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EPNELHISNVKVFDSVDGRITGPVDVTVRGPVIASIAPAGAAALSGPAIDGTGKTLLPGLIDAHWHAMFT TIPAALAQVSEFGYVVARAVVSARETLLRGFTTVRDLGGPVFGVKQAIDEGSIPGPRIYPAGGFISQSGG HGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGEAEVLRGAREMLRRGASQLKLMAGGGVTSAYDPLDVAQ FTETEMRAAVEAAENWGTYVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWCLQPFLDD EDAVAVPPPSVPKFKQMVAGTDTAYQLAIKHGVKIAFGTDTLFDAKLASRQGAQLAKLTRWFTPAEVLQQ ATIRNAELLAMSGPRNPYPGRLGVVAEGALADLILVDGDPIADISLIARPDETFTTIIKNGRVVKGAAS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0954 | - | - | 100% (420) | imidazolonepropionase |
| M. marinum M | MMAR_4746 | - | 4e-40 | 33.16% (395) | imidazolonepropionase |
| M. marinum M | MMAR_1793 | - | 5e-11 | 23.80% (374) | hypothetical protein MMAR_1793 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 6e-24 | 29.65% (425) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2466 | - | 1e-39 | 33.59% (396) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 6e-24 | 29.65% (425) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3236c | - | 2e-13 | 26.52% (396) | amidohydrolase |
| M. avium 104 | MAV_0903 | - | 7e-42 | 33.01% (415) | Xaa-Pro dipeptidase |
| M. smegmatis MC2 155 | MSMEG_0297 | - | 3e-41 | 32.85% (417) | amidohydrolase |
| M. thermoresistible (build 8) | TH_2020 | - | 1e-41 | 33.59% (387) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0705 | - | 0.0 | 100.00% (420) | imidazolonepropionase |
| M. vanbaalenii PYR-1 | Mvan_4215 | - | 2e-43 | 33.81% (417) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAVDFAG
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAVDFAG
Mflv_2466|M.gilvum_PYR-GCK ----MTVTVVKAARWADVEAGVVRS-------PAVIVVEGNRIRSVDPAA
MSMEG_0297|M.smegmatis_MC2_155 ----MTQTVLRAARWVDVAAGVVRA-------PAVVVIEGNRITEVNPAA
TH_2020|M.thermoresistible__bu ------VLTLRAAGLLDVDAGEIVR-------PGLVRIVDDRIVGVGG--
Mvan_4215|M.vanbaalenii_PYR-1 ------MLTLKAAGLLDVVSGEIIR-------PGVVTVDGDRIVSLGGTP
MAV_0903|M.avium_104 ------MQTIKAAGLFDVDAGEIVR-------PGLLRVDGDRIVGVGDSG
MMAR_0954|M.marinum_M --MEPNELHISNVKVFDSVDGRITG-------PVDVTVRGPVIASIAPAG
MUL_0705|M.ulcerans_Agy99 --MEPNELHISNVKVFDSVDGRITG-------PVDVTVRGPVIASIAPAG
MAB_3236c|M.abscessus_ATCC_199 ------MRAHLRGRTLPSEE------------PIDLWVHDGVIS----IE
* : : . *
Mb0076|M.bovis_AF2122/97 SACPDMNLVDLGESTLLPGLVDAHAHLCWDP------DGRPEDLAGDPHA
Rv0074|M.tuberculosis_H37Rv SACPDMNLVDLGESTLLPGLVDAHAHLCWDP------DGRPEDLAGDPHA
Mflv_2466|M.gilvum_PYR-GCK EPPG-AEVLDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDDPA
MSMEG_0297|M.smegmatis_MC2_155 PLPDTAAVIDLGDVTLLPGLMDMELNLLIGG---PEGLPSPMHGVQDDPA
TH_2020|M.thermoresistible__bu PEGGH--VIDLGDAILLPGLMDMEVNLLMGG----RGETPGLSQVQDDPA
Mvan_4215|M.vanbaalenii_PYR-1 PPDVE--VIDLGDSILLPGLMDMEVNLLMGG----RGENPGLSQVQDDPA
MAV_0903|M.avium_104 PTGADDNVIDLGEAILLPGLMDMEVNLLMGG----RGEKPGLSQVQDDPP
MMAR_0954|M.marinum_M AAALSGPAIDGTGKTLLPGLIDAHWHAMFTT-------IPAALAQVSEFG
MUL_0705|M.ulcerans_Agy99 AAALSGPAIDGTGKTLLPGLIDAHWHAMFTT-------IPAALAQVSEFG
MAB_3236c|M.abscessus_ATCC_199 PIADADTVFDGG--WLLPGLVDAHCHVGIGP----------------QGP
.* *****:* . :
Mb0076|M.bovis_AF2122/97 VLVGRARRHAAAALRSGITTIRDLG-----DRDYAALALREEYRQKTTVG
Rv0074|M.tuberculosis_H37Rv VLVGRARRHAAAALRSGITTIRDLG-----DRDYAALALREEYRQKTTVG
Mflv_2466|M.gilvum_PYR-GCK YRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHPG
MSMEG_0297|M.smegmatis_MC2_155 YRTLRGAVNARTTVQAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHQG
TH_2020|M.thermoresistible__bu TRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIEG
Mvan_4215|M.vanbaalenii_PYR-1 TRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDG
MAV_0903|M.avium_104 TRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWIDG
MMAR_0954|M.marinum_M YVVARAVVSARETLLRGFTTVRDLG--------GPVFGVKQAIDEGSIPG
MUL_0705|M.ulcerans_Agy99 YVVARAVVSARETLLRGFTTVRDLG--------GPVFGVKQAIDEGSIPG
MAB_3236c|M.abscessus_ATCC_199 TSLEEAVAQAEAEREVGALLLRDAG----------SPVDTRGFDER-EDL
.. * * :*: * .
Mb0076|M.bovis_AF2122/97 PELVVSGPPLTRSGGHC---------------------WFLGGVADSVEE
Rv0074|M.tuberculosis_H37Rv PELVVSGPPLTRSGGHC---------------------WFLGGVADSVEE
Mflv_2466|M.gilvum_PYR-GCK PRIYPAGHAVTPYGGHLDPTVFQRLAPGIM------PLSVAEGIANGVDD
MSMEG_0297|M.smegmatis_MC2_155 PRIHPAGHAVTPYGGHLDPTVFQRLAPGIM------PLSVAEGIANGVPD
TH_2020|M.thermoresistible__bu PRVVPAGHAITPTGGHLDPTMFAAFMPGAL------ELTVEEGIANGVDE
Mvan_4215|M.vanbaalenii_PYR-1 PRVIPAGHAITPTGGHLDPTMFAAFMPGVL------ELTVEEGIANGVDE
MAV_0903|M.avium_104 PRVVPAGHAITPTGGHLDPTMFAAFAPHAL------ELTVEEGIANGIDE
MMAR_0954|M.marinum_M PRIYPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGEAE
MUL_0705|M.ulcerans_Agy99 PRIYPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGEAE
MAB_3236c|M.abscessus_ATCC_199 PRIIRAGRHLAKPKRYIP---------------------GLPLDIEDDAQ
*.: :* :: : :. :
Mb0076|M.bovis_AF2122/97 LVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQ
Rv0074|M.tuberculosis_H37Rv LVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQ
Mflv_2466|M.gilvum_PYR-GCK VRACVRYQVRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFAAIADEAHR
MSMEG_0297|M.smegmatis_MC2_155 VIACVRYQIRHGARLIKVSASGGVMSHSTAPGAQQYGDAELAAIADEAHR
TH_2020|M.thermoresistible__bu IRKAVRYQIKHGAQVIKVCCSGGVMSLTGEAGAQHYSDEELRAIVDEAHR
Mvan_4215|M.vanbaalenii_PYR-1 IRKAVRYQIKHGAQLIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHR
MAV_0903|M.avium_104 IRKAVRYQIKHGAELIKVCCSGGIMSLTGPPGAQHYSDEELRAIVDEAHR
MMAR_0954|M.marinum_M VLRGAREMLRRGASQLKLMAGGGVTSAYDPLDVAQFTETEMRAAVEAAEN
MUL_0705|M.ulcerans_Agy99 VLRGAREMLRRGASQLKLMAGGGVTSAYDPLDVAQFTETEMRAAVEAAEN
MAB_3236c|M.abscessus_ATCC_199 LPEAVALQARWGDGWVKLVG--DWIDRAVGDLAPLWSDKILKQAIDAAHA
: . * :*: . : . : *.
Mb0076|M.bovis_AF2122/97 VGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQ
Rv0074|M.tuberculosis_H37Rv VGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQ
Mflv_2466|M.gilvum_PYR-GCK AGVRVAAHAVGDSAIRACIRAGIDCIEHGFLATDETLQMMVDHGTFLVST
MSMEG_0297|M.smegmatis_MC2_155 AGVKVAAHAVGDTAIQACIRAGIDCIEHGFLATDETIQMMVDHGTFLVST
TH_2020|M.thermoresistible__bu RGLKVAAHTHGAEAVKHAIECGIDCIEHGFLMDDEAIKMLVDNDRFLVST
Mvan_4215|M.vanbaalenii_PYR-1 RGLRVAAHTHGAEAVKHAVECGIDCIEHGFLMDDEAIQMLVDNDRFLVST
MAV_0903|M.avium_104 RGMRVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHGTFLVST
MMAR_0954|M.marinum_M WGTYVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWCLQ
MUL_0705|M.ulcerans_Agy99 WGTYVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWCLQ
MAB_3236c|M.abscessus_ATCC_199 NGARVTAHVFGEDALPGLIHAGIDCIEHGTGLTDDTIALMVEHGTALVPT
* *:.*. .: : .*: :** : : :
Mb0076|M.bovis_AF2122/97 G-VWCGM----TIPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTD
Rv0074|M.tuberculosis_H37Rv G-VWCGM----TIPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTD
Mflv_2466|M.gilvum_PYR-GCK TYLTEAM----AVDRIAPELRKKAEVVFPQAQAMLPKAIAAGVRIACGTD
MSMEG_0297|M.smegmatis_MC2_155 TYLTDAM----AIDRIAPELRKKALDVFPRAKAMLPKAIAAGVRIACGTD
TH_2020|M.thermoresistible__bu RRLAEYM----DVSKAPPELQAKAAEMFPRARTSIKAAFEAGAKIAVGTD
Mvan_4215|M.vanbaalenii_PYR-1 RRLAEYM----DVSKAPPELQAKAAEMFPKARTSIKAAYEAGVKIAVGTD
MAV_0903|M.avium_104 RRLAEGM----DVSHAPPELQAKAAQMFPKSRTSILAAHRAGVKIAVGTD
MMAR_0954|M.marinum_M PFLDDED----AVAVPPPSVP-KFKQMVAGTDTAYQLAIKHGVKIAFGTD
MUL_0705|M.ulcerans_Agy99 PFLDDED----AVAVPPPSVP-KFKQMVAGTDTAYQLAIKHGVKIAFGTD
MAB_3236c|M.abscessus_ATCC_199 VINIENFPGIADKAGKYPKYAQHMRDLYAGLHTTFGNAYDAGIPIYAGTD
*. : : * : .**
Mb0076|M.bovis_AF2122/97 AGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR----
Rv0074|M.tuberculosis_H37Rv AGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR----
Mflv_2466|M.gilvum_PYR-GCK APAVP---HGQNAKELCALVSRGMTPMQALRAATITSAELIDAEDE----
MSMEG_0297|M.smegmatis_MC2_155 APAIP---HGQNAKELCALVERGMTPMQALQAATVVAAELVDASDE----
TH_2020|M.thermoresistible__bu APAIP---HGRNAEELVTLVQWGLPPAAVLRAATVTAADLIGRSD-----
Mvan_4215|M.vanbaalenii_PYR-1 APAIP---HGKNADELVTLVDWGMPPAAVLRAATVVAADLINRSDS----
MAV_0903|M.avium_104 APAIP---HGRNADELVTLVEWGLPPVAVLRAATVTAAELINSSD-----
MMAR_0954|M.marinum_M TLFDAK-LASRQGAQLAKLTRW-FTPAEVLQQATIRNAELLAMSGPRNPY
MUL_0705|M.ulcerans_Agy99 TLFDAK-LASRQGAQLAKLTRW-FTPAEVLQQATIRNAELLAMSGPRNPY
MAB_3236c|M.abscessus_ATCC_199 AGGSIA--HGRISDEVAALTRIGMSPTDALGAASWRARSWLGRPG-----
: . :: * :.. .* *:
Mb0076|M.bovis_AF2122/97 ---KGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSGTQVPLQASAVG
Rv0074|M.tuberculosis_H37Rv ---KGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSGTQVPLQASAVG
Mflv_2466|M.gilvum_PYR-GCK ---LGRLAPGYLADIIAVDGDVSADIATTLDVRFVMKDGVVHKTVDVAQD
MSMEG_0297|M.smegmatis_MC2_155 ---LGRLAPGYLADVVAVPGDPSTDISAILDVSFVMKDGAVVKHREPSDA
TH_2020|M.thermoresistible__bu ---LGRIAEGCLADIVAVPGDPLADIGVTREVNFVMKGGEVFR----HDA
Mvan_4215|M.vanbaalenii_PYR-1 ---LGRIAEGYLADIIAVPGDPLADIGVTKNVTFVMKGGKVYKNEHATDT
MAV_0903|M.avium_104 ---RGRLAEGYLADVIAVPGNPLEDITVTQHVSFVMKGGKVYV----HNQ
MMAR_0954|M.marinum_M PGRLGVVAEGALADLILVDGDPIADISLIARPDETFTTIIKNGRVVKGAA
MUL_0705|M.ulcerans_Agy99 PGRLGVVAEGALADLILVDGDPIADISLIARPDETFTTIIKNGRVVKGAA
MAB_3236c|M.abscessus_ATCC_199 ------LEHGAPADLLGYRADPRTGPGVLASPDLVMLRGQIR--------
: * **:: .. . .
Mb0076|M.bovis_AF2122/97 YNTPS-
Rv0074|M.tuberculosis_H37Rv YNTPS-
Mflv_2466|M.gilvum_PYR-GCK ASTSTV
MSMEG_0297|M.smegmatis_MC2_155 AVR---
TH_2020|M.thermoresistible__bu N-----
Mvan_4215|M.vanbaalenii_PYR-1 N-----
MAV_0903|M.avium_104 N-----
MMAR_0954|M.marinum_M S-----
MUL_0705|M.ulcerans_Agy99 S-----
MAB_3236c|M.abscessus_ATCC_199 ------