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MADTASIGLKVRDKVVVITGGARGIGLATATALHKLGAKVAIGDIDEVRVKESGAALDLDVYGKLDVTDP HSFSDFLDEVERQLGPIDVLVNNAGIMPLGRVVDESDAVTRRILDINVYGVILGSKLALARMIPRGRGHV INVASLAGETYLAGAATYCASKHAVVGFTDAARIEYRRSGVKFSVVKPTFVNTELIAGTSGAKGVRNAEP SDIADAIVKLVAHPRPRVRVTRTAGAIIASQKFMPRALSEGLNRLLGGEHVFTDAVDVEKRQAYEARARG EQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2854 | - | - | 100% (282) | short chain dehydrogenase |
| M. avium 104 | MAV_2700 | - | 5e-62 | 49.09% (275) | short chain dehydrogenase |
| M. avium 104 | MAV_1382 | - | 4e-30 | 32.95% (264) | short chain alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1896c | - | 1e-125 | 78.65% (281) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0217 | - | 2e-54 | 45.99% (274) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1865c | - | 1e-125 | 78.65% (281) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 2e-28 | 35.87% (223) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4335 | - | 1e-56 | 45.39% (271) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_2743 | - | 1e-129 | 80.78% (281) | short-chain type dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0771 | - | 8e-52 | 43.64% (275) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3427 | - | 5e-49 | 44.57% (276) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3011 | - | 1e-128 | 80.07% (281) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2345 | - | 6e-52 | 43.66% (268) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0217|M.gilvum_PYR-GCK -------------------------MDNIR----GKTIAITGAARGIGYA
MSMEG_0771|M.smegmatis_MC2_155 -------------------------MDNIR----GKTIAITGAARGIGYA
TH_3427|M.thermoresistible__bu -------------------------MDNIR----GKTIAITGAARGIGYA
MMAR_2743|M.marinum_M ------------------MADSTTIGVRVR----DKVIVITGGARGIGLA
MUL_3011|M.ulcerans_Agy99 ------------------MADSTTIGVRVR----NKVIVITGGARGIGLA
MAV_2854|M.avium_104 ------------------MADTASIGLKVR----DKVVVITGGARGIGLA
Mb1896c|M.bovis_AF2122/97 ------------------MPGRTSIGVKIRDKVQDKVIAITGGARGIGLA
Rv1865c|M.tuberculosis_H37Rv ------------------MPGRTSIGVKIRDKVQDKVIAITGGARGIGLA
MAB_4335|M.abscessus_ATCC_1997 ----------------------MGTAVQLA----GKVVAVTGGARGIGRA
Mvan_2345|M.vanbaalenii_PYR-1 MVPSRPARGPRTSAQLGMKGGTVTADRNLT----GRVVAITGAARGIGAA
MLBr_01094|M.leprae_Br4923 -------------------------MEGFA----GKVAVVTGAGSGIGQA
. .:. .:**.. *** *
Mflv_0217|M.gilvum_PYR-GCK TAEALLAHGARVVIGDRDVALQESSVAKLTNLGP-VSGYPLDVTDQESFA
MSMEG_0771|M.smegmatis_MC2_155 TAKALLAHGARVVIGDRDVALQESAVVELSKLGQ-VSGYPLDVTDRESFA
TH_3427|M.thermoresistible__bu TATALLARGARVVIGDRDVALQESAVAQLGRLGP-VSGYPLDVTDRESFA
MMAR_2743|M.marinum_M TATALHKLGAKVAIGDVDEPAVKEAGADLGLE---VYGK-LDVTDPNSFS
MUL_3011|M.ulcerans_Agy99 TATALHKLGAKVAIGDVGEPAVKEAGADLGLE---VYGK-LDVTDPNSFS
MAV_2854|M.avium_104 TATALHKLGAKVAIGDIDEVRVKESGAALDLD---VYGK-LDVTDPHSFS
Mb1896c|M.bovis_AF2122/97 TAAALHNLGAKVAIGDIDEAMAKESGADLDLD---MYGK-LDVTDPDSFS
Rv1865c|M.tuberculosis_H37Rv TAAALHNLGAKVAIGDIDEAMAKESGADLDLD---MYGK-LDVTDPDSFS
MAB_4335|M.abscessus_ATCC_1997 IATAFAAEGAKVAIGDIDKKLCENTAAEIGNS---AIGLPLDVTDHGSFE
Mvan_2345|M.vanbaalenii_PYR-1 TARAFAAAGASVAIGDLDADLAVRTAAEIG-----CLGSGVDVTDHDSVE
MLBr_01094|M.leprae_Br4923 LAIELARSGAKLAISDVDGEGLAQTEGQLKAIGASARTDRLDVTEREAFL
* : ** :.*.* . : : :***: :.
Mflv_0217|M.gilvum_PYR-GCK TFLDKARTDGGGHIDVLINNAGVMPVGPFLDETEQSIRSSLEVNVYGVLT
MSMEG_0771|M.smegmatis_MC2_155 TFLDKARTDGGGHIDVLINNAGVMPVGPFLEQSEQSIRSNIEVNVYGVLT
TH_3427|M.thermoresistible__bu TFLDKARTDGGGHIDVLINNAGVMPIGPFLEQSEQAIRSSIEVNLYGVLT
MMAR_2743|M.marinum_M DFLDQVERQLG-PLDVLVNNAGIMPVGRIVDEPDSVTRRILDINVYGVMV
MUL_3011|M.ulcerans_Agy99 DFLDQVERQLG-PLDVLVNNAGIMPVGRIVDEPDSVTRRILDINVYGVMV
MAV_2854|M.avium_104 DFLDEVERQLG-PIDVLVNNAGIMPLGRVVDESDAVTRRILDINVYGVIL
Mb1896c|M.bovis_AF2122/97 GFLDAVERQLG-PIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVIL
Rv1865c|M.tuberculosis_H37Rv GFLDAVERQLG-PIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVIL
MAB_4335|M.abscessus_ATCC_1997 AFFDTIAATVG-PVDVIVNNAGIMPITPFDDESLESIQRQLDINVRGVMW
Mvan_2345|M.vanbaalenii_PYR-1 KFLDEVEQRLG-PLDVMVNNAGIMPVTQMLDESPESVRRQLAVNVAGVVF
MLBr_01094|M.leprae_Br4923 TYADVVHENFG-KVNQIYNNAGIAFTGDVEVSHFKDIERVMDVDYWGVVN
: * * :: : ****: . . . : :: **:
Mflv_0217|M.gilvum_PYR-GCK GCRLALPDMVKRRSGHIINIASLSGVIPLPGQVVYVGAKYAVVGLTTALA
MSMEG_0771|M.smegmatis_MC2_155 GCQLALPDMVKRRRGHIINIASLSGVIPLPGQVVYVGAKYAVVGLSTALA
TH_3427|M.thermoresistible__bu GCQLALPDMVRRRSGHIINIASMSGLIPVPGQVPYNAAKFGVVGLSVALA
MMAR_2743|M.marinum_M GSKLAAQRMVPRGRGHVINVASLAGEIYVVGLATYCASKHAVIAFTDAAR
MUL_3011|M.ulcerans_Agy99 GSKLAAQRMVPRGRGHVINVASLAGEIYVVGLATYCASKHAVIAFTDAAR
MAV_2854|M.avium_104 GSKLALARMIPRGRGHVINVASLAGETYLAGAATYCASKHAVVGFTDAAR
Mb1896c|M.bovis_AF2122/97 GSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYCASKHAVVAFTDSAR
Rv1865c|M.tuberculosis_H37Rv GSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYCASKHAVVAFTDSAR
MAB_4335|M.abscessus_ATCC_1997 GSQLAIKRMKPRGGGVIVNIASAAGKAGFPGLATYCATKHAVVGLSESLS
Mvan_2345|M.vanbaalenii_PYR-1 GTQHAASRMVARRSGHIVNVASAAGRIAFGGVATYTATKFAVVGFTEAAA
MLBr_01094|M.leprae_Br4923 GTKAFLPYLISSGDGHVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALR
* : : * ::*::* * * . * .:*..* .:: :
Mflv_0217|M.gilvum_PYR-GCK DEMAPHG--VNVSVIMPPFTNTELIAGTKSGGAIKPVEPEDIAAAIVKTL
MSMEG_0771|M.smegmatis_MC2_155 DEMAPYG--VDVSVIMPPFTNTDLISGTKSGGAIKPVEPEEIAAAIVKTL
TH_3427|M.thermoresistible__bu DEMAPYG--VEVSVVMPPFTRTELISGTKETAATKPAEPEDIAAAIVKTL
MMAR_2743|M.marinum_M IEYRSTG--VKFSMVLPTFVNTELASGTPGMKGFKNAEPSDIADAIVALV
MUL_3011|M.ulcerans_Agy99 IEYRTTG--VKFSMVLPTFVNTELASGTPGMKGFKNAEPSDIADAIVALV
MAV_2854|M.avium_104 IEYRRSG--VKFSVVKPTFVNTELIAGTSGAKGVRNAEPSDIADAIVKLV
Mb1896c|M.bovis_AF2122/97 LEYRSAG--VKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLI
Rv1865c|M.tuberculosis_H37Rv LEYRSAG--VKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLI
MAB_4335|M.abscessus_ATCC_1997 LEYEPAG--ISVVCVMPGMVNTELISGLDTHWLLKTVEPEDIANAVVKAV
Mvan_2345|M.vanbaalenii_PYR-1 LELRDSG--VRFTCVLPGVVNTELTSGLRDHWLLRSCEPEEVAAGVVAGV
MLBr_01094|M.leprae_Br4923 EEMALAGRPVNVTTVYPGGIKTAIARNATAAEGLDVSKIASRFDTWVAHT
* * : . : * .* : . : . *
Mflv_0217|M.gilvum_PYR-GCK NKPKTHVSVPPPLRFTAQAAQMLPPKGRRAMNKALGLDTVFLDVD-TDKR
MSMEG_0771|M.smegmatis_MC2_155 NKPKTHVSVPPPLRFTAQAAQMLPPKGRRWLNKKLGLDNVFLEFD-TAKR
TH_3427|M.thermoresistible__bu DKPKTHVSVPGPLRFIAQAAQTLGPRGRRWLNKRLGLDTVFLEFD-QQAR
MMAR_2743|M.marinum_M ANPKPRVRVTKAAGAMIASQKYLPRWLSEGLNRLLGGEHVFTDDVDAAKR
MUL_3011|M.ulcerans_Agy99 ANPKPRVRVTKAAGAMIASQKYLPRWLSEGLNRLLGGEHVFTDDVDAAKR
MAV_2854|M.avium_104 AHPRPRVRVTRTAGAIIASQKFMPRALSEGLNRLLGGEHVFTDAVDVEKR
Mb1896c|M.bovis_AF2122/97 VHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKR
Rv1865c|M.tuberculosis_H37Rv VHPKPRVRVTKAAGSMIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKR
MAB_4335|M.abscessus_ATCC_1997 RRGVFPVFVPKMFGGMYRTMSVLPRSTGKFLTRKLGIQDFMLNAHGSDAR
Mvan_2345|M.vanbaalenii_PYR-1 RRHRRTVYVPARLRPVSWAYGLLPGAARTQVMAALGAGHRMLDGD-DTAR
MLBr_01094|M.leprae_Br4923 SPQHAARIILKAVRKKKARVLVGPDAKVANVVVRFSGGAGYQRLFAQVAS
: : :.
Mflv_0217|M.gilvum_PYR-GCK KGYEERARAARGVVEGSQG---------
MSMEG_0771|M.smegmatis_MC2_155 KAYEDRAQAALGVVESEKK---------
TH_3427|M.thermoresistible__bu QGYEQRAQQALGVLEGGNKQQDRSGQKS
MMAR_2743|M.marinum_M EAYEARARGETGES--------------
MUL_3011|M.ulcerans_Agy99 EAYEARARGETGES--------------
MAV_2854|M.avium_104 QAYEARARGEQ-----------------
Mb1896c|M.bovis_AF2122/97 RTYEARARGEE-----------------
Rv1865c|M.tuberculosis_H37Rv RTYEARARGEE-----------------
MAB_4335|M.abscessus_ATCC_1997 KAYEDRASHSGPSTE-------------
Mvan_2345|M.vanbaalenii_PYR-1 RDYNRRIDTR------------------
MLBr_01094|M.leprae_Br4923 RLILNQR---------------------
. :