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MSFLTVLPDMVATSAENLVDVCSTLGVANAAAAVPTTGIAAAASDEVSTAIATLFGSYAQEYQTLSARAA AFHDEFVSVLKGSGAAYLSAEVANAEQNLIKTVNAPARALLGHPLIPTDGSATAGPGTGVIGTAGLRTVD AVATAVRSGANATLGRVTAAESVVAASATRVASAATLLPGHVAASVESVSASLPASLASLSLLGSTAAPA AQATVDIAAPYQELIENTAANLQSLGSTWAANPAPFLSQILANQLGYGQTIATSLQNAAQDLGAVLYDPS ALNRALADLSPISAIGGQIQQNLINLGGTALTDVAPAVAFVAAGPALSTLQGFGISLNAFTTAVQSGDIA GALGALVDAPAVLANGFLNGGVTLPLLLPIGLGFVVLDVPFDGILVAPHATTATVTWFLPYFQEVVSGPT VGGIVSTLLTSVPQELATAITPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2973 | - | - | 100% (443) | PE-PGRS family protein |
| M. marinum M | MMAR_2458 | - | 3e-63 | 32.65% (634) | PE-PGRS family protein |
| M. marinum M | MMAR_2459 | - | 1e-62 | 33.87% (558) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3842 | PE_PGRS62 | 7e-41 | 30.74% (514) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_1753 | - | 5e-13 | 30.58% (206) | hypothetical protein Mflv_1753 |
| M. tuberculosis H37Rv | Rv3812 | PE_PGRS62 | 7e-41 | 30.74% (514) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 8e-10 | 33.70% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_0978 | - | 2e-05 | 23.85% (369) | hypothetical protein MAB_0978 |
| M. avium 104 | MAV_1346 | - | 1e-16 | 31.87% (273) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_6033 | - | 9e-11 | 29.23% (260) | hypothetical protein MSMEG_6033 |
| M. thermoresistible (build 8) | TH_4350 | - | 1e-15 | 29.45% (309) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1639 | - | 1e-62 | 33.87% (558) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_4536 | - | 3e-11 | 25.08% (331) | hypothetical protein Mvan_4536 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2973|M.marinum_M -----------------------------------------MS-FLTVLP
MUL_1639|M.ulcerans_Agy99 -----------------------------------------MS-FLLVQP
Mb3842|M.bovis_AF2122/97 -----------------------------------------MS-FVVTVP
Rv3812|M.tuberculosis_H37Rv -----------------------------------------MS-FVVTVP
MLBr_01183|M.leprae_Br4923 -----------------------------------------MPLFLNAEP
MAV_1346|M.avium_104 -----------------------------------------MS-FVTTRP
TH_4350|M.thermoresistible__bu -----------------------------------------MLASIRPYA
Mvan_4536|M.vanbaalenii_PYR-1 -----------------------------------------MHVTVRSYL
MSMEG_6033|M.smegmatis_MC2_155 ----------------------------MHHPALASSGDAPAVSRKDKFL
Mflv_1753|M.gilvum_PYR-GCK -----------------------------------------MYTTLRPYA
MAB_0978|M.abscessus_ATCC_1997 MRVRLRATATAAVCSVCIAASVSVPTIQTLSASPEQHRTVSTQAYVLTSN
MMAR_2973|M.marinum_M DMVATSAENLVDVCSTLGVANAAAAVPTTGIAAAASDEVSTA--------
MUL_1639|M.ulcerans_Agy99 EMVSAATESLTAIRSALGEVSAAVAGPTTAVVAAAGDEVSAA--------
Mb3842|M.bovis_AF2122/97 EAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAADDVSIA--------
Rv3812|M.tuberculosis_H37Rv EAVAAAAGDLAAIGSTLREATAAAAGPTTGLAAAAADDVSIA--------
MLBr_01183|M.leprae_Br4923 QALTAAANTLEGLSAATVASNAAAAQLTTEIAPPAADDVSIL--------
MAV_1346|M.avium_104 EALLAVASMLEGLGSSMDAQNAAAAAPTTSIAPAAADEVSAL--------
TH_4350|M.thermoresistible__bu TAGVALVGAGVIAVTPVAPPPADIQVSRQAVALSAISNPGDP--------
Mvan_4536|M.vanbaalenii_PYR-1 TAGVALAGASAIALAPVVVPPSSTVSSSPAMSSVAVELSAAVN-------
MSMEG_6033|M.smegmatis_MC2_155 LGGVAVVAASAMAVTPVVHDSPVVHRAQTIAYDLTATMDATAS-------
Mflv_1753|M.gilvum_PYR-GCK TAGVAMLGASAIAIAPVVVTP---TLPDLKVVSTGVQLNAAID-------
MAB_0978|M.abscessus_ATCC_1997 DGTLSPASIGSLAALPGVTTAAAPTPPEGSTWPSANPLVNLAVGPLQFDP
: .
MMAR_2973|M.marinum_M --------------------------------------IATLFGSYAQEY
MUL_1639|M.ulcerans_Agy99 --------------------------------------ISQVFGAYGQEF
Mb3842|M.bovis_AF2122/97 --------------------------------------VSQLFGRYGQEF
Rv3812|M.tuberculosis_H37Rv --------------------------------------VSQLFGRYGQEF
MLBr_01183|M.leprae_Br4923 --------------------------------------LAHFFSGHGRQY
MAV_1346|M.avium_104 --------------------------------------QAAQFSAYGTWY
TH_4350|M.thermoresistible__bu --------------------------------------VVAYGELIANTI
Mvan_4536|M.vanbaalenii_PYR-1 -------------------------------------PITAWVDVFAGAA
MSMEG_6033|M.smegmatis_MC2_155 -------------------------------------PLSVYGSLISTTI
Mflv_1753|M.gilvum_PYR-GCK -------------------------------------PLTPLLELFNSSE
MAB_0978|M.abscessus_ATCC_1997 KFSRSPVLASPFTIVNAPFQLLTGQSIVNPNGTTSAPTVQNLINAETTAL
MMAR_2973|M.marinum_M QTLSARAAAFHDEFVSVLKGSG--------AAYLSAEVAN------AEQN
MUL_1639|M.ulcerans_Agy99 QALNAQAAAFQAEFEGLLSGGA--------AAYVSAEALNSSVFGPPMQE
Mb3842|M.bovis_AF2122/97 QTVSNQLAAFHTEFVRTLNRGA--------AAYLNTESANGGQLFGQIEA
Rv3812|M.tuberculosis_H37Rv QTVSNQLAAFHTEFVRTLNRGA--------AAYLNTESANGGQLFGQIEA
MLBr_01183|M.leprae_Br4923 QAHASQGATNHQDLIQSLLTSS--------SAYAGTETAN----------
MAV_1346|M.avium_104 QQVSAQAKAIHQTLVQNLDTNA--------DSYGATEAANRVNTSAAALQ
TH_4350|M.thermoresistible__bu GSLQGLGGQFAADPAPVLVKIL--------QNQIANGQLIGSALDEALGF
Mvan_4536|M.vanbaalenii_PYR-1 TNLGGIGNAILEDPFPLLRQAL--------ENVLGYGGTLVSATTGAITG
MSMEG_6033|M.smegmatis_MC2_155 DNLSLLGSAVAANPAPLLRQVV--------ENQLGYAAQFGATFEAIPTS
Mflv_1753|M.gilvum_PYR-GCK VNVAALVDAWLEAPAPILQQII--------ANQIGYLGQLPDIGAILAQM
MAB_0978|M.abscessus_ATCC_1997 GLLAGVPAAYVANTIAVVQAIAQNPGSLLPSGLVPTATTLSAANTTAVSP
:
MMAR_2973|M.marinum_M LIKTVNAPA------RALLGHPLIPTDGSATAGPGTG-----VIGTAGLR
MUL_1639|M.ulcerans_Agy99 LLKVVNAPT------QMLLGRSLIADGANATAAGGDGRPGGILMGKGGDG
Mb3842|M.bovis_AF2122/97 GQRAVSAAA------AAAPGGAYGQLVANTATNLESLYGAWSANPFPFLR
Rv3812|M.tuberculosis_H37Rv GQRAVSAAA------AAAPGGAYGQLVANTATNLESLYGAWSANPFPFLR
MLBr_01183|M.leprae_Br4923 --------------------------HDSL--------------------
MAV_1346|M.avium_104 GLAPNVIPN------AAPAADPPPAGTTSLGTS------------IGWAQ
TH_4350|M.thermoresistible__bu LLQGVEALP------GALEEAFALLTQGDLKGAVDAFMMGIIPAALGMIV
Mvan_4536|M.vanbaalenii_PYR-1 ALNYFSFDN------PAGAWPLIEDAFTQLSEGNISGAITTAGEALLLGP
MSMEG_6033|M.smegmatis_MC2_155 LQNWYNGTNGKVLL-DRAQAELEAGNVGEAYRWFNHSMLYAFQGAFGPLI
Mflv_1753|M.gilvum_PYR-GCK GTNLVAGLRSPFAEDPSTLEPLHASIYELIVDGIPGAIEPAPPQLVPLLE
MAB_0978|M.abscessus_ATCC_1997 TTKTLASTAVTASAATAPAPTAPAGSTWPSTNPVVNLLVGPLQFNSKWQS
MMAR_2973|M.marinum_M TVDAVATAVRSGANATLGRVTAAESVVAASATR-VASAATLLPG------
MUL_1639|M.ulcerans_Agy99 APGGPGQPGGNGGAAGLIGTGGAGGKGAPSMPGGLGGRGGLLWGDGGKGG
Mb3842|M.bovis_AF2122/97 QIIANQQVYWQQIAAALANAVQNFPALVANLPAAIDAAVQQFLAFN--AA
Rv3812|M.tuberculosis_H37Rv QIIANQQVYWQQIAAALANAVQNFPALVANLPAAIDAAVQQFLAFN--AA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 NVGAAASDFITLGEGQFAPVPGAAG-------------------------
TH_4350|M.thermoresistible__bu PLVAG-SMIITNTADNFARAVSAVLDVDAMLPTLLGFAGPVLSAVDG---
Mvan_4536|M.vanbaalenii_PYR-1 ILNIGLPIFTSGALEIPGKIAQNFANVVKSLTSLDTVFPIVLGALG----
MSMEG_6033|M.smegmatis_MC2_155 APGFILSGIPRGGTEYLVGIPEQIAQNVTNLVAATFTSSVVVSALFQG--
Mflv_1753|M.gilvum_PYR-GCK FTTTYLSGVLVGLAGLVMNPVLALGGGIHSVFQSLIGEDADLGAAIN---
MAB_0978|M.abscessus_ATCC_1997 PVLASPFTIVNAPFQLLTGQSIVNPDGTTVAPTVQNFIAAETKAFGLLVG
MMAR_2973|M.marinum_M -----------HVAASVESVSAS-LPASLASLSLLG---------STAAP
MUL_1639|M.ulcerans_Agy99 DGGAPVYDAWGYLLAEAGTGGAGGLPGIFGGLPGVAGAWGGEVPTALAAP
Mb3842|M.bovis_AF2122/97 YYIQQIISSQIGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGD
Rv3812|M.tuberculosis_H37Rv YYIQQIISSQIGFAQLFATTVGQGVTSVIAGWPNLAAELQLAFQQLLVGD
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_4350|M.thermoresistible__bu ----------------FVTSGQAVLDGVLAGDPIAVLN------------
Mvan_4536|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6033|M.smegmatis_MC2_155 -----AFATVSGPAFELARIAESLVTSVSSGEALNVVNILANTPGILVNA
Mflv_1753|M.gilvum_PYR-GCK -------------------------------------------------T
MAB_0978|M.abscessus_ATCC_1997 LPGAYVANTIAVVTALSQNPGSILPSGLIQPATTTANPTVAKTTALSLPE
MMAR_2973|M.marinum_M -----AAQATVDIAAPYQELIENTAANLQSLGSTWA--------------
MUL_1639|M.ulcerans_Agy99 MALSAAASSPAAVGGAYQTLFDNTWTNLQAIGATWN--------------
Mb3842|M.bovis_AF2122/97 YN-AAVANLGKAMTNLLVTGFDTSDVTIGTMGTTIS--------------
Rv3812|M.tuberculosis_H37Rv YN-AAVANLGKAMTNLLVTGFDTSDVTIGTMGTTIS--------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 -----------------IPNFNPGLTAATTAGPPAP--------------
TH_4350|M.thermoresistible__bu ----AVASTPAVLIDAVLNGSGALLGFLPLPGLLTP--------------
Mvan_4536|M.vanbaalenii_PYR-1 ----TVMAPMQALGGSLQAAFDALGEGNLIDAVVEL--------------
MSMEG_6033|M.smegmatis_MC2_155 ALNGFDYADPDPETGQGGFSEWPALLTFAEPGEQGG--------------
Mflv_1753|M.gilvum_PYR-GCK LINIPTAMADAFLNGGQSMVVTPLLTALGLELPIPG--------------
MAB_0978|M.abscessus_ATCC_1997 SSTTATSTTANTLAAPTASAPTGSAVTAPAPTAPAGSTWPSTNPVVNLLV
MMAR_2973|M.marinum_M ------------------------------------------------AN
MUL_1639|M.ulcerans_Agy99 ------------------------------------------------AD
Mb3842|M.bovis_AF2122/97 ------------------------------------------------VT
Rv3812|M.tuberculosis_H37Rv ------------------------------------------------VT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ------------------------------------------------AA
TH_4350|M.thermoresistible__bu ------------------------------------------------AT
Mvan_4536|M.vanbaalenii_PYR-1 ------------------------------------------------IN
MSMEG_6033|M.smegmatis_MC2_155 ------------------------------------------------VR
Mflv_1753|M.gilvum_PYR-GCK ------------------------------------------------ME
MAB_0978|M.abscessus_ATCC_1997 GPLQFNSKWQSPVLASPFTIVNAPFQLLTGQSIVNPDGTTSAPTIQNLIN
MMAR_2973|M.marinum_M PAPFLSQILANQLG--YGQTIATSLQNAAQDLGAVLYDPSALNR------
MUL_1639|M.ulcerans_Agy99 PAPFLSQFIANQQT--YANTVFTSLSNSVQDFGAGLVALPAAYQGAFQAL
Mb3842|M.bovis_AF2122/97 AKPKLLGPLGDLFT--IMTIPAQEAQYFTNLMPPSILRDMSQNFTN----
Rv3812|M.tuberculosis_H37Rv AKPKLLGPLGDLFT--IMTIPAQEAQYFTNLMPPSILRDMSQNFTN----
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 PAAAAGAPVLASMG--RGPSIGGLSVPPSWAPGG----------------
TH_4350|M.thermoresistible__bu AP--IGGPIATLLG--IRNAIADALQPVEQIAAASAAAPMAAKAEVK---
Mvan_4536|M.vanbaalenii_PYR-1 IPASVTGALLNGYTNDMGTTYPGLFTFSENPGEGGLIQALFVTLPKA---
MSMEG_6033|M.smegmatis_MC2_155 VVAGLLQNLLVNLPKTFADAIDNTPEVVPAAVTVQRIAEDVTVAPVAELT
Mflv_1753|M.gilvum_PYR-GCK VELNFGGLLSPGGSMFNSLNLVFGPGDELPGQGAGLIGSLVALSKVIAKA
MAB_0978|M.abscessus_ATCC_1997 AEAKAFGLLVGLPGAYVSNTIAVVTALTQNPASLLPAGLSAPAATTTATS
MMAR_2973|M.marinum_M ------------------------------------ALADLSPISAIGGQ
MUL_1639|M.ulcerans_Agy99 MTGNVSGAVEILGKGYLGLVFNGFDYTNVPVVTVQGALGDLLPMTTIPGQ
Mb3842|M.bovis_AF2122/97 -------------------------------------VLTTLSNPNIQAV
Rv3812|M.tuberculosis_H37Rv -------------------------------------VLTTLSNPNIQAV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_4350|M.thermoresistible__bu --------------------------------------------------
Mvan_4536|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6033|M.smegmatis_MC2_155 ESVTEAP-------------------------------------------
Mflv_1753|M.gilvum_PYR-GCK IGWDGEG-------------------------------------------
MAB_0978|M.abscessus_ATCC_1997 VKAPTSILSALSKTSTTAAKTATAEQKTAVEG----TKAAESKATTSKSS
MMAR_2973|M.marinum_M IQQNLIN----------------LGGTALTDVAPAVAFVAAGPALSTLQG
MUL_1639|M.ulcerans_Agy99 ISQNMTNVLQTVTDTSIMANISLLNPSFTTGFPLTLALDALGAPIVTGQA
Mb3842|M.bovis_AF2122/97 ASFDIATTAG--------------TLSTFFGVPLVLTYATLGAPFASLNA
Rv3812|M.tuberculosis_H37Rv ASFDIATTAG--------------TLSTFFGVPLVLTYATLGAPFASLNA
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 ----------------------------VAPAANATPAQLVGAGFTSAAP
TH_4350|M.thermoresistible__bu --------------------------AEEEVDAVAAVTSVPGENFRTVNL
Mvan_4536|M.vanbaalenii_PYR-1 -----------------------LAAAIAPEEAVATAAAEGPADPDAGSG
MSMEG_6033|M.smegmatis_MC2_155 ----------------------AVAGPAVETAKLVSTVGTVESEAPAAEV
Mflv_1753|M.gilvum_PYR-GCK ---------------------NPLAPPLTPQSTLREATDTSLASVSTVTL
MAB_0978|M.abscessus_ATCC_1997 PEAEPAKAGATKPATPAEAVTPAEPAKPAEPAKSATPAEPVKAAEPAKPA
MMAR_2973|M.marinum_M FGISLNAFTTAVQSGDIAGALGALVDAPAVLANGFLNGGVTLP--LLLPI
MUL_1639|M.ulcerans_Agy99 ALQSATTFIDAVQAGDVAGAFGAIVDAPAVIANGFLNGEETIT--LDLPT
Mb3842|M.bovis_AF2122/97 IATSAETIEQALLAGNYLGAVGALIDAPAHALDGFLNSATVLDTPILVPT
Rv3812|M.tuberculosis_H37Rv IATSAETIEQALLAGNYLGAVGALIDAPAHALDGFLNSATVLDTPILVPT
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 DTAPVTAVPGGVPSMATAGRGGYGLGAPRYGVKPTVMPKPAI--------
TH_4350|M.thermoresistible__bu TTELSTAVENPVAGEPKKSAAVDGVPTTVATEEATTGATESLDPAAATEG
Mvan_4536|M.vanbaalenii_PYR-1 TMITVAEVAETDAAAETEAAAETEAAVVADGDTVVEEAPAVVVDEATAPV
MSMEG_6033|M.smegmatis_MC2_155 EAVKAEVEPAKAESVPAKAETAPAEASPAETEQAVVDSTPAASTGADAEG
Mflv_1753|M.gilvum_PYR-GCK ETGTAAVVDAAEDAESASGGSAPESSTAPAVSEDQDGEGVAEEDDTAAYD
MAB_0978|M.abscessus_ATCC_1997 TPADAATPAEPAKPATAADAAAKPVDAAKPAEPKVNVPKVKLPTPVTKVG
MMAR_2973|M.marinum_M GLG-------FVVLDVPFDGILVAPHATTATVTW---FLPYFQEVVSGPT
MUL_1639|M.ulcerans_Agy99 YLSP-ISGTESLTSAIPIGGILTPLQPVESTIVFR--VLPHTPPVTQHIT
Mb3842|M.bovis_AF2122/97 GLPSPLPPTVGITLHLPFDGILVPPHPVTATISFPGAPVPIPGFPTTVTV
Rv3812|M.tuberculosis_H37Rv GLPSPLPPTVGITLHLPFDGILVPPHPVTATISFPGAPVPIPGFPTTVTV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_1346|M.avium_104 --------------------------------------------------
TH_4350|M.thermoresistible__bu DDGLEDDSAKNANGGTDLSDGNKATPATTAGDTSADSGSNKAGQSTLRAG
Mvan_4536|M.vanbaalenii_PYR-1 DGGEEATTPADDVVTAPVDDVVTAPVDEAGDDVEAAPDETDTADDTAGED
MSMEG_6033|M.smegmatis_MC2_155 AVKSKTKVKVTDRIKAKISEAKEARQAKLKAAKEAKKAKAAAKAEAKAAK
Mflv_1753|M.gilvum_PYR-GCK EAVKDEVETVEEEVEEVAEEAEEVEEAEVADTDVETETETETEKTEAEKT
MAB_0978|M.abscessus_ATCC_1997 EVSGGVAPKTDDSAKADKSEKTDSKTDKADKGSTPKKPEKDSSPAKKPEA
MMAR_2973|M.marinum_M VG----GIVSTLLTSVPQELATAITPA---------------------
MUL_1639|M.ulcerans_Agy99 LGGTEFGGLIPGLQSASAQLADAIKLS---------------------
Mb3842|M.bovis_AF2122/97 FGTPFMGMAPLLINYIPQQLALAIKPAA--------------------
Rv3812|M.tuberculosis_H37Rv FGTPFMGMAPLLINYIPQQLALAIKPAA--------------------
MLBr_01183|M.leprae_Br4923 ------------------------------------------------
MAV_1346|M.avium_104 ------------------------------------------------
TH_4350|M.thermoresistible__bu VKKATAKASAASSTGGSDE-----------------------------
Mvan_4536|M.vanbaalenii_PYR-1 DGDSAGGAGGESGGAGGESGGDD-------------------------
MSMEG_6033|M.smegmatis_MC2_155 AAAKDTKSNTGSESKGSGESKGGSDSSE--------------------
Mflv_1753|M.gilvum_PYR-GCK EKTEAEKTETESGTDAGAE-----------------------------
MAB_0978|M.abscessus_ATCC_1997 AASSSTKSESGSSSSSSDSHAGSSNGSSSSGSSSSGSSHSDSHKASRN