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RSVYSRISSMTAQQRAALSEEFSRASRTTTAEPVAVVGIGCRFPGNVTGPDSFWDLLVEGGNAISGIPAE RWDADDYYHPDPLTPGHMTTKWGAFVADIAGFDAEFFGITPREAASMDPQQRMLLEVTWEALEHAGIPTE SLAGTRTAVMMGVYFNEYQSMLASSRENVDAYTGTGNSHSITAGRISYLLGLRGPAAAIDTACSSSLSAI HLACQSLRLRETDLALAGGVSATLRPETQIAISAWGLLSPEGRCATFDAAADGFVRGEGAGVVVLKRLTD ALRDQDQILAVVRGSAVNQDGRSNGITAPNTAAQCDVIADALRSADVAPESVHYVETHGTGTQLGDPIEF EALAATYGLIKGQDGDSCALGAVKTNIGHLEAASGVAGFIKAVLAVQHGQIPPNLHFSQWNPAIDAASTR LFVPLDNIAWPSDSGPRRAAVSSFGLGGTNAHAIVEQGPELSPAGRRGTDDEVTTLVVAGKTPARVAATA GMLADWMEGPGAEVALADVAHTLNHHRSRQARFGTVVARERAQAVAGLRALAANQHAPGVVNPADAPPEP GTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFLAEAGFSLHDVLANGTELVGIEQIQLGLIGMQ LTLTELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLGLDASQTE ALIADYPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSELAD LAPRTPTIPIISTTYADLGSARESGPTFDAEHWAINMRNPVHFQQAITAAATDKHNFIEISAHPLLTQAI LETLHTVQPGSKHTCLGTLQRDSDDTIVFRTNLNTVRTAPPQTPHPPEPHPQIPTTPWHHTHHWIDNAAS SSPALSRSESRDGTGAALDTRWSPESGSLLDEWSHKVVWAAQSLPDTPSAQTAVHGRWLVLGNADLAAEL GRGADVLDSDSEPAALARALSDVDYVLYAPPVPADPLDVAEAYQLFHQARRLATAMIANGSPAKLLIATR NAQPIAEGDPANPSHGVLWGLGRTITLEHPEIWGAIIDFDNSVPAQVVARQVLDEADATDSEDQVVYRSG VRHVPRLRRHSLAAQPVALDAGASQLVIGATGNIGPHLINQLAEMGAKTIVAVSRNPGQRLQKLAESLAA EGVNLVIAAADATDEAAMTALFDRFGADLPPLEGIYLAAFAGQPVLLTEMTNDDVTAMFAPKLDAAALLH RLSLKVPVRHFVLFSSISGLIGSRWLAHYTATSGYLDALAYARRVMGLPATTVNWGLWKSLADAEHDASQ VSLGSGLVPMQDDVAIGALPLVMSQAAGVHSVVVAADWPLLAAAYRTRGSLRIVDDVLPVSDETTVLESE FRVALRNCAPERRHDMLHDQVAMLAANVMGLHAGESLDPSTGFFQLGMDSLMSVTLQRALSDSLGEFLPP SVVFDYPTVYSLTDYLATILPELETDDESTADVYDELTEAELLEQLSQRLRGT*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1775 | ppsB | - | 100% (1524) | phenolpthiocerol synthesis type-I polyketide synthase PpsB |
M. marinum M | MMAR_1776 | ppsA | 0.0 | 69.17% (1515) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. marinum M | MMAR_1773 | ppsD | 0.0 | 61.90% (916) | phenolpthiocerol synthesis type-I polyketide synthase PpsD |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2957 | ppsB | 0.0 | 73.20% (1552) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
M. gilvum PYR-GCK | Mflv_3393 | - | 0.0 | 52.37% (1516) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2932 | ppsB | 0.0 | 73.13% (1552) | phenolpthiocerol synthesis type-I polyketide synthase PPSB |
M. leprae Br4923 | MLBr_02356 | - | 0.0 | 72.49% (1556) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 34.65% (1550) | polyketide synthase |
M. avium 104 | MAV_1763 | - | 0.0 | 33.38% (1555) | tylactone synthase modules 4 & 5 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 33.42% (1547) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4621 | - | 0.0 | 45.62% (822) | PUTATIVE mycocerosic acid synthase |
M. ulcerans Agy99 | MUL_2018 | ppsB | 0.0 | 99.47% (1514) | phenolpthiocerol synthesis type-I polyketide synthase PpsB |
M. vanbaalenii PYR-1 | Mvan_3126 | - | 0.0 | 53.05% (1525) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment MAB_0939|M.abscessus_ATCC_1997 MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDVLREGRDAISEVPADR MSMEG_0408|M.smegmatis_MC2_155 MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWALLRDGREAISDVPKDR MAV_1763|M.avium_104 MSTVEGLRDPASSFAIVGYAARFPGAADADEFWRVLAEGRDAVSEVPKDR Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 WDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPFFGMSTREVRLMDPQH MSMEG_0408|M.smegmatis_MC2_155 WDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPFFGMSAREVRLMDPQH MAV_1763|M.avium_104 WDADEFFDPDPDAPGKVVTRRAGFVDDVTGFDAPFFGMSAREARLLDPQH Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATHDYLGMASDELTFPEI MSMEG_0408|M.smegmatis_MC2_155 RILMETAWRAVEHSGIAPTSLANSNTGVFVGLATHDYLGMASDELTYPEI MAV_1763|M.avium_104 RLLLETAWRAVEHSGTAPTDLANTNTGVFIGISTHDYLGMASDELTYDQI Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACSSSLVAIHQACQALQL MSMEG_0408|M.smegmatis_MC2_155 EAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL MAV_1763|M.avium_104 EAYTAIGTSSAAAAGRISYRLGLQGPAVAVDTACSSSLVAIHQACQALRL Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GECDLALAGGANVLLTPATMITFSHAHMLAPDGKCKTFDAAADGYVRGEG MSMEG_0408|M.smegmatis_MC2_155 NECDLALAGGANVLLTPATMITFSNAHMLAPDGRCKTFDAAADGYVRGEG MAV_1763|M.avium_104 GECDLALAGGANVLLTPATMITFSQAHMLAPDGRCKTFDAAADGYVRGEG Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA MSMEG_0408|M.smegmatis_MC2_155 CGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA MAV_1763|M.avium_104 CGVLVVKRLEDAIRDGDRIRAVIRGSAINQDGASGGLTVPNGVAQQRVIA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAGAAYGIGRETNDPLLI MSMEG_0408|M.smegmatis_MC2_155 DALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAGEVLGAGRAPEEPLLI MAV_1763|M.avium_104 EALQRAGIAPGDVDYLEAHGTGTSLGDPIEVQAAGAVLGAGREASRPLLI Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHRNFQNPSPHIPWDRLP MSMEG_0408|M.smegmatis_MC2_155 GSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHLNFETPSPHIPWERLP MAV_1763|M.avium_104 GSVKTNIGHLEAAAGIAGVIKVILALEHGMLPQHLHFRDPSPHIPWDRLA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VEVVREARPWGRNGRPRIAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPA MSMEG_0408|M.smegmatis_MC2_155 IEVVRETVPWQRNGKPRIAGVSSFGFAGTNAHVILEEAPAVGTPATTEPV MAV_1763|M.avium_104 VQVVKEATAWQRNGRPRVAGVSSFGFAGTNAHVILEEAPDGTGRAAVPPA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PAGG---RKFSILPLSARTPAALAQLADKYRAWLNAHPEAALADLCFTAG MSMEG_0408|M.smegmatis_MC2_155 EDP----RRYSVLPLSARTPEALVRLAGEYRDWLRAHPQARLADVSHTAG MAV_1763|M.avium_104 AVRPPGQRRFHVLPLSARTPAALVQIAGEYRDWLSAHPDTALADLCLTAG Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VGRAHLEHRAALVVNTREAAVELLSAVADDRPAPGLGRGESHDTPKTAWL MSMEG_0408|M.smegmatis_MC2_155 TARAHLEQRAALVVNSRESAIELLGALADDRPAPGLVRGESHEAPKTAWL MAV_1763|M.avium_104 AGRAHFEHRAALVVDSTGSAGELLAALADDRPAPGLLRGVCEDAPKTAWL Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FTGQGSQYPGMARELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVDG MSMEG_0408|M.smegmatis_MC2_155 FTGQGSQYPGMARELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDADE MAV_1763|M.avium_104 FTGQGSQYAGMARELFDTEPVFAETLTRCATVLADVLEKPLLDVIFDTDD Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PE--AEETLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSA MSMEG_0408|M.smegmatis_MC2_155 LDGDTESPLRHTTYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSA MAV_1763|M.avium_104 PA--SEATLRQTSYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ACVAEVFSLEDGARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFP MSMEG_0408|M.smegmatis_MC2_155 ACVAGVFDVEDGARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYP MAV_1763|M.avium_104 ACVAGVLRVEDGARLIAERGRLFGSLPAGGRMVAAFAAAARVEGLTDEFP Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SLSVAAYNGANTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLD MSMEG_0408|M.smegmatis_MC2_155 SLSVAAYNGANTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLD MAV_1763|M.avium_104 SLSVAAYNGANTVLSGPGQELEQAVARLTAEKVRCDWLDTSHAFHSALLD Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 PILDEFEAYANQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPV MSMEG_0408|M.smegmatis_MC2_155 PILDDFESFAQKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPV MAV_1763|M.avium_104 PILDEFESYANQFDFGPPQRILICNRTGSALGRSVKLDGAYWRRHARQPV Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 EFAKSVRTLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRN MSMEG_0408|M.smegmatis_MC2_155 EFAKSVRTLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPT MAV_1763|M.avium_104 EFAKSVHTLADLGCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRN Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TADHRQITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSD MSMEG_0408|M.smegmatis_MC2_155 TADHRQITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSD MAV_1763|M.avium_104 TADHRQITEALAEAYIVGHLPDFGAAVG-PARKLDLPTYPFQHRQYWFSE Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 KRDGDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLN MSMEG_0408|M.smegmatis_MC2_155 NRAIDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLR MAV_1763|M.avium_104 QRVPPGSQQTS-------TQTTAVRLLEDGRIAELAELLDGASADQHTLD Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VLTKLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVAD MSMEG_0408|M.smegmatis_MC2_155 VLNKLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAA--ADWILVGD MAV_1763|M.avium_104 VLTKLAAQHNQQRKSRSIAEDRYEIRWEKSTVPGPEAEAT----WLVVGD Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADEDSALRI MSMEG_0408|M.smegmatis_MC2_155 DTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG--ELYV MAV_1763|M.avium_104 DDDAVAPLVDALTARGHQHRILVLPASDADEERLEIVLRAAAAEEAPLRI Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VHVAALAGQGSSSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIWIVTRG MSMEG_0408|M.smegmatis_MC2_155 VHIAAGDG-AAAPMRDLLRVQHRTLGGLRRLFRAANDAELRSPIWLVTRD MAV_1763|M.avium_104 ALVAALDSGTAPSMRSLLRMQHRVLAGTRRLFRAAAAAELRQPIWLVTRG Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDEWAQFI MSMEG_0408|M.smegmatis_MC2_155 GQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT-EWPRLI MAV_1763|M.avium_104 AQRVTDADTVFPDQSCLWGFGRAASLEYPQLWGGLADLAQGSAEEWSRLV Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 GRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVRSDATYLV MSMEG_0408|M.smegmatis_MC2_155 ARITSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVREDRTYLV MAV_1763|M.avium_104 RVASAPRDPAVGEDQIALRGSDIYVPRLTRRSGQPAAAALTLRADATYLV Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TGGLGSIGLEIAGYLAGRGAKHLVLTSRREPGEAARQRIDALAAQ-GCEV MSMEG_0408|M.smegmatis_MC2_155 TGGLGAIGLEVAGYLASHGAGHVVLTSRREPGDDARRRLDGLREQYACDV MAV_1763|M.avium_104 TGGLGSIGLEIAGHLAAQGARHLVLTGRRAPGEAAQRRIDALSQQHGCEV Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEV MSMEG_0408|M.smegmatis_MC2_155 RVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEV MAV_1763|M.avium_104 RVIAADVADAHHVARLLGAVRAELPPVAGIVHAAGEIGTTPLSDLEDAEI Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 DRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAAN MSMEG_0408|M.smegmatis_MC2_155 DRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAAN MAV_1763|M.avium_104 DRVFAGKVWGAWHLSEAAADLR--LDFFVSTSSIASVWGGLGQTAYGAAN Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTD MSMEG_0408|M.smegmatis_MC2_155 AFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAE MAV_1763|M.avium_104 AFLDGLAWRLREQGVNGISVNFGPWAAGMADENARARLAQRGIKTLSPAD Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVP MSMEG_0408|M.smegmatis_MC2_155 ALAGMADVVAG----PVQGVVAKIDWSRFLPLYQQAGRRAFLSELESELP MAV_1763|M.avium_104 ALAGLADVMAT---AAAQGVVARIDWTRFLPLYQQAGQRSLLAELAREIP Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SHLAGVAG--AQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDV MSMEG_0408|M.smegmatis_MC2_155 AAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDA MAV_1763|M.avium_104 DFAPAPTP----SGKTGLVERLAGAPVQQRRKLMTEFLRNAVAEVTRVDA Mflv_3393|M.gilvum_PYR-GCK ------------------------MTSASDEAAVRRWLIDYLVTNNGCSP Mvan_3126|M.vanbaalenii_PYR-1 ------------------------MTSAFDEAAVRRWLVDYLVTNNGCSP MMAR_1775|M.marinum_M ------------------------MRSVYSRISS---------------M MUL_2018|M.ulcerans_Agy99 -------------------------------------------------M Mb2957|M.bovis_AF2122/97 -----------------------MMRTAFSRISG---------------M Rv2932|M.tuberculosis_H37Rv -----------------------MMRTAFSRISG---------------M MLBr_02356|M.leprae_Br4923 ------------------------MRTAFSRISG---------------M TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 SEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVAD MSMEG_0408|M.smegmatis_MC2_155 DEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAAD MAV_1763|M.avium_104 AEIREDAGFFDLGMDSLMAIELRRHIEQGVGKQIPATLAMDYPRLSDVAE Mflv_3393|M.gilvum_PYR-GCK EHIERGASMHDLGVGSRDAVVLTGVLSEYLGRTVSPVDFWQYPTVDSLAK Mvan_3126|M.vanbaalenii_PYR-1 EHIERGASMHDLGVGSRDAVVLTGVLSEYLGRAVSPVDFWQYPTVDALAK MMAR_1775|M.marinum_M TAQQRAALSEEFSRASR--------------------------------- MUL_2018|M.ulcerans_Agy99 TAQQRAALSEEFSRASR--------------------------------- Mb2957|M.bovis_AF2122/97 TAQQRTSLADEFDRVSR--------------------------------- Rv2932|M.tuberculosis_H37Rv TAQQRTSLADEFDRVSR--------------------------------- MLBr_02356|M.leprae_Br4923 TTQQRAALIEEFTKLSR--------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 YLLGDVLGLAEQAKPAAQLAS---AVTGRTDEPIAIVAVSCRFPG----- MSMEG_0408|M.smegmatis_MC2_155 YLLVEVLGLGEQTN--VRQAS---TVTARTDDPIAVVAVSCRFPG----- MAV_1763|M.avium_104 YLLGDVLDLRGQPDAKPAPPAGTPAPAGRTDEPIAIVAMACRFPG----- Mflv_3393|M.gilvum_PYR-GCK FLTGGEVEP---------IEVGGAARPAGMDEPIAVIGLGLRLPGGDDLD Mvan_3126|M.vanbaalenii_PYR-1 FLTGGEVEP---------VDPGPGVRPAATNEPIAVIGLGLRLPGGADLD MMAR_1775|M.marinum_M ---------------------------TTTAEPVAVVGIGCRFPG----- MUL_2018|M.ulcerans_Agy99 ---------------------------TTTAEPVAVVGIGCRFPG----- Mb2957|M.bovis_AF2122/97 ---------------------------IAVAEPVAVVGIGCRFPG----- Rv2932|M.tuberculosis_H37Rv ---------------------------IAVAEPVAVVGIGCRFPG----- MLBr_02356|M.leprae_Br4923 ---------------------------IAVAEPIAVVGIGCRFPG----- TH_4621|M.thermoresistible__bu ----------------------VNIVGDTPVNAVAVIGMACRLPG----- :.:*::.:. *:** MAB_0939|M.abscessus_ATCC_1997 --APDPEAFWDVLSGGVDAIREVPEDRFDIDEFYDPDPEVAGKTYTRFGG MSMEG_0408|M.smegmatis_MC2_155 --APDPESFWELLAGGVDAIREVPEDRWDIDEFYDPDPDTPGKTYTRFGG MAV_1763|M.avium_104 --AADPEAFWELLSGGVDAIREVPEDRFDIDEFYDPDPETPGKMYSRFGG Mflv_3393|M.gilvum_PYR-GCK GNIEGPDAYWDFLTEGRSSVREVPEDRWSWFNDGTPEGAAALAATTRWGS Mvan_3126|M.vanbaalenii_PYR-1 SNIEGPEAFWEFLTEGRSSVREVPEDRWEWCEDGTPEGAAALADTTRWGS MMAR_1775|M.marinum_M -NVTGPDSFWDLLVEGGNAISGIPAERWDADDYYHPDPLTPGHMTTKWGA MUL_2018|M.ulcerans_Agy99 -NVTGPDSFWDLLVEGGNAISGIPAERWDADDYYHPDPLTPGHMTTKWGA Mb2957|M.bovis_AF2122/97 -DVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGG Rv2932|M.tuberculosis_H37Rv -DVDGPESFWDFLVAGRNAISTVPADRWDAEAFYHPDPLTPGRMTTKWGG MLBr_02356|M.leprae_Br4923 -DVTGPDSFWDLLIDGRNAISRVPADRWDADAFYDPDPLTPGRMTTKWGG TH_4621|M.thermoresistible__bu -GIDSPQRLWEALLRGDDMVTEIPVDRWDADDYFDPEPGVPGRTVSRWGA .*: *: * * . : :* :*:. *: .. :::*. MAB_0939|M.abscessus_ATCC_1997 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRG MSMEG_0408|M.smegmatis_MC2_155 FLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRG MAV_1763|M.avium_104 YLDQIDEFDPEFFGISPREAVWIDPQQRLVLETVWEGLERAGYSPAALRG Mflv_3393|M.gilvum_PYR-GCK YLRDLDAFDAEFFEIMPREATRMDPQQRLLLEVTHEALENAGIAADALAE Mvan_3126|M.vanbaalenii_PYR-1 FLRDLDAFDAEYFEIIPREATRMDPQQRLLLEVTHEALENAGIAADSLAE MMAR_1775|M.marinum_M FVADIAGFDAEFFGITPREAASMDPQQRMLLEVTWEALEHAGIPTESLAG MUL_2018|M.ulcerans_Agy99 FVADIAGFDAEFFGITPREAASMDPQQRMLLEVTWEALEHAGIPTESLAG Mb2957|M.bovis_AF2122/97 FVPDVAGFDAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGG Rv2932|M.tuberculosis_H37Rv FVPDVAGFDAEFFGITPREAAAMDPQQRMLLEVAWEALEHAGIPPDSLGG MLBr_02356|M.leprae_Br4923 FVSDIAGFDAAFFGITPREAAAMDPQQRILLEVAWEALENAGIPPDSLGN TH_4621|M.thermoresistible__bu FLDDVAGFDPEFFGISEREAISIDPQQRLLLETSWEAMEHAGLTPADVEG :: : **. :* * *** ::****::**. *.:*.** .. : MAB_0939|M.abscessus_ATCC_1997 SRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFE MSMEG_0408|M.smegmatis_MC2_155 SRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFE MAV_1763|M.avium_104 SRSGIFVGVGANEYSHLLSAESVDKIEPHFITGNALNAISGRVAFALGLE Mflv_3393|M.gilvum_PYR-GCK TRTGVFAGASAGDYAQMGAT-DLGGIDAWYGTGGSISIIANRVSYFFDLR Mvan_3126|M.vanbaalenii_PYR-1 TQTGVFAGASAADYAQLGAT-DLSGIDAWYSTGGALSIIANRVSYYFDLR MMAR_1775|M.marinum_M TRTAVMMGVYFNEYQSMLAS-SRENVDAYTGTGNSHSITAGRISYLLGLR MUL_2018|M.ulcerans_Agy99 TRTAVMMGVYFNEYQSMLAS-SRENVDAYTGTGNSHSITAGRISYLLGLR Mb2957|M.bovis_AF2122/97 TRTAVMMGVYFNEYQSMLAA-SPQNVDAYSGTGNAHSITVGRISYLLGLR Rv2932|M.tuberculosis_H37Rv TRTAVMMGVYFNEYQSMLAA-SPQNVDAYSGTGNAHSITVGRISYLLGLR MLBr_02356|M.leprae_Br4923 SRTGVMIGVYFNEYQSMLAS-SLENVDAYSGTGNAHSITVGRISYLLGLR TH_4621|M.thermoresistible__bu SSTGVFVGLSHDDYALLTSD-AGALEEAYGFTGSAFSMASGRIAYRLGVH : :.:: * :* : : :. **.: . .*::: :... MAB_0939|M.abscessus_ATCC_1997 GPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAAS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAAS MAV_1763|M.avium_104 GPAVAVDTACSSSLVAVHQACQALHSGDCDLALAGGVNVLLSPVSNIAAS Mflv_3393|M.gilvum_PYR-GCK GPSVTIDTACSSSLVAVHLAAQSLRTGDSDLALAAGVNLLLSPAGTRGLD Mvan_3126|M.vanbaalenii_PYR-1 GPSVTVDTACSSSLVAIHLACQSLRSGDSELALAAGVNLLLSPAPTRSFD MMAR_1775|M.marinum_M GPAAAIDTACSSSLSAIHLACQSLRLRETDLALAGGVSATLRPETQIAIS MUL_2018|M.ulcerans_Agy99 GPAAAIDTACSSSLSAIHLACQSLRLRETDLALAGGVSATLRPETQIAIS Mb2957|M.bovis_AF2122/97 GPAVAVDTACSSSLVAVHLACQSLRLRETDLALAGGVSITLRPETQIAIS Rv2932|M.tuberculosis_H37Rv GPAVAVDTACSSSLVAVHLACQSLRLRETDLALAGGVSITLRPETQIAIS MLBr_02356|M.leprae_Br4923 GPSLAVDTACSSSLVAVHLACQSLRLRETDLVLAGGVSITLRPETQIAIS TH_4621|M.thermoresistible__bu GPAVTVDTACSSSLLAVHMACRSLQVGESDLALAGGAMVMLEPRKYTSAS **: ::******:* *:* * ::*: : :*.**.*. * * . . MAB_0939|M.abscessus_ATCC_1997 RARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIP MSMEG_0408|M.smegmatis_MC2_155 RARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIP MAV_1763|M.avium_104 RARMLSPVGRCKTFDATADGYVRSEGCGILVLKRMSDAVRDGDRVCAVIP Mflv_3393|M.gilvum_PYR-GCK QAEALSPTGQCHAFDASADGFVRGEGCGVAVLKRLSDAQRDGDRVLAVIR Mvan_3126|M.vanbaalenii_PYR-1 RAKAMSPTGQCHAFDAGADGFVRGEGCGVAVLKRLSDAQRDGDRVLAVIR MMAR_1775|M.marinum_M AWGLLSPEGRCATFDAAADGFVRGEGAGVVVLKRLTDALRDQDQILAVVR MUL_2018|M.ulcerans_Agy99 AWGLLSPEGRCATFDAAADGFVRGEGAGVVVLKRLTDALRDQNQILAVVR Mb2957|M.bovis_AF2122/97 AWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDQVLAVVR Rv2932|M.tuberculosis_H37Rv AWGLLSPQGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDQVLAVVR MLBr_02356|M.leprae_Br4923 AWGLLSPHGRCAAFDAAADGFVRGEGAGVVVLKRLTDAVRDGDLVLAVVR TH_4621|M.thermoresistible__bu GLGMLSPTGRCHAFDVAADGFVRSEGSVMLLLKRLPDALRDNDRILAVVR :** *:* :**. ***:**.**. : :***:.** ** : : **: MAB_0939|M.abscessus_ATCC_1997 GSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTP MSMEG_0408|M.smegmatis_MC2_155 ASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTP MAV_1763|M.avium_104 ASAVNQDGASSGLTVPNGGAQQRLIATALSRAGLSGDDVDYLEAHGTGTA Mflv_3393|M.gilvum_PYR-GCK GSAVNQDGRSNGLMAPNPSAQIAVLRAAYAAAGVNPREVDYVEAHGTGTL Mvan_3126|M.vanbaalenii_PYR-1 GSAVNQDGRSNGLMAPNPSAQMAVLRAAYAAAGVDPREVDYVEAHGTGTL MMAR_1775|M.marinum_M GSAVNQDGRSNGITAPNTAAQCDVIADALRSADVAPESVHYVETHGTGTQ MUL_2018|M.ulcerans_Agy99 GSAVNQDGRSNGITAPNTAAQCDVIADALRSADVAPESVHYVETHGTGTQ Mb2957|M.bovis_AF2122/97 GSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAHGTGTV Rv2932|M.tuberculosis_H37Rv GSAVNQDGRSNGVTAPNTAAQCDVIADALRSGDVAPDSVNYVEAHGTGTV MLBr_02356|M.leprae_Br4923 GSAVNQDGRSNGVTAPNTAAQCDVITDALRSSDVAPESVNYVESHGTGTV TH_4621|M.thermoresistible__bu GTAANQDGRTENISTPSIQAQADVYRSALAVAGVDPATVGMVEAHGTGTP .::.**** :..: .*. ** : . ..: * :*:***** MAB_0939|M.abscessus_ATCC_1997 LGDPIEVQAAAAAYG--GSRDADRPLLMGSVKSNIGHTESASGAAGLIKV MSMEG_0408|M.smegmatis_MC2_155 LGDPIEVQAAAAAYG--AGRDADRPLLMGSVKTNIGHTESASGAAGLIKV MAV_1763|M.avium_104 LGDPIEVQAAGAVYG--ATRDTDRPLLIGSVKTNIGHLEAASGVAGLIKV Mflv_3393|M.gilvum_PYR-GCK LGDPIEARALGTVLG--KGRPADAPLMIGAVKSNLGHLEAAAGIAGFAKA Mvan_3126|M.vanbaalenii_PYR-1 LGDPIEARALGTVLG--KGRAADAPLLLGAVKSNLGHLEAAAGIAGFAKA MMAR_1775|M.marinum_M LGDPIEFEALAATYGLIKGQDGDS-CALGAVKTNIGHLEAASGVAGFIKA MUL_2018|M.ulcerans_Agy99 LGDPIEFEALAATYGLIKGQDGYS-CALGAVKTNIGHLEAASGVAGFIKA Mb2957|M.bovis_AF2122/97 LGDPIEFEALAATY----GHGGDA-CALGAVKTNIGHLEAAAGIAGFIKA Rv2932|M.tuberculosis_H37Rv LGDPIEFEALAATY----GHGGDA-CALGAVKTNIGHLEAAAGIAGFIKA MLBr_02356|M.leprae_Br4923 LGDPIEFEALAATY----GRGESA-CALGAVKTNLGHLEAAAGIAGFIKT TH_4621|M.thermoresistible__bu VGDPIEYNSLTQVYG------KTGPCALTSVKTNFGHAESAAGALGMMKA :***** .: . : :**:*:** *:*:* *: *. MAB_0939|M.abscessus_ATCC_1997 VLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQANGR---PRRA MSMEG_0408|M.smegmatis_MC2_155 VLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQTNGR---VRRA MAV_1763|M.avium_104 VLSLQHEMLPQSLHFETPSPHIPWDSLPLRVVDKAVPWQTNGR---PRRA Mflv_3393|M.gilvum_PYR-GCK VLALQHNRIPGNRGWQTPNPHIPFDKLRLRVIDEHTDWAPAGR---PRRA Mvan_3126|M.vanbaalenii_PYR-1 VLALQHNMIPANLGYQSPNPHIPFEKLRLKVVAEHTDWAPAGR---PRRA MMAR_1775|M.marinum_M VLAVQHGQIPPNLHFSQWNPAIDAASTRLFVPLDNIAWPSDSG---PRRA MUL_2018|M.ulcerans_Agy99 VLAVQHGQIPPNLHFSQWNPAIDAASTRLFVPLDNIAWPSDSG---PRRA Mb2957|M.bovis_AF2122/97 TLAVQRATIPPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEG---PRRA Rv2932|M.tuberculosis_H37Rv TLAVQRATIPPNLHFSQWNPAIDAASTRFFVPTQNSPWPTAEG---PRRA MLBr_02356|M.leprae_Br4923 VLAVQRGQIPPNLHFSQWNPAIDAASTRFFVPTENSSWPISDGQAGPRRA TH_4621|M.thermoresistible__bu ILALQHGVVPQNLHFTRLPDEMAAIETNLFVPQATTLWPVREG--CPRRA *::*. :* . : : . * * *** MAB_0939|M.abscessus_ATCC_1997 GVSSFGFTGTNAHVLIEEAPQPQATPDEDDASTPQSAPVS------VLPL MSMEG_0408|M.smegmatis_MC2_155 GVSSFGFTGTNAHVLVEEAPPQLHTADAAPVEPAATAEAGTDDSPQVLAL MAV_1763|M.avium_104 GVSSFGFTGTNAHVLIEEAPQPVTTQDATPAAESDARPVD------VLPL Mflv_3393|M.gilvum_PYR-GCK GISSFGFGGTNAHVVIEQAPVLPPTPGEAPEGAVTTLVVS---------- Mvan_3126|M.vanbaalenii_PYR-1 GISSFGFGGTNAHVVIEQAPVFAPSPVEEPE-AVTTLVVS---------- MMAR_1775|M.marinum_M AVSSFGLGGTNAHAIVEQGPELSPAGRRGTDDEVTTLVVA---------- MUL_2018|M.ulcerans_Agy99 AVSSFGLGGTNAHAIVEQGPELSPAGRRGTDDEVTTLVVA---------- Mb2957|M.bovis_AF2122/97 AVSSFGLGGTNAHVIIEQGSELAPVSEGGEDTGVSTLVVT---------- Rv2932|M.tuberculosis_H37Rv AVSSFGLGGTNAHVIIEQGSELAPVSEGGEDTGVSTLVVT---------- MLBr_02356|M.leprae_Br4923 AVSSFGLGGTNAHVVIEQGPELTPVTECSSNTAVSTLVVT---------- TH_4621|M.thermoresistible__bu AVSSYGMSGTNVHAVLEQAPEPVQRPEESADTDAAGPLVFALS------- .:**:*: ***.*.::*:.. . MAB_0939|M.abscessus_ATCC_1997 SARSPEALAAVAQRYESWLA-AHPDVDLEDVCLTAGRGRSHFEHRAALVV MSMEG_0408|M.smegmatis_MC2_155 SARSPEALVELARRYDDWLS-ATPGLDIADVCHTAGVGRSHFEYRAALVV MAV_1763|M.avium_104 SARSPEALLALAQRYGEWLH-AHPDADIGDLCFTVGAGRAHFEHRAALVV Mflv_3393|M.gilvum_PYR-GCK -GKSAERIATHAAALAVWMD--GTDASLTEVAHTLNHHRTQHPRFATVTA Mvan_3126|M.vanbaalenii_PYR-1 -GKSPERIASQAAALAEWMAGAGSDASLVEVAHSLNHHRAQHAKFATVVA MMAR_1775|M.marinum_M -GKTPARVAATAGMLADWMEGPGAEVALADVAHTLNHHRSRQARFGTVVA MUL_2018|M.ulcerans_Agy99 -GKTPARVAATAGMLADWMEGPGAEVALADVAHTLNHHRSRQARFGTVVA Mb2957|M.bovis_AF2122/97 -GKTAQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRARQATFGTVVA Rv2932|M.tuberculosis_H37Rv -GKTAQRMAATAQVLADWMEGPGAEVAVADVAHTVNHHRARQATFGTVVA MLBr_02356|M.leprae_Br4923 -GKTASRVAAMAGMLADWVEGPGAEVALADVAHTLNHHRSRHAKFGTVVA TH_4621|M.thermoresistible__bu -STSAEELRRTAGRLAEWVEAHTDEVVPADLAYTLARRRAHRPVRTTVIA . :. : * *: ::. : *:: :: . MAB_0939|M.abscessus_ATCC_1997 DSIQTAREGLLELAQNRLRPGVVRG-EHTNHPTTAWLFTGQGSQYPGMAR MSMEG_0408|M.smegmatis_MC2_155 DSVERAREGLAALAEGRTPAGVVRG-EHVHRPTTAWLFTGQGSQYPGMAR MAV_1763|M.avium_104 DSVRSAREALADLADNRTRPGVARG-ECTDPPTTAWLFTGQGSQYPGMAR Mflv_3393|M.gilvum_PYR-GCK RDKAQAVAGLSALAAGQTVPGVVAAATATPKPGTVFVYSGQGSQWPGMAR Mvan_3126|M.vanbaalenii_PYR-1 RDRDQAIAGLQALAAGQSAPGVVGVAAGNPQPGTVFVYSGQGSQWPGMAR MMAR_1775|M.marinum_M RERAQAVAGLRALAANQHAPGVVNPADAPPEPGTVFVYSGRGSQWAGMGR MUL_2018|M.ulcerans_Agy99 RERAQAVAGLRALAANQHAPGVVNPADAPPEPGTVFVYSGRGSQWAGMGR Mb2957|M.bovis_AF2122/97 RDRAQAIAGLRALAAGQHAPGVVSHQDGSPGPGTVFVYSGRGSQWAGMGR Rv2932|M.tuberculosis_H37Rv RDRAQAIAGLRALAAGQHAPGVVSHQDGSPGPGTVFVYSGRGSQWAGMGR MLBr_02356|M.leprae_Br4923 RDRIQAVAGLRALAAGKQAPGVVGQQDGTPGSGTVFVYSGRGSQWAGMGR TH_4621|M.thermoresistible__bu DGVEALTAGLREVADGDAP---YQPAVGMDDKAPVWVFSGQGSQWAGMGA .* :* . ..::::*:***:.**. MAB_0939|M.abscessus_ATCC_1997 ELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEALRHT MSMEG_0408|M.smegmatis_MC2_155 ELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLLQHT MAV_1763|M.avium_104 ELFDAEPVFAETVTRCADAVDGLLPRPLTEVIFATDKDTGGEAGKTLRNT Mflv_3393|M.gilvum_PYR-GCK RLLADEPVFAEALDEIEPLFAEHVGFSLRDVIAG---------GREVSGD Mvan_3126|M.vanbaalenii_PYR-1 QLLVDEPAFANALAEIEPVFVEQVGFSLRDVIAG---------GETVSGD MMAR_1775|M.marinum_M QLLADEPAFAAAVAELEPVFLAEAGFSLHDVLAN---------GTELVGI MUL_2018|M.ulcerans_Agy99 QLLADEPAFAAAVAELEPVFLAEAGFSLHDVLAN---------GTELVGI Mb2957|M.bovis_AF2122/97 QLLADEPAFAAAVAELEPVFVEQAGFSLRDVIAT---------GKELVGI Rv2932|M.tuberculosis_H37Rv QLLADEPAFAAAVAELEPVFVEQAGFSLRDVIAT---------GKELVGI MLBr_02356|M.leprae_Br4923 QLLADEPAFTAAVAELEPVFVVHAGFSLHDVLAN---------GKELVGI TH_4621|M.thermoresistible__bu ELLATEQVFAAKIAEIEPLVARESGFSVTEAMTAS---------ETVTGI .*: : .*: : . . .: :.: : MAB_0939|M.abscessus_ATCC_1997 SFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIEDG MSMEG_0408|M.smegmatis_MC2_155 SFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDDG MAV_1763|M.avium_104 AFAQPALFAVEMGLARLWQSWGVEPDVVLGHSVGQYAAACVAGVFSLEDG Mflv_3393|M.gilvum_PYR-GCK AEVQPVLMGVQLALTQLWRSYGVHPDAVIGHSMGEVTAAVVAGALDVADG Mvan_3126|M.vanbaalenii_PYR-1 AQVQPVLMGLQLALTELWRSYDVHPDAVIGHSMGEVTAAVVAGALSLADG MMAR_1775|M.marinum_M EQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEG MUL_2018|M.ulcerans_Agy99 EQIQLGLIGMQLTLTELWRSYGIQPDLVIGHSMGEVAAAVVAGALTPAEG Mb2957|M.bovis_AF2122/97 EQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAGALTPAEG Rv2932|M.tuberculosis_H37Rv EQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSMGEVAAAVVAGALTPAEG MLBr_02356|M.leprae_Br4923 EQIQLGLIGMQLTLTELWRSYGVQPDLVIGHSLGEVAAAVVAGALTAAEG TH_4621|M.thermoresistible__bu DRVQPTLFAIQVALAATMQSYGVRPGAVIGHSLGEVAAAVVAGALSLEDG * *:.::: *: :*: :.*. *:***:*: :** ***.: :* MAB_0939|M.abscessus_ATCC_1997 ARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEF--PRVSVGAYNGP MSMEG_0408|M.smegmatis_MC2_155 ARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEF--PRVSVGAYNGP MAV_1763|M.avium_104 ARLMAERGRLFGGLPDGGRMVAVFADAQYVEELANDC--PRVSVAAYNGP Mflv_3393|M.gilvum_PYR-GCK LKVIAARSTIMSRLAGQGAVALLNVDADECAALIGGH--PSVEIAGYLSP Mvan_3126|M.vanbaalenii_PYR-1 LKVIAARSSIMSRLAGQGAVALLNLDADAARSLIADH--PSVEIAGYLSP MMAR_1775|M.marinum_M LRVTAVRSRLMAPLSGQGGMALLGLDASQTEALIADY--PQVTLGIYNSP MUL_2018|M.ulcerans_Agy99 LRVTAVRSRLMAPLSGQGGMALLGLDASQTEALIADY--PQVTLGIYNSP Mb2957|M.bovis_AF2122/97 LRVTATRARLMAPLSGQGGMALLGLDAAATEALIADY--PQVTVGIYNSP Rv2932|M.tuberculosis_H37Rv LRVTATRARLMAPLSGQGGMALLGLDAAATEALIADY--PQVTVGIYNSP MLBr_02356|M.leprae_Br4923 LRVTATRSRLMAPLSGQGGMALLELDAVETEALIVDY--SQVTLAIYNSP TH_4621|M.thermoresistible__bu VKVICRRSRLCLRLAGAGAMAAIELPAQAVREFLAARGVDDVVLSVIASP :: . *. : *. * :. : * . * :. .* MAB_0939|M.abscessus_ATCC_1997 -NTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESY MSMEG_0408|M.smegmatis_MC2_155 -NTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAY MAV_1763|M.avium_104 -NTVLSGPGADLEQIVARGASDGIRCSWLETSHAFHSELLDPVLDEFESY Mflv_3393|M.gilvum_PYR-GCK HQTVVAGLPEEVDAVIATVTSLNTFARRVNMVVASHTALMDPVLDDIRSA Mvan_3126|M.vanbaalenii_PYR-1 RQTVVAGLPEQVDAVIAAVTAQNTFARRVNMVVASHTALMDPVLPDIRAA MMAR_1775|M.marinum_M RQTVISGPTDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSE MUL_2018|M.ulcerans_Agy99 RQTVISGPTDQIDELITVVRARDRFATRVNIEVAPHNPAMDALQPQMRSE Mb2957|M.bovis_AF2122/97 RQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSE Rv2932|M.tuberculosis_H37Rv RQTVIAGPTEQIDELIARVRAQNRFASRVNIEVAPHNPAMDALQPAMRSE MLBr_02356|M.leprae_Br4923 RQTVIAGPTEQIDELIDRVRAQNRFASRVNIEVAPHNPAMDALQPQMRSE TH_4621|M.thermoresistible__bu ESTVIGGATDTVRELVAAWEAQGVMAREVAVDVASHSPQVDPILDELEEI .**:.* : : . . : * *. :*.: :. MAB_0939|M.abscessus_ATCC_1997 AAQVQFAAPTLPLVCNRTGAVLTA---QTPIDGQYWRRHSRQPVQFAESV MSMEG_0408|M.smegmatis_MC2_155 AAQFQFAAPTLPLVCNRTGAVLTG---QTPLDAQYWRRHSRQPVQFAESV MAV_1763|M.avium_104 AAHLDFAVPTLPLVCNRTGTVLTT---ETPLDARYWRRHSRQPVQFAESV Mflv_3393|M.gilvum_PYR-GCK LSDVDPNIPSLPFLSTVTDPGVT-----PEFDADYWVSNVRQPVRFSQAV Mvan_3126|M.vanbaalenii_PYR-1 LAGIEPNIPTLPFLSTVTGADSA-----PVLDADYWVANVRQPVKFSQAI MMAR_1775|M.marinum_M LADLAPRTPTIPIISTTYADLGSARESGPTFDAEHWAINMRNPVHFQQAI MUL_2018|M.ulcerans_Agy99 LADLAPRTPTIPIISTTYADLGAARESGPTFDAEHWAINMRNPVHFQQAI Mb2957|M.bovis_AF2122/97 LADLTPRTPTIGIISTTYADLHTQ----PIFDAEHWATNMRNPVRFQQAI Rv2932|M.tuberculosis_H37Rv LADLTPRTPTIGIISTTYADLHTQ----PIFDAEHWATNMRNPVRFQQAI MLBr_02356|M.leprae_Br4923 LADVAPRTPTIPILSTTYADLGSC----PVFDAQHWATNMRNPVHFQQAI TH_4621|M.thermoresistible__bu LADLQPMTPTVPYYSATSYDPREK----PVCDADYWVDNLRHEVRFAAAV : . *:: . . *. :* : *: *:* :: MAB_0939|M.abscessus_ATCC_1997 RTVAALG---CSVLMEIGPQPVLTGAAVQVWPEHLAPP--RAIVSLRKGV MSMEG_0408|M.smegmatis_MC2_155 RTVAALG---CSVLMEIGPQPVLTGAAVQVWPEHMAAP--RAVASLRKGV MAV_1763|M.avium_104 RTVAALG---CTVLMEIGPQPVLTGAAVQVWPEHLAAP--RAIVSLRKGV Mflv_3393|M.gilvum_PYR-GCK SAAAT----EYGTFVEISPHPTLGQSIRDTLGDGA-------DHLVVGTL Mvan_3126|M.vanbaalenii_PYR-1 VAAAA----DNGTFIEISPHSTLGQAIGNTLGDGP-------DHHMLGTL MMAR_1775|M.marinum_M TAAAT----DKHNFIEISAHPLLTQAILETLHTVQ----PGSKHTCLGTL MUL_2018|M.ulcerans_Agy99 TAAAT----DKHNFIEISAHPLLTQAILETLHTVQ----PGSKYTSLGTL Mb2957|M.bovis_AF2122/97 ASAGSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYLSIGTL Rv2932|M.tuberculosis_H37Rv ASAGSGADGAYHTFIEISAHPLLTQAIADTLEDAHRPTKSAAKYLSIGTL MLBr_02356|M.leprae_Br4923 MTAGT----DHRTFIEISAHPLLTQAITDTLHGTR--------CISIGTL TH_4621|M.thermoresistible__bu QAALEDG---FRVFGELSPHPLLTRAVEQTARGLDMP---VAALPAMRRE :. : *:..:. * : :. MAB_0939|M.abscessus_ATCC_1997 EDRRQIADALASAYVSGHRPNFAALQRHPRRTVELPTYPFQRRRFWPKSS MSMEG_0408|M.smegmatis_MC2_155 ADRRQIADALASAYVGGHRPDFAAVHRQPRRPVELPTYPFQRRRFWPKAS MAV_1763|M.avium_104 GDRRQIAEGLAAAYVSGHRPEFAALHRRPRRKLELPTYPFQRRRFWPKAS Mflv_3393|M.gilvum_PYR-GCK ARDADDTVAFHASVNATHTSRPPHTPHGPEPHLVLPATPWHHTRHWIDVR Mvan_3126|M.vanbaalenii_PYR-1 ARDTDDTVTFHANLNATHTSRPPHTAHHGEPHIVLPTTPWHRSRHWVDVR MMAR_1775|M.marinum_M QRDSDDTIVFRTNLNTVRTA-PPQTPHPPEPHPQIPTTPWHHTHHWIDNA MUL_2018|M.ulcerans_Agy99 QRDSDDTIVFRTNLNTVRTA-PPQTPHPPEPHPQIPTTPWHHTHHWIDNA Mb2957|M.bovis_AF2122/97 QRDADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATT Rv2932|M.tuberculosis_H37Rv QRDADDTVTFRTNLYTADIAHPPHTCHPPEPHPTIPTTPWQHTHHWIATT MLBr_02356|M.leprae_Br4923 QRDADDTVTFHTNLNNVHTVHPPHTPHPAEPHVTIPSTPWQHTRHWITTP TH_4621|M.thermoresistible__bu QEMPHGVRTMVGDLFAAGAAVDFAALYPSGRLVDAPLPTWTRRKLVLSRE . . : * .: : : MAB_0939|M.abscessus_ATCC_1997 GTA-IEGGGGLPSGILGRGEDLASGDSVYISRLSVRSQPWLSDHVIYGTV MSMEG_0408|M.smegmatis_MC2_155 SIA-VDGG-TAASGILGSGKDLASGDTIYTSRLSVKSQPWLADHVIYGTV MAV_1763|M.avium_104 GIAGIDGQGAAASGLLGSAKELASGDSVYTSRLSVKSQPWLADHVIYGTV Mflv_3393|M.gilvum_PYR-GCK PAR----------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 PLR----------------------------------------------- MMAR_1775|M.marinum_M ASSSPALSRSESR------------------------------------- MUL_2018|M.ulcerans_Agy99 ASSSPALSRSESR------------------------------------- Mb2957|M.bovis_AF2122/97 HPSTAAPEDP---------------------------------------- Rv2932|M.tuberculosis_H37Rv HPSTAAPEDP---------------------------------------- MLBr_02356|M.leprae_Br4923 LASTTALQHL---------------------------------------- TH_4621|M.thermoresistible__bu NGEQQTRGGCTITVHPLLGTHVRLPEEPERHVWQADLGTGAQPWLADHQI MAB_0939|M.abscessus_ATCC_1997 VVPGATYAAMALAAVGTPARAKDVFFYEPIILPEKSSREVQLTLHPLEDG MSMEG_0408|M.smegmatis_MC2_155 VVPGATYAAMALAAVGTPARLKDVFFYEPIILPEKASREVQLTLHPADGG MAV_1763|M.avium_104 VVPGATYAAMALAAVGPPARVQNVYFYEPIILPDKASREVQLSLHPLQEG Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu HTVAALPGAAYCEMALAAAREVIDSDGVEVRDVRFEQMLLLDEQTEVSAV MAB_0939|M.abscessus_ATCC_1997 SGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDA MSMEG_0408|M.smegmatis_MC2_155 SVLSFQIHSRPYGERGADWSLNAEGTVDT---AGSDPDAAADEQSDPVDE MAV_1763|M.avium_104 -GWSFRVDSRPYGVPDAEWSLNADGTVVAG-----IEDEPAADPADHIDA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu ASAVEPGTLEFAVETAKDGEHERRATAVLG---------AADDTEPPQAH MAB_0939|M.abscessus_ATCC_1997 AIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLGEGEAIGDVLVGE MSMEG_0408|M.smegmatis_MC2_155 VIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVGDILVGA MAV_1763|M.avium_104 VIERLDRNRPQLLFDSFAESELEWGTTWSTSLKSLWMGDGEAVGDVTVGD Mflv_3393|M.gilvum_PYR-GCK ------------------------------------------------RS Mvan_3126|M.vanbaalenii_PYR-1 ------------------------------------------------RG MMAR_1775|M.marinum_M ----------------------------------------------DGTG MUL_2018|M.ulcerans_Agy99 ----------------------------------------------DGTG Mb2957|M.bovis_AF2122/97 -----------------------------------------------GSN Rv2932|M.tuberculosis_H37Rv -----------------------------------------------GSN MLBr_02356|M.leprae_Br4923 -----------------------------------------------DRN TH_4621|M.thermoresistible__bu DIDALLAEHPTRIEGDELRQWFDQRGVQFGPAFTGLTAARIPEGTVTSVL MAB_0939|M.abscessus_ATCC_1997 ELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVT MSMEG_0408|M.smegmatis_MC2_155 ELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRYGQVT MAV_1763|M.avium_104 ELAEHLGTEPMHPVLLDLCTGVVFPAFPALLAAEQGFNDLLLPLRYGQVS Mflv_3393|M.gilvum_PYR-GCK GGVRAGAVPAGSPVPPEWFCELTWPAKPLAAH-HDPEGT-AKWLVVGDDA Mvan_3126|M.vanbaalenii_PYR-1 GGVRAGALPADSAVPPEWFCGLTWPAKPLVAQ-DGPVDPGASWLVVGDDA MMAR_1775|M.marinum_M AALDTRWSPESGSLLDEWSHKVVWAAQSLPDTPSAQTAVHGRWLVLGNAD MUL_2018|M.ulcerans_Agy99 AALDTRWSPESGSLLDEWSHKVVWAAQSLPDTPSAQTAVHGRWLVLGNAD Mb2957|M.bovis_AF2122/97 KVVVNGQSTSESRALEDWCHQLAWPIRPAVS---ADPPSTAAWLVVADNE Rv2932|M.tuberculosis_H37Rv KVVVNGQSTSESRALEDWCHQLAWPIRPAVS---ADPPSTAAWLVVADNE MLBr_02356|M.leprae_Br4923 RVTTHATGIG-NTELDDWIYQLDWPTRPLTSEPGATWASSGSWLVVSDAG TH_4621|M.thermoresistible__bu AEVGLPGQIRSQQAPYGIHPALLDACFQSVAAHPDVQGAGSGLLLPLGVR : . * MAB_0939|M.abscessus_ATCC_1997 LKEKMPRR-FYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFTVKR MSMEG_0408|M.smegmatis_MC2_155 LAEKMPRR-FYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFTVKR MAV_1763|M.avium_104 LREKMPRR-FYCRGKWRPSALDSETQVFDIDFIDRDGRHLGGIREFTVKR Mflv_3393|M.gilvum_PYR-GCK LADQMRR-------------LGAAVTTGG-------PDDLADATHVLYAP Mvan_3126|M.vanbaalenii_PYR-1 LAAEMGKL------------LGRPVATGD-------GADLSSATHVLYAP MMAR_1775|M.marinum_M LAAELGR--------------GADVLDSD-SEPAALARALSDVDYVLYAP MUL_2018|M.ulcerans_Agy99 LAAELGR--------------GADVLDSD-SEPAALARALSDVDYVLYAP Mb2957|M.bovis_AF2122/97 LCHELAR-----AADSRVDSLSPPALAAG-SDPAALLDALRGVDNVLYAP Rv2932|M.tuberculosis_H37Rv LCHELAR-----AADSRVDSLSPPALAAG-SDPAALLDALRGVDNVLYAP MLBr_02356|M.leprae_Br4923 LSDELARLVVLADPASRVEYLAPSALDHDVSTLHDLHNALRGVDNVLYAP TH_4621|M.thermoresistible__bu RLQAFGPTRGARYCYARVTDADGSKAEADLDVLDEHGNVLLRVQGLLMGG : * . MAB_0939|M.abscessus_ATCC_1997 APREALLRGLGGDATRLLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGF MSMEG_0408|M.smegmatis_MC2_155 APREALLRGLGGDATRLLYTLGWHEVPPPPSADD------AVGTWLIAGF MAV_1763|M.avium_104 APREALLRGLGGDATRLLYTLGWHEVPPQPSNDG---VANPSGTWLIAGF Mflv_3393|M.gilvum_PYR-GCK ST-SDELG-------YELFETGRALARAAAQDP----------------- Mvan_3126|M.vanbaalenii_PYR-1 TS-GDELG-------YELFEAGRAIATTASRVS----------------- MMAR_1775|M.marinum_M PVPADPLD---VAEAYQLFHQARRLATAMIAN------------------ MUL_2018|M.ulcerans_Agy99 PVPADPLD---VAEAYQLFHQARRLATAMIAN------------------ Mb2957|M.bovis_AF2122/97 PVPGELLD---IESAYQVFHATRRLAAAMVASSA---------------- Rv2932|M.tuberculosis_H37Rv PVPGELLD---IESAYQVFHATRRLAAAMVASSA---------------- MLBr_02356|M.leprae_Br4923 SVSTESVDPVDPESGYRLFHAVRRLAAAMVAG------------------ TH_4621|M.thermoresistible__bu AAADGDDRDRVLGERLLTIEWQRRDLPEADSAAGKWLLVSTSATADVSAT . MAB_0939|M.abscessus_ATCC_1997 DELAAKVPGCIPLNRETDPELLGEVLVAAKERGVPFSGVVWRAAGPGATE MSMEG_0408|M.smegmatis_MC2_155 DELAAKVPGCVPIDRNTDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKE MAV_1763|M.avium_104 DELGAQLPGCIPFDRNTDPESFGQLLARAEDRGGPVTGIVWRATQSGGRE Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu RLSDALKQAGAESTSMCWPQQADHADNVDRFRAGIADGVTGVVVLTGPKN MAB_0939|M.abscessus_ATCC_1997 S--TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATE MSMEG_0408|M.smegmatis_MC2_155 SGSASAESARLEAEITNLLSAVHAAQ---GPSVKLPGGLWIVTEHGVACE MAV_1763|M.avium_104 S--SAESVARLETEIAGLLTAVHALQNADGSAVKLPGGLWIVTERGVATE Mflv_3393|M.gilvum_PYR-GCK ----------------------------------TPPKLFLLTRNAQPVE Mvan_3126|M.vanbaalenii_PYR-1 ----------------------------------QPPKLFLLTRNAQPVS MMAR_1775|M.marinum_M ---------------------------------GSPAKLLIATRNAQPIA MUL_2018|M.ulcerans_Agy99 ---------------------------------GSPAKLLIATRNAQPIA Mb2957|M.bovis_AF2122/97 -------------------------------TAISPPKLFIMTRNAQPIS Rv2932|M.tuberculosis_H37Rv -------------------------------TAISPPKLFIMTRNAQPIS MLBr_02356|M.leprae_Br4923 ---------------------------------TSKPKLVVVTRNAQPVA TH_4621|M.thermoresistible__bu G----NPDDAAARRGSDYVRHLVRITRELAEIDGDAPRLFVVTRGAQAVL * : *. . . MAB_0939|M.abscessus_ATCC_1997 SGEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP MSMEG_0408|M.smegmatis_MC2_155 SGEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAP MAV_1763|M.avium_104 SGEPVDPVQAALWGLGRTIVNEEPALRCRLVDSDGSEQAVRSLAGLLGAP Mflv_3393|M.gilvum_PYR-GCK AGDRADPAQAVLWGLGRTLALEHPEIWGGVLDVDASVPAVVAARWALAEA Mvan_3126|M.vanbaalenii_PYR-1 EGDRANPGQAVLWGLGRTLALEHPDIWGALIDTDESVPAVVAARWVLAEA MMAR_1775|M.marinum_M EGDPANPSHGVLWGLGRTITLEHPEIWGAIIDFDNSVPAQVVARQVLDEA MUL_2018|M.ulcerans_Agy99 EGDPANPSHGVLWGLGRTITLEHPEIWCAIIDFDNSVPAQVVARQVLDEA Mb2957|M.bovis_AF2122/97 EGDRANPGHAVLWGLGRSLALEHPEIWGGIIDLDDSMPAELAVRHVLTAA Rv2932|M.tuberculosis_H37Rv EGDRANPGHAVLWGLGRSLALEHPEIWGGIIDLDDSMPAELAVRHVLTAA MLBr_02356|M.leprae_Br4923 VGERANPAHAVLWGFGRTLALEHPEIWGSVIDLDASMPPELAARCILDEV TH_4621|M.thermoresistible__bu PQDRPNLEQAGLRGLLRVIGAEHPHLRTTQIDIADDADLDRVAVQLLGGG : : :. * *: * *.* : :* . * MAB_0939|M.abscessus_ATCC_1997 -VDEPEIAVRQGKLLASRLLPWSRTGHLTVPRGSDYVLAPTERGAIDNLR MSMEG_0408|M.smegmatis_MC2_155 GIQEPEIAVRQGKLLASRLLPWARSGHLTLPRGGDFVLAPTERGAIDNLR MAV_1763|M.avium_104 -LDEPELAVRQGKLLASRLLPWARSGHLAVPRGTDYVLAPTERGAIDNLR Mflv_3393|M.gilvum_PYR-GCK HAG----------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 HAG----------------------------------------------- MMAR_1775|M.marinum_M DA------------------------------------------------ MUL_2018|M.ulcerans_Agy99 DA------------------------------------------------ Mb2957|M.bovis_AF2122/97 HG------------------------------------------------ Rv2932|M.tuberculosis_H37Rv HG------------------------------------------------ MLBr_02356|M.leprae_Br4923 ASQDE--------------------------------------------- TH_4621|M.thermoresistible__bu AEDETAWRDGQWYTARLSLSPLRPE------------------------- MAB_0939|M.abscessus_ATCC_1997 ITEKEVPAPDEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGIV MSMEG_0408|M.smegmatis_MC2_155 LTETDVPEPDEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTV MAV_1763|M.avium_104 LIEQEAPPPAEGCVQVRVEAGGLNFREVLNVLGLYPGDPGPLGGDFAGTV Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 TQLGEGVTGVEVGQRVYGSMQGAFGSRFNVPAQFLAPIPDGISGVEAATI MSMEG_0408|M.smegmatis_MC2_155 TQLGAGVSGLEIGQRVYGSMQGAFASRFNVPAQFLAPIPDGIGAVEAATI MAV_1763|M.avium_104 TQLGSGVTGLEVGTRVYGFMQGAFASRFNVPVQLLAPIPDGVSAVDAATI Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu ---------------------------------------ERKQAVVDCER MAB_0939|M.abscessus_ATCC_1997 PAAALTVRLSFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEVFATA MSMEG_0408|M.smegmatis_MC2_155 PAAALTVRLAFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEVFATA MAV_1763|M.avium_104 PAAALTARLAFDWAQLKPGDRVLIHAASGGVGLAAIQLAQRHGATVFATA Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu DGMRLEIRTPGDLETMELAAFDRVPPGPGQIEVAVTASSINFADVLIAFG MAB_0939|M.abscessus_ATCC_1997 STFKRATLRKLGVKYVYDSRTTDFADQILADTDGAGVDVVLNSLTSEGFI MSMEG_0408|M.smegmatis_MC2_155 STFKRSTLRRLGVKYVYDSRTTDFADQILADTNGAGVDVVLNSLTSAGFV MAV_1763|M.avium_104 STYKRATLRKLGVEYVYDSRSTDFADQILADTDGAGVDVVLNSLTNEGFI Mflv_3393|M.gilvum_PYR-GCK ----------------------DGEDQVVYRAG----------------- Mvan_3126|M.vanbaalenii_PYR-1 ----------------------DGEDQLVYRAG----------------- MMAR_1775|M.marinum_M ---------------------TDSEDQVVYRSG----------------- MUL_2018|M.ulcerans_Agy99 ---------------------TDSEDQVVYRSG----------------- Mb2957|M.bovis_AF2122/97 ---------------------TDGEDQVVYRSG----------------- Rv2932|M.tuberculosis_H37Rv ---------------------TDGEDQVVYRSG----------------- MLBr_02356|M.leprae_Br4923 ---------------------KDREDQVVYRAC----------------- TH_4621|M.thermoresistible__bu RYPTFDGRRPQLGTDFAGVVTAVGPDVTSHRVG----------------- * MAB_0939|M.abscessus_ATCC_1997 EATLRATAKNGRFAEIAKRDIWTTEQMAQSRPDIAYEIVALDTVMFQEPD MSMEG_0408|M.smegmatis_MC2_155 EATLKATAQGGRFAEIAKRDIWSHEQMAEARPDIAYEIVALDTVMFTEPD MAV_1763|M.avium_104 EATVRATAQHGRFVEIAKRDIWTREQMAAARPDIAYEIVALDWACVEQPE Mflv_3393|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_3126|M.vanbaalenii_PYR-1 -------------------------------------------------- MMAR_1775|M.marinum_M -------------------------------------------------- MUL_2018|M.ulcerans_Agy99 -------------------------------------------------- Mb2957|M.bovis_AF2122/97 -------------------------------------------------- Rv2932|M.tuberculosis_H37Rv -------------------------------------------------- MLBr_02356|M.leprae_Br4923 -------------------------------------------------- TH_4621|M.thermoresistible__bu -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 RIRVLLTEVSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARHIGKIVCQ MSMEG_0408|M.smegmatis_MC2_155 RIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARHIGKIVLQ MAV_1763|M.avium_104 HIHALLTEVSDGLASGEWRPLPAEIYPLAEAKTAFRRMQQARHIGKIVLQ Mflv_3393|M.gilvum_PYR-GCK ----------------------------------IRRVARLVHALPPAPT Mvan_3126|M.vanbaalenii_PYR-1 ----------------------------------IRRVARLVHALPPAPT MMAR_1775|M.marinum_M ----------------------------------VRHVPRLRRHSLAAQP MUL_2018|M.ulcerans_Agy99 ----------------------------------VRHVPRLRRHSLAAQP Mb2957|M.bovis_AF2122/97 ----------------------------------ARHVPRLQRRTLPGKP Rv2932|M.tuberculosis_H37Rv ----------------------------------ARHVPRLQRRTLPGKP MLBr_02356|M.leprae_Br4923 ----------------------------------LRRAPRLQRRTASAVS TH_4621|M.thermoresistible__bu ---DRVGGLSPNGCWSTFVTCDADLAVPLPDGLTEGQAAAVSTAHATAWY : MAB_0939|M.abscessus_ATCC_1997 MPNPLAPR-PDRTYLITGGLGAIGLHTAAYLAQLGAGDIVLTSRRAPDTD MSMEG_0408|M.smegmatis_MC2_155 VPKPLQPQ-QDRSYLITGGLGAIGLHTAAYLAQLGAGDIVLTSRRDPDES MAV_1763|M.avium_104 MPKPLQPR-GDRSYLITGGLGAIGLHLAAYLAQLGAGEIVLTSRRAPDAA Mflv_3393|M.gilvum_PYR-GCK GPTTLA---RDGAHLVIGATGNIGPGLIEQLAAMGAGTVVAVSRNPG--T Mvan_3126|M.vanbaalenii_PYR-1 GSGTLD---ADGAHLVIGATGNIGPRLVEQLAAMGAKTVVAVSRNPG--S MMAR_1775|M.marinum_M --VALD---AGASQLVIGATGNIGPHLINQLAEMGAKTIVAVSRNPG--Q MUL_2018|M.ulcerans_Agy99 --VALD---AGASQLVIGATGNIGPHLINQLAEMGAKTIVAVSRNPG--Q Mb2957|M.bovis_AF2122/97 --VTLN---ADASQLVIGATGNIGPHLIRQLARMGAKTIVAMARKP---G Rv2932|M.tuberculosis_H37Rv --VTLN---ADASQLVIGATGNIGPHLIRQLARMGAKTIVAMARKP---G MLBr_02356|M.leprae_Br4923 S-VKLSSG-QDTTQLVIGATGNIGPHLIRQLAAMGATTIVAVSRNPS--T TH_4621|M.thermoresistible__bu GLHDLARLGAGEKVLIHSATGGVGLAAIAIARSVGAQIYATAGSPARRDL * . *: .. * :* :** . . MAB_0939|M.abscessus_ATCC_1997 AQRVIGEITERSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLA MSMEG_0408|M.smegmatis_MC2_155 AQRAIDEITERHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLA MAV_1763|M.avium_104 AWRAIDDITERYRCRVHTFAADVGDAAQVEQLLARIRAELPPLAGVAHLA Mflv_3393|M.gilvum_PYR-GCK RLDELTARLAATGTTVVTVAADASDESSLRPVFERFGADLPPLKGVYLAA Mvan_3126|M.vanbaalenii_PYR-1 RLDELTARLAASGTTVVTAAADASDASSLRAVFDRFGADLPPLKGVYLAA MMAR_1775|M.marinum_M RLQKLAESLAAEGVNLVIAAADATDEAAMTALFDRFGADLPPLEGIYLAA MUL_2018|M.ulcerans_Agy99 RLQKLAESLAAEGVNLVIAAADATDEAAMTALFDRFGADLPPLEGIYLAA Mb2957|M.bovis_AF2122/97 ALDELTQCLAATGTDLIAVAADATDPAAMQTLFDRFGTELPPLEGIYLAA Rv2932|M.tuberculosis_H37Rv ALDELTQCLAATGTDLIAVAADATDPAAMQTLFDRFGTELPPLEGIYLAA MLBr_02356|M.leprae_Br4923 RLLELDKNLAATGTNLISVAADATDPTAMTALFDRFGVDLPPLEGIYLAA TH_4621|M.thermoresistible__bu LRDMGIEHVYDSRSTAFADEIRRDTDGYGVDVVLNSLPGAAQRAGLELLS :. . . *: : MAB_0939|M.abscessus_ATCC_1997 GVLDDALLGQ----------------------------------QSVERF MSMEG_0408|M.smegmatis_MC2_155 GVLDDALLSA----------------------------------QNPERF MAV_1763|M.avium_104 GVLDDALLSQ----------------------------------QSPERF Mflv_3393|M.gilvum_PYR-GCK MAGGPVTLAE----------------------------------MTHEDV Mvan_3126|M.vanbaalenii_PYR-1 MSGGPVTLDE----------------------------------MTHDDV MMAR_1775|M.marinum_M FAGQPVLLTE----------------------------------MTNDDV MUL_2018|M.ulcerans_Agy99 FAGQPVLLTE----------------------------------MTNDDV Mb2957|M.bovis_AF2122/97 FAGRPALLSE----------------------------------MTDDDV Rv2932|M.tuberculosis_H37Rv FAGRPALLSE----------------------------------MTDDDV MLBr_02356|M.leprae_Br4923 FAGRPVLLSD----------------------------------MTDNDV TH_4621|M.thermoresistible__bu FGGRFIEIGKRDIYGDTRLGLFPFRRNLAFHGVDLGLMADSHPHKIRELL : : . MAB_0939|M.abscessus_ATCC_1997 RTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANAL MSMEG_0408|M.smegmatis_MC2_155 RTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAM MAV_1763|M.avium_104 RVALAPKAFGASYLDHATRTDDLDFFIVSSSVSSLLGSPGQANYSTANAW Mflv_3393|M.gilvum_PYR-GCK VAMFRPKLDAAAAVHTLSLSHPVEQFVLFSSISGVLGSRWLAHYAATTTF Mvan_3126|M.vanbaalenii_PYR-1 VAMFRSKMDAAALLHQLSAGHPVEQFVLFSSISGVLGSRWLAHYAATTTF MMAR_1775|M.marinum_M TAMFAPKLDAAALLHRLSLKVPVRHFVLFSSISGLIGSRWLAHYTATSGY MUL_2018|M.ulcerans_Agy99 TAMFAPKLDAAALLHRLSLKVPVRHFVLFSSISGLIGSRWLAHYTATSGY Mb2957|M.bovis_AF2122/97 TTMFRPKLDALALLHRLSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAF Rv2932|M.tuberculosis_H37Rv TTMFRPKLDALALLHRRSLKSPVRHFVLFSSVSGLLGSRWLAHYTATSAF MLBr_02356|M.leprae_Br4923 VAMFRPKLDVASLLHRLSLKQPVKYFLLFSSISGLIGSRWLAHYTATSAF TH_4621|M.thermoresistible__bu ETVYRLTADGVLPMPQSTHYPLAEAATAIRVMSAAEHVGKLVLDVPHTGR . . : : :*. . . MAB_0939|M.abscessus_ATCC_1997 LDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATANISAQGLIPLDPSA MSMEG_0408|M.smegmatis_MC2_155 LDGLVAKRRAQGLVATGINFGPWGQGGMASSEAATANITAQGLIPLDPSA MAV_1763|M.avium_104 LDGLVAARQARGLPATGVNLGPWAQGGMASSEAARANIGAQGLIPLEPTA Mflv_3393|M.gilvum_PYR-GCK LDTFAFARRAAGLPASAINWGLWKSLADAQTGFEAQATHESGLEPMDDAV Mvan_3126|M.vanbaalenii_PYR-1 LDTFAFARRAAGLPACAINWGLWKSLADAQTGFERQATQESGLEPMDDAV MMAR_1775|M.marinum_M LDALAYARRVMGLPATTVNWGLWKSLADAEHDAS-QVSLGSGLVPMQDDV MUL_2018|M.ulcerans_Agy99 LDALAYARRVMGLPATTVNWGLWKSLADAEHDAS-QVSLGSGLVPMQDDV Mb2957|M.bovis_AF2122/97 LDSFAGARRTMGLPATVVDWGLWKSLADVQKDAT-QISAESGLQPMADEV Rv2932|M.tuberculosis_H37Rv LDSFAGARRTMGLPATVVDWGLWKSLADVQKDAT-QISAESGLQPMADEV MLBr_02356|M.leprae_Br4923 LDILGYARRLVGLPATVVAWGLWKSLADAQQDAT-QVSAESGLQPMTDDV TH_4621|M.thermoresistible__bu ADVVVPPEQASPFRSDGAYIVTGGMGGLGLYLAGEMAAAGAGCIVLNGRS * . .: : : . * : MAB_0939|M.abscessus_ATCC_1997 ALA--ALAEVVANGT-GQATILKANWQ--------------RAAKVLGS- MSMEG_0408|M.smegmatis_MC2_155 ALH--ALAEVIANGS-GQATVLKANWQ--------------RAAKVLGS- MAV_1763|M.avium_104 ALA--ALAEVVANGT-GQATVIKANWQ--------------RAAKLLGG- Mflv_3393|M.gilvum_PYR-GCK AIT--ALQAFVGPQAPVRGTVVAADWP--------------RLAAAYHTR Mvan_3126|M.vanbaalenii_PYR-1 AIT--ALRSFIGPQAPARATVVAADWP--------------RLAAAYHTR MMAR_1775|M.marinum_M AIG--ALPLVMSQAAGVHSVVVAADWP--------------LLAAAYRTR MUL_2018|M.ulcerans_Agy99 AIG--ALPLVMSQAAGVHSVVVAADWP--------------LLAAAYRTR Mb2957|M.bovis_AF2122/97 AIG--ALPLVMNPDAAVATVVVAADWP--------------LLAAAYRTR Rv2932|M.tuberculosis_H37Rv AIG--ALPLVMNPDAAVATVVVAADWP--------------LLAAAYRTR MLBr_02356|M.leprae_Br4923 AIG--ALPLVMSPDAPVHSVVAAADWP--------------LLAAAYQTR TH_4621|M.thermoresistible__bu APSGEALRTIEQLRAAGTEVIVECGXXXRGQPVEVAVPTELRHADEHPDR * ** . : .: .. * MAB_0939|M.abscessus_ATCC_1997 SRPPILDLVLPSAVGEVT-----GDSELLKQLMEIPVPQRAGFVTEFLQR MSMEG_0408|M.smegmatis_MC2_155 ARPPILDLVLPSAAGEAT-----GDSELLKQLMEIPIPQRAGFVTEFLQR MAV_1763|M.avium_104 ARPPILDLVLPSAVGEAS-----GDSELLKQLQEIPVAQRAAFITEFLQR Mflv_3393|M.gilvum_PYR-GCK AQLHILDDLLAEEGTAASGPALTGDTKFRQELKDRDPEQRRDMLTDFVIS Mvan_3126|M.vanbaalenii_PYR-1 AQLHILDDLLATEGTAATGLTPTGDTRFRQELKECEPQRRVELLTDHVLS MMAR_1775|M.marinum_M GSLRIVDDVLPVSDETTV-----LESEFRVALRNCAPERRHDMLHDQVAM MUL_2018|M.ulcerans_Agy99 GSLRIVDDVLPVSDETTV-----LESEFRVALRNCAPERRHDMLHDQVAM Mb2957|M.bovis_AF2122/97 GALRIVDDLLPAPEDVGK-----GESEFRTSLRSCPAEKRRDMLFDHVGA Rv2932|M.tuberculosis_H37Rv GALRIVDDLLPAPEDVGK-----GESEFRTSLRSCPAEKRRDMLFDHVGA MLBr_02356|M.leprae_Br4923 GVLRMVDDLLPAPGEVLM-----QESEFRKALRTCQAERRHNMLFDHVSA TH_4621|M.thermoresistible__bu RGAQLCDEFARGEQGAQR-----NQHRTDAGEGQRDAHPPGAVGHDQPDP : * . : . . : MAB_0939|M.abscessus_ATCC_1997 EVQNFLRLAQPP--AATSRFLDLGTDSLMAIELRNRLHSQFGGKFTINAT MSMEG_0408|M.smegmatis_MC2_155 EVQNFLRLASPP--AASSRFLDLGTDSLMAIELRNRLHSQFGGKFTINAT MAV_1763|M.avium_104 EVQGFLRLAQPP--AATSRFLDLGTDSLMAVELRNRLHSQFGGAFTINAT Mflv_3393|M.gilvum_PYR-GCK QVAAAMGLASAHTLDPGVGFFQFGMDSLMSVTLQRSLSESLG--ETLPAS Mvan_3126|M.vanbaalenii_PYR-1 QIAAAMGLASTHTLDPTVGFFQFGMDSLMSVTLQRSLSESLG--EALPAS MMAR_1775|M.marinum_M LAANVMGLHAGESLDPSTGFFQLGMDSLMSVTLQRALSDSLG--EFLPPS MUL_2018|M.ulcerans_Agy99 LAANVMGLHAGESPDPSTGFFQLGMDSLMSVTLQRALSDSLG--EFLPPS Mb2957|M.bovis_AF2122/97 LAATVMGMPPTEPLDPSAGFFQLGMDSLMSVTLQRALSESLG--EFLPAS Rv2932|M.tuberculosis_H37Rv LAATVMGMPPTEPLDPSAGFFQLGMDSLMSVTLQRALSESLG--EFLPAS MLBr_02356|M.leprae_Br4923 LVAKAMGLLPAETLDPSAGFFQLGMDSLMSVTLQRALSDSLG--EFLPAS TH_4621|M.thermoresistible__bu GALSDTGLDERGGQFPGVGVQIPVADPGVGIDHRGAVRVDSG--VPAQQG : . . *. :.: : : . * MAB_0939|M.abscessus_ATCC_1997 AVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASDA MSMEG_0408|M.smegmatis_MC2_155 AVFDYPTIGGLAEYLVGQLPDAEAPETA---------------------- MAV_1763|M.avium_104 AVFDYPTIGGLAEYLAGQLPDAESEPGAAVAANPNPGSETGTGEAEPERE Mflv_3393|M.gilvum_PYR-GCK VVFDYPTVEALTDYLASVLPEIIETAGTE-GGDVISDEADDTYDDLAEDE Mvan_3126|M.vanbaalenii_PYR-1 VVFDYPTVEALTDYLASVLPEIIETAGTDNDVDGGPSVIEDAYDDLAEDE MMAR_1775|M.marinum_M VVFDYPTVYSLTDYLATILPELETD----------DESTADVYDELTEAE MUL_2018|M.ulcerans_Agy99 VVFDYPTVYSLTDYLATILPELETD----------DESTADIYDELTEAE Mb2957|M.bovis_AF2122/97 VVFDYPTVYSLTDYLATVLPELLEIGATA----VATQQATDSYHELTEAE Rv2932|M.tuberculosis_H37Rv VVFDYPTVYSLTDYLATVLPELLEIGATA----VATQQATDSYHELTEAE MLBr_02356|M.leprae_Br4923 VVFDYPTVYSLTDYLATILPEFLEP--EA----PSGRTTADAYDEFTESE TH_4621|M.thermoresistible__bu VDGEVVRHRTLSSVRSGRSSRWTAPGSRCGSGRRYGGESCRRTTGPAAGA . : *:. . MAB_0939|M.abscessus_ATCC_1997 VSELKE------------------------------ MSMEG_0408|M.smegmatis_MC2_155 ------------------------------------ MAV_1763|M.avium_104 AAPEPS------------------------------ Mflv_3393|M.gilvum_PYR-GCK LLARLSERLS-------------------------- Mvan_3126|M.vanbaalenii_PYR-1 LLARLSERLS-------------------------- MMAR_1775|M.marinum_M LLEQLSQRLRGT------------------------ MUL_2018|M.ulcerans_Agy99 LLEQLSQRLRGT------------------------ Mb2957|M.bovis_AF2122/97 LLEQLSERLRGTQ----------------------- Rv2932|M.tuberculosis_H37Rv LLEQLSERLRGTQ----------------------- MLBr_02356|M.leprae_Br4923 LLDQLSERLRGTQ----------------------- TH_4621|M.thermoresistible__bu AARRGRTRRRRRPRRPPPPPDRVRHRAGPAHGPVRR