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MSFVIAVPDAVTAAVSDLANIGSVLTTANAAAALPTTTVVAAAGDEISAAVAALFGSYAQGYQSLSAQAA AFHERFLQTLSGGAGAYAAAEAANASPLDQLMGVVNAPAQALLGRPLIGNGANGADGTGAAGGDGGILLG NGGNGGSGAAGQVGGTGGAAGLFGNGGTGGTGGEGAAGGLGGRGGLLLGNGGAGGVGGVGATGLAGGTGG AAGFLGNGGTGGAGGASNMGGDGGMGGTGGTGGFFGNGGFGGDGGDGAVGGAGGAGSFLGGGGVGGTGGV GAAGGMGGAGPLIGNGGNGGMGGAGAAGGDGGAGGTLLGDGGSGGQGGAAMTGILGGLPGQGGNGGNANW FGSGGAGGQGGTGLAGTDGTNPTPGATAGTGSAGADQSNNGNVTGDNGNPGDAGTGDEIGGTGGAGGLGE STDGNSGTGGMGGGGGTAGPNGGNGGEGGMGGEGRTDGSSGGTATGGDGGAGADGGTGGGDGGAGGDGGF GNNTISGAAIGGNGGIGGAGSTLQGATGGNGDTGGAGGNGGRGGMFIGNGGAGGAGGTGGTGGTGAAGYA GGIGGDGGAAFSDAAAATGGDGAVGGVGGLGGNGGTGGAGGAGGTGGAAGFIGIGGNGGAGGIGGVGGIG GIGGAGGDGGIGGAATTTSGTTTGGIGANGVLGGDGGTGGDGGAGGTTGGSGGAGGVIGWAGSTGATGAG GTGGQGGQGGAGGSGGNGGTAQTGGTGGAGGDLALGGQGGAGGAAGGTGGDTGLDGLLGVPGSNGQTGEI VP
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_2067 | - | - | 100% (772) | PE-PGRS family protein |
M. marinum M | MMAR_2033 | - | 0.0 | 50.18% (855) | PE-PGRS family protein |
M. marinum M | MMAR_3758 | - | 0.0 | 50.72% (836) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2667c | PE_PGRS46 | 0.0 | 70.68% (781) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_5091 | - | 1e-158 | 46.90% (742) | triple helix repeat-containing collagen |
M. tuberculosis H37Rv | Rv2634c | PE_PGRS46 | 0.0 | 70.68% (781) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01183 | - | 7e-12 | 35.42% (96) | hypothetical protein MLBr_01183 |
M. abscessus ATCC 19977 | MAB_4284c | - | 6e-47 | 33.88% (484) | hypothetical protein MAB_4284c |
M. avium 104 | MAV_1346 | - | 3e-24 | 36.06% (269) | PE family protein |
M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-130 | 40.58% (892) | hypothetical protein MSMEG_0868 |
M. thermoresistible (build 8) | TH_3810 | - | 1e-44 | 41.14% (299) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4367 | - | 0.0 | 46.11% (926) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-156 | 46.16% (730) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 ----------------------------------MSFVIAVPEALTMAAS Rv2634c|M.tuberculosis_H37Rv ----------------------------------MSFVIAVPEALTMAAS MMAR_2067|M.marinum_M ----------------------------------MSFVIAVPDAVTAAVS MUL_4367|M.ulcerans_Agy99 ----------------------------------MSFVSVGPGLLEAAAR MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ----------------------------------MSIIDFILNLFRDPVE Mflv_5091|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP-- MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 DLANIGSTINAANAAAALPTTGVVAAAADEVSAAVAALFGSYAQSYQAFG Rv2634c|M.tuberculosis_H37Rv DLANIGSTINAANAAAALPTTGVVAAAADEVSAAVAALFGSYAQSYQAFG MMAR_2067|M.marinum_M DLANIGSVLTTANAAAALPTTTVVAAAGDEISAAVAALFGSYAQGYQSLS MUL_4367|M.ulcerans_Agy99 DLAGLGAGLREANLAAAGATVGVLPAAGDEVSAAIAELFGGFGREYQAMG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 AASYVADPEAALANAGLSAVSAAQVGAVMPVVAESVASNYGYQSQWVNTG Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 --------------------------AQLSAFHAQFVQSLTNGARSYVVA Rv2634c|M.tuberculosis_H37Rv --------------------------AQLSAFHAQFVQSLTNGARSYVVA MMAR_2067|M.marinum_M --------------------------AQAAAFHERFLQTLSGGAGAYAAA MUL_4367|M.ulcerans_Agy99 --------------------------ARVALLHDDFVRALTAGGSAYGQA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----------------------NPIHDLSGNLQNYYAAQPDGPSILSPS Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 ----------------------------------------EATSAAPLQD Rv2634c|M.tuberculosis_H37Rv ----------------------------------------EATSAAPLQD MMAR_2067|M.marinum_M ----------------------------------------EAANASPLDQ MUL_4367|M.ulcerans_Agy99 ----------------------------------------EALNMWPLQE MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------------------------------LLSPRDNDFLSH Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 L------------------------LGVVNAPAQALLGRPLIGNGANGAD Rv2634c|M.tuberculosis_H37Rv L------------------------LGVVNAPAQALLGRPLIGNGANGAD MMAR_2067|M.marinum_M L------------------------MGVVNAPAQALLGRPLIGNGANGAD MUL_4367|M.ulcerans_Agy99 LE--------------------QQALGVVNAPSMALFGRPSIGNGVDGVA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 N---------------------DTDFASHNPIASGNQVMSPSGNVDSFNR Mflv_5091|M.gilvum_PYR-GCK QN------GGILFGNGGSGWNSDVVGMDGGNGGNGGLFGG--NGGNGGNG Mvan_1264|M.vanbaalenii_PYR-1 QN------GGILFGNGGSGWNSEIAGVSGGNGGNAGLFGG--NGGNGGNG MSMEG_0868|M.smegmatis_MC2_155 DNPN-GGTGGLLFGDGGHGYDGSAAGLAGGNGGNAGLFG---NGGNGGVG TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 GTGAPGGPGGLLLGNGGNGG-SGAPGQPGGAGGDAGLIGNGGTGGKGGDG Rv2634c|M.tuberculosis_H37Rv GTGAPGGPGGLLLGNGGNGG-SGAPGQPGGAGGDAGLIGNGGTGGKGGDG MMAR_2067|M.marinum_M GTGAAGGDGGILLGNGGNGG-SGAAGQVGGTGGAAGLFGNGGTGGTGGE- MUL_4367|M.ulcerans_Agy99 GTGQAGGAGGILWGNGGNGG-LGAAGANGGAGGSAGLIGTGGVGGAGGVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQGSTAVNGDVR Mflv_5091|M.gilvum_PYR-GCK LG---GGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG-------- Mvan_1264|M.vanbaalenii_PYR-1 LG---SGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG-------- MSMEG_0868|M.smegmatis_MC2_155 WA---GLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGG------ TH_3810|M.thermoresistible__bu -V---DGDGGSGGRTGLFSKLSRGGDGGDGGLG----------------- Mb2667c|M.bovis_AF2122/97 LV-GSGAAGGVGGRGG--WLLGNGGTGGAGGAAGAT-------------- Rv2634c|M.tuberculosis_H37Rv LV-GSGAAGGVGGRGG--WLLGNGGTGGAGGAAGAT-------------- MMAR_2067|M.marinum_M -----GAAGGLGGRGG--LLLGNGGAGGVGGVGATG-------------- MUL_4367|M.ulcerans_Agy99 AAGMTGGSGGAGGGGG--WLWGAGGSGGAAGAGGSGGSGGWLWGNAGQTA MLBr_01183|M.leprae_Br4923 -----------------MPLFLNAEPQALTAAAN---------------- MAV_1346|M.avium_104 -----------------MS-FVTTRPEALLAVAS---------------- MAB_4284c|M.abscessus_ATCC_199 DSNIINADHGSNVGVDQSQTRVGGDYTNVSGHGSAD-------------- . . Mflv_5091|M.gilvum_PYR-GCK ----------------------------------APGVAGATGATG---- Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------APGVAGATGATG---- MSMEG_0868|M.smegmatis_MC2_155 ----------------------------------TGGTGGTGGGTG---- TH_3810|M.thermoresistible__bu ------------------------------------GNGGHGGGTG---- Mb2667c|M.bovis_AF2122/97 ---------------------------------LVGGTGGVGGATG---- Rv2634c|M.tuberculosis_H37Rv ---------------------------------LVGGTGGVGGATG---- MMAR_2067|M.marinum_M ---------------------------------LAGGTG---GAAG---- MUL_4367|M.ulcerans_Agy99 GAGVGGAGGAGGAGDAGDQGVSGVAPGEAGAVGFAGGAGGAGGAGGNGVG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 ---------------------------------IDKSVTVVDDHSQ---- Mflv_5091|M.gilvum_PYR-GCK ----VTSGVVGGNG------------------EDAVGYGATGAAGAAGAA Mvan_1264|M.vanbaalenii_PYR-1 ----VTSNVTGGNG------------------ADAVGYGATGAAGAAGAA MSMEG_0868|M.smegmatis_MC2_155 ----GTGGIGGTGG------------------GLFGLLGHSGSTGAAGAA TH_3810|M.thermoresistible__bu ----IIS--------------------------------------LLSLA Mb2667c|M.bovis_AF2122/97 --LIGSGGFGGAG---------------------------GAAAGVGTTG Rv2634c|M.tuberculosis_H37Rv --LIGSGGFGGAG---------------------------GAAAGVGTTG MMAR_2067|M.marinum_M --FLGNGGTGGAG---------------------------GASN-MGGDG MUL_4367|M.ulcerans_Agy99 GGVNGAGGAGGAGGVGGGGGAGASGVGAGVAGGDGGTGGAGGAAGVGGAA MLBr_01183|M.leprae_Br4923 --------------------------------------------TLEGLS MAV_1346|M.avium_104 --------------------------------------------MLEGLG MAB_4284c|M.abscessus_ATCC_199 ---RNTTNINDSFN-----------------------------TDRSTNI Mflv_5091|M.gilvum_PYR-GCK GAAGAAG--------------AVGSAGAAGEAGETGTWG---------NA Mvan_1264|M.vanbaalenii_PYR-1 GAAGKAG--------------AVGSAGTAGSAGAPGVWG---------NA MSMEG_0868|M.smegmatis_MC2_155 GNGGDGGNGGFGYVLIAGPNVTVGSETRGGTGGAGGTGGQS-------TA TH_3810|M.thermoresistible__bu GNGGNGG---------------NGYRTTDNNALDGGHGG----------- Mb2667c|M.bovis_AF2122/97 GVGGSGG--------------VGGVFGNGGFGGAGGLGAAG--------- Rv2634c|M.tuberculosis_H37Rv GVGGSGG--------------VGGVFGNGGFGGAGGLGAAG--------- MMAR_2067|M.marinum_M GMGGTGG--------------TGGFFGNGGFGGDGGDGAVG--------- MUL_4367|M.ulcerans_Agy99 GTGGTGG--------------AAGVAGTGGDGGDGGAGGAGSDASLAGQA MLBr_01183|M.leprae_Br4923 AATVASN--------------AAAAQLTTEIAP----------------- MAV_1346|M.avium_104 SSMDAQN--------------AAAAAPTTSIAP----------------- MAB_4284c|M.abscessus_ATCC_199 GSGNTTN-------------TEIGSHNQANIGTSTSAGG----------- . . . . Mflv_5091|M.gilvum_PYR-GCK GLPGKAGDAGGAG----------------AVGAAGAAG------TVGTAG Mvan_1264|M.vanbaalenii_PYR-1 GLPGAAGAAGGAG----------------AIGTAGVAG------AAGTAG MSMEG_0868|M.smegmatis_MC2_155 AGPGKGGGGGGGGGGAILIGANGGTVDGHAIGGNGGNGGNGSTTAAGGNG TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 -------GVGGAAS---------------YFGTGGG-------GGVGGDG Rv2634c|M.tuberculosis_H37Rv -------GVGGAAS---------------YFGTGGG-------GGVGGDG MMAR_2067|M.marinum_M -------GAGGAGS---------------FLGGGGV-------GGTGGVG MUL_4367|M.ulcerans_Agy99 GFAGGSGGAGGVGG---------------SAGAGGVNG----SGGDGGAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK ATGGTG---------------TGANGGAGGVGGVGGTGAAG--------- Mvan_1264|M.vanbaalenii_PYR-1 ATGGTG---------------VGGNGGAGQAGGIGGTGAAG--------- MSMEG_0868|M.smegmatis_MC2_155 GTGGTGRVIAEGTGSTAEGTATGGDGGHSTGTGIGGNGGIGSVYAYGNNG TH_3810|M.thermoresistible__bu ---------------------NGGNVGFFSLFNLGG-------------- Mb2667c|M.bovis_AF2122/97 APGGDG-------GAGPLLIGNGGVGGLGGAGAAGGNGGAGG-------- Rv2634c|M.tuberculosis_H37Rv APGGDG-------GAGPLLIGNGGVGGLGGAGAAGGNGGAGG-------- MMAR_2067|M.marinum_M AAGGMG-------GAGP-LIGNGGNGGMGGAGAAGGDGGAGG-------- MUL_4367|M.ulcerans_Agy99 AAGGAG-------GASATVAGSGGVGGDGGAGGAAGGGVGAA-------- MLBr_01183|M.leprae_Br4923 --------------------PAADDVSILLAHFFSGHGRQYQ-------- MAV_1346|M.avium_104 --------------------AAADEVSALQAAQFSAYGTWYQ-------- MAB_4284c|M.abscessus_ATCC_199 ------------------SAAVGGNAGLAGNAGLAGNAGLAG-------- . . .. Mflv_5091|M.gilvum_PYR-GCK -----AAGGAGGLGETGTTGGAGGVGGQ--GTAGGTGGVGGIGGAGSTGA Mvan_1264|M.vanbaalenii_PYR-1 -----AAGQAGTAGETGVTGGVGGIGGQ--GTEGGTGGVGGVGGVGATGG MSMEG_0868|M.smegmatis_MC2_155 AVSGTATGGRGGDGIDGGTGGAGGMGEIYSGADGEATGISAGGDGGSATG TH_3810|M.thermoresistible__bu ------AGGWGGSGVDG---------------------VDVVGGNP---- Mb2667c|M.bovis_AF2122/97 -----MLLGDGGAGGQGGP-----------AVAGVLGGMPGAGGNGGNAN Rv2634c|M.tuberculosis_H37Rv -----MLLGDGGAGGQGGP-----------AVAGVLGGMPGAGGNGGNAN MMAR_2067|M.marinum_M -----TLLGDGGSGGQGGA-----------AMTGILGGLPGQGGNGGNAN MUL_4367|M.ulcerans_Agy99 -----SLGGDGGHAGAGGAGGEGLSGGFNTGAAGGIGGAGGAGGTGGDSG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----NAGLAGNAGLAGNAG---------------LAGNAGLAGNAGLAG Mflv_5091|M.gilvum_PYR-GCK VGGVGGKG----IQGGQG-------------LQGGKGGDGGAGGKGGDAD Mvan_1264|M.vanbaalenii_PYR-1 AGGVGGKG----IQGGQG-------------LQGGQGGDGGTGGTGGDAT MSMEG_0868|M.smegmatis_MC2_155 ADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKASDGGKGGNGGDAL TH_3810|M.thermoresistible__bu --------------------------------------DGGTPG------ Mb2667c|M.bovis_AF2122/97 WFG----SGGAGGQGGTGLAG-----TNGVNPGSIANPNTGAN--GTDNS Rv2634c|M.tuberculosis_H37Rv WFG----SGGAGGQGGTGLAG-----TNGVNPGSIANPNTGAN--GTDNS MMAR_2067|M.marinum_M WFG----SGGAGGQGGTGLAG-----TDGTNPTPGATAGTGSA--GADQS MUL_4367|M.ulcerans_Agy99 GVGGVNGDGGAGGGGGRGGDGGSSTSTSGVGGAGGAGGNGGNAGFGVSAG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_5091|M.gilvum_PYR-GCK SMGS------------------AGATGGKGGNGGNGGRGGLFG------- Mvan_1264|M.vanbaalenii_PYR-1 SMGE------------------AGATGGKGGNGGNGGRGSLFG------- MSMEG_0868|M.smegmatis_MC2_155 VMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNIAAIHGSITDSSA TH_3810|M.thermoresistible__bu ------------------------AHGESHTPGVYTDRQ----------- Mb2667c|M.bovis_AF2122/97 GNGN-----------------QTGGNGGPGPAGGVGEAG----------- Rv2634c|M.tuberculosis_H37Rv GNGN-----------------QTGGNGGPGPAGGVGEAG----------- MMAR_2067|M.marinum_M NNGN-----------------VTGDNGNPGDAGTGDEIG----------- MUL_4367|M.ulcerans_Agy99 GTGG-----------------SAGDGGAGGGAGGVDGVGGASG------- MLBr_01183|M.leprae_Br4923 ------------------------AHASQGATNHQDLIQS---------- MAV_1346|M.avium_104 ------------------------QVSAQAKAIHQTLVQN---------- MAB_4284c|M.abscessus_ATCC_199 ------------------------NAGLAGNAGLAGNAG----------- . Mflv_5091|M.gilvum_PYR-GCK --------KGGNAGNGAD----------------------GGTGGAGGAG Mvan_1264|M.vanbaalenii_PYR-1 --------RGGNAGNGGN----------------------GGTGGNGGNG MSMEG_0868|M.smegmatis_MC2_155 TSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGKAAGGNGGDGGFN TH_3810|M.thermoresistible__bu --------------------------------------------GEDGED Mb2667c|M.bovis_AF2122/97 -------------GVGGQG---------------------GLGESLDGND Rv2634c|M.tuberculosis_H37Rv -------------GVGGQG---------------------GLGESLDGND MMAR_2067|M.marinum_M -------------GTGGAG---------------------GLGESTDGNS MUL_4367|M.ulcerans_Agy99 --------NGGAAGAGGAG---------------------GSGIGAGIDG MLBr_01183|M.leprae_Br4923 -----------------------------------------LLTSSSAYA MAV_1346|M.avium_104 -----------------------------------------LDTNADSYG MAB_4284c|M.abscessus_ATCC_199 ------------------------------------------LAGNAGLA . Mflv_5091|M.gilvum_PYR-GCK GTGG-TGGAGGTGG-----------------TGGTGGIGGAGSTGGTGGT Mvan_1264|M.vanbaalenii_PYR-1 GTGG-TGGNGGTGG-----------------TGGTGGIGGAGSTGGTGGT MSMEG_0868|M.smegmatis_MC2_155 GTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGA TH_3810|M.thermoresistible__bu GTGTGIGGRGGNGG----------------SSSGTHPMAEDG-------- Mb2667c|M.bovis_AF2122/97 GTGG-KGGAGGTAGT----------------DGGAGGAGGAGGIGETDGS Rv2634c|M.tuberculosis_H37Rv GTGG-KGGAGGTAGT----------------DGGAGGAGGAGGIGETDGS MMAR_2067|M.marinum_M GTGG-MGGGGGTAGP----------------NGGNGGEGGMGGEGRTDGS MUL_4367|M.ulcerans_Agy99 GAGG-AGGTGGAAGFPG-----GGGTTGAWGTGGAGGAGGAGGAGDHGGV MLBr_01183|M.leprae_Br4923 GTETAN-------------------------------------------- MAV_1346|M.avium_104 ATEAANRVNTSAAAL--------------------------------QGL MAB_4284c|M.abscessus_ATCC_199 GNAGLAGNAGLAGNAG---------------LAGNAGLAGNAGLAGNAGL . Mflv_5091|M.gilvum_PYR-GCK GGTGGTGGTGGTG-GTGGTGGTGGT---------GGKGGTGGTGGAGGTG Mvan_1264|M.vanbaalenii_PYR-1 GGTGGTGGTGGTG-GTGGTGGTGGT---------GGKGGTGGTGGDGGTG MSMEG_0868|M.smegmatis_MC2_155 NGNGGAGGAGGVSEGEGGTGGHGGD---------GGRGGDGALGGNGGTG TH_3810|M.thermoresistible__bu EHVKALDGRPGLD---GGNGSHGGN---------GGHGGRGGFLGIGGSG Mb2667c|M.bovis_AF2122/97 -----AGGVA--TGGEGGDGATG-----------GVDGGVGGAGGKGGQG Rv2634c|M.tuberculosis_H37Rv -----AGGVA--TGGEGGDGATG-----------GVDGGVGGAGGKGGQG MMAR_2067|M.marinum_M -----SGGTA--TGGDGGAGADG-----------GTGGGDGGAGGDGGFG MUL_4367|M.ulcerans_Agy99 GVNPGDSGTAGWAGGAGGAGGAGGSAAFNGVNGAGGAGGNGGAGGGGGAG MLBr_01183|M.leprae_Br4923 ------------------HDSL---------------------------- MAV_1346|M.avium_104 APNVIPNAAPAADPPPAGTTSLGTS------------IGWAQNVGAAASD MAB_4284c|M.abscessus_ATCC_199 AGNAGLAGNAGLAGNAGLAGNAAVAG-------NAAVAGNAAVAGNAAVG Mflv_5091|M.gilvum_PYR-GCK ----GDGGTGGTGGTGGTG----------------GTGGTG--GTGGAG- Mvan_1264|M.vanbaalenii_PYR-1 ----GTGGTGGTGGTGGTG----------------GTGGTG--GTGGAG- MSMEG_0868|M.smegmatis_MC2_155 GVGLGNGGKGGNGGNGGNGGTY-------VDPSHTGAGGNG--GNGGAGR TH_3810|M.thermoresistible__bu -------GWGGHGGNGGD------------------TDADG--GNGGDG- Mb2667c|M.bovis_AF2122/97 HNTGVGDAFGGDGGIGGDG--------------NGALGAAG--GNGGTG- Rv2634c|M.tuberculosis_H37Rv HNTGVGDAFGGDGGIGGDG--------------NGALGAAG--GNGGTG- MMAR_2067|M.marinum_M NNTISGAAIGGNGGIGGAG--------------STLQGATG--GNGDTG- MUL_4367|M.ulcerans_Agy99 ASGIGAGVAGGDGGTGGTGGAAGTGGAAGTGGTGGAAGAAGSAGDGGAG- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 FITLGEGQFAPVPGAAGIP-----------------NFNPGLTAATTAG- MAB_4284c|M.abscessus_ATCC_199 G-VLNTGVSGAIGGSSHVG----------------GAINESLGGSGSVG- Mflv_5091|M.gilvum_PYR-GCK ----------DGTGGTGGTGG----TGGQGGQGGQGG------------- Mvan_1264|M.vanbaalenii_PYR-1 ----------DGLGGTGGTGG----TGGFGGQGGQGG------------- MSMEG_0868|M.smegmatis_MC2_155 IRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNA TH_3810|M.thermoresistible__bu --------------GNGGSAG----------------------------- Mb2667c|M.bovis_AF2122/97 --------------GAGGNG------GRGGMLIGN--------------- Rv2634c|M.tuberculosis_H37Rv --------------GAGGNG------GRGGMLIGN--------------- MMAR_2067|M.marinum_M --------------GAGGNG------GRGGMFIGN--------------- MUL_4367|M.ulcerans_Agy99 --------------GAGGAGD----DGSAGVVSGDPGTA----------- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----------------PPAP----------------------------- MAB_4284c|M.abscessus_ATCC_199 --------------GSTAVGG----------------------------- Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGQGG-LGGGGGTG-----------------------GQGGT Mvan_1264|M.vanbaalenii_PYR-1 ----TGGTGGQGG-LGGVGGTG-----------------------GTGGT MSMEG_0868|M.smegmatis_MC2_155 SGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGS TH_3810|M.thermoresistible__bu ----RGGTGGLRGVFGINGGNG------------------------RAGL Mb2667c|M.bovis_AF2122/97 -----GGAGGAGG----TGG--------------------------TGGG Rv2634c|M.tuberculosis_H37Rv -----GGAGGAGG----TGG--------------------------TGGG MMAR_2067|M.marinum_M -----GGAGGAGG----TGG--------------------------TGGT MUL_4367|M.ulcerans_Agy99 --GKAGGAGGAGG----VGGNGVAG--------------------GVNGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----AAPAAAAG---------------------------------APVL MAB_4284c|M.abscessus_ATCC_199 -----GAHTGVGGGVSTGVGVG-----------------------SHVGG Mflv_5091|M.gilvum_PYR-GCK GGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGSGGT Mvan_1264|M.vanbaalenii_PYR-1 GGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFGGVGGT MSMEG_0868|M.smegmatis_MC2_155 GINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNGGDGVV TH_3810|M.thermoresistible__bu GGRGXXXXGGGVG---------------AAVRSGNGVFSGGGGTPSAGFG Mb2667c|M.bovis_AF2122/97 GAAGFAGGVGGAGGEGLTDG-------AGTAEGGTGGLGGLGGVGGTGGM Rv2634c|M.tuberculosis_H37Rv GAAGFAGGVGGAGGEGLTDG-------AGTAEGGTGGLGGLGGVGGTGGM MMAR_2067|M.marinum_M GAAGYAGGIGGDGGAAFSD--------AAAATGGDGAVGGVGGLGGNGGT MUL_4367|M.ulcerans_Agy99 GGAGGAGGAGGTGGAGASGV-------PASVDGGDGGAGGAGGAAGTGGS MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 ASMGRGPSIGGLSVPPSWAP-------GGVAPAANATPAQLVGAGFTSAA MAB_4284c|M.abscessus_ATCC_199 GISESLGGSGSVGGSTAVGG-------GAHTGVGGGVSTGVGVGSHVGGG Mflv_5091|M.gilvum_PYR-GCK GG------QGGLGGPGGSTGG--AGGAGG--QAGTAGKGGLFG----GSG Mvan_1264|M.vanbaalenii_PYR-1 GG------QGGQGGPGGSTGG--AGGAGG--QAGVAGKGGLFG----GSG MSMEG_0868|M.smegmatis_MC2_155 NT------TANAANPGSATGT--ATGGDGGKATGTASQGGNGGPSWVQSG TH_3810|M.thermoresistible__bu VP------TTIQFPAGSCTSR--AVSREG--------------------- Mb2667c|M.bovis_AF2122/97 GG------SGGVGGNGGAAGS--LIGLGGGGGAGGVGGTGGIGG------ Rv2634c|M.tuberculosis_H37Rv GG------SGGVGGNGGAAGS--LIGLGGGGGAGGVGGTGGIGG------ MMAR_2067|M.marinum_M GG------AGGAGGTGGAAG---FIGIGGNGGAGGIGGVGGIGG------ MUL_4367|M.ulcerans_Agy99 GGSAGNTGAGGAGGAGGAGGSAASTGVNGDGGAGGAGGVGGLGGDSAATA MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 PD---------TAPVTAVPGG----------------------------- MAB_4284c|M.abscessus_ATCC_199 IS-------ESLGGSGSVGGSTAVGGGAHTGVGGGVNTGVGVGS------ Mflv_5091|M.gilvum_PYR-GCK SAGKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAG- Mvan_1264|M.vanbaalenii_PYR-1 SAGTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASG- MSMEG_0868|M.smegmatis_MC2_155 YGSTLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTA- TH_3810|M.thermoresistible__bu ---IMPSSRAASARAG---------------------------AACASS- Mb2667c|M.bovis_AF2122/97 ----IGGAGGNGGAGGAGTT-----------------TGGGATIGGGGG- Rv2634c|M.tuberculosis_H37Rv ----IGGAGGNGGAGGAGTT-----------------TGGGATIGGGGG- MMAR_2067|M.marinum_M ----IGGAGGDGGIGGAATT-----------------TSG-TTTGGIGA- MUL_4367|M.ulcerans_Agy99 GGGGAGGDGGKGGAGGAGVNGVGGGDGGKG------GTGGAGGAGGAGSD MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----VPSMATAGRGGYGLG------------------------------ MAB_4284c|M.abscessus_ATCC_199 ----HVGGGISESLGGSGSVG-----------------GSTAVGGGAHT- Mflv_5091|M.gilvum_PYR-GCK -----KAGATGAAGAAGAAG--------SAG----------------TTG Mvan_1264|M.vanbaalenii_PYR-1 -----AQGSAGSAGSAGVAG--------SAG----------------TTG MSMEG_0868|M.smegmatis_MC2_155 -----TGGDGGAATTAGATG--------GAGGFSNIAAIHGA-----ITD TH_3810|M.thermoresistible__bu -----TSRSRRSFCCSRA-------------------------------- Mb2667c|M.bovis_AF2122/97 -----TGGVGGAGGTGGTGG---------AG-----------------GT Rv2634c|M.tuberculosis_H37Rv -----TGGVGGAGGTGGTGG---------AG-----------------GT MMAR_2067|M.marinum_M -----NGVLGGDGGTGGDGG---------AG-----------------GT MUL_4367|M.ulcerans_Agy99 GIIPSNGGLGGNGGNGGNGGQAFGDGVGGAGGIGGKGGNAAIGTIVINGG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -----APRYGVKPTVMPKPAI----------------------------- MAB_4284c|M.abscessus_ATCC_199 -----SAINDALGGSGSVGG---------------------------STA Mflv_5091|M.gilvum_PYR-GCK AQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGEDGDA Mvan_1264|M.vanbaalenii_PYR-1 AQGSAGTNGA-NGANGSQGAAGKAGATGTTGATG--------AAGDAGDP MSMEG_0868|M.smegmatis_MC2_155 STAISGHGGAGNGGNGGKGADGWVQAYDPAGPVGSKIANSSAVAGNGGDG TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 TGGSGGAGGL----------IGWAGAAGGTG-----------AGGTGGQG Rv2634c|M.tuberculosis_H37Rv TGGSGGAGGL----------IGWAGAAGGTG-----------AGGTGGQG MMAR_2067|M.marinum_M TGGSGGAGGV----------IGWAGSTGATG-----------AGGTGGQG MUL_4367|M.ulcerans_Agy99 VGGAGGSGGLGGATEDGVGGVGCAGGAGGNGGRGDMLFTVGGSGGTGGDG MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 VGGGAHTSAINESMNSSINASHSSSMNESFG----------SSMGSHGAA Mflv_5091|M.gilvum_PYR-GCK GSGGSG-INGGAGGAGG-----------AGGEGGEGGDGGKGGAGAE--- Mvan_1264|M.vanbaalenii_PYR-1 GSEAVD-INGGAGGAGG-----------AGGEGGEGGAGGAGGDGSE--- MSMEG_0868|M.smegmatis_MC2_155 GVNGTGGASGGDGGNGGNTSVWKSGGQTADGEHNTGGNGGNGGDGSEPGP TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 G-------LGGQGGNGG-----------NGG---TGATGGQGGDFAL--- Rv2634c|M.tuberculosis_H37Rv G-------LGGQGGNGG-----------NGG---TGATGGQGGDFAL--- MMAR_2067|M.marinum_M G-------QGGAGGSGG-----------NGGTAQTGGTGGAGGDLAL--- MUL_4367|M.ulcerans_Agy99 G-------GGGSASGSG-----------TGGSGGTGGVGGIGGDGKL--- MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 G----------------------------TGFEAQGHAQGHASETAH--- Mflv_5091|M.gilvum_PYR-GCK -----GGAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGS-----GGSGGA Mvan_1264|M.vanbaalenii_PYR-1 -----GGAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGA-----GGSGGA MSMEG_0868|M.smegmatis_MC2_155 GGNGAGGAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGT-----PGTAGT TH_3810|M.thermoresistible__bu -------------------------------------------------- Mb2667c|M.bovis_AF2122/97 -----GGNGGAGGAGG---------SPGGSSGIQGNMGP-----PGTQGA Rv2634c|M.tuberculosis_H37Rv -----GGNGGAGGAGG---------SPGGSSGIQGNMGP-----PGTQGA MMAR_2067|M.marinum_M -----GGQGGAGGAAG---------GTGGDTGLDGLLGV-----PGSNGQ MUL_4367|M.ulcerans_Agy99 -----GGFGGDGGDGGDGGFGVI-GGQGGGGGFGGLGGTGAGGAPSDKGI MLBr_01183|M.leprae_Br4923 -------------------------------------------------- MAV_1346|M.avium_104 -------------------------------------------------- MAB_4284c|M.abscessus_ATCC_199 -----TTLPGAEHH------------------------------------ Mflv_5091|M.gilvum_PYR-GCK AGDSDD-- Mvan_1264|M.vanbaalenii_PYR-1 AGDSD--- MSMEG_0868|M.smegmatis_MC2_155 TGANNP-- TH_3810|M.thermoresistible__bu -------- Mb2667c|M.bovis_AF2122/97 DG------ Rv2634c|M.tuberculosis_H37Rv DG------ MMAR_2067|M.marinum_M TGEIVP-- MUL_4367|M.ulcerans_Agy99 NGEPGNPG MLBr_01183|M.leprae_Br4923 -------- MAV_1346|M.avium_104 -------- MAB_4284c|M.abscessus_ATCC_199 --------