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MDPRSRPPYKIIGLAALMVLVFFGAMLYWQFRGTFIPKTRLTMIAPRAGLVTDPGAKVTFNGVQIGRVSS ITEVTHDGAPAARFALDVTPKYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYATSVT TEFNTLFENVTAISEKVDPVKLNLTLSAAAQALSGLGDRLGTALVNGNAILDDVNPLMPQVHRDITGLAA LGDIYADASTDLWDAVNSTVTVARTVNQRRSDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQ LLDEYSPEIFCTIRNYDEVAPRIRNALGFNGYSLGAASSGAISGAPNPYIYPENLPRVNARGGPGGRPGC WQTITRDLWPAPYLVMDVGANMAPYNHLEIGQPLLNEYVWGRQFGENTINP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4883 | mce2A | - | 100% (401) | MCE-family protein Mce2A |
| M. marinum M | MMAR_0412 | mce1A | e-150 | 61.08% (424) | MCE-family protein Mce1A |
| M. marinum M | MMAR_4051 | mce3A_1 | 6e-61 | 37.54% (357) | MCE-family protein Mce3A_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | 1e-146 | 58.14% (442) | MCE-family protein MCE1A |
| M. gilvum PYR-GCK | Mflv_0711 | - | 1e-145 | 59.60% (401) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0169 | mce1A | 1e-146 | 58.14% (442) | MCE-family protein MCE1A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 1e-145 | 56.74% (430) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 8e-58 | 34.16% (401) | MCE-family protein |
| M. avium 104 | MAV_4126 | - | 1e-151 | 61.23% (423) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0134 | - | 1e-146 | 62.03% (395) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_0154 | - | 1e-138 | 58.65% (399) | virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_0415 | mce2A | 0.0 | 98.00% (401) | MCE-family protein Mce2A |
| M. vanbaalenii PYR-1 | Mvan_0134 | - | 1e-149 | 61.35% (401) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4883|M.marinum_M ----------MDPRSRPPYKIIGLAALMVLVFFGAMLYWQFRGTFIPKTR
MUL_0415|M.ulcerans_Agy99 ----------MDPRSRPPCKIIGLAALMVLVFFGAMLYWQFRGTFIPKTR
Mflv_0711|M.gilvum_PYR-GCK MTAP------MNTKRQPPYKIAGVVLALVTILILVLVYLQFRGDFLPRTQ
Mvan_0134|M.vanbaalenii_PYR-1 MTVPQA---ALNTRRQPPYKLAGLVLAILTVIAVTLVYLQFRGDFMARTQ
TH_0154|M.thermoresistible__bu MTAP------LNAPRTPPYKIVGVVLLLVVALVVTLVWMQFRGAFTPRTQ
MSMEG_0134|M.smegmatis_MC2_155 MTEPPAPTAPLNKPKTPPYKLAGLILGLVGVLVLALTWMQFRGQFEDKVQ
Mb0175|M.bovis_AF2122/97 MTTP----GKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQ
Rv0169|M.tuberculosis_H37Rv MTTP----GKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTPKTQ
MLBr_02589|M.leprae_Br4923 MTSS----TKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTPKSK
MAV_4126|M.avium_104 --------MQINSQRIPPYKLLAVAVLLVLALILALIYGQFRGAFTEKTQ
MAB_4153c|M.abscessus_ATCC_199 ---------MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFADTKP
: . : . : . : : :.. *
MMAR_4883|M.marinum_M LTMIAPRAGLVTDPGAKVTFNGVQIGRVSSITEVTHDGAPAARFALDVTP
MUL_0415|M.ulcerans_Agy99 LTMIAPRAGLVTDPGAKVTFNGVQIGRVSSITEVTHDGAPAARFALDVTP
Mflv_0711|M.gilvum_PYR-GCK LTMISARSGLSLDSGSKVTFNGVEIGKVSEVEETTVGGEPRAKILLEVNP
Mvan_0134|M.vanbaalenii_PYR-1 LTMISARSGLSMDPGAKVTYNGVEIGRVGNVEETSVDGEPRAKIILDVNP
TH_0154|M.thermoresistible__bu LTLLADRAGLVMDPGSKVTFNGVEIGRVAQIHADTSDDRTRANIVLDVDP
MSMEG_0134|M.smegmatis_MC2_155 LTVLSGRAGLSMDPGSKVTFNGVPIGRLASIDVVEVDDNPEARLTLDVDP
Mb0175|M.bovis_AF2122/97 LTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDP
Rv0169|M.tuberculosis_H37Rv LTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILDVDP
MLBr_02589|M.leprae_Br4923 LTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLDVYP
MAV_4126|M.avium_104 LTMIASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTLEVYP
MAB_4153c|M.abscessus_ATCC_199 ITVVSPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELAVNA
:*::: *:** : *.*:.::*: **:: : *.: * * .
MMAR_4883|M.marinum_M KYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYATSVT
MUL_0415|M.ulcerans_Agy99 KYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYATSVT
Mflv_0711|M.gilvum_PYR-GCK KYLKLIPRNVNADISATTVFGNKYVSFTSPENPQSERISASDVIDVTSVT
Mvan_0134|M.vanbaalenii_PYR-1 KYLDLIPSNVNADISATTVFGNKYVSFTTPEDPRPERISASDVIDVTSVT
TH_0154|M.thermoresistible__bu KYVDLIPSNADVEIKASTVFGNKYVAFASPPDPSLTPITSAATIDVTKVT
MSMEG_0134|M.smegmatis_MC2_155 KYLDLIPENANVELRATTVFGNKYISFLSPKNPSAERLSASTPIRAQGVT
Mb0175|M.bovis_AF2122/97 RYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVT
Rv0169|M.tuberculosis_H37Rv RYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVRSVT
MLBr_02589|M.leprae_Br4923 RYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDARSVT
MAV_4126|M.avium_104 RYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKITPHTIIDARSVT
MAB_4153c|M.abscessus_ATCC_199 KDLRLIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAEAVA
: : ** *. . : .:**** * : : :* .* : . : . *:
MMAR_4883|M.marinum_M TEFNTLFENVTAISEKVDPVKLNLTLSAAAQALSGLGDRLGTALVNGNAI
MUL_0415|M.ulcerans_Agy99 TEFNTLFENVTAISEKVDPDKLNLTLNAAAQALSGLGDRLGTALVNGNAI
Mflv_0711|M.gilvum_PYR-GCK TEFNTLFETVVEIAEQVDPIKLNQTLTATAQALDGLGDRFGESIINGNQI
Mvan_0134|M.vanbaalenii_PYR-1 TEFNTLFETVVSLADQVDPIKLNQTLTATAQALDGLGDRFGESIINGNQI
TH_0154|M.thermoresistible__bu TEFNTLFQTVVDIARQVDPIKLNQTLTATAQALDGLGDRFGESIIDGNAI
MSMEG_0134|M.smegmatis_MC2_155 TEFNTLFETITAISEQVDPIKLNETLTAAAQALDGLGDKFGRSIVDGNAI
Mb0175|M.bovis_AF2122/97 TEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTV
Rv0169|M.tuberculosis_H37Rv TEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNANTV
MLBr_02589|M.leprae_Br4923 TEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNGNSV
MAV_4126|M.avium_104 TEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNANAL
MAB_4153c|M.abscessus_ATCC_199 LEVNTVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVELDQY
*.**:*:.:. : ::** :** **.*..:.* * *:.:* .::: :
MMAR_4883|M.marinum_M LDDVNPLMPQVHRDITGLAALGDIYADASTDLWDAVNSTVTVARTVNQRR
MUL_0415|M.ulcerans_Agy99 LDDVNPLMPQVHRDIRGLAALGDIYADASADLWDAVNSTVTVARTVNQRR
Mflv_0711|M.gilvum_PYR-GCK LAEINPQMPQIRRDNQLLADFGEVYSNAAPDLFDGLQNAVTTARTLNEQQ
Mvan_0134|M.vanbaalenii_PYR-1 LSEINPQMPQIRRDNQLLADLGDVYADAAPDLFDGLQNAVTTARTLNEQQ
TH_0154|M.thermoresistible__bu LDDLNPQMPQIRYDVQRLADLNAVYAAAAPDLFDGLENAVTTAQTLYQER
MSMEG_0134|M.smegmatis_MC2_155 LADVNPRMPQIRRDITGLANLGEVYADASPDLFDGLDNAVTTARTLNEQR
Mb0175|M.bovis_AF2122/97 LDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQ
Rv0169|M.tuberculosis_H37Rv LDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTINAQQ
MLBr_02589|M.leprae_Br4923 LDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTINQQQ
MAV_4126|M.avium_104 LDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTINAQQ
MAB_4153c|M.abscessus_ATCC_199 LDQLNPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVVDQQ
* ::*. :* : * . .. *. ::.*: ::. ::*: .:
MMAR_4883|M.marinum_M SDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQLLDEYSPEIF
MUL_0415|M.ulcerans_Agy99 SDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQLLDEYSPEIF
Mflv_0711|M.gilvum_PYR-GCK GDVDQALMAAVGFGNTGGDIFERGGPYLVRGARDLVPTSALLDKYSPSFF
Mvan_0134|M.vanbaalenii_PYR-1 GDVDQALMAAVGFGNTGGDVFERGGPYLARGAEDLVPTTALLDKYSPSFF
TH_0154|M.thermoresistible__bu GNLDQTLLASIGFGNTAGEVFERGGPYLVRGSEDLVTVTEILDYHSPALF
MSMEG_0134|M.smegmatis_MC2_155 GNLDQALVAAVGFGNTGGDIFERGGPYLVRGAQDLLPTSALLDEYSPALF
Mb0175|M.bovis_AF2122/97 AELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELF
Rv0169|M.tuberculosis_H37Rv AELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSPELF
MLBr_02589|M.leprae_Br4923 KDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSPAIF
MAV_4126|M.avium_104 KDLDQALLSAAGFGNTGADLFTKGGPYLARGAHDLVPTAQLLDTYSPELY
MAB_4153c|M.abscessus_ATCC_199 QDLKATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSPEIP
::. .*::: *:.*. : : . * . * . :*. :** :
MMAR_4883|M.marinum_M CTIRNYDEVAPRIRNALGF-NGYSLGAASSGAISG---------------
MUL_0415|M.ulcerans_Agy99 RTIRNYDEVAPRIRNALGF-NGYSLGAAPSGAISG---------------
Mflv_0711|M.gilvum_PYR-GCK CMMRNYHDVEPKIADALGG-NGYSLKTH-SQVLGLG--------------
Mvan_0134|M.vanbaalenii_PYR-1 CMIRNYHDVEPKIADALGG-NGYSLKTH-SEVLGLG--------------
TH_0154|M.thermoresistible__bu CMIRNYHDVAPKVAASLGG-NGYSLRQH-AFLVGP---------------
MSMEG_0134|M.smegmatis_MC2_155 CTIRNYHDAAPKLAGALGG-NGYSLLTN-SLVVGV---------------
Mb0175|M.bovis_AF2122/97 CTIRNFYDADPLAKAAAGGGNGYSLRTN-SEILSGIGISLLSPLALATNG
Rv0169|M.tuberculosis_H37Rv CTIRNFYDADPLAKAASGGGNGYSLRTN-SEILSGIGISLLSPLALATNG
MLBr_02589|M.leprae_Br4923 CTLRNYHDIEPKVTSFLGG-NGYSINDH-VELLSGLGFLLNPTSAISIIG
MAV_4126|M.avium_104 CTLHNYHDIVPITGASEGGFNGYSLNMN-TEVTSGLGLLLNPVATIPVLA
MAB_4153c|M.abscessus_ATCC_199 CTLQAISKALVTFTPLIGGVRPGLFLTN-SFPLGAP--------------
:: . * . : .
MMAR_4883|M.marinum_M --------------------------------APNPYIYPENLPRVNARG
MUL_0415|M.ulcerans_Agy99 --------------------------------APNPYIYPENLPRVNARG
Mflv_0711|M.gilvum_PYR-GCK --------------------------------AGNAYVYPDNLPRVNAKG
Mvan_0134|M.vanbaalenii_PYR-1 --------------------------------AGNAYVYPDNLPRVNAKG
TH_0154|M.thermoresistible__bu ---------------------------------GNPYVYPDNLPRVNATG
MSMEG_0134|M.smegmatis_MC2_155 ---------------------------------GNPYVYPDNLPRVNAKG
Mb0175|M.bovis_AF2122/97 AAIGIGLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARG
Rv0169|M.tuberculosis_H37Rv AAIGIGLVAGLIAPPLAVAANLAGALPGIVGGAPNPYTYPENLPRVNARG
MLBr_02589|M.leprae_Br4923 AGV---LSQGLLAP---------LGLAGVVNGAANPYIYPENLPRVNARG
MAV_4126|M.avium_104 S---------LVG-----------GIAGLVGGAPNPYIYPENLPRVNARG
MAB_4153c|M.abscessus_ATCC_199 -----------------------------------VYTYPDSLPIVNASG
* **:.** *** *
MMAR_4883|M.marinum_M GP--GGRPGCWQTITRDLWP-APYLVMDVG-ANMAPYNHLEIGQPLLNEY
MUL_0415|M.ulcerans_Agy99 GP--GGRPGCWQTITRDLWP-APYLVMNVG-ANMAPYNHLEIGQPLLNEY
Mflv_0711|M.gilvum_PYR-GCK GP--GGRPGCWQPITRDLWP-APFLVLDTG-ASVAPYNHMELGQPLFTEY
Mvan_0134|M.vanbaalenii_PYR-1 GP--GGRPGCWQPITRDLWP-APFLVLDTG-ASIAPYNHMELGQPLLTEY
TH_0154|M.thermoresistible__bu GP--GGRPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHIELGKPFAIEY
MSMEG_0134|M.smegmatis_MC2_155 GP--EGRPGCWQPITRDLWP-FPYLVMDTG-ASIAPYNHFELGQPMFAEY
Mb0175|M.bovis_AF2122/97 GP--GGAPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHMEVGSPYAVEY
Rv0169|M.tuberculosis_H37Rv GP--GGAPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHMEVGSPYAVEY
MLBr_02589|M.leprae_Br4923 GP--GGAPGCWQHITRDLWP-TPELVMDTG-NSIAPYNHLDSGSPYAIEY
MAV_4126|M.avium_104 GP--GGAPGCWQPITHDLWP-APELVMDTG-NSLAPYNHLETGSPYANEY
MAB_4153c|M.abscessus_ATCC_199 GPNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPDTLQY
** * *. : .. * * ** : . * :.:: . * :*
MMAR_4883|M.marinum_M VWGRQFGENTINP
MUL_0415|M.ulcerans_Agy99 VWGRQFGENTINP
Mflv_0711|M.gilvum_PYR-GCK VWGRQVGEHTINP
Mvan_0134|M.vanbaalenii_PYR-1 VWGRQVGEHTINP
TH_0154|M.thermoresistible__bu VWGRQIGEYTINP
MSMEG_0134|M.smegmatis_MC2_155 VWGRQVGENTINP
Mb0175|M.bovis_AF2122/97 VWGRQVGDNTINP
Rv0169|M.tuberculosis_H37Rv VWGRQVGDNTINP
MLBr_02589|M.leprae_Br4923 VWGRQVGDNTINP
MAV_4126|M.avium_104 VWGRQVGDNTINP
MAB_4153c|M.abscessus_ATCC_199 LYNGAFAKRSEF-
::. ... :