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M. tuberculosis H37Rv Rv1472 (echA12)

annotation: enoyl-CoA hydratase
coordinates: 1659763 - 1660620
length: 285

VPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVMVPLKEALAQVSYDNSVRVVVLT
GAGRGFSPGADHKSAGVVPHVENLTRPTYALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAA
DIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERIGLVSRQVPDEQL
LDACYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPV
FTDDT

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1472 echA12 - 100% (285) enoyl-CoA hydratase
M. tuberculosis H37Rv Rv1070c echA8 6e-29 31.84% (267) enoyl-CoA hydratase
M. tuberculosis H37Rv Rv3516 echA19 1e-23 32.00% (250) enoyl-CoA hydratase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1507 echA12 1e-157 99.65% (285) enoyl-CoA hydratase
M. gilvum PYR-GCK Mflv_3669 - 1e-112 83.88% (242) enoyl-CoA hydratase
M. leprae Br4923 MLBr_01241 - 1e-107 71.96% (271) enoyl-CoA hydratase
M. abscessus ATCC 19977 MAB_2737c - 1e-113 75.66% (267) enoyl-CoA hydratase
M. marinum M MMAR_2278 echA12 1e-133 89.93% (268) enoyl-CoA hydratase, EchA12
M. avium 104 MAV_3307 - 1e-134 90.67% (268) enoyl-CoA hydratase
M. smegmatis MC2 155 MSMEG_3139 - 1e-122 82.26% (265) enoyl-CoA hydratase
M. thermoresistible (build 8) TH_2798 - 1e-124 83.40% (265) PUTATIVE Enoyl-CoA hydratase
M. ulcerans Agy99 MUL_1480 echA12 1e-132 89.55% (268) enoyl-CoA hydratase
M. vanbaalenii PYR-1 Mvan_2741 - 1e-122 82.64% (265) enoyl-CoA hydratase

CLUSTAL 2.0.9 multiple sequence alignment


Rv1472|M.tuberculosis_H37Rv         --MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
Mb1507|M.bovis_AF2122/97            --MPHRCAAQVVAGYRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
MAV_3307|M.avium_104                ------------------MSLVLVDHPRPGVALITLNRPERMNSMAFDVM
MMAR_2278|M.marinum_M               ------------------MALVLLEHPRPDIALVTLNRPERMNSMAFDVM
MUL_1480|M.ulcerans_Agy99           ------------------MSLVLLEHPRPDIALVTLNRPERMNSIAFDVM
Mflv_3669|M.gilvum_PYR-GCK          --------------------------------------------MAFDVM
TH_2798|M.thermoresistible__bu      ---------------------VLVDHPRPHIALVTLNRPERMNSMAFDVM
Mvan_2741|M.vanbaalenii_PYR-1       -----------MHAVTDGDGFVLVEHPRPHVALVTLNRPERMNSMAFDVM
MSMEG_3139|M.smegmatis_MC2_155      --------------MTDDTRFVLLDRSRPGVALVTLNRPERMNSMAFDVM
MAB_2737c|M.abscessus_ATCC_199      ------------------MSFVLVDRPRPEIALVTLNRPERMNAMAFDVM
MLBr_01241|M.leprae_Br4923          MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
                                                                                :*:*:*

Rv1472|M.tuberculosis_H37Rv         VPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHKSAGVVPHVENLTRPT
Mb1507|M.bovis_AF2122/97            VPLKEALAQVSYDNSVRVVVLTGAGRGFSSGADHKSAGVVPHVENLTRPT
MAV_3307|M.avium_104                VPLKEALQKVTYDNAVRVVVLTGAGRGFSSGADHKSAGTVPHVEGLTRPT
MMAR_2278|M.marinum_M               VPLKEVLEEVSYDNSVRVVVLTGAGRGFSSGADHKSAGAVPNVGGLTRPT
MUL_1480|M.ulcerans_Agy99           VPLKEVLEEVSYDNSVRVVVLTGAGRGFSSGADHKSAGAVPNVGGLTRPT
Mflv_3669|M.gilvum_PYR-GCK          VPLKAALDELTYDNDVRAVVLTGAGHGFSSGADHKSAGSVPHVDGLTRPA
TH_2798|M.thermoresistible__bu      VPLKAALDEITYDNDVRVVVLTGAGRGFSSGADHKSAGTVPHVDGLTRPS
Mvan_2741|M.vanbaalenii_PYR-1       VPLKTALDEITHDNDIRVVVLTGAGAGFSSGADHKSAGSVPHVAGLTRPT
MSMEG_3139|M.smegmatis_MC2_155      VPLLELLGDLRHDNSVRVVILTGAGRGFSSGADHKSAGSVPHVDGLTRPT
MAB_2737c|M.abscessus_ATCC_199      LPFKQMLVDISHDNDVRAVVITGAGKGFCSGADQKSAGPIPHIGGLTQPT
MLBr_01241|M.leprae_Br4923          KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPV
                                     .:   *  : :*: :*.*::**** **..***:* :. :*:: .**:* 

Rv1472|M.tuberculosis_H37Rv         YALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSS
Mb1507|M.bovis_AF2122/97            YALRSMELLDDVILMLRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSS
MAV_3307|M.avium_104                YALRSMEILDEVILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASTS
MMAR_2278|M.marinum_M               YALRSMELLDEVILMLRRLHQPVIAAVNGPAIGGGLCLALAADVRVAAAS
MUL_1480|M.ulcerans_Agy99           YALRSMELLDEVILMLRRLHQPVIAAVNGPAIGGGLCLALAADVRVAAAS
Mflv_3669|M.gilvum_PYR-GCK          FGLRSMEVLDDVILALRKLHQPVIAAVNGAAIGGGLCLALAADIRVASTS
TH_2798|M.thermoresistible__bu      YGLRSMEVLDDVILTLRKLHQPVIAAVNGAAIGGGLCLALAADIRIASTE
Mvan_2741|M.vanbaalenii_PYR-1       FGLRSMEVLDDVILALRKLHQPVIAAVNGAAIGGGLCLALAADIRVAGSD
MSMEG_3139|M.smegmatis_MC2_155      YALRSMEVLDNVILALRRLHQPVIAAVNGAAIGGGLCLALACDVRIAAHN
MAB_2737c|M.abscessus_ATCC_199      IALRSMELLDEVILTLRRMHQPVIAAINGAAIGGGLCLALACDVRVASQD
MLBr_01241|M.leprae_Br4923          RALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTR
                                     .**:**:*::*** **::*******:**.***********.*:*:*.  

Rv1472|M.tuberculosis_H37Rv         AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERI
Mb1507|M.bovis_AF2122/97            AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVSAEEAERI
MAV_3307|M.avium_104                AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVTAEEAERI
MMAR_2278|M.marinum_M               AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVTAEEAERI
MUL_1480|M.ulcerans_Agy99           AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVTAEEAERI
Mflv_3669|M.gilvum_PYR-GCK          AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVDAEEAERI
TH_2798|M.thermoresistible__bu      AYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTGRDVDAEEAERI
Mvan_2741|M.vanbaalenii_PYR-1       AYFRAAGINNGLTASELGLSYLLPRAIGASRAFEIMLTGRDVDADEAERI
MSMEG_3139|M.smegmatis_MC2_155      AYFRAAGINNGLTASELGLSYLLPRAIGTSRAFEIMLTGRDVDAAEAERI
MAB_2737c|M.abscessus_ATCC_199      AYFRAAGINNGLTASELGLSYLLPRAIGTSRASDIMLTGRDVDADEAERI
MLBr_01241|M.leprae_Br4923          AYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQI
                                    ************:*************:*:*** :***:**** * ***:*

Rv1472|M.tuberculosis_H37Rv         GLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAH
Mb1507|M.bovis_AF2122/97            GLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLWSGLDAASLEAH
MAV_3307|M.avium_104                GLVSCQVPEEQLLDTCYAIAARIAAFSRPGIELTKRTLWSGLDAGSLEGH
MMAR_2278|M.marinum_M               GLVSCRVPDGQLLDTCYAIAARMAAFSRPGIELTKRTLWSGLDAASLEGH
MUL_1480|M.ulcerans_Agy99           GLVSCRVPDGQLLDTCYAITARMAAFSRPGIELTKRTLWSGLDAASLEGH
Mflv_3669|M.gilvum_PYR-GCK          GLVSRRVADEDLLETCYELAERIAGFSRPGTELTKRTLWSGLDAGSLEAH
TH_2798|M.thermoresistible__bu      GLVSRRVPPAELLDTCYELADRIAGFSRPGTELTKRTLWSGLDAGSLESH
Mvan_2741|M.vanbaalenii_PYR-1       GLVSRRVPAEDLLPTCYDIAERIAGFSRPGTELTKRTLWTGLDAGSLEAH
MSMEG_3139|M.smegmatis_MC2_155      GLVSRTVPDDDLLETCFEMAQRMRGFSRPGIELTKRTLWSGLDAASLEGH
MAB_2737c|M.abscessus_ATCC_199      GLVSRKVASESLLEECYAIGERIAGFSRPGIELTKRTIWSGLDAASLESH
MLBr_01241|M.leprae_Br4923          GLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLDKH
                                    ****  *.   **  *: :  *:  ***.* *****::* ****.**: *

Rv1472|M.tuberculosis_H37Rv         MQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT-------
Mb1507|M.bovis_AF2122/97            MQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT-------
MAV_3307|M.avium_104                MQAEGLGQLFVRLLTANFEEAVAARAERRPPVFTDDK-------
MMAR_2278|M.marinum_M               MQAEGLGQLFVRLLTANFEEAVAARAEKRPAVFTDDK-------
MUL_1480|M.ulcerans_Agy99           MQAEGLGQLFVRLLTANFEEAVAARAEKRPAVFTDDK-------
Mflv_3669|M.gilvum_PYR-GCK          MQAEGLGQLYIRLLTDNFEEAVAARREKRAPRFSDDR-------
TH_2798|M.thermoresistible__bu      MHAEGLGQLYIRLLTHNFEEAVAARKEKRAPRFPDDKI------
Mvan_2741|M.vanbaalenii_PYR-1       MQAEGLGQLYIRLLTSNFEEAVAARKEKRPPSFTDDK-------
MSMEG_3139|M.smegmatis_MC2_155      MQAEGLGQLFVRLLTANFEEAVAARAEKRPPAFTDDK-------
MAB_2737c|M.abscessus_ATCC_199      MHQEGLGQLYVRLLTDNFEEATAARKEKRPAEFRDKR-------
MLBr_01241|M.leprae_Br4923          MQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
                                    *: *.*.**:: * * *****.*.  *:*.. : *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1472	echA12	-	100% (285)	enoyl-CoA hydratase
M. tuberculosis H37Rv	Rv1070c	echA8	6e-29	31.84% (267)	enoyl-CoA hydratase
M. tuberculosis H37Rv	Rv3516	echA19	1e-23	32.00% (250)	enoyl-CoA hydratase