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MTEPNQFTVPAAADAVAAVIGDREFIIQGERRYTYAQIVERSNRLAAFLHAQGLGCHTERSELPGHEVGQ DLLGIYAYNGPEYVEGMLGAWRARVAPFNVNYRYVKSELQYLLADAGATALLYHSAFAPRLAEVLADLPS LKVLIQIADDSGNELLPGAVDYESIVAEGPAEVPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMASF GGRSLYTGELISSLDDVAQRCVESPGTTLMVLPPLMHGAAQWAVFTAMNTGQSVVFSPVTEHLDVDDVVA TIEREKVLAVTVVGDAMARPLADAFERTTADLSALAVVANGGAQLTPSAKQRLIDVKKNLMVVDGVGSSE TGAQMTHMSAPGAVSTGKFTAGPDTFVASEDLSTILEPGHDGMGWLAQRGYVPLGYKGDATKTAATFPVI EGVRYSVPGDRARHLADGAVELLGRDSVTINSGGEKIFAEEVESAIASHPAVADVVVAGRPSERWGQEVV AVVALDSGATATAEELIDHASAVIARYKLPKAVVFRPAIERSPAGKADYRWAREQAISGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4335 | - | - | 100% (550) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4349 | - | e-109 | 40.56% (540) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_1543 | - | e-103 | 40.37% (540) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3544c | fadD19 | 1e-103 | 39.85% (537) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 1e-103 | 39.85% (537) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 2e-25 | 25.38% (532) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 1e-106 | 39.85% (532) | acyl-CoA synthetase |
| M. marinum M | MMAR_4007 | fadD19_2 | 0.0 | 74.63% (544) | fatty-acid-CoA ligase FadD19_2 |
| M. avium 104 | MAV_1600 | - | 0.0 | 76.98% (543) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_2241 | - | 0.0 | 74.91% (546) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4443 | - | 0.0 | 73.20% (541) | PUTATIVE AMP-dependent synthetase and ligase |
| M. ulcerans Agy99 | MUL_3870 | fadD19_2 | 0.0 | 73.53% (544) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2010 | - | 0.0 | 90.73% (550) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3544c|M.bovis_AF2122/97 -----------------------------------------MAVALNIAD
Rv3515c|M.tuberculosis_H37Rv -----------------------------------------MAVALNIAD
MAB_4163c|M.abscessus_ATCC_199 -------------------------------------------MALNIAD
Mflv_4335|M.gilvum_PYR-GCK ---------------------------------------MTEPNQFTVPA
Mvan_2010|M.vanbaalenii_PYR-1 ---------------------------------------MTESIQFTVPA
MMAR_4007|M.marinum_M -----------------------------------------MTTQFTVPA
MUL_3870|M.ulcerans_Agy99 -----------------------------------------MTTQFTVPA
MAV_1600|M.avium_104 --------------------------------------MSDTTTAFTVPA
MSMEG_2241|M.smegmatis_MC2_155 -------------------------------------------MLFTVPA
TH_4443|M.thermoresistible__bu -----------------------------------------MTTEFTVPQ
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:.
Mb3544c|M.bovis_AF2122/97 LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD----
Rv3515c|M.tuberculosis_H37Rv LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD----
MAB_4163c|M.abscessus_ATCC_199 LIEHAIDTMPDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGPG----
Mflv_4335|M.gilvum_PYR-GCK AADAVAAVIGDREFIIQGERRYTYAQIVERSNRLAAFLHAQGLGCHTERS
Mvan_2010|M.vanbaalenii_PYR-1 AADAVAAAIGDREFIVQGDRRYTYTQIVERSNRLAAYLHAQGLGCHTERT
MMAR_4007|M.marinum_M VASAVTAAIGDRELIVGGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS
MUL_3870|M.ulcerans_Agy99 VASAVTAAIGDRELVVQGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS
MAV_1600|M.avium_104 VAKAVAAAIPDRELIIQGDRRYSYRQVIERSNRLAAYLHSQGLGCHTERE
MSMEG_2241|M.smegmatis_MC2_155 VAEAVAAAIPDRPLIVQGERRHTYRQVMDRSNRLASYLHSQGLGVHTERD
TH_4443|M.thermoresistible__bu VADTVAAVLPDRELVVHRDRRFTYTDIIARSNRLAAYLHSRGLGCHTERD
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG----
.* :: : :* :: :: *. * :*:
Mb3544c|M.bovis_AF2122/97 ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
Rv3515c|M.tuberculosis_H37Rv ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
MAB_4163c|M.abscessus_ATCC_199 ---------DKVGLYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHY
Mflv_4335|M.gilvum_PYR-GCK ELPGHEVGQDLLGIYAYNGPEYVEGMLGAWRARVAPFNVNYRYVKSELQY
Mvan_2010|M.vanbaalenii_PYR-1 ALPGHEVGQDLLGIYSHNGPEYVEGMLGAWRARVAPFNVNYRYVKSELHY
MMAR_4007|M.marinum_M ELAGHEVGQDLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNELQY
MUL_3870|M.ulcerans_Agy99 ELAGHEVGQNLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNEPQY
MAV_1600|M.avium_104 ALAGHEVGQDLLGLYAYNGNEFVEALLGAFAARVAPFNVNFRYVKSELHY
MSMEG_2241|M.smegmatis_MC2_155 GLAGHEVGQDLLGIYAHNGPEYVESMLGSFRARVAPFNVNYRYVKNELHY
TH_4443|M.thermoresistible__bu GLAPHECGQDLLGIYAYNGSEYLEGLLGAFRARVAPFNVNFRYVRAELEY
MLBr_02546|M.leprae_Br4923 ---------DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKE
: :.: . * : . . . . :* .: : .
Mb3544c|M.bovis_AF2122/97 LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
Rv3515c|M.tuberculosis_H37Rv LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
MAB_4163c|M.abscessus_ATCC_199 LFENSDMAALVHERRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGV
Mflv_4335|M.gilvum_PYR-GCK LLADAGATALLYHSAFAPRLAEVLADLPSLKVLIQIADDSGNELLP-GAV
Mvan_2010|M.vanbaalenii_PYR-1 LLADSGATALLYHAAFAPRLAEVLADLPNLKVLIQIADDSGNELLP-GAV
MMAR_4007|M.marinum_M LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV
MUL_3870|M.ulcerans_Agy99 LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV
MAV_1600|M.avium_104 LLADSEATALIYHAAFAPRVAEILPDLPRLRVLIQIADESGNELLD-GAV
MSMEG_2241|M.smegmatis_MC2_155 LLTDAGATALVYHATFAPRIAEIRDELPTLRVLIQIADGSGNELLD-GAV
TH_4443|M.thermoresistible__bu LLTDAGATALLYHAAFAPRVAEILPNLPRRPVLIQIADDSGHELLE-GAV
MLBr_02546|M.leprae_Br4923 VSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGST--DE
: .:::. :: ::: . *
Mb3544c|M.bovis_AF2122/97 EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
Rv3515c|M.tuberculosis_H37Rv EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
MAB_4163c|M.abscessus_ATCC_199 PFADALAQGSPERDFEERSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLF
Mflv_4335|M.gilvum_PYR-GCK DYESIVAEGPAEVPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMASF
Mvan_2010|M.vanbaalenii_PYR-1 DYESIVAEGPADVPPVEPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MMAR_4007|M.marinum_M DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MUL_3870|M.ulcerans_Agy99 DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMTKGVLWRQHDIFMTSF
MAV_1600|M.avium_104 DYEDALASVSAEPPPVRHCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MSMEG_2241|M.smegmatis_MC2_155 DYEQIVNFETAAPP-VQPCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAF
TH_4443|M.thermoresistible__bu DYESIVSNGPADPPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTAF
MLBr_02546|M.leprae_Br4923 TLAELIARSSSAPAPKVRKRASIIILTSG-TTGTPKGAN-RNTPASLAPL
. : .. : :: :* *** .**. *: :
Mb3544c|M.bovis_AF2122/97 GGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFS
Rv3515c|M.tuberculosis_H37Rv GGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFS
MAB_4163c|M.abscessus_ATCC_199 GGINYVTGEYIEGEWDLAKQGAEAAPFIGFPIPPMIHGATQAATFMALFQ
Mflv_4335|M.gilvum_PYR-GCK GGRSLYTGELISSLDDVAQRCVESPGTTLMVLPPLMHGAAQWAVFTAMNT
Mvan_2010|M.vanbaalenii_PYR-1 GGRSLYTGELVSTYDDIAARCSESPGTKLMVLPPLMHGAAQWAVFTAMNT
MMAR_4007|M.marinum_M GGRDLYSGQPVNSVDEIVARTTAGPGTKLLVLPPLIHGAAQWTVMTALTT
MUL_3870|M.ulcerans_Agy99 GGRDLYSGQPVNSVDEIVARTTAGPGTKLLVLPPLIHGAAQWTVMTALTT
MAV_1600|M.avium_104 GGRNLMTGEPSSSIDEIVQRAASGPGTKLMILPPLIHGAAQWSVMTAITT
MSMEG_2241|M.smegmatis_MC2_155 GGRNMMTGEAATSVDEIVDRAVENPGTRLMILPPLIHGAAQWAAMTAVTT
TH_4443|M.thermoresistible__bu GGRSLYGGEAAGSYGEIAERAAANPGTKMMILPPLMHGAAQWAAMTALTT
MLBr_02546|M.leprae_Br4923 GG--------------ILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFL
** : . .*::*. . *:
Mb3544c|M.bovis_AF2122/97 GQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL---VK
Rv3515c|M.tuberculosis_H37Rv GQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL---VK
MAB_4163c|M.abscessus_ATCC_199 GRTTVLAP---EFNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDT-ET
Mflv_4335|M.gilvum_PYR-GCK GQSVVFSPVTEHLDVDDVVATIEREKVLAVTVVGDAMARPLADAF----E
Mvan_2010|M.vanbaalenii_PYR-1 GQTVVFSPVTSHLDVDDVVATIEREQILAVTVVGDAMARPLAEAF----E
MMAR_4007|M.marinum_M GQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGDAIARPLVASI----E
MUL_3870|M.ulcerans_Agy99 GQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGNAIARPLVASI----E
MAV_1600|M.avium_104 GQTVVFPTVVDHLDAEDVVRTIEREKVMVVTVVGDAMARPLVAAI----E
MSMEG_2241|M.smegmatis_MC2_155 GQTLVFPDVTDRFDAEDVVRTIEREQVLVATVVGDAMARPLLDAIRSGIQ
TH_4443|M.thermoresistible__bu GQTVVFGSVVDRVDAVDALQTIKREDVSVVTVVGDAIARPLADAL----E
MLBr_02546|M.leprae_Br4923 GSTLVLRR---RFKPATVLEDIEKHQATAMVVVPVMLSR-ILDTLEN--L
* : *: ... . *.:. .. :.* : ::
Mb3544c|M.bovis_AF2122/97 GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
Rv3515c|M.tuberculosis_H37Rv GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
MAB_4163c|M.abscessus_ATCC_199 GRARDLSSLWVLASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGL
Mflv_4335|M.gilvum_PYR-GCK RTTADLSALAVVANGGAQLTPSAKQRLIDVKKNLMVVDGVGSSETGAQMT
Mvan_2010|M.vanbaalenii_PYR-1 RTSADLSSLAVVANGGAQLTPTAKQRLIDAKQNLMVVDGVGSSETGAQMT
MMAR_4007|M.marinum_M KGTADVSSLVAVANGGALLTPYVKQRLIEALPNAVITDGVGSSETGAQMH
MUL_3870|M.ulcerans_Agy99 KGTADVSSLVAVANGGALLTPYVKQRLIAALPNAVIIDGVGSSETGAQMH
MAV_1600|M.avium_104 KGIADVSSLAVVANGGALLTPFVKQRLIEVLPNAVVVDGVGSSETGAQMH
MSMEG_2241|M.smegmatis_MC2_155 NGTVDVSSLSVIANGGAQLTPHVKQQLIDSKPNLIVVDGVGSSETGAQMS
TH_4443|M.thermoresistible__bu QGVCETPSLAVIANGGAFLTPTTKQRLIDLLPDAIVVDGVGSSETGAQMT
MLBr_02546|M.leprae_Br4923 ETKSDLSSLRVVFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATI
: .:* : .: : : : :: : *::* .
Mb3544c|M.bovis_AF2122/97 SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
Rv3515c|M.tuberculosis_H37Rv SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
MAB_4163c|M.abscessus_ATCC_199 STVTKGQMHPGGPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVG
Mflv_4335|M.gilvum_PYR-GCK HMSAPGAVSTGKFTAGPD-TFVASEDLSTILEPGHDGMGWLAQRGYVPLG
Mvan_2010|M.vanbaalenii_PYR-1 HMSAPGAVSTGKFNAGPD-TFVAAEDLGSILEPGHDGIGWLAQRGYVPLG
MMAR_4007|M.marinum_M HLSASGAVSTGTFNAGPD-TNVAAEDLSAILPAGHEGIGWLAQRGYVPLG
MUL_3870|M.ulcerans_Agy99 HLSASGAISTGTFNAGPD-INVAAEDLSAILPAGHEGIGWLAQRGYVPLG
MAV_1600|M.avium_104 HMSTPGAVATGTFNAGPD-TFVAAEDLSAILPPGHEGMGWLAQRGYVPLG
MSMEG_2241|M.smegmatis_MC2_155 HMSAPGAVSTGTFKAGPD-TCVVAEDFSCVLPEAHDGLGWLAQRGYVPLG
TH_4443|M.thermoresistible__bu HMSMNGAVATGTFNPGPD-TCVLAEDFSTVLPPGHAGLGWLGQRGYVPLG
MLBr_02546|M.leprae_Br4923 AGPKDLQINSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEG
. . . : . : . *
Mb3544c|M.bovis_AF2122/97 YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
Rv3515c|M.tuberculosis_H37Rv YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
MAB_4163c|M.abscessus_ATCC_199 YFKDEKKTAETFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGE
Mflv_4335|M.gilvum_PYR-GCK YKGDATKTAATFPVIEGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
Mvan_2010|M.vanbaalenii_PYR-1 YKGDAAKTAATFPVIGGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
MMAR_4007|M.marinum_M YKGDAAKTAATFPVINGVRYAVPGDRARHRADECIELLGRDSATINSGGE
MUL_3870|M.ulcerans_Agy99 YKGDAAKTATTFPVINGVRYAVPGDRARHRADGCIELLGRDSATINSGGE
MAV_1600|M.avium_104 YKGDAAKTAKTFPVIDGVRYAVPGDRARHHADGHIELLGRDSVCINSGGE
MSMEG_2241|M.smegmatis_MC2_155 YKGDAAKTAATFPVIDGVRYAIPGDRARQLDGGMIELLGRDSVTINSGGE
TH_4443|M.thermoresistible__bu YKGDADKTARTFPVIDTVRYAVPGDRARHLDGGAIELLGRDSVTINSGGE
MLBr_02546|M.leprae_Br4923 YTGGGGK-----QIIDGLLS--SGDVGYFDEHDLLYISGRDDEMIVSGGE
* . * : : .** . : : **.. * :***
Mb3544c|M.bovis_AF2122/97 KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
Rv3515c|M.tuberculosis_H37Rv KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
MAB_4163c|M.abscessus_ATCC_199 KVFPEEVESVLKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFED
Mflv_4335|M.gilvum_PYR-GCK KIFAEEVESAIASHPAVADVVVAGRPSERWGQEVVAVVALDSGATATAEE
Mvan_2010|M.vanbaalenii_PYR-1 KIFAEEVESAIASHPAVADVVVAGRPSDRWGQEVVAVVALADGAQATADE
MMAR_4007|M.marinum_M KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE
MUL_3870|M.ulcerans_Agy99 KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE
MAV_1600|M.avium_104 KIFVEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALSDGAAVDAGE
MSMEG_2241|M.smegmatis_MC2_155 KVFAEEVEAAIASHPAVRDVVVAGRPSERWGQEVVAVVAVDDGAQVDADE
TH_4443|M.thermoresistible__bu KIFAEEVEMALASHPAVADVVVTGRPSDRWGQEVVAVVALAEGATADAEA
MLBr_02546|M.leprae_Br4923 NVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDA
::: *** : .** * :. . * . .:* .: *.: .
Mb3544c|M.bovis_AF2122/97 LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
Rv3515c|M.tuberculosis_H37Rv LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
MAB_4163c|M.abscessus_ATCC_199 LDAHARKEIAGYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVN
Mflv_4335|M.gilvum_PYR-GCK LIDHASAVIARYKLPKAVVFRPAIERSPAGKADYRWAREQAISGS-----
Mvan_2010|M.vanbaalenii_PYR-1 LVEHASSVIARYKLPKAVVFRPVIERSPAGKADYRWAREQAISGS-----
MMAR_4007|M.marinum_M LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------
MUL_3870|M.ulcerans_Agy99 LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------
MAV_1600|M.avium_104 LIAHASNSLARYKLPKAIVFRPVIERSPSGKADYRWAREQAVDG------
MSMEG_2241|M.smegmatis_MC2_155 LIRHADGSIARYKLPKAVVFRPAIERSPAGKADYRWAREQALSETS----
TH_4443|M.thermoresistible__bu LIEHAAGALARYKLPKAIVFRPVIQRSPAGKADYRWAREQATASVAAE--
MLBr_02546|M.leprae_Br4923 IKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
: .. :* **:*: : : : *.*:** * ::
Mb3544c|M.bovis_AF2122/97 AGHVTSGG
Rv3515c|M.tuberculosis_H37Rv AGHVTSGG
MAB_4163c|M.abscessus_ATCC_199 SKHVNTGA
Mflv_4335|M.gilvum_PYR-GCK --------
Mvan_2010|M.vanbaalenii_PYR-1 --------
MMAR_4007|M.marinum_M --------
MUL_3870|M.ulcerans_Agy99 --------
MAV_1600|M.avium_104 --------
MSMEG_2241|M.smegmatis_MC2_155 --------
TH_4443|M.thermoresistible__bu --------
MLBr_02546|M.leprae_Br4923 --------