For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MSFVFAVPETMAAVTSELATIGSNLEMANAAAALPTTGLLAAGADEVSAAIAALFDEHALGYQTISAQAS AFHARFMSALNTGAGAYAAAEAANSSPLQALQDLTLNAINAPAQSLFGRPLIGDGANATTPGGNGGAGGI LWGNGGAGATGAAGQTGGNGGAAGFIGNGGAGGAGGAGATGGVGGSGGMLFGNGGAGGNGGTAMVVGGTG GNGGAGGSAGLFGAGGAGGQGGQGAQGPDAVNPGPVSPTGQATSGTGGGVGENGGPGDSSTVTGEEGGDG GSGGQGSPGASTASGGTGGDGGLAGDGGPGAPGGTGGGGGNGGAGANNFSGGSATSGGAGGNGNNGGTGG DGAAGGDGGNGGNGGSGGTTTSKVSNAGSGANGGDGGDGGDGGAGAVGGNGGNGGKGGDSGSGGFFTPSP GTGGAGGDGGHGGSGSNGQAGGSGGQGGAGGNGGLLAGDGGAGGAGGLGGQGGAAAAGANGGVAGNGGNG GHGPFGEKIPAGGSGGDGGTGGIGGDGGLGGDGGAGGQGGAGGRAGLLAGLGGAGGDGGLGGNGGVGGDG AQGGLGGNGGVRNSDNLSYDGIIGNGGTGGNGGVGGHGGDGGAGGEGGSGSLLGAAGSAGSNAAGGSGGT GGLRGQGGDPGSTGRAGTGSAGADGMNGTDGDPGDPGGMA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4270 | - | - | 100% (670) | PE-PGRS family protein |
| M. marinum M | MMAR_2067 | - | 0.0 | 49.93% (763) | PE-PGRS family protein |
| M. marinum M | MMAR_4995 | - | e-180 | 47.58% (826) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 0.0 | 51.04% (772) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-138 | 48.89% (585) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1091 | PE_PGRS22 | 0.0 | 51.03% (774) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01556 | infB | 1e-09 | 43.33% (90) | translation initiation factor IF-2 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 5e-46 | 28.42% (665) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 2e-25 | 42.00% (200) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-112 | 41.30% (707) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 3e-47 | 43.75% (288) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0572 | - | 1e-167 | 48.74% (753) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-134 | 47.99% (573) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1121|M.bovis_AF2122/97 --------------------------------------------------
Rv1091|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4270|M.marinum_M --------------------------------------------------
MUL_0572|M.ulcerans_Agy99 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 --------------------------------------------------
Mb1121|M.bovis_AF2122/97 ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL
Rv1091|M.tuberculosis_H37Rv ----------MSFVIAAPEALVAVASDLAGIGSALAEANAAALAPTTALL
MMAR_4270|M.marinum_M ----------MSFVFAVPETMAAVTSELATIGSNLEMANAAAALPTTGLL
MUL_0572|M.ulcerans_Agy99 ----------MSYVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTGVM
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------MSIIDFILNLFRDPVEAASYVADPEAALANAGLSAV
MAV_4827|M.avium_104 ------MNIVLGVSMAPSSIQMVVLEGEYADGATVEEDAIDVTGADDAAT
MLBr_01556|M.leprae_Br4923 ----------MAGKARVHELAKELGVTSKEVLARLNEQGEFVKSASSTVE
Mb1121|M.bovis_AF2122/97 AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA
Rv1091|M.tuberculosis_H37Rv AAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQALTGGGGAYAAA
MMAR_4270|M.marinum_M AAGADEVSAAIAALFDEHALGYQTISAQASAFHARFMSALNTGAGAYAAA
MUL_0572|M.ulcerans_Agy99 AAADDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAA
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDG
MAV_4827|M.avium_104 ASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQLEAAALRDALAARRI
MLBr_01556|M.leprae_Br4923 APVARRLRESFGGIKPAADKGAEQVATKAQAKRLGESLDQTLDRALDKAV
Mb1121|M.bovis_AF2122/97 EAANVS--------------------------------AAQSTDQRLLDL
Rv1091|M.tuberculosis_H37Rv EAANVS--------------------------------AAQSTDQRLLDL
MMAR_4270|M.marinum_M EAANSS--------------------------------PLQALQDLTLNA
MUL_0572|M.ulcerans_Agy99 EAANAS--------------------------------PLQAAEQEVLAV
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 P---------------------------------------SILSPSLLSP
MAV_4827|M.avium_104 DNVMLVS---------------------------------AFLAAAALAQ
MLBr_01556|M.leprae_Br4923 AGNGATTAAP----------------------------VQVDHSAAVVPI
Mb1121|M.bovis_AF2122/97 IN--------------------GPTQALLG--------RPLIGDGANGG-
Rv1091|M.tuberculosis_H37Rv IN--------------------GPTQALLG--------RPLIGDGANGG-
MMAR_4270|M.marinum_M IN--------------------APAQSLFG--------RPLIGDGANATT
MUL_0572|M.ulcerans_Agy99 IN--------------------APTNALLG--------RPLIGNGTDGLA
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGT-
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGT-
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGT-
TH_3810|M.thermoresistible__bu ---------------------------------------------VDGD-
MAB_4284c|M.abscessus_ATCC_199 RD-------------------------------------NDFLSHNDTDF
MAV_4827|M.avium_104 NVG------------------------------------GAMGYERTAVL
MLBr_01556|M.leprae_Br4923 VAG----------------------------------EGPSTAHREELAP
Mb1121|M.bovis_AF2122/97 -PGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIGNGGAGGGGGAG
Rv1091|M.tuberculosis_H37Rv -PGQDGGPGGLLYGNGGNGGTSTTAGVAGGNGGAAGLIGNGGAGGGGGAG
MMAR_4270|M.marinum_M -PGGNGGAGGILWGNGGAGATG-AAGQTGGNGGAAGFIGNGGAGGAGGAG
MUL_0572|M.ulcerans_Agy99 GTGAAGGAGGLLWGNGGNGGSG-AAGQAGGAGGAAGLIGTGGAGGMGGAG
Mflv_5091|M.gilvum_PYR-GCK GQN-----GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGGNGGNGGNGLG
Mvan_1264|M.vanbaalenii_PYR-1 GQN-----GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGGNGGNGGNGLG
MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG-NGGNGGVGWA
TH_3810|M.thermoresistible__bu ----------------------------GGSGGRTGLFSKLSRGG-----
MAB_4284c|M.abscessus_ATCC_199 ASHNPIASGNQVMSPSGNVDSFNRGPLLDLSFGDLQFGNRDTTAIGDGAV
MAV_4827|M.avium_104 LVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVAGLEKLE
MLBr_01556|M.leprae_Br4923 PAGQPSEQPGVPLPGQQGTPAAPHPGHPGMPTGPHPGPAPKPGGRPPRVG
*
Mb1121|M.bovis_AF2122/97 -AAGGNGGAGG--WLYGNGGAGGAGGTSV----------IPGVAGGNGGA
Rv1091|M.tuberculosis_H37Rv -AAGGNGGAGG--WLYGNGGAGGAGGTSV----------IPGVAGGNGGA
MMAR_4270|M.marinum_M -ATGGVGGSGG--MLFGNGGAGGNGGTAM----------VVGGTGGNGGA
MUL_0572|M.ulcerans_Agy99 GGAGGMGGSGG--WLLGNGGAGGAGGVG-----------CAGVSGGVGGT
Mflv_5091|M.gilvum_PYR-GCK GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGAT
Mvan_1264|M.vanbaalenii_PYR-1 SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGAT
MSMEG_0868|M.smegmatis_MC2_155 GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGGT
TH_3810|M.thermoresistible__bu --DGGDGGLGG------NGGHGG-------------------------GT
MAB_4284c|M.abscessus_ATCC_199 AVGGSNSGPIAS----GQGSTAVNGDVRD----------SNIINADHGSN
MAV_4827|M.avium_104 SLPGGLLLVGS----------------------------------GVDVA
MLBr_01556|M.leprae_Br4923 NNPFSSAQSVARPIPRPPAPRPSASPSSMS----------PRPGGAVGGG
. .
Mb1121|M.bovis_AF2122/97 GGSAGLWGTGG-----AGGDGGNGRSGPVNVAGSAG--------------
Rv1091|M.tuberculosis_H37Rv GGSAGLWGTGG-----AGGDGGNGRSGPVNVAGSAG--------------
MMAR_4270|M.marinum_M GGSAGLFGAGG-----AGGQGGQGAQGPDAVN------------------
MUL_0572|M.ulcerans_Agy99 GGNAMLFGNGG-----AGGMGGAGADGAVGAAGTAG--------------
Mflv_5091|M.gilvum_PYR-GCK GVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG--------------
Mvan_1264|M.vanbaalenii_PYR-1 GVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG--------------
MSMEG_0868|M.smegmatis_MC2_155 GGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPNV
TH_3810|M.thermoresistible__bu GIISLLSLAGN------GGNGGNGYRTTDNNALDGG--------------
MAB_4284c|M.abscessus_ATCC_199 VGVDQSQTRVGGDYTNVSGHGSADIDKSVTVVDDHS--------------
MAV_4827|M.avium_104 PLKQVLQTTTFLDVSVAEEPETALARGAALAAANAP--------------
MLBr_01556|M.leprae_Br4923 GPRPPRTGVPRPGGGRPGAPVGGRSDAGGGNYRGGG--------------
Mb1121|M.bovis_AF2122/97 -----GNGGAGGAAGLFGDAGAGGNGGKGGAGGAA---------------
Rv1091|M.tuberculosis_H37Rv -----GNGGAGGAAGLFGDAGAGGNGGKGGAGGAA---------------
MMAR_4270|M.marinum_M ----------PGPVSPTGQATSGTGGGVGENGGPG---------------
MUL_0572|M.ulcerans_Agy99 -----TSTSAGGVGGAGWDATAAGVLAATGGDGGD---------------
Mflv_5091|M.gilvum_PYR-GCK AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGAAG-----
Mvan_1264|M.vanbaalenii_PYR-1 AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGTAG-----
MSMEG_0868|M.smegmatis_MC2_155 TVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVDG
TH_3810|M.thermoresistible__bu ---------HGGNGGNVGFFSLFNLGGAGGWGGSG---------------
MAB_4284c|M.abscessus_ATCC_199 ------------QRNTTNINDSFNTDRSTNIGSGN---------------
MAV_4827|M.avium_104 --------LFASSTAALAYAQDPGTGAVDQYSLPD---------------
MLBr_01556|M.leprae_Br4923 ----VGALPGGGSGGFRGRPGGGGHGGGGRPGQRG---------------
.
Mb1121|M.bovis_AF2122/97 ------------FSINFTAGDGGAGGAG-----GSGGHALLWGAGGAGGN
Rv1091|M.tuberculosis_H37Rv ------------FSINFTAGDGGAGGAG-----GSGGHALLWGAGGAGGN
MMAR_4270|M.marinum_M ------------DSSTVTGEEGGDGGSG-----GQG---------SPGAS
MUL_0572|M.ulcerans_Agy99 ------------SGGGGAGGNGGAGGAG-----GHG--SALFGADGANGN
Mflv_5091|M.gilvum_PYR-GCK --AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGAAGGAGGL
Mvan_1264|M.vanbaalenii_PYR-1 --VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGAAGQAGTA
MSMEG_0868|M.smegmatis_MC2_155 HAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGGH
TH_3810|M.thermoresistible__bu -----------VDGVDVVGGNPDGGTPG------------------AHGE
MAB_4284c|M.abscessus_ATCC_199 -------------TTNTEIGSHNQANIG--------------TSTSAGGS
MAV_4827|M.avium_104 --------------YLYVPVDPEPGDDE-------------LAYSAVGEE
MLBr_01556|M.leprae_Br4923 ------------GAAGAFGRPGGAPRRGRKSKRQKRQEYDSMQAPVVGGV
Mb1121|M.bovis_AF2122/97 GGSGGTGGAGGSTA-------------------GAGGNGGAGGGGGTGGL
Rv1091|M.tuberculosis_H37Rv GGSGGTGGAGGSTA-------------------GAGGNGGAGGGGGTGGL
MMAR_4270|M.marinum_M TASGGTGGDGG-LA-------------------GDGGPGAPGGTGGGG--
MUL_0572|M.ulcerans_Agy99 GGAGGAGGNPG-AP-------------------GNGGTGGVGPDAATSGG
Mflv_5091|M.gilvum_PYR-GCK GETGTTGGAGGVG--------------------GQGTAGGTGGVGGIGGA
Mvan_1264|M.vanbaalenii_PYR-1 GETGVTGGVGGIG--------------------GQGTEGGTGGVGGVGGV
MSMEG_0868|M.smegmatis_MC2_155 STGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGEI
TH_3810|M.thermoresistible__bu SHTPGVYTDRQ----------------------GEDGEDGTG--------
MAB_4284c|M.abscessus_ATCC_199 AAVGGNAGLAG----------------------NAGLAGNAGLAGNAG--
MAV_4827|M.avium_104 DAESPTVVIEKLFLP-------------------EDSEPRRRPVLLVG--
MLBr_01556|M.leprae_Br4923 RLPHGNGETIRLAR-------------------GASLSDFAEKIDANPAA
.
Mb1121|M.bovis_AF2122/97 LF---------GNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGG-------
Rv1091|M.tuberculosis_H37Rv LF---------GNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGG-------
MMAR_4270|M.marinum_M -----------GNGGAG------------ANNFS----GGSAT-------
MUL_0572|M.ulcerans_Agy99 MG---------GTGGDPGAVGGRGNSGAAGGAGAVAGASGAAGT------
Mflv_5091|M.gilvum_PYR-GCK G----------STGAVGG-------VGGKG----IQGGQG----------
Mvan_1264|M.vanbaalenii_PYR-1 G----------ATGGAGG-------VGGKG----IQGGQG----------
MSMEG_0868|M.smegmatis_MC2_155 YSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGT
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
MLBr_01556|M.leprae_Br4923 LVQALFNLGEMVTATQSVGDETLELLGSEMNYNVQVVSPEDEDR------
Mb1121|M.bovis_AF2122/97 ----TGGAGGDGGAGGAGGNARLWGV----------------GGAGGAGG
Rv1091|M.tuberculosis_H37Rv ----TGGAGGDGGAGGAGGNARLWGV----------------GGAGGAGG
MMAR_4270|M.marinum_M ----SGGAGGNGNNGGTGGD----------------------GAAGGDGG
MUL_0572|M.ulcerans_Agy99 ---IIAGNGGNGGAGGAGYAADG-PA----------------GPAIGNGG
Mflv_5091|M.gilvum_PYR-GCK ---LQGGKGGDGGAGGKGGDADSMGS------------------AGATGG
Mvan_1264|M.vanbaalenii_PYR-1 ---LQGGQGGDGGTGGTGGDATSMGE------------------AGATGG
MSMEG_0868|M.smegmatis_MC2_155 AKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGA
TH_3810|M.thermoresistible__bu -----TGIGGRGGNGGSSSGTHPMAE-------------------DGEHV
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGNAGLAGNAGLAGN------------------AGLAGN
MAV_4827|M.avium_104 -----SGLAVVGISAVLALEIALAIG------------------IRTTGT
MLBr_01556|M.leprae_Br4923 -ELLEPFDLTYGEDQGDEDELQVRPP------------------VVTVMG
.
Mb1121|M.bovis_AF2122/97 DGGAGGAG---GKGGS-----------GLSGNANGGAGGD----------
Rv1091|M.tuberculosis_H37Rv DGGAGGAG---GKGGS-----------GLSGNANGGAGGD----------
MMAR_4270|M.marinum_M NGGNGGSG---GTTTS-----------KVSNAGSGANGGD----------
MUL_0572|M.ulcerans_Agy99 DGGHGGAGGFYGNGGA-----------GGAGGNSAPGGGT----------
Mflv_5091|M.gilvum_PYR-GCK KGGNGGNGGRGGLFG---------------KGGNAGNGAD----------
Mvan_1264|M.vanbaalenii_PYR-1 KGGNGGNGGRGSLFG---------------RGGNAGNGGN----------
MSMEG_0868|M.smegmatis_MC2_155 VGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNG
TH_3810|M.thermoresistible__bu KALDGRPG---------------------LDGGNGSHGGN----------
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAG----------------------LAGNAGLAGN----------
MAV_4827|M.avium_104 VALQPTPN-----------------QHLIVPTEQAPAPPP----------
MLBr_01556|M.leprae_Br4923 HVDHGKTRLLDTIRKAN--------VREAEAGGITQHIGAYQVG------
Mb1121|M.bovis_AF2122/97 ------------SGRGGTGGAGGEGGAAGLLVGTGGH-------------
Rv1091|M.tuberculosis_H37Rv ------------SGRGGTGGAGGEGGAAGLLVGTGGH-------------
MMAR_4270|M.marinum_M ------------GGDGGDGGAGAVGGNG----GNGGK-------------
MUL_0572|M.ulcerans_Agy99 ------------GGNGGTGGDSGAMGSSGGRGGDGGV-------------
Mflv_5091|M.gilvum_PYR-GCK ------------GGTGGAGGAGGTGG-TGGAGGTGG--------------
Mvan_1264|M.vanbaalenii_PYR-1 ------------GGTGGNGGNGGTGG-TGGNGGTGG--------------
MSMEG_0868|M.smegmatis_MC2_155 PAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTG
TH_3810|M.thermoresistible__bu ------------GGHGGRGGFLGIGG------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------AGLAGNAGLAGNAGLAGNAGLAGNAG------------
MAV_4827|M.avium_104 ------------VQASAPQPKISVPEPVAAPKPLSPP-------------
MLBr_01556|M.leprae_Br4923 ------------VDLDGSERLITFIDTPGHEAFTAMR-------------
.
Mb1121|M.bovis_AF2122/97 ----GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRG-GAGGSGGSGGDGGG
Rv1091|M.tuberculosis_H37Rv ----GGDGGAGGAAVKGGDGGAAAGTGIAGAGGRG-GAGGSGGSGGDGGG
MMAR_4270|M.marinum_M ----GGDSGSGGFFTP---------------------SPGTGGAGGDGG-
MUL_0572|M.ulcerans_Agy99 ----GTNGGAGGGGGNATSYGTANATGGAGGDGGT-GSTGNGGSGGDGGN
Mflv_5091|M.gilvum_PYR-GCK ---TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGK
Mvan_1264|M.vanbaalenii_PYR-1 ---TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGK
MSMEG_0868|M.smegmatis_MC2_155 QTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGR
TH_3810|M.thermoresistible__bu -------------------------------------SGGWGGHGGNGG-
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------LAGNAGLAGNAG-
MAV_4827|M.avium_104 ------------------------------------VAAPLPAAPPPAAP
MLBr_01556|M.leprae_Br4923 --------ARGAKATDIAILVVAADDGVMPQTVEAINHAQAADVPIVVAV
.
Mb1121|M.bovis_AF2122/97 GAAGPAGWLFGDGGAG-------GNGGAAAAGGAGG--------QAGGGG
Rv1091|M.tuberculosis_H37Rv GAAGPAGWLFGDGGAG-------GNGGAAAAGGAGG--------QAGGGG
MMAR_4270|M.marinum_M -----------HGGSG-------SNG------------------QAGGSG
MUL_0572|M.ulcerans_Agy99 GGTG-------HGGGG-------GPGGTAINYGAGD--------AFGGAA
Mflv_5091|M.gilvum_PYR-GCK GGTGGTG---GAGGTG----GDGGTGGTGGTGGTG---------GTGGTG
Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTG---GDGGTG----GTGGTGGTGGTGGTG---------GTGGTG
MSMEG_0868|M.smegmatis_MC2_155 GGDGALG---GNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNG
TH_3810|M.thermoresistible__bu --------------------------------------------DTDADG
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------LAGNAG
MAV_4827|M.avium_104 P-------------------------------------------LPEAPP
MLBr_01556|M.leprae_Br4923 N-----------------------------------------KIDKEGAD
Mb1121|M.bovis_AF2122/97 GNGGNG------------GNGGNGGNGGNGATGGWLYGNGGAGG------
Rv1091|M.tuberculosis_H37Rv GNGGNG------------GNGGNGGNGGNGATGGWLYGNGGAGG------
MMAR_4270|M.marinum_M GQGGAG------------GNGG------------LLAGDGGAGG------
MUL_0572|M.ulcerans_Agy99 GKGGTG------------VVGGNGGSGG----AAYNYGTGNATG------
Mflv_5091|M.gilvum_PYR-GCK GTGGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG------
Mvan_1264|M.vanbaalenii_PYR-1 GTGGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG------
MSMEG_0868|M.smegmatis_MC2_155 GNGGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRA
TH_3810|M.thermoresistible__bu GNGGDG-------------------------------GNGGSAG------
MAB_4284c|M.abscessus_ATCC_199 LAGNAG-----------------------------LAGNAGLAG------
MAV_4827|M.avium_104 IPAAPP-----------------------------VVPVPVVVP------
MLBr_01556|M.leprae_Br4923 PAKIRG------------QLTEYGLVAEDFGGDTMFIDISAKVG------
Mb1121|M.bovis_AF2122/97 -----------QGATAGAGG-AGANGVSSTNGG-----------------
Rv1091|M.tuberculosis_H37Rv -----------QGATAGAGG-AGANGVSSTNGGG----------------
MMAR_4270|M.marinum_M -----------AGGLGGQGG-AAAAGAN----------------------
MUL_0572|M.ulcerans_Agy99 -----------AGGSSGSGG-AASVPNSASTATA----------------
Mflv_5091|M.gilvum_PYR-GCK -----------TGGTGGQGG-LGGGGGTG---------------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------TGGTGGQGG-LGGVGGTG---------------------
MSMEG_0868|M.smegmatis_MC2_155 TVIGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTA
TH_3810|M.thermoresistible__bu -----------RGGTGGLRG------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------NAAVAGNAAVAGNAAVAG---------------------
MAV_4827|M.avium_104 -----------PVPVPVPVRIPVPDPVSP---------------------
MLBr_01556|M.leprae_Br4923 -----------TNIEALLEAVLLTADAALDLRAN----------------
Mb1121|M.bovis_AF2122/97 --GNGGIGGT---GGSGGAGGNAGLLGVG--------GAGGHGASG--GA
Rv1091|M.tuberculosis_H37Rv TGGNGGIGGT---GGSGGAGGNAGLLGVG--------GAGGHGASG--GA
MMAR_4270|M.marinum_M ----GGVAGN---GGNGGHGPFGEKIPAG--------GSGGDGGTG--GI
MUL_0572|M.ulcerans_Agy99 TSGSGGAGGDGTDGGNGGSGGFAFTFGTGNIIA----GVGGGGGTGSTGV
Mflv_5091|M.gilvum_PYR-GCK --GQGGTGGT---GGQGGTGGTGGTGGTG--------GTGGAGGDG--GL
Mvan_1264|M.vanbaalenii_PYR-1 --GTGGTGGT---GGQGGTGGTGGTGGTG--------GTGGAGGDG--GL
MSMEG_0868|M.smegmatis_MC2_155 TDGHGGSGIN---GGHGGNGGQGTIEANGPSAVASGIGAGGNGGDG--ID
TH_3810|M.thermoresistible__bu -----VFGIN---GGNGRAG------------------LGGRGXXX----
MAB_4284c|M.abscessus_ATCC_199 ---NAAVGGVLNTGVSGAIGGSSHVGGAIN------ESLGGSGSVG--GS
MAV_4827|M.avium_104 ---PQLLAPPRLSVPQPVQPPVRVPQPPSPP------QVGGTVPQS----
MLBr_01556|M.leprae_Br4923 -SGMEAQGVAIEAHLDRGRGPVATVLVQRG-----TLRIGDSVVAGDAYG
. *.
Mb1121|M.bovis_AF2122/97 GDRGGAGGTGFIS-------SDGGAGGDGGDGG--NGGAGGTGG------
Rv1091|M.tuberculosis_H37Rv GDRGGAGGTGFIS-------SDGGAGGDGGDGG--NGGAGGTGG------
MMAR_4270|M.marinum_M G-------------------GDGGLGGDGGAGG--QGGAGGRAG------
MUL_0572|M.ulcerans_Agy99 GGIGGSGGGADINNGAFTVVPQGGAGGHGGDGAT-DGGAGGAGGFTEIDS
Mflv_5091|M.gilvum_PYR-GCK GGLGGFGGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG---
Mvan_1264|M.vanbaalenii_PYR-1 GGLGGFGGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG---
MSMEG_0868|M.smegmatis_MC2_155 GGLGGNGGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGP--
TH_3810|M.thermoresistible__bu --------------------XGGGVGAAVRSGN----GVFSGGG------
MAB_4284c|M.abscessus_ATCC_199 TAVGGGAHTG----------VGGGVSTGVGVGSHVGGGISESLG------
MAV_4827|M.avium_104 --------------------PPQHQTPPGEGTPPKPDGPGNYGG------
MLBr_01556|M.leprae_Br4923 RVRRMVDEHGVDIEAALPSSPVQVIGFTSVPGAGDNFLVVDEDRIAR---
Mb1121|M.bovis_AF2122/97 ---LLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDG-------------
Rv1091|M.tuberculosis_H37Rv ---LLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDG-------------
MMAR_4270|M.marinum_M ---LLAGLGGAGGDGG------LGGNGGVGGDGAQGG-------------
MUL_0572|M.ulcerans_Agy99 SASVIAATGGAGGDGGSGGTGRGGTGGGGTGGGGTGGGGGVGINNGSGEA
Mflv_5091|M.gilvum_PYR-GCK ------GSGSAGKAGATGAAGASGGKGAQGATGAQGATG----------A
Mvan_1264|M.vanbaalenii_PYR-1 ------GSGSAGTAGVTGASGASGGKGAQGATGAQGATG----------A
MSMEG_0868|M.smegmatis_MC2_155 ---SWVQSGYGSTLGGNATGTATAGKGGEASNGGVAGNGG----NALVMA
TH_3810|M.thermoresistible__bu ----------GTPSAGFGVPTTIQFPAGSCTSRAVSR-------------
MAB_4284c|M.abscessus_ATCC_199 ------GSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVG----------
MAV_4827|M.avium_104 --------GHVPTPGAGGSGGSGGGHVPTPGAGGSGGSG-----------
MLBr_01556|M.leprae_Br4923 ---QIADRRSARKRNALAARSRKRISLEDLDSALKETSQLN------LIL
Mb1121|M.bovis_AF2122/97 NGGNGGSGGGAGSGGDGGGAGGNGAW----LFGNGG--------------
Rv1091|M.tuberculosis_H37Rv NGGNGGSGGGAGSGGDGGGAGGNGAW----LFGNGG--------------
MMAR_4270|M.marinum_M LGGNGGVRNSDNLSYDG-------------IIGNGG--------------
MUL_0572|M.ulcerans_Agy99 IGGAPGAGGTGAVGGDGGQGGAAYSYGTGDATGSAG--------------
Mflv_5091|M.gilvum_PYR-GCK QGATG-ATGAAGKAGATGAAGAAG------AAGSAG-----------TTG
Mvan_1264|M.vanbaalenii_PYR-1 QGATG-ATGASGAQGSAGSAGSAG------VAGSAG-----------TTG
MSMEG_0868|M.smegmatis_MC2_155 AGTTGVATGNTATGGDGGAATTAG------ATGGAGGFSNIAAIHGAITD
TH_3810|M.thermoresistible__bu EGIMPSSRAASARAGAACASSTSR--------------------------
MAB_4284c|M.abscessus_ATCC_199 -GGISESLGGSGSVGGSTAVG-----------------------------
MAV_4827|M.avium_104 -GGHVPTPGTGGPGGTGGS-------------------------------
MLBr_01556|M.leprae_Br4923 KGDNAGTVEALEEALMGIQVDDEVALRVIDRGVGG--------------I
*
Mb1121|M.bovis_AF2122/97 AGGGGGKGGNGAGGGLGGGSFGLPGLNGSGGDGG-------------DGG
Rv1091|M.tuberculosis_H37Rv AGGGGGKGGNGAGGGLGGGSFGLPGLNGSGGDGG-------------DGG
MMAR_4270|M.marinum_M TGGNGGVGG-------------------HGGDGG-------------AGG
MUL_0572|M.ulcerans_Agy99 AAGTAGTTGVGGTGGAGGAAYTLNGASTATATGG-------------IGG
Mflv_5091|M.gilvum_PYR-GCK AQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------------AAG
Mvan_1264|M.vanbaalenii_PYR-1 AQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG-------------AAG
MSMEG_0868|M.smegmatis_MC2_155 STAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKI-----ANSSAVAG
TH_3810|M.thermoresistible__bu SRRSFCCSRA----------------------------------------
MAB_4284c|M.abscessus_ATCC_199 GGAHTGVGGGVNTGVGVGSHVGGGISESLGGSGS-------------VGG
MAV_4827|M.avium_104 GGGHVPTPGAGTPGGSGGGHLPFPGAGSTPGGSG--------------GG
MLBr_01556|M.leprae_Br4923 TETNVNLASASDAIIIGFNVRAEGKATELASREGVEIRYYLVIYQAIDDI
Mb1121|M.bovis_AF2122/97 NGAPGGVLYG---NGGAGGQGS-----------SGGIGGPG-ATGGAGGK
Rv1091|M.tuberculosis_H37Rv NGAPGGVLYG---NGGAGGQGS-----------SGGIGGPG-ATGGAGGK
MMAR_4270|M.marinum_M EGGSGSLLGA---AGSAG---------------SNAAGGSG-GTGGLRGQ
MUL_0572|M.ulcerans_Agy99 NGGDGGTANGS--NGGNGGAGG-----------YASTTGTGTASVGNGGR
Mflv_5091|M.gilvum_PYR-GCK EDGDAGSGGSG-INGGAGGAGG-----------AGGEGGEG-GDGGKGGA
Mvan_1264|M.vanbaalenii_PYR-1 DAGDPGSEAVD-INGGAGGAGG-----------AGGEGGEG-GAGGAGGD
MSMEG_0868|M.smegmatis_MC2_155 NGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTG-GNGGNGGD
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 STAVGGGAHTSAINDALGGSGS-------------VGGSTAVGGGAHTSA
MAV_4827|M.avium_104 HLPTPG------------------------------AGTPGGGLGGFGGG
MLBr_01556|M.leprae_Br4923 EKALRGMLKPIYEENQLGRAEIR---------ALFRSSKVGIIAGCIISS
Mb1121|M.bovis_AF2122/97 GGDG--GDAQLIGDGGNGGNGGAG-GTGGTPGPGGPGGSGGLGGLLFGQT
Rv1091|M.tuberculosis_H37Rv GGDG--GDAQLIGDGGNGGNGGAG-GTGGTPGPGGPGGSGGLGGLLFGQT
MMAR_4270|M.marinum_M GGDP--GSTGRAGTG----SAGAD-GMNGTD--GDPGDPGGMA-------
MUL_0572|M.ulcerans_Agy99 GGDGT-ATVATGGTGGVGGNAHAP-AGSPVPGVGGKGGNPGPGGKP-GPN
Mflv_5091|M.gilvum_PYR-GCK GAE--------GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSG-GSG
Mvan_1264|M.vanbaalenii_PYR-1 GSE--------GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAG-GSG
MSMEG_0868|M.smegmatis_MC2_155 GSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTP-GTA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 INESMNSSINASHSSSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAH
MAV_4827|M.avium_104 HAPAP-------GGGLGGGGGHAPAPGGGLGGFGGGHSGGGLGGLGGGHK
MLBr_01556|M.leprae_Br4923 GVVRRNAKVRLLRDNIVVTDNLTVTSLRREKDDVTEVREGFECGMTLGYS
Mb1121|M.bovis_AF2122/97 GTAGVSP------------
Rv1091|M.tuberculosis_H37Rv GTAGVSP------------
MMAR_4270|M.marinum_M -------------------
MUL_0572|M.ulcerans_Agy99 GADGIVV------------
Mflv_5091|M.gilvum_PYR-GCK GAAGDSDD-----------
Mvan_1264|M.vanbaalenii_PYR-1 GAAGDSD------------
MSMEG_0868|M.smegmatis_MC2_155 GTTGANNP-----------
TH_3810|M.thermoresistible__bu -------------------
MAB_4284c|M.abscessus_ATCC_199 TTLPGAEHH----------
MAV_4827|M.avium_104 -------------------
MLBr_01556|M.leprae_Br4923 DIKEGDVIESYELVEKQRA