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MTSSVAGKVVAITGGARGIGLAIATALHGLGTKVAIGDIDESTAKSSGDRLGLPLACGLDVTNRQSFTAF LDTVEDKLGPLDVLVNNAGLISVGSAVDEPDDATHRLFDVNVHGVILGTKLAAQRMLPRRRGHVINIGSV GSMLPTEGIATYCATKHAVLGYTDAVRMETRGKGVHFSVIMPTLTNTEMVAGVGHAKGFKNAEPEDVARA VVGVIAKPEPHVAVPRSLGVTLWAQRLMPLGLAEALGRALGSGRVFTTDLRRDQHDVYTRRTGIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3040 | - | - | 100% (275) | short-chain dehydrogenase |
| M. marinum M | MMAR_2743 | - | 4e-81 | 54.68% (267) | short-chain type dehydrogenase |
| M. marinum M | MMAR_2981 | fabG3_1 | 6e-28 | 34.25% (219) | 20-beta-hydroxysteroid dehydrogenase FabG3_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1896c | - | 5e-84 | 56.93% (267) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0217 | - | 2e-51 | 42.28% (272) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1865c | - | 5e-84 | 56.93% (267) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 3e-26 | 32.62% (187) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 5e-51 | 44.05% (252) | putative short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_2854 | - | 2e-78 | 55.43% (267) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0771 | - | 7e-48 | 40.86% (257) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3427 | - | 1e-46 | 41.86% (258) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2282 | - | 1e-153 | 98.55% (275) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2345 | - | 6e-53 | 42.80% (271) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MMAR_3040|M.marinum_M --------------------------------------------------
MUL_2282|M.ulcerans_Agy99 --------------------------------------------------
Mb1896c|M.bovis_AF2122/97 --------------------------------------------------
Rv1865c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2854|M.avium_104 --------------------------------------------------
Mflv_0217|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0771|M.smegmatis_MC2_155 --------------------------------------------------
TH_3427|M.thermoresistible__bu --------------------------------------------------
MAB_4335|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2345|M.vanbaalenii_PYR-1 ---------------------------------------MVPSRPARGPR
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_3040|M.marinum_M -----------MTSSVAG----------KVVAITGGARGIGLAIATALHG
MUL_2282|M.ulcerans_Agy99 -----------MTSSAAG----------KVVAITGRARGIGLAIATALHG
Mb1896c|M.bovis_AF2122/97 -----------MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHN
Rv1865c|M.tuberculosis_H37Rv -----------MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHN
MAV_2854|M.avium_104 -----------MADTASIGLKVR----DKVVVITGGARGIGLATATALHK
Mflv_0217|M.gilvum_PYR-GCK -----------MDNIRG-----------KTIAITGAARGIGYATAEALLA
MSMEG_0771|M.smegmatis_MC2_155 -----------MDNIRG-----------KTIAITGAARGIGYATAKALLA
TH_3427|M.thermoresistible__bu -----------MDNIRG-----------KTIAITGAARGIGYATATALLA
MAB_4335|M.abscessus_ATCC_1997 -----------MGTAVQLAG--------KVVAVTGGARGIGRAIATAFAA
Mvan_2345|M.vanbaalenii_PYR-1 TSAQLGMKGGTVTADRNLTG--------RVVAITGAARGIGAATARAFAA
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
: :** . *** * *:
MMAR_3040|M.marinum_M LGTKVAIGDIDESTAKSSGDRLG--LPLAC--GLDVTNRQSFTAFLDTVE
MUL_2282|M.ulcerans_Agy99 LGTKVAIGDFDESTAKSSGDRLG--LPLAC--GLDVTNRQSFTAFLDTVE
Mb1896c|M.bovis_AF2122/97 LGAKVAIGDIDEAMAKESGADLD--LDMYG--KLDVTDPDSFSGFLDAVE
Rv1865c|M.tuberculosis_H37Rv LGAKVAIGDIDEAMAKESGADLD--LDMYG--KLDVTDPDSFSGFLDAVE
MAV_2854|M.avium_104 LGAKVAIGDIDEVRVKESGAALD--LDVYG--KLDVTDPHSFSDFLDEVE
Mflv_0217|M.gilvum_PYR-GCK HGARVVIGDRDVALQESSVAKLTN-LGPVSGYPLDVTDQESFATFLDKAR
MSMEG_0771|M.smegmatis_MC2_155 HGARVVIGDRDVALQESAVVELSK-LGQVSGYPLDVTDRESFATFLDKAR
TH_3427|M.thermoresistible__bu RGARVVIGDRDVALQESAVAQLGR-LGPVSGYPLDVTDRESFATFLDKAR
MAB_4335|M.abscessus_ATCC_1997 EGAKVAIGDIDKKLCENTAAEIGN-SAIGLP--LDVTDHGSFEAFFDTIA
Mvan_2345|M.vanbaalenii_PYR-1 AGASVAIGDLDADLAVRTAAEIG---CLGSG--VDVTDHDSVEKFLDEVE
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVS
*: *.:.* * : : :**:: :. * :
MMAR_3040|M.marinum_M DKLG-PLDVLVNNAGLISVGSAVDEPDDATHRLFDVNVHGVILGTKLAAQ
MUL_2282|M.ulcerans_Agy99 DKLG-PLDVLVNNAGLISVGSAVDEPDDATHRLFDVNVHGVILGTKLATQ
Mb1896c|M.bovis_AF2122/97 RQLG-PIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQ
Rv1865c|M.tuberculosis_H37Rv RQLG-PIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQ
MAV_2854|M.avium_104 RQLG-PIDVLVNNAGIMPLGRVVDESDAVTRRILDINVYGVILGSKLALA
Mflv_0217|M.gilvum_PYR-GCK TDGGGHIDVLINNAGVMPVGPFLDETEQSIRSSLEVNVYGVLTGCRLALP
MSMEG_0771|M.smegmatis_MC2_155 TDGGGHIDVLINNAGVMPVGPFLEQSEQSIRSNIEVNVYGVLTGCQLALP
TH_3427|M.thermoresistible__bu TDGGGHIDVLINNAGVMPIGPFLEQSEQAIRSSIEVNLYGVLTGCQLALP
MAB_4335|M.abscessus_ATCC_1997 ATVG-PVDVIVNNAGIMPITPFDDESLESIQRQLDINVRGVMWGSQLAIK
Mvan_2345|M.vanbaalenii_PYR-1 QRLG-PLDVMVNNAGIMPVTQMLDESPESVRRQLAVNVAGVVFGTQHAAS
MLBr_00862|M.leprae_Br4923 AKHG-VPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
* *:::****: : . : :*: **: :
MMAR_3040|M.marinum_M RMLPRRRG-HVINIGSVGSMLPTEGIATYCATKHAVLGYTDAVRMETRGK
MUL_2282|M.ulcerans_Agy99 RMLPRRRG-HVINIGSVGSMLPTEGIATYCATKHAVLGYTDAVRMETRGK
Mb1896c|M.bovis_AF2122/97 RMVPRGRG-HVINVASLAGEIYAVGVATYCASKHAVVAFTDSARLEYRSA
Rv1865c|M.tuberculosis_H37Rv RMVPRGRG-HVINVASLAGEIYAVGVATYCASKHAVVAFTDSARLEYRSA
MAV_2854|M.avium_104 RMIPRGRG-HVINVASLAGETYLAGAATYCASKHAVVGFTDAARIEYRRS
Mflv_0217|M.gilvum_PYR-GCK DMVKRRSG-HIINIASLSGVIPLPGQVVYVGAKYAVVGLTTALADEMAPH
MSMEG_0771|M.smegmatis_MC2_155 DMVKRRRG-HIINIASLSGVIPLPGQVVYVGAKYAVVGLSTALADEMAPY
TH_3427|M.thermoresistible__bu DMVRRRSG-HIINIASMSGLIPVPGQVPYNAAKFGVVGLSVALADEMAPY
MAB_4335|M.abscessus_ATCC_1997 RMKPRGGG-VIVNIASAAGKAGFPGLATYCATKHAVVGLSESLSLEYEPA
Mvan_2345|M.vanbaalenii_PYR-1 RMVARRSG-HIVNVASAAGRIAFGGVATYTATKFAVVGFTEAAALELRDS
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
: * * ::*:.* .. . * :* .. : . *
MMAR_3040|M.marinum_M GVHFSVIMPTLTNTEMVAGVGHAKGFKNAEPEDVARAVVGVIAKPEPHVA
MUL_2282|M.ulcerans_Agy99 GVHFSVIMPTLTNTEMVAGVGHAKGFKNAEPEDVARAVVGVIAKPEPHVA
Mb1896c|M.bovis_AF2122/97 GVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVR
Rv1865c|M.tuberculosis_H37Rv GVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVR
MAV_2854|M.avium_104 GVKFSVVKPTFVNTELIAGTSGAKGVRNAEPSDIADAIVKLVAHPRPRVR
Mflv_0217|M.gilvum_PYR-GCK GVNVSVIMPPFTNTELIAGTKSGGAIKPVEPEDIAAAIVKTLNKPKTHVS
MSMEG_0771|M.smegmatis_MC2_155 GVDVSVIMPPFTNTDLISGTKSGGAIKPVEPEEIAAAIVKTLNKPKTHVS
TH_3427|M.thermoresistible__bu GVEVSVVMPPFTRTELISGTKETAATKPAEPEDIAAAIVKTLDKPKTHVS
MAB_4335|M.abscessus_ATCC_1997 GISVVCVMPGMVNTELISGLDTHWLLKTVEPEDIANAVVKAVRRGVFPVF
Mvan_2345|M.vanbaalenii_PYR-1 GVRFTCVLPGVVNTELTSGLRDHWLLRSCEPEEVAAGVVAGVRRHRRTVY
MLBr_00862|M.leprae_Br4923 GVGLTTICPGVIDTNIIQSTR-------IDTPTAKQERVRDRRGQLDMMF
*: . : * . *:: . :. * :
MMAR_3040|M.marinum_M VPRSLGVTLWAQRLMPLGLAEALGRALGSGRVFTTDLRRDQHDVYTRRTG
MUL_2282|M.ulcerans_Agy99 VPRSLGVTLWAQRLMPLGLAEALGRALGSGRVFTTDLRRDQHDVYTRRTG
Mb1896c|M.bovis_AF2122/97 VTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARAR
Rv1865c|M.tuberculosis_H37Rv VTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARAR
MAV_2854|M.avium_104 VTRTAGAIIASQKFMPRALSEGLNRLLGGEHVFTDAVDVEKRQAYEARAR
Mflv_0217|M.gilvum_PYR-GCK VPPPLRFTAQAAQMLPPKGRRAMNKALGLDTVFL-DVDTDKRKGYEERAR
MSMEG_0771|M.smegmatis_MC2_155 VPPPLRFTAQAAQMLPPKGRRWLNKKLGLDNVFL-EFDTAKRKAYEDRAQ
TH_3427|M.thermoresistible__bu VPGPLRFIAQAAQTLGPRGRRWLNKRLGLDTVFL-EFDQQARQGYEQRAQ
MAB_4335|M.abscessus_ATCC_1997 VPKMFGGMYRTMSVLPRSTGKFLTRKLGIQDFMLNAHGSDARKAYEDRAS
Mvan_2345|M.vanbaalenii_PYR-1 VPARLRPVSWAYGLLPGAARTQVMAALGAGHRMLDGD-DTARRDYNRRID
MLBr_00862|M.leprae_Br4923 RLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTAR
: : :.
MMAR_3040|M.marinum_M IS------------------
MUL_2282|M.ulcerans_Agy99 IS------------------
Mb1896c|M.bovis_AF2122/97 GEE-----------------
Rv1865c|M.tuberculosis_H37Rv GEE-----------------
MAV_2854|M.avium_104 GEQ-----------------
Mflv_0217|M.gilvum_PYR-GCK AARGVVEGSQG---------
MSMEG_0771|M.smegmatis_MC2_155 AALGVVESEKK---------
TH_3427|M.thermoresistible__bu QALGVLEGGNKQQDRSGQKS
MAB_4335|M.abscessus_ATCC_1997 HSGPSTE-------------
Mvan_2345|M.vanbaalenii_PYR-1 TR------------------
MLBr_00862|M.leprae_Br4923 IRVI----------------