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MAEPGAPTIHGIIAYPVTPFTAEGDVDARRLAALVDRLVCSGVHAIAALGSTGELAYLDEAEFDTAVDTA VAAVSGRLPVVVGVSDVTTAKTIRRARYAQHVGADAVMILPVSYWKLNEHEIFQHYRSVGDAITIPIMAY NNPATSGVDMRPELLVRMFESIDNLTMVKESTGDLSRMRRIAELSGGRLPFYNGSNPLVLDALKVGAAGW CTAAPNLWPQPCIDLYEAVCAGDLEKAQILYDDLKPLLEFIVAGGLATTVKAGLGLLGFPVGDPRPPLLP LDEHGRAKLGRLLAGC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2154 | dapA_1 | - | 100% (296) | dihydrodipicolinate synthase DapA_1 |
| M. marinum M | MMAR_1962 | dapA | 1e-25 | 29.89% (261) | dihydrodipicolinate synthase DapA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2774c | dapA | 1e-27 | 30.65% (261) | dihydrodipicolinate synthase |
| M. gilvum PYR-GCK | Mflv_4000 | - | 8e-26 | 29.70% (266) | dihydrodipicolinate synthase |
| M. tuberculosis H37Rv | Rv2753c | dapA | 1e-27 | 30.65% (261) | dihydrodipicolinate synthase |
| M. leprae Br4923 | MLBr_01513 | dapA | 3e-30 | 32.20% (264) | dihydrodipicolinate synthase |
| M. abscessus ATCC 19977 | MAB_1047c | - | 1e-112 | 71.18% (288) | dihydrodipicolinate synthetase DapA |
| M. avium 104 | MAV_3450 | - | 1e-129 | 80.21% (288) | dihydrodipicolinate synthetase family protein |
| M. smegmatis MC2 155 | MSMEG_0877 | - | 3e-29 | 30.99% (284) | dihydrodipicolinate synthase |
| M. thermoresistible (build 8) | TH_0834 | dapA | 3e-30 | 30.48% (269) | PROBABLE DIHYDRODIPICOLINATE SYNTHASE DAPA (DHDPS) |
| M. ulcerans Agy99 | MUL_1739 | dapA_1 | 1e-170 | 99.66% (296) | dihydrodipicolinate synthase DapA_1 |
| M. vanbaalenii PYR-1 | Mvan_0452 | - | 1e-117 | 73.17% (287) | dihydrodipicolinate synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2154|M.marinum_M -----MAEPGAPTIHGIIAYPVTPFTAEGD-VDARRLAALVDRLVCSGVH
MUL_1739|M.ulcerans_Agy99 -----MAEPGAPTIHGIIAYPVTPFTAEGD-VDARRLAALVDRLVCSGVH
MAV_3450|M.avium_104 -----MTEP---KIHGIIAYPVTPFADNG--IDTQRLAALVERLVSAGVH
Mvan_0452|M.vanbaalenii_PYR-1 -----MTTATT-EIHGIIAYPVTPFTSNGEDIDTGKLAALVEQLVATGAH
MAB_1047c|M.abscessus_ATCC_199 -----MTSTP--QFHGIIAYPVTPFLPDDT-VDIDRLAELVSRLVDDGAH
Mb2774c|M.bovis_AF2122/97 --MTTVGFDVAARLGTLLTAMVTPFSGDGS-LDTATAARLANHLVDQGCD
Rv2753c|M.tuberculosis_H37Rv --MTTVGFDVAARLGTLLTAMVTPFSGDGS-LDTATAARLANHLVDQGCD
MLBr_01513|M.leprae_Br4923 --MTTVGFDVPARLGTLLTAMVTPFDADGS-VDTAAATRLANRLVDAGCD
Mflv_4000|M.gilvum_PYR-GCK MPVSTSGFDAPARLGTLLTAMATPFKPDGS-LDIETAARLATRLVDAGCD
TH_0834|M.thermoresistible__bu --VSTGGFDVTAQLGTVLTAMVTPFKKDGS-LDLDAAASLANRLVDAGCD
MSMEG_0877|M.smegmatis_MC2_155 -----MTRELTSDLAGIIPPLTTPLTADGD-VDTASLERLCGFLLDAGVD
: ::. .**: :. :* * *: * .
MMAR_2154|M.marinum_M AIAALGSTGELAYLDEAEFDTAVDTAVAAVSGRLPVVVGVSDVTTAKTIR
MUL_1739|M.ulcerans_Agy99 AIAALGSTGELAYLDEAEFDTAVDTAVAAVSGRLPVVVGVSDVTTAKTIR
MAV_3450|M.avium_104 AIAPLGSTGELAYLEEPEVDAVIDTTLSAVAGRVPVIVGVSDVTTAKTIR
Mvan_0452|M.vanbaalenii_PYR-1 AIAPLGSTGESAYLTEAEFDTVVDTTVGVVNGRVPVIVGASDLTTANTIR
MAB_1047c|M.abscessus_ATCC_199 AIAPLGSTGESAYLEEREFDAVVDTTVAAVNKRVPVIVGASDLTTANTIR
Mb2774c|M.bovis_AF2122/97 GLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIR
Rv2753c|M.tuberculosis_H37Rv GLVVSGTTGESPTTTDGEKIELLRAVLEAVGDRARVIAGAGTYDTAHSIR
MLBr_01513|M.leprae_Br4923 GLVLSGTTGESPTTTDDEKLQLLRVVLEAVGDRARVIAGAGSYDTAHSVR
Mflv_4000|M.gilvum_PYR-GCK GLVVSGTTGESPTTTDDEKILLLRTVLEAVGDRARIVAGAGTYDTAHSIH
TH_0834|M.thermoresistible__bu GLVVSGTTGEAPTTTDDEKLQLLRTVLDAVGDRARIIAGAGTYDTAHSVR
MSMEG_0877|M.smegmatis_MC2_155 GLFVCGSSGEVALLSDAQRAKAIQVAAGAASGQVPVLGGVIDTGTARVVD
.: *::** . : : : .. .. : :: *. **. :
MMAR_2154|M.marinum_M RARYAQHVGADAVMILPVSYWKLNEHEIFQHYRSVGDAITIPIMAYNNPA
MUL_1739|M.ulcerans_Agy99 RARYAQHVGADAVMILPVSYWKLNEHEIFQHYRSVGDAITIPIMAYNNPA
MAV_3450|M.avium_104 RAQYAQRAGADAVMILPVSYWKLTEREIFHHYRSISDAISIPIMAYNNPA
Mvan_0452|M.vanbaalenii_PYR-1 RGKYAQRAGADALMILPVSYWKLTDREIARHYASVAAATDLPIMAYNNPA
MAB_1047c|M.abscessus_ATCC_199 RARHAQQAGADAVMVLPISYWKLSDREIAQHYASVAAAIDIPLMAYNNPA
Mb2774c|M.bovis_AF2122/97 LAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPG
Rv2753c|M.tuberculosis_H37Rv LAKACAAEGAHGLLVVTPYYSKPPQRGLQAHFTAVADATELPMLLYDIPG
MLBr_01513|M.leprae_Br4923 LVKACAGEGAHGLLVVTPYYSKPPQTGLFAHFTAVADATELPVLLYDIPG
Mflv_4000|M.gilvum_PYR-GCK LAKASAAEGAHGLLVVTPYYSRPPQAGLVAHFTAVADATDLPNILYDIPP
TH_0834|M.thermoresistible__bu LAKACQDAGAHGLLLVTPYYSRPPQDGLYAHFTTIADAVEVPIVLYDIPP
MSMEG_0877|M.smegmatis_MC2_155 NALAAQKAGADAVVATPPFYVAPHADEVIRHYRLIAAAVDVPVVAYDIPS
. **..:: . * : *: :. * :* : *: *
MMAR_2154|M.marinum_M TSGVDMRPELLVRMFESIDNLTMVKESTGDLSRM-RRIAELSGGRLPFYN
MUL_1739|M.ulcerans_Agy99 TSGVDMRPELLVRMFESIDNLTMVKESTGDLSRM-RRIAELSGGRLPFYN
MAV_3450|M.avium_104 TSGVDMPPELLVRMFESIDNVAMVKESTGDLTRM-RRIAELSGNRLPFYN
Mvan_0452|M.vanbaalenii_PYR-1 TSGIDMSPELLVRMFTDIDNVAMVKESTGDLSRM-QRIKELTGGALPFYN
MAB_1047c|M.abscessus_ATCC_199 TSGVDMKPELLVSMFGDIDNFTMVKESTGDLNRM-LEIKRLTNGLLPFYN
Mb2774c|M.bovis_AF2122/97 RSAVPIEPDTIRALASHPN-IVGVKDAKADLHSG-AQIMADTG--LAYYS
Rv2753c|M.tuberculosis_H37Rv RSAVPIEPDTIRALASHPN-IVGVKDAKADLHSG-AQIMADTG--LAYYS
MLBr_01513|M.leprae_Br4923 RSVVPIEPDTIRALASHPN-IVGVKEAKADLYSG-ARIMADTG--LAYYS
Mflv_4000|M.gilvum_PYR-GCK RSVVPIEWDTIRRLAQHPN-IVAIKDAKADLHGG-GQIIAETG--LAYYS
TH_0834|M.thermoresistible__bu RSVVPLAWDTIRRLSEHRN-IVAIKDAKGDLHGA-AQIIAETG--LAYYS
MSMEG_0877|M.smegmatis_MC2_155 ATHSPLTRSVVAQLAGEKT-VAALKDSSGDLDGFRAHLAANADTGLRVFT
: : . : : .. :*::..** .: :. * :.
MMAR_2154|M.marinum_M GSNPLVLDALKVGAAGWCTAAPNLWPQPCIDLYEAVCAGDLEKAQILYDD
MUL_1739|M.ulcerans_Agy99 GSNPLVLDALKVGAAGWCTAAPNLWPQPCIDLYEAVCAGDLEKAQILYDD
MAV_3450|M.avium_104 GSNPLVLDALKAGASGWCTAAPCLRPQPCIDLYDAVRANDLDTAQRLYDD
Mvan_0452|M.vanbaalenii_PYR-1 GSNPLVLDALTEGAAGWCTAAPNLRPQPCLDLYTAVRDGERSRAQEIYDD
MAB_1047c|M.abscessus_ATCC_199 GSNPLVLDALNAGASGWCTAAPCLAPQPCLDLYEAVRAGRDDDAASLYTA
Mb2774c|M.bovis_AF2122/97 GDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIA
Rv2753c|M.tuberculosis_H37Rv GDDALNLPWLAMGATGFISVIAHLAAGQLRELLSAFGSGDIATARKINIA
MLBr_01513|M.leprae_Br4923 GDDALNLPWLAVGAIGFISVISHLAAGQLRELLSAFGSGDITTARKINVA
Mflv_4000|M.gilvum_PYR-GCK GDDALNLPWLAMGAVGFISVWGHLAASQLRDMLSAFASGDVATARKINVA
TH_0834|M.thermoresistible__bu GDDSLNLPWLAVGAVGFISVWGHLAAGQLRDMLTAFNSGDMTTARKIAVT
MSMEG_0877|M.smegmatis_MC2_155 GSETMTDVALNLGAHGAVPGLANVDPHGYVRIRQAARVGDWATAASEQER
*.:.: * ** * . : . : * . *
MMAR_2154|M.marinum_M LKPLLEFIVAGGLATTVKAGLGLLGFPVGDPRP----------PLLPLDE
MUL_1739|M.ulcerans_Agy99 LKPLLEFIVAGRLATTVKAGLGLLGFPVGDPRP----------PLLPLDE
MAV_3450|M.avium_104 LKPLLTFIVAGGLATTVKAGLELLDFKVGDPRA----------PLLPLDE
Mvan_0452|M.vanbaalenii_PYR-1 LAPLLRFIVAGGLPTTVKAGLELLGVSVGDPRA----------PLLALDD
MAB_1047c|M.abscessus_ATCC_199 LKPLLQFIVAGGLPTTVKAGLELQGRPVGDPRR----------PLLPLDP
Mb2774c|M.bovis_AF2122/97 VAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRL----------PQVAATP
Rv2753c|M.tuberculosis_H37Rv VAPLCNAMSRLGGVTLSKAGLRLQGIDVGDPRL----------PQVAATP
MLBr_01513|M.leprae_Br4923 IGPLCSAMDRLGGVTMSKAGLRLQGIDVGDPRL----------PQMPATA
Mflv_4000|M.gilvum_PYR-GCK LGPLSAAQSRLGGVTLSKAGLRLQGFEVGDPRL----------PQIPAND
TH_0834|M.thermoresistible__bu LSPLNAAQTRLGGVSMSKAGLRLLGIEVGDPRL----------PQVPPGP
MSMEG_0877|M.smegmatis_MC2_155 LRRIFAIVDVADRTRIGLTAGALGAFKAAQYLRGVIDTPRCADPLLPLES
: : :. * ..: * :.
MMAR_2154|M.marinum_M HGRAKLGRLLAGC----
MUL_1739|M.ulcerans_Agy99 HGRAKLGRLLAGC----
MAV_3450|M.avium_104 QGRAELRKLLAA-----
Mvan_0452|M.vanbaalenii_PYR-1 TGRAELKTLLAVA----
MAB_1047c|M.abscessus_ATCC_199 EGRETLKGILASTP---
Mb2774c|M.bovis_AF2122/97 EQIDALAADMRAASVLR
Rv2753c|M.tuberculosis_H37Rv EQIDALAADMRAASVLR
MLBr_01513|M.leprae_Br4923 EQIDELAVDMRAASVLR
Mflv_4000|M.gilvum_PYR-GCK VQLQALAADMRAASVLR
TH_0834|M.thermoresistible__bu EQLRLLADDMRAAAVLR
MSMEG_0877|M.smegmatis_MC2_155 SEIDAVRTILEREGVLG
: :