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STYVIAAPDAFSVASGELAGIEAAVKGAAAAAAPSTTGIISAAADEVSTAIARLFGSYADEFQTLSAQAT RFQAQFERALSEAGAAYAAAEAANVSPLRALLQEAESLGVFAPIERLIGRPLFGNGSVAAASTGATEASS LLTSGTNQAGLGGAVNYAAAEALAAPATGATGVKSGFSFLQIPIGPSEFLGITIPQFNFPAPAHWYFPTQ ADGSVNANGVIYLQHGFGAIGWFYQPLAMQLAQQTNSIVVVPTVPSIPLPFGMWIGGAQMQQGVGSLFLG SQTALNISANQAGYLGTLPQDFILSGHSAGGGLASIAAGSYLANLGAATNHLQGVVMFDGVASNSSAFGA AVANLQAANVPIYVVAAPPQPWNAFGATTNQLVSLYPGQFTGVEIVNGSHVDSMLGGNPLIDFAAQLLTG FSPPGATQAVYTLSSGWINDIWAGADPLNPIYGIYGPTGGYVAPGGQAIFLGPTAGIVLPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3402 | - | - | 100% (482) | PE-PGRS family protein |
| M. marinum M | MMAR_2116 | - | 9e-33 | 45.66% (173) | PE-PGRS family protein |
| M. marinum M | MMAR_0609 | - | 1e-32 | 46.20% (171) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3621c | PE_PGRS58 | 2e-31 | 45.83% (168) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_0299 | - | 4e-73 | 40.85% (448) | Lipocalin family protein |
| M. tuberculosis H37Rv | Rv3590c | PE_PGRS58 | 2e-31 | 45.83% (168) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 1e-09 | 33.68% (95) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_0534 | - | 2e-11 | 38.95% (95) | PE family protein |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0572 | - | 1e-32 | 46.20% (171) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_0445 | - | 1e-80 | 47.46% (354) | Lipocalin family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3621c|M.bovis_AF2122/97 -----MS-FVIVAPEALMSVASEVAGIGSALNAANAAAAAPTTG-VLAAA
Rv3590c|M.tuberculosis_H37Rv -----MS-FVIVAPEALMSVASEVAGIGSALNAANAAAAAPTTG-VLAAA
MUL_0572|M.ulcerans_Agy99 -----MS-YVVAIPDMLASAAADVAGIGSSVGAANTAAVGATTG-VMAAA
MAV_0534|M.avium_104 -----MS-FLMVRPEILDAAARELHGINAAVLQSNSAAVTPTTA-LAPAA
MLBr_01183|M.leprae_Br4923 -----MPLFLNAEPQALTAAANTLEGLSAATVASNAAAAQLTTE-IAPPA
Mflv_0299|M.gilvum_PYR-GCK MTSQRWAIWLGAFGAGACIALGAGHGVAAADSDTADAADTSSQS------
Mvan_0445|M.vanbaalenii_PYR-1 MTSRRWALWLWTLGAGACITLGAGTGVAAADTETSGGDGPSSQSDDRDAS
MMAR_3402|M.marinum_M -----MSTYVIAAPDAFSVASGELAGIEAAVKGAAAAAAPSTTG-IISAA
. :: . . *: :: : . :
Mb3621c|M.bovis_AF2122/97 ADEVSAAMAALFGAHAQEYQRLSAQAAGFHAQFVQALNAGVNSYASAEAA
Rv3590c|M.tuberculosis_H37Rv ADEVSAAMAALFGAHAQEYQRLSAQAAGFHAQFVQALNAGVNSYASAEAA
MUL_0572|M.ulcerans_Agy99 DDEVSVAIAALFSGHGQAYQAISAQAAAFHDQFLRALTGAGGAYAAAEAA
MAV_0534|M.avium_104 ADVVSLVTAARFSRHGLAFQEVSAQAAQLRDQFATTLGISAGSYAAAEIA
MLBr_01183|M.leprae_Br4923 ADDVSILLAHFFSGHGRQYQAHASQGATNHQDLIQSLLTSSSAYAGTETA
Mflv_0299|M.gilvum_PYR-GCK -AETRTAADQPAAREPDEPEARETEAEAEETDADAAAESEGEGADTDDTA
Mvan_0445|M.vanbaalenii_PYR-1 EASSHGAPDQGTGETPDPNAGDGVDADDSSDPATVPASVELADDVVRDAD
MMAR_3402|M.marinum_M ADEVSTAIARLFGSYADEFQTLSAQATRFQAQFERALSEAGAAYAAAEAA
. :. . :
Mb3621c|M.bovis_AF2122/97 NASPLQAVEQQVLGLINGPAQTLLGRPLIGNGADGAPGTGQPGGPGGLLW
Rv3590c|M.tuberculosis_H37Rv NASPLQAVEQQVLGLINGPAQTLLGRPLIGNGADGAPGTGQPGGPGGLLW
MUL_0572|M.ulcerans_Agy99 NASPLQAAEQEVLAVINAPTNALLGRPLIGNGTDGLAGTGAAGGAGGLLW
MAV_0534|M.avium_104 NTAAVG--------------------------------------------
MLBr_01183|M.leprae_Br4923 NHDSL---------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK DVTAEEDAAVESASARKPRAERREA------VAEAASETEPASEQAP---
Mvan_0445|M.vanbaalenii_PYR-1 DEAAQEADAAEEVDADTEADTDVDT------AADTAAEAEPAAESGSGSG
MMAR_3402|M.marinum_M NVSPLRALLQEAESLGVFAPIERLIGRPLFGNGSVAAASTGATEASSLLT
: .
Mb3621c|M.bovis_AF2122/97 GNGGNGG---SGVAG-------------VGGPGGSGGAAG----------
Rv3590c|M.tuberculosis_H37Rv GNGGNGG---SGVAG-------------VGGPGGSGGAAG----------
MUL_0572|M.ulcerans_Agy99 GNGGNGG---SGAAGQAGGAGGAAGLIGTGGAGGMGGAGGGAGGMGGSGG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0445|M.vanbaalenii_PYR-1 SGSASTVVDETP----------------------------------AQPA
MMAR_3402|M.marinum_M SGTN---------------------------------------------Q
Mb3621c|M.bovis_AF2122/97 -LFGHGGNGGAGGSNAAG-AGGVGGAGGAGWLVGNGGAGGFGGVGTT---
Rv3590c|M.tuberculosis_H37Rv -LFGHGGNGGAGGSNAAG-AGGVGGAGGAGWLVGNGGAGGFGGVGTT---
MUL_0572|M.ulcerans_Agy99 WLLGNGGAGGAGGVGCAGVSGGVGGTGGNAMLFGNGGAGGMGGAGADGAV
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK ----EPAQTPAAPTQAVASAP-TGVKTGRAPLTIPVGDK-----------
Mvan_0445|M.vanbaalenii_PYR-1 AADAEPVRATAPEAANVAPAPVTGVKTGRAKLTIPVGPH-----------
MMAR_3402|M.marinum_M AGLGGAVNYAAAEALAAPATGATGVKSGFSFLQIPIGPSEF---------
Mb3621c|M.bovis_AF2122/97 ------------------------------VSGNGGAGGAAGAFGNGGVG
Rv3590c|M.tuberculosis_H37Rv ------------------------------VSGNGGAGGAAGAFGNGGVG
MUL_0572|M.ulcerans_Agy99 GAAGTAGTSTSAGGVGGAGWDATAAGVLAATGGDGGDSGGGGAGGNGGAG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK -----------------------------------GYRTRADWYLPTQGD
Mvan_0445|M.vanbaalenii_PYR-1 -----------------------------------DYRTRADWYLPTQAD
MMAR_3402|M.marinum_M ---------------------------LGITIPQFNFPAPAHWYFPTQAD
Mb3621c|M.bovis_AF2122/97 GAG--GAAVIG--GLPGNGGAGGNAGLIGAGGDGGVGGVG--APGTNGMN
Rv3590c|M.tuberculosis_H37Rv GAG--GAAVIG--GLPGNGGAGGNAGLIGAGGDGGVGGVG--APGTNGMN
MUL_0572|M.ulcerans_Agy99 GAGGHGSALFGADGANGNGGAGGAGGNPGAPGNGGTGGVGPDAATSGGMG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK GTVTATGVIWLQHGFLGNKSFVSALARNLSQQTNSIVVAPNLSSFPLACA
Mvan_0445|M.vanbaalenii_PYR-1 GSVAATGVIWLQHGFLGNKASLSKLAQTLSQQTNSIVVAPNLSSFPLACA
MMAR_3402|M.marinum_M GSVNANGVIYLQHGFGAIGWFYQPLAMQLAQQTNSIVVVPTVPSIPLPFG
Mb3621c|M.bovis_AF2122/97 PPPNQ--------TSQAANGS----------------PGANNGAGSGGAG
Rv3590c|M.tuberculosis_H37Rv PPPNQ--------TSQAANGS----------------PGANNGAGSGGAG
MUL_0572|M.ulcerans_Agy99 GTGGDPGAVGGRGNSGAAGGAGAVAGASGAAGTIIAGNGGNGGAGGAGYA
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK ACWING-------------------------------VPMREAVAGMFLD
Mvan_0445|M.vanbaalenii_PYR-1 GCWING-------------------------------VPMQEAVAAMFLG
MMAR_3402|M.marinum_M -MWIGG-------------------------------AQMQQGVGSLFLG
Mb3621c|M.bovis_AF2122/97 LPGNPGAVPGRAG-----------GAGGLGGSGSDTSEGPVTGGNGGNGG
Rv3590c|M.tuberculosis_H37Rv LPGNPGAVPGRAG-----------GAGGLGGSGSDTSEGPVTGGNGGNGG
MUL_0572|M.ulcerans_Agy99 ADGPAGPAIGNGGDGGHGGAGGFYGNGGAGGAGGNSAPGGGTGGNGGTGG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK QRTSLTASAQAAGYVGALPEDFVLSGQSAGGGFAAAVGGFYAANP-LGDN
Mvan_0445|M.vanbaalenii_PYR-1 DRTSLNASANTAGYLGTLPQDFVMSGQSAGGGFATAVGGYYTEDP-GNNG
MMAR_3402|M.marinum_M SQTALNISANQAGYLGTLPQDFILSGHSAGGGLASIAAGSYLANLGAATN
Mb3621c|M.bovis_AF2122/97 D-GGPGAPGGNGAPGGIGVNTGTG------------WAYGGNGGNGGDG-
Rv3590c|M.tuberculosis_H37Rv D-GGPGAPGGNGAPGGIGVNTGTG------------WAYGGNGGNGGDG-
MUL_0572|M.ulcerans_Agy99 DSGAMGSSGGRGGDGGVGTNGGAGGGGGNATSYGTANATGGAGGDGGTGS
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK DLRGVVMFDGFAFDG-ALADSLAKLDDPFVPVYQIAAPSQPWNGKGSSTR
Mvan_0445|M.vanbaalenii_PYR-1 SLRGVMMFDGFSFGG-VLTKSLAKLDDPFIPVYQIAAPPQPWNSSGASTK
MMAR_3402|M.marinum_M HLQGVVMFDGVASNSSAFGAAVANLQAANVPIYVVAAPPQPWNAFGATTN
Mb3621c|M.bovis_AF2122/97 -GAGARGGDGGNGGNGLALNGGNG-----IGG---NGGAGGRGGTGAAGG
Rv3590c|M.tuberculosis_H37Rv -GAGARGGDGGNGGNGLALNGGNG-----IGG---NGGAGGRGGTGAAGG
MUL_0572|M.ulcerans_Agy99 TGNGGSGGDGGNGGTGHGGGGGPGGTAINYGAGDAFGGAAGKGGTGVVGG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK ELVVARPDQ----FVGVTLAGGSHSDSLLGGNPITDLLLQLVTGRSPAGN
Mvan_0445|M.vanbaalenii_PYR-1 ELVAARPGQ----FVGVTLAGGSHADALIGGNALFDFFAQLVAGFSPPGN
MMAR_3402|M.marinum_M QLVSLYPGQ----FTGVEIVNGSHVDSMLGGNPLIDFAAQLLTGFSPPGA
Mb3621c|M.bovis_AF2122/97 NGGIGGGAT--GTLTFFGSGGDGGPGGAG---------ANTAGTGGVGGV
Rv3590c|M.tuberculosis_H37Rv NGGIGGGAT--GTLTFFGSGGDGGPGGAG---------ANTAGTGGVGGV
MUL_0572|M.ulcerans_Agy99 NGGSGGAAYNYGTGNATGAGGSSGSGGAASVPNSASTATATSGSGGAGGD
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK TAAAYTLANGWINDMYAGLGPADGT-GIYGTPDQYIVMGDTAAVVLAPPP
Mvan_0445|M.vanbaalenii_PYR-1 TAAVYTLATGWINDMYQGLGPNDGT-GIYGDPDQYIVMGDTAAIVLAPPP
MMAR_3402|M.marinum_M TQAVYTLSSGWINDIWAGADPLNPIYGIYGPTGGYVAPGG-QAIFLGP--
Mb3621c|M.bovis_AF2122/97 GGAGGQGG------------LLFGDGGNGGAG--GAGGIGGTG-------
Rv3590c|M.tuberculosis_H37Rv GGAGGQGG------------LLFGDGGNGGAG--GAGGIGGTG-------
MUL_0572|M.ulcerans_Agy99 GTDGGNGGSGGFAFTFGTGNIIAGVGGGGGTGSTGVGGIGGSGGGADINN
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK PVDLDRYLGTWFEVGSVKQFFSIGLVNTKAQYSLNPDGSVRVEN------
Mvan_0445|M.vanbaalenii_PYR-1 VVDIDRYLGTWYEVGSVKQFFSIGLVNTKAVYSLNPDASIKVEN------
MMAR_3402|M.marinum_M --------------------------------------------------
Mb3621c|M.bovis_AF2122/97 -----------------------------------------ASGGAGGKG
Rv3590c|M.tuberculosis_H37Rv -----------------------------------------ASGGAGGKG
MUL_0572|M.ulcerans_Agy99 GAFTVVPQGGAGGHGGDGATDGGAGGAGGFTEIDSSASVIAATGGAGGDG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK -----------------------------------SGNYFVNNGPQSSIV
Mvan_0445|M.vanbaalenii_PYR-1 -----------------------------------SGNYFFNNGPESSIV
MMAR_3402|M.marinum_M ------------------------------------------------TA
Mb3621c|M.bovis_AF2122/97 GSGLVG---------GDGGNGGAG----------------GAGGNGGKGG
Rv3590c|M.tuberculosis_H37Rv GSGLVG---------GDGGNGGAG----------------GAGGNGGKGG
MUL_0572|M.ulcerans_Agy99 GSGGTGRGGTGGGGTGGGGTGGGGGVGINNGSGEAIGGAPGAGGTGAVGG
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK GSALPVDATNNRLTVRFFGPPSAA----PPGNYWIVDLDPEYRWAVVTDP
Mvan_0445|M.vanbaalenii_PYR-1 GSALPVDPTNNKLNVRFFGPPSAR----PPGNYWIVDLDPDYQWAVVTDP
MMAR_3402|M.marinum_M GIVLPA--------------------------------------------
Mb3621c|M.bovis_AF2122/97 AGGAG------------GGAGMFSQPGVHGAGGTGGQG------------
Rv3590c|M.tuberculosis_H37Rv AGGAG------------GGAGMFSQPGVHGAGGTGGQG------------
MUL_0572|M.ulcerans_Agy99 DGGQGGAAYSYGTGDATGSAGAAGTAGTTGVGGTGGAGGAAYTLNGASTA
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK TGLSGFLLSREAVVTDAFYRELLDRASVYG--------------------
Mvan_0445|M.vanbaalenii_PYR-1 TGLSGFLLSRDPVVSADFYQELLDRASVNG--------------------
MMAR_3402|M.marinum_M --------------------------------------------------
Mb3621c|M.bovis_AF2122/97 ---------------------GAGGAGGAGGAAGAGTVVAGN--------
Rv3590c|M.tuberculosis_H37Rv ---------------------GAGGAGGAGGAAGAGTVVAGN--------
MUL_0572|M.ulcerans_Agy99 TATGGIGGNGGDGGTANGSNGGNGGAGGYASTTGTGTASVGNGGRGGDGT
MAV_0534|M.avium_104 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK ---------------------VKARITPTRQPAAQTTTI-----------
Mvan_0445|M.vanbaalenii_PYR-1 ---------------------VKGWITRTRQPAANQTQL-----------
MMAR_3402|M.marinum_M --------------------------------------------------
Mb3621c|M.bovis_AF2122/97 ----PGDPGGFG-------------AAGADGLPG---------------
Rv3590c|M.tuberculosis_H37Rv ----PGDPGGFG-------------AAGADGLPG---------------
MUL_0572|M.ulcerans_Agy99 ATVATGGTGGVGGNAHAPAGSPVPGVGGKGGNPGPGGKPGPNGADGIVV
MAV_0534|M.avium_104 -------------------------------------------------
MLBr_01183|M.leprae_Br4923 -------------------------------------------------
Mflv_0299|M.gilvum_PYR-GCK -------------------------------------------------
Mvan_0445|M.vanbaalenii_PYR-1 -------------------------------------------------
MMAR_3402|M.marinum_M -------------------------------------------------