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SGKRRQNDFDVLLVGAGPVGLTLANILGLQGVRTLVIEERATLIDYPRGVGLDDEALRTFQSIGLVEGIL PHTVPNQILRFFDAKRRILAEMAPPDARFGWPKRNGFVQPLVDAELLRGLDRFDHVEVWWGRPVTSCVQT ETAVAVECGTAADDSGKSRRVRAGYVVGCDGGRSITRRMMGVSFDGTTSPTRWLVVDIANDPLGHPNSEV GADPSRPYASISIAHGIRRFEFMIHADESDEQADDPAFLTRMLARLVPHPERVEVIRRRVYTHHSRIAGA FRSGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVRGQAGEALLDSYDLERRKHARAMIDLST MVGRVISPTDRRIAAVRNAVVRSASVLPSLKRYVLEMRFKPMPRYEVGAVVHDRPRRPRSPVGTLFIQPR VDTRGQQNILLDDVLGGWFAVLCWNNNPRKILGDTAFATWKALGAKFVAARPAVQLHWTGDDDPDVVIVG DRTGEIKAWFDSHDESVLFVRPDRCIAGACIAQLAPDLSRSLVTALSLASGGGDAENGSGSVLYVPQPAA ESTGAAARPT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4777 | mhpA | - | 100% (571) | hydroxylase |
| M. marinum M | MMAR_1503 | - | 1e-68 | 33.14% (513) | FAD-dependent oxidoreductase |
| M. marinum M | MMAR_2987 | mhpA | 5e-52 | 32.73% (440) | 3-(3-hydroxy-phenyl) propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1170c | - | 4e-08 | 25.84% (387) | putative oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 0.0 | 73.11% (569) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv1138c | - | 4e-08 | 25.84% (387) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2573c | mhpA | 6e-57 | 31.40% (516) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. avium 104 | MAV_0878 | mhpA | 0.0 | 79.79% (569) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_4866 | mhpA | 0.0 | 76.61% (560) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 0.0 | 74.73% (562) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_0979 | - | 2e-07 | 26.77% (310) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4245 | mhpA | 0.0 | 73.53% (563) | 3-(3-hydroxyphenyl)propionate hydroxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4777|M.marinum_M --MSGKRR-QNDFDVLLVGAGPVGLTLANILGLQGVRTLVIEERATLIDY
MAV_0878|M.avium_104 MIAPGPRATDHDTDVLVVGAGPVGLTLANILGLQGIRTVVVEERDTLIDY
Mflv_2401|M.gilvum_PYR-GCK --MTEQT----DVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKLIDY
Mvan_4245|M.vanbaalenii_PYR-1 --MTAPSGSTPDVDVVVVGAGPSGLTLANILGLQGVATLVVDERDTLIDY
TH_0968|M.thermoresistible__bu --MTERV------DVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDY
MSMEG_4866|M.smegmatis_MC2_155 -MMNSPG----AVDVVIVGAGPVGLTLANILGGQGVRTLIIEERETLIDY
Mb1170c|M.bovis_AF2122/97 --MTSYDT-----DLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDK
Rv1138c|M.tuberculosis_H37Rv --MTSYDT-----DLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDK
MUL_0979|M.ulcerans_Agy99 --MTTYDT-----DVLVVGGGPGGLATALNARKRGLSVIVADPRESPIDK
MAB_2573c|M.abscessus_ATCC_199 --MNASAQLS--FPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATVYPQ
::::*.** *:: * .*: :: : .
MMAR_4777|M.marinum_M PRGVGLDDEALRTFQSIGLVEGILPHTVPNQILRFFDAKRRILAEMA-PP
MAV_0878|M.avium_104 PRGVGLDDEALRTFQSIGLVERVLPHTVPNQILRFMDAKRRVLAEMA-PP
Mflv_2401|M.gilvum_PYR-GCK PRGVGLDDESLRTFQAIGLVDRVLPHTVPNQILRFFDAKRNLLAEMA-PP
Mvan_4245|M.vanbaalenii_PYR-1 PRGVGLDDESLRTFQAIGLVERVLPHTVPNQILRFFDADRRLLAEMA-PP
TH_0968|M.thermoresistible__bu PRGVGLDDEALRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMA-PP
MSMEG_4866|M.smegmatis_MC2_155 PRGVGLDDESLRTFQSIGLVDAILPHTVPNQILRFYDANRRLLAEMA-PP
Mb1170c|M.bovis_AF2122/97 ACGEGLMPGGLAELTSLG----VDPVGLPFHGIAYVGEHR--------RV
Rv1138c|M.tuberculosis_H37Rv ACGEGLMPGGLAELTSLG----VDPVGLPFHGIAYVGEHR--------RV
MUL_0979|M.ulcerans_Agy99 ACGEGLMPGGLAELKSLD----VDPAGVPFQGIAYVSQQR--------RA
MAB_2573c|M.abscessus_ATCC_199 PRAVHLDDEIYRILAQLGIAEQFATISRPGAGMRLLDHRGQILSQIARAP
. . * : :. . . * : .
MMAR_4777|M.marinum_M DARFGWPKRNGFVQPLVDAELLRGLDRFDHVEVWWGRPVTSCVQTETA--
MAV_0878|M.avium_104 DARFGWPKRNGFVQPLVDAELLAGLDRFAHVQVRWGSPMTGCREDADG--
Mflv_2401|M.gilvum_PYR-GCK DARFGWPKRNGFVQPMVDAELFGGLQRFDNVEVRFGHRMHQCTQTTDR--
Mvan_4245|M.vanbaalenii_PYR-1 DARFGWPKRNGFVQPLVDAELFGGLERFDHVEVRFDHRMQSCSETAGG--
TH_0968|M.thermoresistible__bu DARFGWPKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAGE
MSMEG_4866|M.smegmatis_MC2_155 DARFGWPKRNGFVQPMVDAELLAGLDRFDHVEVMWGRRMQTIAEDADG--
Mb1170c|M.bovis_AF2122/97 QARFRTGPGRGVRRTTLHAALAARAKEQDTEWIRS--RVATIQQDAHG--
Rv1138c|M.tuberculosis_H37Rv QARFRTGPGRGVRRTTLHAALAARAKEQDTEWIRS--RVATIQQDAHG--
MUL_0979|M.ulcerans_Agy99 EARFRTGPGRGVRRTTVHATLAARAKEQDAEWIRT--RVTDVVQDAHG--
MAB_2573c|M.abscessus_ATCC_199 IGTHGYPQANMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHISAS--
. . . . :. :. * . : : .
MMAR_4777|M.marinum_M --VAVECGTAADDSG------KSRRVRAGYVVGCDGGRSITRRMMGVSFD
MAV_0878|M.avium_104 --VNVELGADGGNVGDGGGDGHPAGLRARYVVGCDGGRSMTRRVMGVSFD
Mflv_2401|M.gilvum_PYR-GCK --VEVEFDG------------GQASVSARYVVGCDGGRSVTRRLMGVSFD
Mvan_4245|M.vanbaalenii_PYR-1 --VTVTFDG------------DRDPVRARYVVGCDGGRSTTRRQMGVSFD
TH_0968|M.thermoresistible__bu DGVTVEFAD------------GHPPVRASYVVGCDGGRSTTRRLMGVSFD
MSMEG_4866|M.smegmatis_MC2_155 --VTVEVSGPD----------GPASVHAQYVVGCDGGRSATRHLMGVSFD
Mb1170c|M.bovis_AF2122/97 --------------------VTAAGVRAKWLVAADGLHSAVRRAVGIKAT
Rv1138c|M.tuberculosis_H37Rv --------------------VTAAGVRAKWLVAADGLHSAVRRAVGIKAT
MUL_0979|M.ulcerans_Agy99 --------------------VTAAGVRAKWLVAADGLHSAVRRAVGITAT
MAB_2573c|M.abscessus_ATCC_199 -QVQVTFTDRDS--------GDEHKVTATYVLGCDGANSVVRAAIGASMT
: * :::..** .* .* :* .
MMAR_4777|M.marinum_M GTTSPTRWLVVDIANDP-LGHPN-SEVGADPSRPYASISIAHGIRRFEFM
MAV_0878|M.avium_104 GTTSSTRWLVVDIANDP-LGHPN-SEVGADPERPYASISIAHGIRRFEFM
Mflv_2401|M.gilvum_PYR-GCK GTTSSTRWLVVDIANDP-LGHPN-SEVGADPRRPYVSIAIAHGIRRFEFM
Mvan_4245|M.vanbaalenii_PYR-1 GTTSSTRWLVVDVANDP-LGHPN-SEVGADPARPYVSISIAHGIRRFEFM
TH_0968|M.thermoresistible__bu GTTSSTRWLVVDVANDP-LGHPN-SEVGADPARPYVSISIAHGIRRFEFM
MSMEG_4866|M.smegmatis_MC2_155 GTTSSTRWVVIDLANDP-LGHPN-SEVGADPQRPYASISIAHGIRRFEFM
Mb1170c|M.bovis_AF2122/97 AGTP-RRYGVRWHYRLP-VWSDF-VEVHWSRWGEAYVTPVEPDLVGVAIL
Rv1138c|M.tuberculosis_H37Rv AGTP-RRYGVRWHYRLP-VWSDF-VEVHWSRWGEAYVTPVEPDLVGVAIL
MUL_0979|M.ulcerans_Agy99 AGTP-RRYGVRRHYRVP-AWSEF-VEVHWSPWGEAYVTPVEPDLVGVAIL
MAB_2573c|M.abscessus_ATCC_199 ARRFAQRWLVVDLNTDADLGHWDGVHHLCDPDRATTFMRVGERRYRWEFK
. *: * . . . : :
MMAR_4777|M.marinum_M IHADESDEQADDPAFLTRMLARLVPHPER--VEVIRRRVYTHHSRIAGAF
MAV_0878|M.avium_104 IHADESDEQAEDPEFLTRMLARMVPHPDR--VDVIRRRVYTHHSRIAGEF
Mflv_2401|M.gilvum_PYR-GCK IHPDETDEEADDPAFVRRMLGQLIPYPER--VDMIRHRVYTHHSRIAGSF
Mvan_4245|M.vanbaalenii_PYR-1 IHPDETDEQADDPAFVRRMLGQRVPYPER--VDIIRHRVYTHHSRIAGSF
TH_0968|M.thermoresistible__bu IHPHETDAEVDDPAFVRRMLGRRIPYPER--VDMIRYRVYTHHSRIAGSF
MSMEG_4866|M.smegmatis_MC2_155 IHADETDEQAEDPEFVAELLRPFVPHPDR--VDVIRRRVYTHHSRIAGSF
Mb1170c|M.bovis_AF2122/97 SRQRP--ELAWFPSLAHHLQDASRGHARG--CGPLR--------QVVSRR
Rv1138c|M.tuberculosis_H37Rv SRQRP--ELAWFPSLAHHLQDASRGHARG--CGPLR--------QVVSRR
MUL_0979|M.ulcerans_Agy99 SRQRP--EIDWFPWLAQQLRGASPGAARG--CGPLR--------QVVSRR
MAB_2573c|M.abscessus_ATCC_199 LHPGETAADYDTVEKLRPLIAVWTGASAISELTLIRVTEYTFRAHVASHW
: : . :* ::..
MMAR_4777|M.marinum_M RSGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVRGQAGEALL
MAV_0878|M.avium_104 RRGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVSGRAGDKLL
Mflv_2401|M.gilvum_PYR-GCK REGRLMLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVTGRAGEELL
Mvan_4245|M.vanbaalenii_PYR-1 RKGRLMLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGQADDALL
TH_0968|M.thermoresistible__bu RKGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALL
MSMEG_4866|M.smegmatis_MC2_155 RKGRMLLAGDAAHLMPVWQGQGYNSGIRDAFNLGWKLAAVVRGQAGDALL
Mb1170c|M.bovis_AF2122/97 VAGRVLLVGDAAGYEDALTGEGIS--------LAVKQAAAAVSAIVDDTP
Rv1138c|M.tuberculosis_H37Rv VAGRVLLVGDAAGYEDALTGEGIS--------LAVKQAAAAVSAIVDDTP
MUL_0979|M.ulcerans_Agy99 VAGRVLLVGDAAGYEDALTGEGIT--------LAVKQAAAAVRAIADNDP
MAB_2573c|M.abscessus_ATCC_199 RDRNVFILGDAAHLTPPFVGQGMGAGIRDAANLTWKLAGVLDGQLPTRVL
.::: **** *:* * * *..
MMAR_4777|M.marinum_M DSYDLERRKHARAMIDLSTMVGRVISPTDRRIAAVRNAVVRSASVLPSLK
MAV_0878|M.avium_104 DTYDMERRKHARAMIDLSTMVGRVISPTNRRVAGARDLLVRSASIVPTLK
Mflv_2401|M.gilvum_PYR-GCK DTYDVERRKHARAMIDLSTMVGRVISPTNRKVAALRDRVIHAASAVPSLK
Mvan_4245|M.vanbaalenii_PYR-1 DTYDLERRKHARAMIDLSTMVGKVISPTNRGLAALRDRVIHAASVVPTLK
TH_0968|M.thermoresistible__bu DTYDLERREHARAMIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLK
MSMEG_4866|M.smegmatis_MC2_155 DTYDAERRKHARAMIDLSTMVGRVISPTNRKVAALRDKLIRGASIVPTLK
Mb1170c|M.bovis_AF2122/97 ASYEAAWHRITRDYRLVTRGLVLASTPR-----AARRAIVPLCALLP---
Rv1138c|M.tuberculosis_H37Rv ASYEAAWHRITRDYRLVTRGLVLASTPR-----AARRAIVPLCALLP---
MUL_0979|M.ulcerans_Agy99 ASYEAAWHRVTRSYRWLTRGLVLASAPR-----PARRAIVPACALLP---
MAB_2573c|M.abscessus_ATCC_199 DTYEQERKPHAWKMITIALAVGAAMTARGTAATAIRNLLVPRLQYIPGLR
:*: : : :: : . :. * :: :*
MMAR_4777|M.marinum_M RYVLEMRFKPMPRYEVGAVVHDRPRRPRSPVG--TLFIQPRVDTRGQQNI
MAV_0878|M.avium_104 RYVLEMRFKPMPRYEHGAVVHANPGRADSPVG--TLFIQPRVDTRDQQDV
Mflv_2401|M.gilvum_PYR-GCK RYVLEMRFKPMPRYQQGAVLHHAHAAPNSPTG--TLFIQPRVDTRDTQNA
Mvan_4245|M.vanbaalenii_PYR-1 RYILEMRFKPMPRYQQGAVYHDAQPSPTSPTG--TLFIQPRVDTREEFNV
TH_0968|M.thermoresistible__bu RYVLEMRFKPMPRYLQGAVYHGGPRSKSSPTG--TLFIQPRVDTRDAENV
MSMEG_4866|M.smegmatis_MC2_155 RYVLEMRFKPMPRYHEGAVYHAKPPTPASPVG--TLFIQPRVDTREQDNV
Mb1170c|M.bovis_AF2122/97 -----TAF----RYGVNILAY-----------------------------
Rv1138c|M.tuberculosis_H37Rv -----TAF----RYGVNILAY-----------------------------
MUL_0979|M.ulcerans_Agy99 -----PVFPVWGKYPGKLTAQSGGHQADAAHPGHRLIPAPPKPSLPARIQ
MAB_2573c|M.abscessus_ATCC_199 S---RIQHSGTPALTRSALVNKTPRCR-------QLAGTQIPNLVLSQGH
.
MMAR_4777|M.marinum_M LLDDVLGGWFAVLCWNNNPRKILGDTAFATWKALGAKFVAARPAVQLHWT
MAV_0878|M.avium_104 LLDDVLGPWFAVLCWNNNPRKILGETAFANWKALGARFFALRPATQLRWT
Mflv_2401|M.gilvum_PYR-GCK LLDDVLGTGFAVVCWSNNLRAVLGEEAFGRWKALGAKFVEVRPMSQLRWP
Mvan_4245|M.vanbaalenii_PYR-1 LLDDVLGPGFAVVCWSNNLRAVLGDEAFDRWKGLGARFVEARPMTQLHWP
TH_0968|M.thermoresistible__bu LLDDVLGPGFAVLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWP
MSMEG_4866|M.smegmatis_MC2_155 LLDDVLGTGFAVLCWNNNPRTLLGEAAFTRWKALGATFIAARPSTQLHWT
Mb1170c|M.bovis_AF2122/97 --------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0979|M.ulcerans_Agy99 IGPIPSAAHCQPSAPGVPLLPSAPAAPLPNWPYPPAPPEAAPPPAPPGPP
MAB_2573c|M.abscessus_ATCC_199 RIDTLLGSGFALVASET---------------------VDADQQAQLRRR
MMAR_4777|M.marinum_M GDDDPDVVIVGDRTGEIKAWFDSHDESVLFVRPDRCIAGACIAQLAPDLS
MAV_0878|M.avium_104 GHDDPDVVVVGDRRGDLKSWFDIHAESVLFLRPDRCIAGACIAQRAPDLS
Mflv_2401|M.gilvum_PYR-GCK GHDDPDVAVIGDRTGALKAWFDVHTESVLFVRPDRCIAAACIAQRAPEIS
Mvan_4245|M.vanbaalenii_PYR-1 GYDDADVEVVGDRTGALKKWFDVSTDSVLFVRPDRCIAGACIAQRAPEVS
TH_0968|M.thermoresistible__bu GHDDPDVVVVGDRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETS
MSMEG_4866|M.smegmatis_MC2_155 KDDDPDVVIVGDRTGALKAFFDAHTESVLVLRPDRCIAGADIAQRAPELS
Mb1170c|M.bovis_AF2122/97 --------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0979|M.ulcerans_Agy99 G-------------------------------------------------
MAB_2573c|M.abscessus_ATCC_199 G----AAIIVEPRGSELDRWLRRGGARAALIRPDRTVMQTARSPSQIAFT
MMAR_4777|M.marinum_M RSLVTALSLAS-------GGGDAENGSGSVLYVPQPAAESTGAAARPT
MAV_0878|M.avium_104 AALFDALTLTP-------RGGDPQSGTGSVLYVAQPAPESSGAVAGPA
Mflv_2401|M.gilvum_PYR-GCK EGLFAALHLTSGAHLTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGTS
Mvan_4245|M.vanbaalenii_PYR-1 TALFAVLHLTR----EGGAGSHGEKSDGTVLHVAQSAAEPSGTSAGTP
TH_0968|M.thermoresistible__bu AALSEVMCLTQ------GGGNGAASP---VLHVAQSAAEPSGTATRST
MSMEG_4866|M.smegmatis_MC2_155 TALFGILHLRQ------GGENGATGP---VLYVPQPTAESSGTVGRAS
Mb1170c|M.bovis_AF2122/97 ------------------------------------------------
Rv1138c|M.tuberculosis_H37Rv ------------------------------------------------
MUL_0979|M.ulcerans_Agy99 ------------------------------------------------
MAB_2573c|M.abscessus_ATCC_199 TTLFAP--------------------------THQPAPTYRETP----