDLR
MUL_4210|M.ulcerans_Agy99 AGSDVGGGQRFNIGTGVETSDRQLHSAVAAAVGG-PDDPEFHPPRLGDLK
: : : : . : * *.
Mb3813|M.bovis_AF2122/97 RFPADIS-LAKSIGFQP-QVEIWDGIDRYINWAKDQPQYPYEQDGFSGSS
Rv3784|M.tuberculosis_H37Rv RFPADIS-LAKSIGFQP-QVEIWDGIDRYINWAKDQPQYPYEQDGFSGSS
MMAR_5346|M.marinum_M RFPADIS-LARSIGFEP-QVDIWEGIDRYIAWAKDQPQHAYELDGLGDRS
MLBr_01964|M.leprae_Br4923 RYAIDPTPLYNELCWAPKHANFDEGLRATIDWYRNNESWWRPLKDAVEAR
MAV_4406|M.avium_104 RYAIDPSTLYDELCWAPKHTDFEEGLRETIDWYRANESWWRPLKDASEAR
MSMEG_1512|M.smegmatis_MC2_155 RYAIDPSTLQDELGWAPKHTDFEAGLTDTIDWYRANESWWRPLKDTVEAK
Mvan_1365|M.vanbaalenii_PYR-1 RYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKDAVEAT
TH_0330|M.thermoresistible__bu RYAIDPSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKDATEDA
Mflv_3296|M.gilvum_PYR-GCK RYAIDPTKLREELGWQPGYGDFEHGLAATIEWYRTHEDWWTPAKEATEAF
MAB_0503|M.abscessus_ATCC_1997 QSCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFRS---------------
MUL_4210|M.ulcerans_Agy99 RSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS-----------
: * : : * : *: : : :
Mb3813|M.bovis_AF2122/97 VL----
Rv3784|M.tuberculosis_H37Rv VL----
MMAR_5346|M.marinum_M TANG--
MLBr_01964|M.leprae_Br4923 YEERGR
MAV_4406|M.avium_104 YEERGQ
MSMEG_1512|M.smegmatis_MC2_155 YQERGQ
Mvan_1365|M.vanbaalenii_PYR-1 YQRRRR
TH_0330|M.thermoresistible__bu YAERGQ
Mflv_3296|M.gilvum_PYR-GCK YARIGQ
MAB_0503|M.abscessus_ATCC_1997 ------
MUL_4210|M.ulcerans_Agy99 ------