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NFELPPELVDYLAELDGFIDREIVPLEQADDNIRFFDHRREDSRTDWERGGLPNREWEALLGEARRRADV AGHFRYPFPAEFGGRDGSNLGMAVIREHLARRGLGLHCDLQNEHAIVGNNVGLLLMLEYGSDEQKAAWVE GLAGGTKVFAFGITEPEHGSDATYMETRAVKDGPDWVINGEKTWNTGVHVADADLIFARTSGEPGDGRGI TAFLVPADAPGFKVEEYLWTFNMPTDHAHVSLTDVRVPDAAIFGGEGRGLGVVQHFFNENRIRQAASSLG AAQFCIDRSVAYAKERRPFGKALASNQAIQFPLVELQTQCEMLRALIHKTAWSMDTYGPFSVSEQVSMCN YVANRLCCEAADRAMQVHGGMGYSRHMPFEHIYRHHRRYRITEGAEEIQMRRVAGYMFGFMSQKAPKGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3636c | - | - | 100% (420) | acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4538c | - | 1e-43 | 32.94% (343) | putative acyl-CoA dehydrogenase FadE |
| M. abscessus ATCC 19977 | MAB_1070c | - | 3e-41 | 29.80% (349) | acyl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2528c | fadE19 | 5e-43 | 30.68% (339) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4468 | - | 1e-153 | 63.99% (411) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv2500c | fadE19 | 5e-43 | 30.68% (339) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-34 | 26.80% (403) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_1491 | fadE12_3 | 1e-152 | 64.48% (411) | acyl-CoA dehydrogenase FadE12_3 |
| M. avium 104 | MAV_4027 | - | 1e-149 | 63.02% (411) | acyl-CoA dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2070 | - | 1e-157 | 66.18% (411) | acyl-CoA dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3506 | - | 1e-126 | 61.33% (362) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_3778 | fadE19 | 2e-46 | 32.14% (336) | acyl-CoA dehydrogenase FadE19 |
| M. vanbaalenii PYR-1 | Mvan_1892 | - | 1e-155 | 65.21% (411) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4468|M.gilvum_PYR-GCK MDFTLPDYLPGLLAEMDAFIEAEIKPLER--EHIQYFDHRREHARTDWDN
Mvan_1892|M.vanbaalenii_PYR-1 MDFNLPEHLPALLAEMDAFIEAEIKPLER--ENIQYFDHRREHARTDWDN
MSMEG_2070|M.smegmatis_MC2_155 MDFTLPEHLRDTLAEMDAFIEAEIKPLER--ENIQYFDHRREHARTDWDN
MMAR_1491|M.marinum_M MEFTLPEHLQSLLAQMDEFIEAEIKPLEH--EHIQYFDHRREHARTDWDN
MAV_4027|M.avium_104 MDFTLPEHLPGVLAAMDAFIEDEIKPLER--EHIQYFDQRREHARTDWDN
TH_3506|M.thermoresistible__bu VEFALPDHLPGLLAEMDAFIEAEIKPLER--EHMQYFDHRREYARTDWES
MAB_3636c|M.abscessus_ATCC_199 MNFELPPELVDYLAELDGFIDREIVPLEQADDNIRFFDHRREDSRTDWER
Mb2528c|M.bovis_AF2122/97 ----------MT--TTTTTISGGILPKEY----QDLRDTVADFARTVVAP
Rv2500c|M.tuberculosis_H37Rv ----------MT--TTTTTISGGILPKEY----QDLRDTVADFARTVVAP
MUL_3778|M.ulcerans_Agy99 ---------------MTTAISAGTLPKEY----QDLRDTVADFARSVVAP
MLBr_00737|M.leprae_Br4923 ----------MVGWSGNPLFDLFKLPEEH----NELRATIRALAEKEIAP
:. * * :..
Mflv_4468|M.gilvum_PYR-GCK GGVPRREWEELLDEMRRRADAAGWLRYGLPSQFGGRDGSNLDMAVIREHL
Mvan_1892|M.vanbaalenii_PYR-1 GGVPRREWEDLLDEMRRRADAAGWLRYGLPSQFGGRDGSNIDMAVIREHL
MSMEG_2070|M.smegmatis_MC2_155 GGVPRREWEELLDEMRRRADAAGWLRYGLPARFGGRDGTNLDMAVIREHL
MMAR_1491|M.marinum_M DGVPRREWEELLAEMRRRADQAGWLRYGLPARFGGRDGTNLDMAVIREHL
MAV_4027|M.avium_104 DGIPTREWEDLLAEMRRRADRAGWLRYGLPASLGGRDGSNVDMAVIREHL
TH_3506|M.thermoresistible__bu GGIPRREWEDLLDEMRRRADAAGWLRYGLPARFGGRDGTNLDMAVIREHL
MAB_3636c|M.abscessus_ATCC_199 GGLPNREWEALLGEARRRADVAGHFRYPFPAEFGGRDGSNLGMAVIREHL
Mb2528c|M.bovis_AF2122/97 VSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEEL
Rv2500c|M.tuberculosis_H37Rv VSAKHDAEHSFPYEIVAKMGEMGLFGLPFPEEYGGMGGDYFALSLVLEEL
MUL_3778|M.ulcerans_Agy99 VSAKHDEEHSFPYEVVAKMGEMGLFGLPFPEEYGGMGGDYFALALALEEL
MLBr_00737|M.leprae_Br4923 HAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEV
. : * . * .* ** .. . .: *.:
Mflv_4468|M.gilvum_PYR-GCK AAKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEEQKREWTDALVTGKRSM
Mvan_1892|M.vanbaalenii_PYR-1 AAKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEEQKKEWTDALITGARSM
MSMEG_2070|M.smegmatis_MC2_155 AHKGLGLHNDLQDESSIVGNFPQVIMMDRFGTETQKDEWVEAMITGKRSM
MMAR_1491|M.marinum_M AHKGLGLHNDLQNESSIVGNFPQVIMMDRFGTDAQKSEWTEALITGERSM
MAV_4027|M.avium_104 AHKGLGLHNDLQNESSIVGNFPQVIMMERFGTDEQRREWSQALITGERSM
TH_3506|M.thermoresistible__bu AHKGLGLHNDLQDESSIVGNFPQVIMMDRFGTEQQKQEWIEPMITGERSM
MAB_3636c|M.abscessus_ATCC_199 ARRGLGLHCDLQNEHAIVGNNVGLLLMLEYGSDEQKAAWVEGLAGGTKVF
Mb2528c|M.bovis_AF2122/97 GKVDQSVAITLEAAVGLG-----AMPIYRFGTEEQKQKWLPDLTSGRALA
Rv2500c|M.tuberculosis_H37Rv GKVDQSVAITLEAAVGLG-----AMPIYRFGTEEQKQKWLPDLTSGRALA
MUL_3778|M.ulcerans_Agy99 GKVNQSVAITLEAGVGLG-----AMPIYRFGNEEQKSKWLPDLLAGRALA
MLBr_00737|M.leprae_Br4923 ARVDASASL-IPAVNKLG-----TMGLILRGSEELKKQVLPSLAAEGAMA
. . . : : : : *.: : :
Mflv_4468|M.gilvum_PYR-GCK AFGLTEPNHGSDATWLETTAVQDGDEWIINGAKRFNTGVHRATHDLVFAR
Mvan_1892|M.vanbaalenii_PYR-1 AFGLTEPNHGSDATWLETTAVAVGDDWIINGAKRWNTGVHRATHDLIFAR
MSMEG_2070|M.smegmatis_MC2_155 AFGLTEPGHGSDATWLETTAVRDGEDWIINGTKRWNTGVHRATHDLIFAR
MMAR_1491|M.marinum_M AFGLTEPLHGSDATWMQTRAEHAGDSWIINGAKRFNTGVHRATHDLVFAR
MAV_4027|M.avium_104 AFGLTEPQHGSDATWLQTRAERDGDGWVINGAKRFNTGVHRATHDLIFAR
TH_3506|M.thermoresistible__bu AFGLTEPNHGSDATWLETRAEPDGDGWIINGRKRWNTGVHRATHDLIFAR
MAB_3636c|M.abscessus_ATCC_199 AFGITEPEHGSDATYMETRAVKDGPDWVINGEKTWNTGVHVADADLIFAR
Mb2528c|M.bovis_AF2122/97 GFGLTEPGAGSDAGSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVT
Rv2500c|M.tuberculosis_H37Rv GFGLTEPGAGSDAGSTRTTARLEGDEWIINGSKQFITNSGTDITSLVTVT
MUL_3778|M.ulcerans_Agy99 GFGLTEPGAGSDAGSTRTTARLDGGEWVVNGSKQFITNSGTDITSLVTIT
MLBr_00737|M.leprae_Br4923 SYALSEREAGSDAASMRTRAKADGDDWILNGFKCWITNGGK--STWYTVM
.:.::* **** .* * * *::** * : *.
Mflv_4468|M.gilvum_PYR-GCK TSGE-----AGQARGITAFLVPCDSPGFTVPYYWWTFNMP-TDHGEVLLE
Mvan_1892|M.vanbaalenii_PYR-1 TSGE-----PGQARGITAFLVPTDAPGFSVPYYWWTFNMP-TDHGEVVLE
MSMEG_2070|M.smegmatis_MC2_155 TSGE-----RGQALGITAFLVPTDAPGFHVPFYWWTFNMP-TDHGEVELT
MMAR_1491|M.marinum_M TSGE-----PGQARGITAFLVPTDTAGFNVPYYWWTLNMP-TDHGEVELT
MAV_4027|M.avium_104 TSGE-----PGTAVGITAFLVPTDAPGFTVPYYWWTFNMP-TDHGEVELT
TH_3506|M.thermoresistible__bu TSGE-----PGQAHGITAFLVPTDAEGFKVPFYWWTFNMP-SDHGEVELD
MAB_3636c|M.abscessus_ATCC_199 TSGE-----PGDGRGITAFLVPADAPGFKVEEYLWTFNMP-TDHAHVSLT
Mb2528c|M.bovis_AF2122/97 AVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTFA
Rv2500c|M.tuberculosis_H37Rv AVTGTTGTAADAKKEISTIIVPSGTPGFTVEPVYNKVGWNASDTHPLTFA
MUL_3778|M.ulcerans_Agy99 AVTG---SIADGKKEISTIIVPSGTPGFIVEPVYNKVGWNASDTHPLSFD
MLBr_00737|M.leprae_Br4923 AVTD----PDKGANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFD
: *::::* . ** : ... : : :
Mflv_4468|M.gilvum_PYR-GCK NVRVPSGAILGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVTYA
Mvan_1892|M.vanbaalenii_PYR-1 NVRVPAGAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVAYA
MSMEG_2070|M.smegmatis_MC2_155 NVRVPADAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVTYA
MMAR_1491|M.marinum_M NVRVPDDAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVGYA
MAV_4027|M.avium_104 DVRVPADAVLGEVDRGLEVAQTFLHENRIRQAASSLGAAQYCIDRAAEYA
TH_3506|M.thermoresistible__bu NVWVPADAVLGEVDRGLEVGQTFLHENRIRQAASSLGAAQYCIDRAVEYA
MAB_3636c|M.abscessus_ATCC_199 DVRVPDAAIFGGEGRGLGVVQHFFNENRIRQAASSLGAAQFCIDRSVAYA
Mb2528c|M.bovis_AF2122/97 DARVPRENLLGARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVKYA
Rv2500c|M.tuberculosis_H37Rv DARVPRENLLGARGSGYANFLSILDEGRIAIAALATGAAQGCVDESVKYA
MUL_3778|M.ulcerans_Agy99 DARVPEENLLGIRGKGYANFLSILDEGRIAIAALATGVAQGCVDESVKYA
MLBr_00737|M.leprae_Br4923 KCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYT
. :* ::* . * :.. * .* : * ** .:* : *:
Mflv_4468|M.gilvum_PYR-GCK NDRKVFGKPLATHQAVQWPLVELQTEAQMVRLLVRYAASELDRNHHMEVS
Mvan_1892|M.vanbaalenii_PYR-1 NDRKVFGKPLAVNQAVQWPLVELQTEAQMVRLLVRYAASELDRNHHMEVS
MSMEG_2070|M.smegmatis_MC2_155 GEREVFGKPLAVNQAVQWPLVELQTEAQMVRLLVYYAATQLDANHHMEVS
MMAR_1491|M.marinum_M GERRVFGKPLSVNQAIQWPLVELQTEAQMVRLLVYYAAWHLDRNHHMEVS
MAV_4027|M.avium_104 GSRTVFGKPLSVNQAVQWPLAELQTEAQMVRLLVQYAAWHLDRDHHMEVS
TH_3506|M.thermoresistible__bu NERVVFGKPLSVNQAVQWPLVELQTEAQMVRLLVYFAAWHLDHDHHMQVS
MAB_3636c|M.abscessus_ATCC_199 KERRPFGKALASNQAIQFPLVELQTQCEMLRALIHKTAWSMDTYGPFSVS
Mb2528c|M.bovis_AF2122/97 NQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-FKK
Rv2500c|M.tuberculosis_H37Rv NQRQSFGQPIGAYQAIGFKIARMEARAHVARTAYYDAAAKMLAGKP-FKK
MUL_3778|M.ulcerans_Agy99 KERQSFGQPIGSYQAISFKIARMEARAHVARTAYYEAAAKMLAGKP-FKK
MLBr_00737|M.leprae_Br4923 KDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGF
.* **:.:. *:: : :. : . . * :*
Mflv_4468|M.gilvum_PYR-GCK DKVSMANYRANRLVCEAADR------------------------------
Mvan_1892|M.vanbaalenii_PYR-1 DKVSMANYRANRLVCEAADR------------------------------
MSMEG_2070|M.smegmatis_MC2_155 DKVSMANYRANRLVCEAADR------------------------------
MMAR_1491|M.marinum_M DKVSMANYRANRLVCEAADR------------------------------
MAV_4027|M.avium_104 DKVSMANYRANRLVCDAADR------------------------------
TH_3506|M.thermoresistible__bu DKVSMANYRANRLVCEAAHPXTAATSRSSTSTATTAGTGSPRAPRRSRSG
MAB_3636c|M.abscessus_ATCC_199 EQVSMCNYVANRLCCEAADR------------------------------
Mb2528c|M.bovis_AF2122/97 EAAIAKMISSEAAMDNSRD-------------------------------
Rv2500c|M.tuberculosis_H37Rv EAAIAKMISSEAAMDNSRD-------------------------------
MUL_3778|M.ulcerans_Agy99 EAAIAKMISSEAAMDNARD-------------------------------
MLBr_00737|M.leprae_Br4923 ISAASKCFASDIAMEVTTD-------------------------------
. :: : .
Mflv_4468|M.gilvum_PYR-GCK -------------AMQVFG----GVGYSRHEPFEHIYRHHR---------
Mvan_1892|M.vanbaalenii_PYR-1 -------------AMQVFG----GVGYSRHEPFEHIYRHHR---------
MSMEG_2070|M.smegmatis_MC2_155 -------------AMQVHG----GIGYSRHEPFEHIYRHHR---------
MMAR_1491|M.marinum_M -------------AMQVFG----GVGYSRHEPFEHIYRHHR---------
MAV_4027|M.avium_104 -------------AMQIFG----GLGYSRHEPFEHIYRHHR---------
TH_3506|M.thermoresistible__bu ASPSGCSASAGADAGPTRGGAGAGAGRRRHGRRSHPADRRRQPHHLGVRC
MAB_3636c|M.abscessus_ATCC_199 -------------AMQVHG----GMGYSRHMPFEHIYRHHR---------
Mb2528c|M.bovis_AF2122/97 -------------ATQIHG----GYGFMNEYPVARHYRDSK---------
Rv2500c|M.tuberculosis_H37Rv -------------ATQIHG----GYGFMNEYPVARHYRDSK---------
MUL_3778|M.ulcerans_Agy99 -------------AAQVHG----GYGFMNEYPVARHYRDSK---------
MLBr_00737|M.leprae_Br4923 -------------AVQLFG----GAGYTSDFPVERFMRDAK---------
* * * * . : :
Mflv_4468|M.gilvum_PYR-GCK -RYRITEGAEEIQ--IRRVAQRLFGFGRK-----------------
Mvan_1892|M.vanbaalenii_PYR-1 -RYRITEGAEEIQ--IRRVAQRLFGFGRR-----------------
MSMEG_2070|M.smegmatis_MC2_155 -RYRITEGAEEIQ--MRRVAQRLFGFGRAKK---------------
MMAR_1491|M.marinum_M -RYRITEGAEEIQ--IRRVAQRLFKFGQK-----------------
MAV_4027|M.avium_104 -RYRITEGAEEIQ--IRRVAQRLFKFGKK-----------------
TH_3506|M.thermoresistible__bu GRRRDPHPADPADGATRRGARRYGTGGRGAAAGGRRRRPGPADSHR
MAB_3636c|M.abscessus_ATCC_199 -RYRITEGAEEIQ--MRRVAGYMFGFMSQKAPKGV-----------
Mb2528c|M.bovis_AF2122/97 -VLEIGEGTTEVQ---LMLIARSLGLQ-------------------
Rv2500c|M.tuberculosis_H37Rv -VLEIGEGTTEVQ---LMLIARSLGLQ-------------------
MUL_3778|M.ulcerans_Agy99 -ILEIGEGTTEVQ---LMLIARSLGLS-------------------
MLBr_00737|M.leprae_Br4923 -ITQIYEGTNQIQ---RVVMSRALLR--------------------
. . : :