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EFTLPEHLQSLLAQMDEFIEAEIKPLEHEHIQYFDHRREHARTDWDNDGVPRREWEELLAEMRRRADQAG WLRYGLPARFGGRDGTNLDMAVIREHLAHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTDAQKSEWTEAL ITGERSMAFGLTEPLHGSDATWMQTRAEHAGDSWIINGAKRFNTGVHRATHDLVFARTSGEPGQARGITA FLVPTDTAGFNVPYYWWTLNMPTDHGEVELTNVRVPDDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAA QYCIDRAVGYAGERRVFGKPLSVNQAIQWPLVELQTEAQMVRLLVYYAAWHLDRNHHMEVSDKVSMANYR ANRLVCEAADRAMQVFGGVGYSRHEPFEHIYRHHRRYRITEGAEEIQIRRVAQRLFKFGQK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1491 | fadE12_3 | - | 100% (412) | acyl-CoA dehydrogenase FadE12_3 |
| M. marinum M | MMAR_4034 | fadE | 1e-40 | 32.61% (417) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_0374 | fadE2 | 8e-40 | 31.49% (397) | acyl-CoA dehydrogenase FadE2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0997c | fadE12 | 6e-39 | 29.87% (375) | acyl-CoA dehydrogenase FADE12 |
| M. gilvum PYR-GCK | Mflv_4468 | - | 0.0 | 86.89% (412) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0972c | fadE12 | 5e-39 | 29.87% (375) | acyl-CoA dehydrogenase FADE12 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 5e-32 | 27.68% (401) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3636c | - | 1e-152 | 64.48% (411) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_4027 | - | 0.0 | 87.62% (412) | acyl-CoA dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2070 | - | 0.0 | 87.83% (411) | acyl-CoA dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3506 | - | 0.0 | 86.11% (360) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4707 | fadE12 | 1e-38 | 29.60% (348) | acyl-CoA dehydrogenase FadE12 |
| M. vanbaalenii PYR-1 | Mvan_1892 | - | 0.0 | 87.14% (412) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0997c|M.bovis_AF2122/97 -------------MTDTSFIESEER---QALR--------KAVASWVANY
Rv0972c|M.tuberculosis_H37Rv -------------MTDTSFIESEER---QALR--------KAVASWVANY
MUL_4707|M.ulcerans_Agy99 ------------MMTGTSFIENEDR---RALR--------KAVSEWASNY
MMAR_1491|M.marinum_M MEFTLPEHLQSLLAQMDEFIEAEIK---PLEH--EHIQYFDHRREHARTD
MAV_4027|M.avium_104 MDFTLPEHLPGVLAAMDAFIEDEIK---PLER--EHIQYFDQRREHARTD
Mflv_4468|M.gilvum_PYR-GCK MDFTLPDYLPGLLAEMDAFIEAEIK---PLER--EHIQYFDHRREHARTD
Mvan_1892|M.vanbaalenii_PYR-1 MDFNLPEHLPALLAEMDAFIEAEIK---PLER--ENIQYFDHRREHARTD
MSMEG_2070|M.smegmatis_MC2_155 MDFTLPEHLRDTLAEMDAFIEAEIK---PLER--ENIQYFDHRREHARTD
TH_3506|M.thermoresistible__bu VEFALPDHLPGLLAEMDAFIEAEIK---PLER--EHMQYFDHRREYARTD
MAB_3636c|M.abscessus_ATCC_199 MNFELPPELVDYLAELDGFIDREIV---PLEQADDNIRFFDHRREDSRTD
MLBr_00737|M.leprae_Br4923 ------MVGWSGNPLFDLFKLPEEHNELR-----------ATIRALAEKE
* * .
Mb0997c|M.bovis_AF2122/97 GHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVM
Rv0972c|M.tuberculosis_H37Rv GHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVM
MUL_4707|M.ulcerans_Agy99 GHEYYLKKARAHEHTTELWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVM
MMAR_1491|M.marinum_M WDNDGVPRREWEELLAEMRRRADQAGWLRYGLPARFGGRDGTNLDMAVIR
MAV_4027|M.avium_104 WDNDGIPTREWEDLLAEMRRRADRAGWLRYGLPASLGGRDGSNVDMAVIR
Mflv_4468|M.gilvum_PYR-GCK WDNGGVPRREWEELLDEMRRRADAAGWLRYGLPSQFGGRDGSNLDMAVIR
Mvan_1892|M.vanbaalenii_PYR-1 WDNGGVPRREWEDLLDEMRRRADAAGWLRYGLPSQFGGRDGSNIDMAVIR
MSMEG_2070|M.smegmatis_MC2_155 WDNGGVPRREWEELLDEMRRRADAAGWLRYGLPARFGGRDGTNLDMAVIR
TH_3506|M.thermoresistible__bu WESGGIPRREWEDLLDEMRRRADAAGWLRYGLPARFGGRDGTNLDMAVIR
MAB_3636c|M.abscessus_ATCC_199 WERGGLPNREWEALLGEARRRADVAGHFRYPFPAEFGGRDGSNLGMAVIR
MLBr_00737|M.leprae_Br4923 IAPHAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVI
. * . * .* ** .. .::
Mb0997c|M.bovis_AF2122/97 EEMAAAGSALLLMVVS-PAING-----TIIAKFGTDDQKKRWLPGIADGS
Rv0972c|M.tuberculosis_H37Rv EEMAAAGSALLLMVVS-PAING-----TIIAKFGTDDQKKRWLPGIADGS
MUL_4707|M.ulcerans_Agy99 EEMAAAGSALLLMVVS-PAING-----TIISKFGTDEQKQRWLPGIADGT
MMAR_1491|M.marinum_M EHLAHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTDAQKSEWTEALITGE
MAV_4027|M.avium_104 EHLAHKGLGLHNDLQNESSIVGNFPQVIMMERFGTDEQRREWSQALITGE
Mflv_4468|M.gilvum_PYR-GCK EHLAAKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEEQKREWTDALVTGK
Mvan_1892|M.vanbaalenii_PYR-1 EHLAAKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEEQKKEWTDALITGA
MSMEG_2070|M.smegmatis_MC2_155 EHLAHKGLGLHNDLQDESSIVGNFPQVIMMDRFGTETQKDEWVEAMITGK
TH_3506|M.thermoresistible__bu EHLAHKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEQQKQEWIEPMITGE
MAB_3636c|M.abscessus_ATCC_199 EHLARRGLGLHCDLQNEHAIVGNNVGLLLMLEYGSDEQKAAWVEGLAGGT
MLBr_00737|M.leprae_Br4923 EEVARVDASAS--LIPAVNKLG----TMGLILRGSEELKKQVLPSLAAEG
*.:* . . : * : *:: : :
Mb0997c|M.bovis_AF2122/97 LTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLV
Rv0972c|M.tuberculosis_H37Rv LTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLV
MUL_4707|M.ulcerans_Agy99 LTMAFAITEPEAGSNSHKITTTARRDGSDWIIKGQKVYISGIDQAQAVLV
MMAR_1491|M.marinum_M RSMAFGLTEPLHGSDATWMQTRAEHAGDSWIINGAKRFNTGVHRATHDLV
MAV_4027|M.avium_104 RSMAFGLTEPQHGSDATWLQTRAERDGDGWVINGAKRFNTGVHRATHDLI
Mflv_4468|M.gilvum_PYR-GCK RSMAFGLTEPNHGSDATWLETTAVQDGDEWIINGAKRFNTGVHRATHDLV
Mvan_1892|M.vanbaalenii_PYR-1 RSMAFGLTEPNHGSDATWLETTAVAVGDDWIINGAKRWNTGVHRATHDLI
MSMEG_2070|M.smegmatis_MC2_155 RSMAFGLTEPGHGSDATWLETTAVRDGEDWIINGTKRWNTGVHRATHDLI
TH_3506|M.thermoresistible__bu RSMAFGLTEPNHGSDATWLETRAEPDGDGWIINGRKRWNTGVHRATHDLI
MAB_3636c|M.abscessus_ATCC_199 KVFAFGITEPEHGSDATYMETRAVKDGPDWVINGEKTWNTGVHVADADLI
MLBr_00737|M.leprae_Br4923 AMASYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTV
::.::* **:: : * * * *:::* * : :. : :
Mb0997c|M.bovis_AF2122/97 VGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSP-ERQFQVFLDDV
Rv0972c|M.tuberculosis_H37Rv VGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSP-ERQFQVFLDDV
MUL_4707|M.ulcerans_Agy99 VGRTEEAKTGKLRPALFVVPTDTPGFTYTAIDMELVSP-ERQFQVFLDDV
MMAR_1491|M.marinum_M FARTSGEPGQARGITAFLVPTDTAGFNVPYYWWTLNMP-TDHGEVELTNV
MAV_4027|M.avium_104 FARTSGEPGTAVGITAFLVPTDAPGFTVPYYWWTFNMP-TDHGEVELTDV
Mflv_4468|M.gilvum_PYR-GCK FARTSGEAGQARGITAFLVPCDSPGFTVPYYWWTFNMP-TDHGEVLLENV
Mvan_1892|M.vanbaalenii_PYR-1 FARTSGEPGQARGITAFLVPTDAPGFSVPYYWWTFNMP-TDHGEVVLENV
MSMEG_2070|M.smegmatis_MC2_155 FARTSGERGQALGITAFLVPTDAPGFHVPFYWWTFNMP-TDHGEVELTNV
TH_3506|M.thermoresistible__bu FARTSGEPGQAHGITAFLVPTDAEGFKVPFYWWTFNMP-SDHGEVELDNV
MAB_3636c|M.abscessus_ATCC_199 FARTSGEPGDGRGITAFLVPADAPGFKVEEYLWTFNMP-TDHAHVSLTDV
MLBr_00737|M.leprae_Br4923 MAVTDPDKGAN-GISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKC
.. :. : *:* * ** : .: : .
Mb0997c|M.bovis_AF2122/97 RLPADALVGAEDAAIAHLFAGLNPERIMGAASAVGMGRFALGRAVDYVKT
Rv0972c|M.tuberculosis_H37Rv RLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKT
MUL_4707|M.ulcerans_Agy99 RLPADALVGAQDAAIAQLFAGLNPERIMGAASAVGMGRFALNRAVDYVKT
MMAR_1491|M.marinum_M RVPDDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVGYAGE
MAV_4027|M.avium_104 RVPADAVLGEVDRGLEVAQTFLHENRIRQAASSLGAAQYCIDRAAEYAGS
Mflv_4468|M.gilvum_PYR-GCK RVPSGAILGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVTYAND
Mvan_1892|M.vanbaalenii_PYR-1 RVPAGAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVAYAND
MSMEG_2070|M.smegmatis_MC2_155 RVPADAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVTYAGE
TH_3506|M.thermoresistible__bu WVPADAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVEYANE
MAB_3636c|M.abscessus_ATCC_199 RVPDAAIFGGEGRGLGVVQHFFNENRIRQAASSLGAAQFCIDRSVAYAKE
MLBr_00737|M.leprae_Br4923 RIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKD
:* :.* . .: :. * .*.::* .: .:. : *.
Mb0997c|M.bovis_AF2122/97 RKVWSTPIGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEA
Rv0972c|M.tuberculosis_H37Rv RKVWSTPIGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEA
MUL_4707|M.ulcerans_Agy99 RQVWSTPIGAHQGLAHPLAQCHIEVELAKLMMQKAATLYDHGDDGGAAEA
MMAR_1491|M.marinum_M RRVFGKPLSVNQAIQWPLVELQTEAQMVRLLVYYAAWHLDRNHHMEVSDK
MAV_4027|M.avium_104 RTVFGKPLSVNQAVQWPLAELQTEAQMVRLLVQYAAWHLDRDHHMEVSDK
Mflv_4468|M.gilvum_PYR-GCK RKVFGKPLATHQAVQWPLVELQTEAQMVRLLVRYAASELDRNHHMEVSDK
Mvan_1892|M.vanbaalenii_PYR-1 RKVFGKPLAVNQAVQWPLVELQTEAQMVRLLVRYAASELDRNHHMEVSDK
MSMEG_2070|M.smegmatis_MC2_155 REVFGKPLAVNQAVQWPLVELQTEAQMVRLLVYYAATQLDANHHMEVSDK
TH_3506|M.thermoresistible__bu RVVFGKPLSVNQAVQWPLVELQTEAQMVRLLVYFAAWHLDHDHHMQVSDK
MAB_3636c|M.abscessus_ATCC_199 RRPFGKALASNQAIQFPLVELQTQCEMLRALIHKTAWSMDTYGPFSVSEQ
MLBr_00737|M.leprae_Br4923 RKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEP-DLGFI
* :. .:. *.: *.: : : : : :* : .
Mb0997c|M.bovis_AF2122/97 ANMAKYAAAEASSRAVDQ--------------------------------
Rv0972c|M.tuberculosis_H37Rv ANMAKYAAAEASSRAVDQ--------------------------------
MUL_4707|M.ulcerans_Agy99 ANMAKYAAAEASARSVDQ--------------------------------
MMAR_1491|M.marinum_M VSMANYRANRLVCEAADR--------------------------------
MAV_4027|M.avium_104 VSMANYRANRLVCDAADR--------------------------------
Mflv_4468|M.gilvum_PYR-GCK VSMANYRANRLVCEAADR--------------------------------
Mvan_1892|M.vanbaalenii_PYR-1 VSMANYRANRLVCEAADR--------------------------------
MSMEG_2070|M.smegmatis_MC2_155 VSMANYRANRLVCEAADR--------------------------------
TH_3506|M.thermoresistible__bu VSMANYRANRLVCEAAHPXTAATSRSSTSTATTAGTGSPRAPRRSRSGAS
MAB_3636c|M.abscessus_ATCC_199 VSMCNYVANRLCCEAADR--------------------------------
MLBr_00737|M.leprae_Br4923 SAASKCFASDIAMEVTTD--------------------------------
.: * .
Mb0997c|M.bovis_AF2122/97 -----------AVQSMG----GNGLTKEYGVAAMMTSAR----------L
Rv0972c|M.tuberculosis_H37Rv -----------AVQSMG----GNGLTKEYGVAAMMTSAR----------L
MUL_4707|M.ulcerans_Agy99 -----------AVQSMG----GNGLTQEYGVAAMLTSSR----------L
MMAR_1491|M.marinum_M -----------AMQVFG----GVGYSRHEPFEHIYRHHR----------R
MAV_4027|M.avium_104 -----------AMQIFG----GLGYSRHEPFEHIYRHHR----------R
Mflv_4468|M.gilvum_PYR-GCK -----------AMQVFG----GVGYSRHEPFEHIYRHHR----------R
Mvan_1892|M.vanbaalenii_PYR-1 -----------AMQVFG----GVGYSRHEPFEHIYRHHR----------R
MSMEG_2070|M.smegmatis_MC2_155 -----------AMQVHG----GIGYSRHEPFEHIYRHHR----------R
TH_3506|M.thermoresistible__bu PSGCSASAGADAGPTRGGAGAGAGRRRHGRRSHPADRRRQPHHLGVRCGR
MAB_3636c|M.abscessus_ATCC_199 -----------AMQVHG----GMGYSRHMPFEHIYRHHR----------R
MLBr_00737|M.leprae_Br4923 -----------AVQLFG----GAGYTSDFPVERFMRDAK----------I
* * * * . :
Mb0997c|M.bovis_AF2122/97 ARIAPISREMV--LNFVAQTSLGLPRSY----------------
Rv0972c|M.tuberculosis_H37Rv ARIAPISREMV--LNFVAQTSLGLPRSY----------------
MUL_4707|M.ulcerans_Agy99 ARIAPISREMV--LNFVAQTSLGLPRSY----------------
MMAR_1491|M.marinum_M YRITEGAEEIQ--IRRVAQRLFKFGQK-----------------
MAV_4027|M.avium_104 YRITEGAEEIQ--IRRVAQRLFKFGKK-----------------
Mflv_4468|M.gilvum_PYR-GCK YRITEGAEEIQ--IRRVAQRLFGFGRK-----------------
Mvan_1892|M.vanbaalenii_PYR-1 YRITEGAEEIQ--IRRVAQRLFGFGRR-----------------
MSMEG_2070|M.smegmatis_MC2_155 YRITEGAEEIQ--MRRVAQRLFGFGRAKK---------------
TH_3506|M.thermoresistible__bu RRDPHPADPADGATRRGARRYGTGGRGAAAGGRRRRPGPADSHR
MAB_3636c|M.abscessus_ATCC_199 YRITEGAEEIQ--MRRVAGYMFGFMSQKAPKGV-----------
MLBr_00737|M.leprae_Br4923 TQIYEGTNQIQ---RVVMSRALLR--------------------
: : .