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M. marinum M MMAR_3605 (-)

annotation: ATP-dependent exoDNAse (exonuclease V)
coordinates: 4426055 - 4428859
length: 934

LTIAKLSRWSINYYNDTARAAGAAAADAQRAGGGLGEYYAEHDTRTPVWLCAGDAHTAAKLVGLTDVQRA
GGPADPEVVQRWLDDGTAPNGASGRAFGNRGVHGFDLTFCAPKSVSLIRALRAGDVADKAIATAHATAVS
EALEYLAAHAGYTRVHNPVTGEKDLLRLPGLVAIAYQHETSRAGDPHLHTHVIVPNRQARADGQLVSIDG
TSLYHEAKAAGVIYQATLRRELHQSLGFEWLPVDPATGMAEVAGIAPESVTAWSQRSSQLREWAAGNLAL
ADGQNLSPAQLSAAQKATRPAKPEQLSFAELRAAWRADERGVRLDDAARRAARQARREGSRQPFDRRRLA
AAAEQIDKAGFTRADLVEIVGAQLPVDTEQSPRRLVEAAVEEIGILLTAARQPHQREGHDRFTLDRILAE
EAALLQLVDAQDIRAELWVKERDTEGLSPDQKRVVENIATSPWLVQPLSAPAGAGKTTSLRALATMARRR
HTARVFVLAPTGTAVDVAIREGAGDVGYTIAKALHELDKGTLTLGHLDLVVVDEAAMVGTDDLRRLLAAT
TTARTKTVLVGDAHQLAPVKARGGMFAQLCADLPWAQQLSEVWRMRDPEERTASLALRDGGPAPVRRAVE
WYRTHDRLHTGDAITMAADALAAYNRDTAAGRNALLICDTTEMADALNRRIHRDIIAADQPAVIAARGHR
IAVGDLIISRRNDPTLPVFDATDIKKGADPVRNGNRWRIYAVDPGNNRVAARRLHDGARAAFTGDYLREH
ITYGYAITVHSAQGVTADTTHAVLGENTTRALLYVAMTRGRSANTAYLHERIAGENEHRQPNGVHIPRRG
TAKEAAQRARTIIANQDEQARTADQIAQDADASALPERVRSLLRRRSDAIRQRCTTYQQWRNAVAGMNIT
DGYTLGQHIDRSRGQYVGYQAGL*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3605--100% (934)ATP-dependent exoDNAse (exonuclease V)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2338-3e-3774.23% (97) hypothetical protein Mb2338
M. gilvum PYR-GCKMflv_2792-2e-7230.93% (873) exonuclease V subunit alpha
M. tuberculosis H37RvRv2311-3e-3774.23% (97) hypothetical protein Rv2311
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0398c-1e-0725.00% (464) exodeoxyribonuclease V, alpha subunit (RecD)
M. avium 104MAV_4544recD4e-0826.11% (429) exodeoxyribonuclease V, alpha subunit
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_3254-9e-7230.64% (878) exonuclease V subunit alpha

CLUSTAL 2.0.9 multiple sequence alignment


Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               -----------------------MLTIAKLSRWSINYYNDTARAAGAAAA
Mflv_2792|M.gilvum_PYR-GCK          MVMTLHKLTAGDGYLYLVRQVAAADSTERGRSTLADYYSAKGESPGRWMG
Mvan_3254|M.vanbaalenii_PYR-1       --MSMHKLTAGDGYLYLVRQVAAADSTERGRSSLADYYSAKGESPGRWMG
MAB_0398c|M.abscessus_ATCC_199      -------------------------------------------------M
MAV_4544|M.avium_104                -----------------------------------------MLPERVFDA
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               DAQRAGGGLGEYYAEHDTRTPVWLCAG-----------------------
Mflv_2792|M.gilvum_PYR-GCK          RGLAALSNTGRFEVSPTAREEIWTVEEGSGVSETQMRALYGVGLHPNAQR
Mvan_3254|M.vanbaalenii_PYR-1       RGLAALADTGAREVSDEVRQNVWAVEGGSVVTEAQMKALFGLGWHPNADK
MAB_0398c|M.abscessus_ATCC_199      SLVEAFG--EILEPAD----------------------------------
MAV_4544|M.avium_104                GPLRPFADAGIFEAAD----------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               ------------DAHTAAKLVGLTDVQRAGGPADPEVVQRWLDDGTAPNG
Mflv_2792|M.gilvum_PYR-GCK          IQTYVTGHN-MGNQRAASRLGREFQVRDG-KPEFSRRLAVAFRDHNAEIG
Mvan_3254|M.vanbaalenii_PYR-1       IYGHLSPRLGVQPATAAGQLGRKYPAQEEPSSEFTRRVGKAFRAHNIEAG
MAB_0398c|M.abscessus_ATCC_199      -------------VHVAQRLTALASETDESVELAIALAVRALRGG-----
MAV_4544|M.avium_104                -------------IHVAQRLTALTGESDDRVALAVALLVRALRGG-----
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               ASG------------------------------------------RAFGN
Mflv_2792|M.gilvum_PYR-GCK          AHWNATIGPEIRSGIRTRMAMELFGEEYGRPPADDRELSGFIARNTRAKT
Mvan_3254|M.vanbaalenii_PYR-1       LAGNATIDDDVRAGIRTQVAREMFAEQFGRDPADDRELSGFVARATRART
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               RGVHGFDLTFCAPKSVSLIRALRAGDVADKAIATAHATAVSEALEYLAAH
Mflv_2792|M.gilvum_PYR-GCK          TAVAGYDLTFSPVKSVSALWAIAP-LPVAEQIEAAHDAAVADVLEWLQEQ
Mvan_3254|M.vanbaalenii_PYR-1       TAVAGYDLTFSPVKSISALWAIAP-PEIAEQIEAAHEAAVADVLEWLQDK
MAB_0398c|M.abscessus_ATCC_199      --SVCVDLRAVAAQVDMPSLPWPAADDWLAAVRASPLAGEPPVLRLFGDL
MAV_4544|M.avium_104                --SVCVDLRAVPAQVGAADLPWPAAGDWLAAVRASPLLGPPPVLRFFGDL
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               AGYTRVHNPVTGEKDLLRLPGLVAIAYQHETSRAGDPHLHTHVIVPNRQA
Mflv_2792|M.gilvum_PYR-GCK          AAFTRTG---AGGVAQVDTEGLIAAVFTHRDSRAGDPDLHTHVAISNKVS
Mvan_3254|M.vanbaalenii_PYR-1       AAFTRTG---TNGVAQVDTEGLIAAVFTHRDSRAGDPDLHTHVAIANKVS
MAB_0398c|M.abscessus_ATCC_199      LYLDRYWR----EEQQVCTDVQALMAAAQPRTEVPTYERLFPQGFEEQRA
MAV_4544|M.avium_104                LYFDRYWL----EEEQVCTDLLALSAPAG-DVESSCYERLFPPGYEEQRA
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               RADG----QLVSIDGTSLYHEAKAAGVIYQATLRRELHQSLGFEWLPVDP
Mflv_2792|M.gilvum_PYR-GCK          YVDANGVRRWLALDGQPLHRVTVAASELYNTRLEAHLIARLGVRFAEQSR
Mvan_3254|M.vanbaalenii_PYR-1       YLDQNGVRRWLALDGQPLHRVIVAASEMYNTRMEVHTIDRLGVDFAEASR
MAB_0398c|M.abscessus_ATCC_199      AADIALSQGLTVLTGGPGTGKTTTVARLLALLADQASSASAAPLRIALAA
MAV_4544|M.avium_104                AARIAVSQALTVLTGGPGTGKTTTVARLLALLVEQAERAGEPRPRIALAA
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               ATGMAEVAGIAPESVTAWSQRSSQLREWAAGNLALADGQNLSP-------
Mflv_2792|M.gilvum_PYR-GCK          GRGKRPVREIVGMSARLMERWSSRRAAIKARTAELAKQFQADHGREPTNV
Mvan_3254|M.vanbaalenii_PYR-1       GRGKRPVREIVGMSVELMMRWSSRGIAIKARTAELAKQFQHDHGREPTTI
MAB_0398c|M.abscessus_ATCC_199      PTGKAAARLQEAVQLEVNQLDAVDRSRLAG--------------------
MAV_4544|M.avium_104                PTGKAAARLAEAVAAEIEHLDPADRARLAG--------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               ---AQLSAAQKATRPAKPEQLSFAELRAAWRADERGVRLDD---------
Mflv_2792|M.gilvum_PYR-GCK          EIIALAQHATLESREAKHEPRSLGEQRQEWRTQAVEVLGERGVNQMLSDT
Mvan_3254|M.vanbaalenii_PYR-1       ESLALAQQATLESREAKHEPRSFAEQRATWRNQAIEVLGHDGLNRMLATV
MAB_0398c|M.abscessus_ATCC_199      ---LQATTLHRLLGSRPDTSSRFKHDRGNRLPHDVIVVDET---------
MAV_4544|M.avium_104                ---LTGTTLHRLLGPRPDTSVRFKHNRGNRLPHDIIVVDET---------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               ------------------AARRAARQARREGSRQPFDRRRLAAAAEQIDK
Mflv_2792|M.gilvum_PYR-GCK          LAAPQTTREAVTIDEEWFASRAGELIATVAESRSTWQRHHVRAEALRMAR
Mvan_3254|M.vanbaalenii_PYR-1       LAP-RRAQKTPEITAEWVASRAVALVATVAETRATWQAHHVRAEALRMVR
MAB_0398c|M.abscessus_ATCC_199      ------------------SMVSLTMMARLLEAVRPQARLLLVGDPDQLAS
MAV_4544|M.avium_104                ------------------SMVSLTMMARLAEAVRPDTRLILVGDPDQLAS
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               AGFTRADLVEIVGAQLPVDTEQSPRRLVEAAVEEIGILLTAARQP----H
Mflv_2792|M.gilvum_PYR-GCK          GHDVAHDVALVERLTDTALGEGFSVPHARVEDAELGEPVALRRRDGASVY
Mvan_3254|M.vanbaalenii_PYR-1       AEGVAHVAGLVERLTDTALSEAFSVPHARVEDGELGEPVALRRRDGSSVY
MAB_0398c|M.abscessus_ATCC_199      VEAGAVLADLVEGLE---SERVAALRTSHRFGAAIGALAAAVRDGD----
MAV_4544|M.avium_104                VEAGAVLADLVDGLAGRAGVRVAALATPHRFGSAIGALAAAIRAGD----
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               QREGHDRFTLDRILAEEAALLQLVD--------AQDIRAELWVKERDTEG
Mflv_2792|M.gilvum_PYR-GCK          RRHGVALYTSQETLAAEQRILDAVHRGDGRVASAADVEMALADSTARGRT
Mvan_3254|M.vanbaalenii_PYR-1       SRHGVATYTSRDVLAAEERILAAVARRDGRMATASEVDLALSDSAARGKP
MAB_0398c|M.abscessus_ATCC_199      --------------------------------ADRALEVLASGDPHVEWS
MAV_4544|M.avium_104                --------------------------------ADRVVELLAAGGEHIEWV
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               LSPDQKRVVENIATSPWLVQPLSAPAGAGKTTSLRALATMARRRHTARVF
Mflv_2792|M.gilvum_PYR-GCK          LNPGQAALVTEMATAGRRVALALAPAGTGKTTAMAALAHAWRS-SGGHVI
Mvan_3254|M.vanbaalenii_PYR-1       LNLGQAALVEQMATSGRRVALALAPAGAGKTTAMAALAHAWRS-SGGHVL
MAB_0398c|M.abscessus_ATCC_199      TD---SEGLRDVLVPQALALRAASLSGDATAALAVLDEHRMLCAHRHGPF
MAV_4544|M.avium_104                DSERPADRLREVLVSHALRLRSAALLGAAQAALATLDEHRLLCAHRDGPH
                                                                                      

Mb2338|M.bovis_AF2122/97            -MAPTGQAVDVAVREGAGDVGYSVE-------------------------
Rv2311|M.tuberculosis_H37Rv         -MAPTGQAVDVAVREGAGDVGYSVE-------------------------
MMAR_3605|M.marinum_M               VLAPTGTAVDVAIREGAGDVGYTIAKALHELDKGTLTLGHLDLVVVDEAA
Mflv_2792|M.gilvum_PYR-GCK          GLAPT-ADAAIVLGEDLGATTDTLDKYVWSADPAKAATSHVPDWFSRVGP
Mvan_3254|M.vanbaalenii_PYR-1       GLAPT-AAAAIVLGEDLGATTDTLDKYVHCADPDNAATFGTPQWFTDIGP
MAB_0398c|M.abscessus_ATCC_199      GVTHWNRQVERWITEETGEPHWAPWYAG----------------------
MAV_4544|M.avium_104                GAVRWNTLVHNWIAEETGQPAWSQWYAG----------------------
                                      .     .   : *  *    :                           

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               MVGTDDLRRLLAATTTARTKTVLVGDAHQLAPVKARGGMFAQLCADLPWA
Mflv_2792|M.gilvum_PYR-GCK          DTLIVVDEAGKAATAGLDAMIRDALKKGASVRLVGDDGQLSSISAGGILR
Mvan_3254|M.vanbaalenii_PYR-1       DTLIIVDEAGMASTAGLDAMIADAQRKGASVRLVADDCQLASISAGGVLR
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               QQLSEVWRMRDPEERTASLALRDGGPAPVRRA----VEWYRTHDRLHTGD
Mflv_2792|M.gilvum_PYR-GCK          DIAEATDALTLSEVVRFKSPAEAAAGLALHDADPAGIGFYIDHHRIHVGT
Mvan_3254|M.vanbaalenii_PYR-1       DIATETGALTLSEVVRFHSRAEAAASLALRGGDPAGIGFYIDSGRIHVGT
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            ----------------------------------------RENLPAD---
Rv2311|M.tuberculosis_H37Rv         ----------------------------------------RENLPAD---
MMAR_3605|M.marinum_M               AITMAADALAAYNRDTAAGRNALLICDTTEMADALNRRIHRDIIAADQPA
Mflv_2792|M.gilvum_PYR-GCK          DETAADMAYQAWRADLAAGGDSILLAPTNDVINELNARARIDRLAADPEA
Mvan_3254|M.vanbaalenii_PYR-1       EQTAADTAFSAWLADRNAGRDSLLLGPTNAIVDDLNARARTARIAAHVEA
MAB_0398c|M.abscessus_ATCC_199      ---------------------------------------RPILVTAN---
MAV_4544|M.avium_104                ---------------------------------------RPLLVTAN---
                                                                               :.*.   

Mb2338|M.bovis_AF2122/97            --------------------------------------DPVRNGNRWRVI
Rv2311|M.tuberculosis_H37Rv         --------------------------------------DPVRNGNRWRVI
MMAR_3605|M.marinum_M               VIAARGHRIAVGDLIISRRNDPTLPVFDATDIK--KGADPVRNGNRWRIY
Mflv_2792|M.gilvum_PYR-GCK          AK----SPTVVLAEQLHASVGDTIRTRKNNRRIGIGRNDFVRNGYRYTIT
Mvan_3254|M.vanbaalenii_PYR-1       DPNWRPGRETVLADQLRASVGDVIRTRHNARWLPLSGTDYVRNGYTFDIL
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------DYGLRLYNGDTG
MAV_4544|M.avium_104                --------------------------------------DYGLRLYNGDTG
                                                                          *   .       

Mb2338|M.bovis_AF2122/97            AVDTEHHRIAARRLGDGARAAFSGDYLHEHITHGYAITVHASQGTTAH--
Rv2311|M.tuberculosis_H37Rv         AVDTEHHRIAARRLGDGARAAFSGDYLHEHITHGYAITVHASQGTTAH--
MMAR_3605|M.marinum_M               AVDPGNNRVAARRLHDGARAAFTGDYLREHITYGYAITVHSAQGVTAD--
Mflv_2792|M.gilvum_PYR-GCK          EVLADG-GVKARHLRSGRIVTLPADYIAEHVTLGYAATIDSAQGLTSGSR
Mvan_3254|M.vanbaalenii_PYR-1       DVARDG-ALRARHSGTGHEITLPADYVTEHVTLGYASTINGAQGSTAG--
MAB_0398c|M.abscessus_ATCC_199      VTVAGPDGLRAVIGAAS----FATSRLVEVETM-HAMTIHKSQGSQAN--
MAV_4544|M.avium_104                VTVAGADGLRAVIAGAAGPLDFATSRLGEVETM-HAMTIHKSQGSQAD--
                                     .      : *     .    :. . : *  *  :* *:. :**  :   

Mb2338|M.bovis_AF2122/97            ----STHAVLGDNTSRATLYVAMTPARESNTAYLCERTAGEG--------
Rv2311|M.tuberculosis_H37Rv         ----STHAVLGDNTSRATLYVAMTPARESNTAYLCERTAGEG--------
MMAR_3605|M.marinum_M               ----TTHAVLGENTTRALLYVAMTRGRSANTAYLHERIAGENEHRQPNGV
Mflv_2792|M.gilvum_PYR-GCK          DTRGTCHIVGSDMLTRQHLYVALTRGTDENHLYLSTAEGDPHRLLSPKAT
Mvan_3254|M.vanbaalenii_PYR-1       ---YSCHVVGAEHLTRQQLYVALTRGRAENHLYLSTAETDPHRILAPKAT
MAB_0398c|M.abscessus_ATCC_199      EVTVLLPSEDSRLLTRELFYTAVTRAKQ----------------------
MAV_4544|M.avium_104                EVTVLIPPEDSRLLTRELFYTAVTRAKS----------------------
                                              .   :*  :*.*:* .                        

Mb2338|M.bovis_AF2122/97            --------------ARVDLAGWDLWVSGKAEAMSDEKSASPVWCRVGARC
Rv2311|M.tuberculosis_H37Rv         --------------ARVDLAGWDLWVSGKAEAMSDEKSASPVWCRVGARC
MMAR_3605|M.marinum_M               HIPRRGTAKEAAQRARTIIANQDEQAR-TADQIAQDADASALPERVRSLL
Mflv_2792|M.gilvum_PYR-GCK          HPDTAVDVLTRILARNGAQVSATTAARQAADPAARLQAAADMYYDALGAA
Mvan_3254|M.vanbaalenii_PYR-1       HPDTAVDVLSRIVARGGGQVSATTTARQAADPTRRLAAAADMFTDALGAA
MAB_0398c|M.abscessus_ATCC_199      ---------------RVRVVGSEAEVRAAIQRQAVRASGLGRRLRHSPN-
MAV_4544|M.avium_104                ---------------RVRVVGPEASVRAAIERRAIRATGLRQRLRVVG--
                                                       ..    .    :       .           

Mb2338|M.bovis_AF2122/97            DHRG---------------------KRSCW--------------------
Rv2311|M.tuberculosis_H37Rv         DHRG---------------------KRSCW--------------------
MMAR_3605|M.marinum_M               RRRSDAI------------------RQRCTTYQQWRNAVAGMNITDGYTL
Mflv_2792|M.gilvum_PYR-GCK          AENRLGVGARDRLDAIADEVIPQLSQREAWPVLRRNLSVLALRGADPREL
Mvan_3254|M.vanbaalenii_PYR-1       AEHQLGAGARDRLDAIAESVHTDLSTCAAWPVLRRRLAVRALSGADPGEL
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               GQHIDRSRGQYVGYQAGL--------------------------------
Mflv_2792|M.gilvum_PYR-GCK          LTEALAKGSVSDAADPAAVLDHRIDPAGTHSSGIGVLRWLPAVPEALAED
Mvan_3254|M.vanbaalenii_PYR-1       LAAAHARGGLDDAADAAAVLDYRIDPTGSAGRDCGPLRWLPAIPDRLAGD
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          PQWGAYLARREKLVEDLAGEIRERARGWTNATAPAWARPLITVNPVLTAE
Mvan_3254|M.vanbaalenii_PYR-1       PQWGDYLRRRGQLVSDLADQIREQARAWTPDTAPSWAQPLVTANPALAAE
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          SAVFRAATGVAEADTRITGARQFPVRSRGVQAALQRQAAADIGRHSADTS
Mvan_3254|M.vanbaalenii_PYR-1       IAVFRAATGVDGADTRLTGPAQYPVATRAIQDLLQRHGTDAIERNSADPT
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          RWNDVIDGIDPRLRSDAYWPQLADQLVKAARITPQLRQIITTAARQGPLP
Mvan_3254|M.vanbaalenii_PYR-1       RFNDLLDQIDPRIRADAYWPTLAAHLTNAARGN-DISDAITAAAQRGPLP
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          DELPAAALWWRISGALSPTATLATTHSRLRPPWVTDIDVVFGTSLAETIT
Mvan_3254|M.vanbaalenii_PYR-1       DEMPAAALWWRLADALSRTAAIPDRT-------VVDHATAQGDGLHASIA
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          SDPAWPGLVAAIGAADPRKWTPRDLLHVAAEQLADATDGDHPIPPGDYAR
Mvan_3254|M.vanbaalenii_PYR-1       AERALVEVLAAS-------WRNADPLPLARPR------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          LITYTVDAFTHRLQARLGVDFQDLPAPEDTPIDPAEEALFPPDPQDPSAH
Mvan_3254|M.vanbaalenii_PYR-1       -------------------------------TDPAAVALSLP--------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          VEEHSPFDDSVDLAPPEEIDSFEYGSEGYAGLRFEDLSANRPTPELGITM
Mvan_3254|M.vanbaalenii_PYR-1       -------------------------------YVVATVAAERYTPEL----
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          DAFIALRAEYRNVCDEIKTLAADIRAGNGPALRAAAGDLLRMRHQVDADR
Mvan_3254|M.vanbaalenii_PYR-1       -------------AEAIHTAATDANR------------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          PYSHAITDVMEQWSDADRAYNDTLRLIEHSRSQLDLLLATPDAEELDIIS
Mvan_3254|M.vanbaalenii_PYR-1       ---------------------------HHVR-----ITATPQPDRLSLNH
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          ARQQIAFYTDMLPEQPPSLQFQQALADAQAARAAAAGGGGGGDKIVTERD
Mvan_3254|M.vanbaalenii_PYR-1       LAEQITIH------------------------------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          IAAARGAAERTDIAALNVLRVRRPVLRRELERAERDIATAFAAAQTSTSD
Mvan_3254|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          TLEQLLESARSEVALLRVSGHLDPERTPLRIPDAALSGLEPQTADRLKSV
Mvan_3254|M.vanbaalenii_PYR-1       ----------------------EPTRR-----------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          AAQPYRLAVIRADITDSETAAALYTLRNAANAEDRKVLWLSPTEASLTPA
Mvan_3254|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          HDAELADTITTIRHAHQQVSEQQWALSAGAIVVIEDPAAAEPDQLVGLAR
Mvan_3254|M.vanbaalenii_PYR-1       ----------------------------GPVIVVEDAAAADPDALAAVAT
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          HAADADARLVLLDPGTSRGPSSSAVQLLTNSLPWNNALTTTPSTPEDPLL
Mvan_3254|M.vanbaalenii_PYR-1       ALVPAHGRLLLVDN----GQLGSARRLLDG-LTLPWAENTRPAAGID---
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            --------------------------------------------------
Rv2311|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_3605|M.marinum_M               --------------------------------------------------
Mflv_2792|M.gilvum_PYR-GCK          ASTPAVTLADRLGRKRLSEPWQQLLTHYDIAARAIRSAQRRQLARGWHTT
Mvan_3254|M.vanbaalenii_PYR-1       -NPRLAAAAD---------------EHRAIAARSWRTLTTG------PTR
MAB_0398c|M.abscessus_ATCC_199      --------------------------------------------------
MAV_4544|M.avium_104                --------------------------------------------------
                                                                                      

Mb2338|M.bovis_AF2122/97            ------------------
Rv2311|M.tuberculosis_H37Rv         ------------------
MMAR_3605|M.marinum_M               ------------------
Mflv_2792|M.gilvum_PYR-GCK          DLAPSKDRDRTLGAGIDD
Mvan_3254|M.vanbaalenii_PYR-1       DRG--RDRDRGHGLDID-
MAB_0398c|M.abscessus_ATCC_199      ------------------
MAV_4544|M.avium_104                ------------------