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SFVSVIPEQLTAAATNLAGVGSTISTANATAAGPTAAALAAGADDVSAAVSSFFGAYARDYQAFSVQVEA LHDQFVRAVTSGAASYAGAEATSVQQILLDAINAPTQALLGRPLIGNGANAAPGSGANGGDGGILYGNGG AGGSGAAGGNGGAGGAAGLVGNGGAGGAGGNNAAGGSGGAGGLLYGNGGAGGIGGTSAGSGGAGGAGGLL FGTGGAGGTGGFGGGLMTSGGAGGTGGAGGLLFGTGGSGGAGGGSNAFTAGDGGAGGAGGLLFGTGGSGG DGGLAPGAMFGNGGHGGTGGAGGTLSGIGGHGGAGGLGQVSGGAGGDGGNGGVFFGGGGDGGIGGHGITG SGGSGGSGGSGGFLPGGAGVAGLIGDGGAGGHGGSGGSGGGTGGSGGSAGTLLGNGGAGGGGGSGSTTAG GGGSGGDAGALFGNGGAGGAGGSGAATGGSGGTGGSSALLFGTGGVGGVGGSGGDSGGTGGAGGQGGAMF GNGGAGGGGGDGINVGGKGGAGGAAATLFGSGGTGGDGGNAGAGVTFGGAGGEGGAAALLGGNGGSGGHG GIGNVGGKGGAGAAGAMLLGNGGDGGDGGNSLASLAGAGGAAGNAGLIGSGGTGGAGGQSFSGTGGKGGD GGSALLIGDGGNGGNGGTGATAGVGGTAGTGGFLFGLDGMNGSP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0478 | - | - | 100% (675) | PE-PGRS family protein |
| M. marinum M | MMAR_3290 | - | 0.0 | 55.45% (734) | PE-PGRS family protein |
| M. marinum M | MMAR_5044 | - | 0.0 | 50.56% (801) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1121 | PE_PGRS22 | 0.0 | 49.07% (856) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-131 | 45.66% (692) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv1759c | wag22 | 0.0 | 52.44% (757) | PE-PGRS family protein |
| M. leprae Br4923 | MLBr_01183 | - | 4e-11 | 33.70% (92) | hypothetical protein MLBr_01183 |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-48 | 36.69% (447) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4827 | - | 6e-25 | 46.11% (167) | hypothetical protein MAV_4827 |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-112 | 42.57% (700) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3810 | - | 1e-43 | 41.67% (312) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1339 | - | 0.0 | 54.22% (734) | PE-PGRS family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 1e-127 | 44.68% (696) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MMAR_0478|M.marinum_M --------------------------------------------------
Mb1121|M.bovis_AF2122/97 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_1339|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MMAR_0478|M.marinum_M --------------------MSFVSVIPEQLTAAATNLAGVGSTISTANA
Mb1121|M.bovis_AF2122/97 --------------------MSFVIAAPEALVAVASDLAGIGSALAEANA
Rv1759c|M.tuberculosis_H37Rv --------------------MSFVIAVPETIAAAATDLADLGSTIAGANA
MUL_1339|M.ulcerans_Agy99 --------------------MSYVIAAPEEFASAARNLANIGVTINAANA
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 -----------------MSIIDFILNLFRDPVEAASYVADPEAALANAGL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------MNIVLGVSMAPSSIQMVVLEGEYADGATVE
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MMAR_0478|M.marinum_M TAAGPTAAALAAGADDVSAAVSSFFGAYARDYQAFSVQVEALHDQFVRAV
Mb1121|M.bovis_AF2122/97 AALAPTTALLAAGADEVSAAIAALFGAHGQAYQTVSAQASAFHAQFVQAL
Rv1759c|M.tuberculosis_H37Rv AAAANTTSLLAAGADEISAAIAALFGAHGRAYQAASAEAAAFHGRFVQAL
MUL_1339|M.ulcerans_Agy99 NAILATTEVIQPGADAVSAAITALINSHGLGYQSISQQTTAFHDRFVQTV
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SAVSAAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQ
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 EDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQLSSIGVTWTDQL
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MMAR_0478|M.marinum_M TS--------------------------------------GAASYAGAEA
Mb1121|M.bovis_AF2122/97 TG--------------------------------------GGGAYAAAEA
Rv1759c|M.tuberculosis_H37Rv TT--------------------------------------GGGAYAAAEA
MUL_1339|M.ulcerans_Agy99 NA--------------------------------------AAASYTTTDL
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 PD--------------------------------------GPSILSPSLL
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 EA--------------------------------------AALRDALAAR
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDG-T
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDG-T
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGING-T
MMAR_0478|M.marinum_M T----------SVQQILLDAINAPTQALLG--------RPLIGNGANAAP
Mb1121|M.bovis_AF2122/97 ANVSA----AQSTDQRLLDLINGPTQALLG--------RPLIGDGANGGP
Rv1759c|M.tuberculosis_H37Rv A--------AVTPLLNS---INAPVLAATG--------RPLIGNGANGAP
MUL_1339|M.ulcerans_Agy99 T--------AASLLKSMPTAVNAPAQALFG--------RPLIGNGSNGTP
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 SPRDNDFLSHNDTDFASHNPIASGNQVMSP-----------SGNVDSFNR
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 R---------------------IDNVMLVS--------AFLAAAALAQNV
Mflv_5091|M.gilvum_PYR-GCK GQN-----GGILFGNGGSGWNSDVVGMDGGNGG---NGGLFGGNGGNGGN
Mvan_1264|M.vanbaalenii_PYR-1 GQN-----GGILFGNGGSGWNSEIAGVSGGNGG---NAGLFGGNGGNGGN
MSMEG_0868|M.smegmatis_MC2_155 ADNPNGGTGGLLFGDGGHGYDGSAAGLAGGNGG---NAGLFG-NGGNGGV
MMAR_0478|M.marinum_M GSGANGGDGGILYGNGGAGG-SGAAGGNGGAGG---AAGLVG-NGGAGGA
Mb1121|M.bovis_AF2122/97 GQ--DGGPGGLLYGNGGNGGTSTTAGVAGGNGG---AAGLIG-NGGAGGG
Rv1759c|M.tuberculosis_H37Rv GTGANGGDAGWLIGNGGAGG-SGAKGANGGAGGPGGAAGLFG-NGGAGGA
MUL_1339|M.ulcerans_Agy99 GTGAPGGDGGILFGSGGAGG-SGAGGQDGGAGG---RAGLFG-NGGAGGA
TH_3810|M.thermoresistible__bu ------------------------VDGDGGSGG---RTGLFS-KLSRGGD
MAB_4284c|M.abscessus_ATCC_199 GPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNS----GPIASGQGSTAVN
MLBr_01183|M.leprae_Br4923 ---------MPLFLNAEPQALTAAANTLEGLSA----ATVAS-NAAAAQL
MAV_4827|M.avium_104 GGAMGYERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQ
. .
Mflv_5091|M.gilvum_PYR-GCK GLGGGNG----GNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGV
Mvan_1264|M.vanbaalenii_PYR-1 GLGSGDG----GNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGV
MSMEG_0868|M.smegmatis_MC2_155 GWAGLDG----GNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGT
MMAR_0478|M.marinum_M GGNNAAG----GSGGAGG--LLYGNGGAGGIG-----GTSAG----SGGA
Mb1121|M.bovis_AF2122/97 GGAGAAG----GNGGAGG--WLYGNGGAGGAG-----GTSVIPGV-AGGN
Rv1759c|M.tuberculosis_H37Rv GGTATANNGIGGAGGAGGSAMLFGAGGAGGAG-----GAATSLVGGIGGT
MUL_1339|M.ulcerans_Agy99 GGTGQTQ---GGAGGAGG--LFFGNGGAGGPG-----GSG-GLNGGAGGA
TH_3810|M.thermoresistible__bu GGDGGLG----GNGGHGG--------GTGIIS------------------
MAB_4284c|M.abscessus_ATCC_199 GDVRDSNIINADHGSNVGVDQSQTRVGGDYTN---------------VSG
MLBr_01183|M.leprae_Br4923 TTEIAPP-----AADDVSILLAHFFSGHGR--------------------
MAV_4827|M.avium_104 LSAMVAG---LEKLESLPGGLLLVGSGVDVAP----LKQVLQTTTFLDVS
* .
Mflv_5091|M.gilvum_PYR-GCK AGATGATGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------
Mvan_1264|M.vanbaalenii_PYR-1 AGATGATGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------
MSMEG_0868|M.smegmatis_MC2_155 GGTGGGTGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYV
MMAR_0478|M.marinum_M GGAGG---LLFGTGGAGG--TGGFG--GGLMTSGGAG-------------
Mb1121|M.bovis_AF2122/97 GGAGGS-AGLWGTGGAGG--DGGNGRSGPVNVAGSAG-------------
Rv1759c|M.tuberculosis_H37Rv GGTGGNAGMLAGAAGAGG--AGGFS----FSTAGGAG-------------
MUL_1339|M.ulcerans_Agy99 GGVG---GLLFGAGGAGG--AGGSG----TSGIGGLG-------------
TH_3810|M.thermoresistible__bu ---------LLSLAGNGG--------------------------------
MAB_4284c|M.abscessus_ATCC_199 HGSADIDKSVTVVDDHSQRNTTNINDSFNTDRSTNIG-------------
MLBr_01183|M.leprae_Br4923 ---------QYQAHASQG--------------------------------
MAV_4827|M.avium_104 VAEEPETALARGAALAAANAPLFASSTAALAYAQDPG-------------
Mflv_5091|M.gilvum_PYR-GCK -------AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG----AVGA
Mvan_1264|M.vanbaalenii_PYR-1 -------AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG----AIGT
MSMEG_0868|M.smegmatis_MC2_155 LIAGPNVTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGA
MMAR_0478|M.marinum_M ---------GTGGAGG--LLFGTGG------SGGAGGGSNA---------
Mb1121|M.bovis_AF2122/97 ---------GNGGAGGAAGLFGDAG------AGGNGGKGGAGGAA-----
Rv1759c|M.tuberculosis_H37Rv ---------GAGGAGGLFTTGGVGGAGGQGHTGGAGGAGGAGG-------
MUL_1339|M.ulcerans_Agy99 ---------GDGGSAGALSIS----------AGGAGGNGGTG--------
TH_3810|M.thermoresistible__bu -------------------------------NGGNGYRTTDN--------
MAB_4284c|M.abscessus_ATCC_199 ---------SGNTTNTEIGSHNQANIGTSTSAGGSAAVGGNAG-------
MLBr_01183|M.leprae_Br4923 -------------------------------ATNHQDLIQSL--------
MAV_4827|M.avium_104 --------------TGAVDQYSLPDYLYVPVDPEPGDDELAYS-------
Mflv_5091|M.gilvum_PYR-GCK AG-------AAGTVGTAGATGGTGTGANGGAGGVG-----GVGGTGAAGA
Mvan_1264|M.vanbaalenii_PYR-1 AG-------VAGAAGTAGATGGTGVGGNGGAGQAG-----GIGGTGAAGA
MSMEG_0868|M.smegmatis_MC2_155 NGGTVDGHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTA
MMAR_0478|M.marinum_M --------FTAGDGGAGGAGG-----LLFGTGGSG-----GDGG-----L
Mb1121|M.bovis_AF2122/97 ----FSINFTAGDGGAGGAGGSGGHALLWGAGGAG-----GNGGSGGTGG
Rv1759c|M.tuberculosis_H37Rv ---------LFGAGGMGGAGGF-GDHGTLGTGGAG-----GDGGGGGLFG
MUL_1339|M.ulcerans_Agy99 ---------LSGFGGAGGAG---GNAGLYGHGGGG-----GAGGTGTGMG
TH_3810|M.thermoresistible__bu ---------NALDGGHGGNGGNVGFFSLFNLGGAG-----GWGGSG----
MAB_4284c|M.abscessus_ATCC_199 ---------LAGNAGLAGNAGLAGNAGLAGNAGLAG----NAGLAGNAGL
MLBr_01183|M.leprae_Br4923 ---------LTSSSAYAGTET-------ANHDSL----------------
MAV_4827|M.avium_104 ---------AVGEEDAESPTVVIEKLFLPEDSEPR-----RRPVLLVGSG
.
Mflv_5091|M.gilvum_PYR-GCK AGGAGGLG-ETGTTGGAGGVG--------------------GQGTAGGTG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGTAG-ETGVTGGVGGIG--------------------GQGTEGGTG
MSMEG_0868|M.smegmatis_MC2_155 TGGDGGHS-TGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTG
MMAR_0478|M.marinum_M APGAMFG------NGGHGGTG-------------------GAGGTLSGIG
Mb1121|M.bovis_AF2122/97 AGGSTAG------AGGNGGAG-------------------GGGGTGGLLF
Rv1759c|M.tuberculosis_H37Rv AGGDGGAGGSGLTTGGAAGNG-------------------GNAGTL-SLG
MUL_1339|M.ulcerans_Agy99 VDNDG--------IGGAGGAG-------------------GAGG---WLI
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 AGNAGLAG---------------------------------NAGLAGNAG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 LAVVGISAVLALEIALAIGIR--------------------TTGTVALQP
Mflv_5091|M.gilvum_PYR-GCK GVGGIGGAG----------STGAVGG-------VGGKG----IQGGQG--
Mvan_1264|M.vanbaalenii_PYR-1 GVGGVGGVG----------ATGGAGG-------VGGKG----IQGGQG--
MSMEG_0868|M.smegmatis_MC2_155 GAGGMGEIYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPT
MMAR_0478|M.marinum_M GHGGAGGLG----------QVSGG---------AGGD------GGNGGV-
Mb1121|M.bovis_AF2122/97 GNGGAGGHG----------AAAGNGL-------AAGNGVSSSGGGGAGG-
Rv1759c|M.tuberculosis_H37Rv AAGGAGGTG----------GAGGTVF-------GGGKGGAGGAGGNAGM-
MUL_1339|M.ulcerans_Agy99 GTGGTGGTG----------GFG-----------DGPLGGQGGDGGNAG--
TH_3810|M.thermoresistible__bu -VDGVDVVG------------------------------------GNP--
MAB_4284c|M.abscessus_ATCC_199 LAGNAGLAG-----------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 TPNQHLIVP-----------------------------------------
Mflv_5091|M.gilvum_PYR-GCK -----------LQGGKGGDGGAGGKGGDADSMGS----------------
Mvan_1264|M.vanbaalenii_PYR-1 -----------LQGGQGGDGGTGGTGGDATSMGE----------------
MSMEG_0868|M.smegmatis_MC2_155 TGGKASGTAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNG
MMAR_0478|M.marinum_M ------------FFGGGGDGGIGGHG------------------------
Mb1121|M.bovis_AF2122/97 ------------TGGAGGDGGAGGAGGNARLWG-----------------
Rv1759c|M.tuberculosis_H37Rv ------------LFGSGGGGGTGGFG-FAAGGQGGV----------GGSA
MUL_1339|M.ulcerans_Agy99 ------------LFGVGGDGGLGGTGFFGAGGAGGA----------AGNA
TH_3810|M.thermoresistible__bu ------------------DGGT----------------------------
MAB_4284c|M.abscessus_ATCC_199 ------------NAGLAGNAGLAGNAG-----------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ------------TEQAPAPPPVQASAPQPKISVPEP--------------
Mflv_5091|M.gilvum_PYR-GCK --AGATGGKGGNGGNGGRGGLFG---------------KGGNAGNGAD--
Mvan_1264|M.vanbaalenii_PYR-1 --AGATGGKGGNGGNGGRGSLFG---------------RGGNAGNGGN--
MSMEG_0868|M.smegmatis_MC2_155 GAASANGAVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGW
MMAR_0478|M.marinum_M --ITGSGGSGGSGGSGGF-------------------LPGGAGV----AG
Mb1121|M.bovis_AF2122/97 --VGGAGGAGGDGGAGG---------------------AGGKGG----SG
Rv1759c|M.tuberculosis_H37Rv GMLSGSGGSGGAGGSGGPA----------------GTAAGGAGGAGGAPG
MUL_1339|M.ulcerans_Agy99 GLISGTGDVGGQGGVGG-------------------FGEGGAGGDGGGAG
TH_3810|M.thermoresistible__bu --PGAHGESHTPGVYTD---------------------------------
MAB_4284c|M.abscessus_ATCC_199 --LAGNAGLAGNAGLAG---------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --VAAPKPLSPPVAAPLP--------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------GGTGGAGGAGGTGG-TGGAGGTGG------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------GGTGGNGGNGGTGG-TGGNGGTGG------
MSMEG_0868|M.smegmatis_MC2_155 VQAYDPNGPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGAS---
MMAR_0478|M.marinum_M LIG----------------DGGAGGHGGSGGSGGGTGGSGG---------
Mb1121|M.bovis_AF2122/97 LSGN--------------ANGGAGGDSGRGGTGG-AGGEGG---------
Rv1759c|M.tuberculosis_H37Rv LIG----------------NGGNGGNGGESGGTGGVGGAGGNAVLIGNGG
MUL_1339|M.ulcerans_Agy99 LIG----------------NGGSGGTGGNAVGNSGVGGHGG---------
TH_3810|M.thermoresistible__bu ----------------------RQGEDGEDGTGTGIGGRGG---------
MAB_4284c|M.abscessus_ATCC_199 -------------------NAGLAGNAGLAGNAGLAGNAGLAG-------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------AAPPPAAPPLPEAPPIPAAPPVVP------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0478|M.marinum_M --------------------------------------------------
Mb1121|M.bovis_AF2122/97 --------------------------------------------------
Rv1759c|M.tuberculosis_H37Rv EGGIGALAGKSGFGGFGGLLLGADGYNAPESTSPWHNLQQDILSFINEPT
MUL_1339|M.ulcerans_Agy99 --------------------------------------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------TGGTGGIGGAGSTGGTGGTGGTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155 --------VWKANGQHSTGQTDTGGNGGRGGDGGTFVNAGANGNGGAGGA
MMAR_0478|M.marinum_M ------------------------SAGTLLGNGGAGGGGGSGSTTAGGGG
Mb1121|M.bovis_AF2122/97 ------------------------AAGLLVGTGGHGGDGGAGGAAVKGGD
Rv1759c|M.tuberculosis_H37Rv EALTGRPLIGNGDSGTPGTGDDGGAGGWLFGNGGNGGAGAAGTNGSAGGA
MUL_1339|M.ulcerans_Agy99 ---------------------AGGRGGRLYGNGGVGGNGGFSGPITAGGA
TH_3810|M.thermoresistible__bu ------------------------NGGSSSGTHPMAEDGEHVKALD----
MAB_4284c|M.abscessus_ATCC_199 -------------------------NAGLAGNAAVAGNAAVAGNAAVAGN
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -------------------------VPVVVPPVPVPVPVRIPVPDPVSPP
Mflv_5091|M.gilvum_PYR-GCK GGTG-GTGGTGGTGGTGGKGGTGGTGGAGGTG------GDGGTGGTG---
Mvan_1264|M.vanbaalenii_PYR-1 GGTG-GTGGTGGTGGTGGKGGTGGTGGDGGTG------GTGGTGGTG---
MSMEG_0868|M.smegmatis_MC2_155 GGVSEGEGGTGGHGGDGGRGGDGALGGNGGTGGVG--LGNGGKGGNG---
MMAR_0478|M.marinum_M ---------SGGDAG-ALFGN-GGAGGAGGSGA----ATG-GSGGTG---
Mb1121|M.bovis_AF2122/97 ---------GGAAAGTGIAGA-GGRGGAGGSGG----SGGDGGGGAA---
Rv1759c|M.tuberculosis_H37Rv GGAGGILFGTGGAGGAGGVGT-AGAGGAGGAGGSAFLIGSGGTGGVGGAA
MUL_1339|M.ulcerans_Agy99 GGTG----GTGGS--AGLPGD-GGAGGAGGASG----FAGGGTGGIG---
TH_3810|M.thermoresistible__bu ----------GRPGLDGGNGSHGGNGGHGGRGG---FLGIGGSGGWG---
MAB_4284c|M.abscessus_ATCC_199 -------AAVGGVLNTGVSGAIGGSSHVGGAIN----ESLGGSGSVG---
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 QLLAPPRLSVPQPVQPPVRVPQPPSPPQVGGTVPQSPPQHQTPPGEG---
Mflv_5091|M.gilvum_PYR-GCK ----------GTGGTG---------GTGGTGGTGGAG-----------DG
Mvan_1264|M.vanbaalenii_PYR-1 ----------GTGGTG---------GTGGTGGTGGAG-----------DG
MSMEG_0868|M.smegmatis_MC2_155 ----------GNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNGTATGTA
MMAR_0478|M.marinum_M ----------GSSALL--------FGTGGVGG------------------
Mb1121|M.bovis_AF2122/97 ----------GPAGWL--------FGDGGAGGNGGAA-------------
Rv1759c|M.tuberculosis_H37Rv TTTGGVGGAGGNAGLL--------IGAAGLGGCGGG--------------
MUL_1339|M.ulcerans_Agy99 ----------GTGGLP--------FGAAGDGGNGG---------------
TH_3810|M.thermoresistible__bu -------------------------GHGGNGGDTDAD-------------
MAB_4284c|M.abscessus_ATCC_199 ----------GSTAVG---------GGAHTGVGGGVS-------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 -------------------------TPPKPDGPGNYG-------------
Mflv_5091|M.gilvum_PYR-GCK TGGTGGTGG----TGGQGGQGGQGG-----------------TGGTGGQG
Mvan_1264|M.vanbaalenii_PYR-1 LGGTGGTGG----TGGFGGQGGQGG-----------------TGGTGGQG
MSMEG_0868|M.smegmatis_MC2_155 TGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATGGDGGNG
MMAR_0478|M.marinum_M ---VGGSGGDS---GGTGGAGGQGG----------------AMFGNGGAG
Mb1121|M.bovis_AF2122/97 --AAGGAGGQA---GGGGGNGGNGGNGGNGGNG-GNGATGGWLYGNGGAG
Rv1759c|M.tuberculosis_H37Rv ---AFTAGVTT---GGAGGTGGAAG-----------------LFANGGAG
MUL_1339|M.ulcerans_Agy99 ----FGAGGR----GGSGGAGGDAW-----------------LFGSGGSG
TH_3810|M.thermoresistible__bu --------------GGNGGDGGNGG-----------------SAGRGGTG
MAB_4284c|M.abscessus_ATCC_199 -------------TGVGVGSHVGGG----------------ISESLGGSG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------GGHVPTPGAGG--------------------SGGSG
Mflv_5091|M.gilvum_PYR-GCK G------LGGGGGTG-----------------------GQGGTGGTGGQG
Mvan_1264|M.vanbaalenii_PYR-1 G------LGGVGGTG-----------------------GTGGTGGTGGQG
MSMEG_0868|M.smegmatis_MC2_155 GT-----LGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGHG
MMAR_0478|M.marinum_M G------GGGDGIN----------------------VGGKGGAGGAA--A
Mb1121|M.bovis_AF2122/97 GQGATAGAGGAGANGVSST----------NGGGNGGIGGTGGSGGAGGNA
Rv1759c|M.tuberculosis_H37Rv G------AGGTGSTAGGAG----------GAGGAGGLYAHGGTGGPGGNG
MUL_1339|M.ulcerans_Agy99 G------SGGAGAIN------------------------DGGSGGAVGNG
TH_3810|M.thermoresistible__bu G------LRGVFGIN-------------------------GGN-------
MAB_4284c|M.abscessus_ATCC_199 S------VGGSTAVG-------------------------GGAHTGVGGG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 G-------GHVPTPG------------------------AGGSGGSGG--
Mflv_5091|M.gilvum_PYR-GCK GTGGTGGTGGTG---------------------GTGGAGGDGGLGGLGGF
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGTG---------------------GTGGAGGDGGLGGLGGF
MSMEG_0868|M.smegmatis_MC2_155 GNGGQGTIEANGPSA-------------VASGIGAGGNGGDGIDGGLGGN
MMAR_0478|M.marinum_M TLFGSGGTG------------------------------GDGGNAGAGVT
Mb1121|M.bovis_AF2122/97 GLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGGAGGDGGDGGNGGAGGT
Rv1759c|M.tuberculosis_H37Rv GSTGAGGTGGAGGPG------------------GLYGAGGSGGAGGHGGM
MUL_1339|M.ulcerans_Agy99 G--------------------------------RLFGDAGAGGSGGAGGT
TH_3810|M.thermoresistible__bu ---------------------------------------GRAGLGGRGXX
MAB_4284c|M.abscessus_ATCC_199 VSTGVG----------------------------VGSHVGGGISESLGGS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------------------------------GHVPTPGTGGP
Mflv_5091|M.gilvum_PYR-GCK GGSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSA
Mvan_1264|M.vanbaalenii_PYR-1 GGVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSA
MSMEG_0868|M.smegmatis_MC2_155 GGDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYG
MMAR_0478|M.marinum_M ------------------FGGAGGEGGA--AALLG---------------
Mb1121|M.bovis_AF2122/97 GG---------LLFGAGGNGGPGGSGGA--ADIGGNGGAGN---------
Rv1759c|M.tuberculosis_H37Rv AGGGGGVGGNAGSLTLNASGGAGGSGGSSLSGKAGAGGAGG---------
MUL_1339|M.ulcerans_Agy99 S--------FLDTVIVSSNGGAAGNGGS--AGLVGNGGAG----------
TH_3810|M.thermoresistible__bu X-----------------XGGGVGAAVR----------------------
MAB_4284c|M.abscessus_ATCC_199 G----------------SVGGSTAVGGG----------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 GG----------------TGGSGGGHVP----------------------
Mflv_5091|M.gilvum_PYR-GCK GKAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAG
Mvan_1264|M.vanbaalenii_PYR-1 GTAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQG
MSMEG_0868|M.smegmatis_MC2_155 STLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGG
MMAR_0478|M.marinum_M -------------GNGGSGGHGG---------------------------
Mb1121|M.bovis_AF2122/97 -------GGGT-DGNGGNGGSGGG--------------------------
Rv1759c|M.tuberculosis_H37Rv -------SAGLFYGSGGAGGNGGYSLNG----------------------
MUL_1339|M.ulcerans_Agy99 ----------------GAGGQGGLIVSA----------------------
TH_3810|M.thermoresistible__bu --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ATGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAA
Mvan_1264|M.vanbaalenii_PYR-1 SAGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAA
MSMEG_0868|M.smegmatis_MC2_155 DGGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGAD
MMAR_0478|M.marinum_M ----IGNVGGKGGAG------------AAGAMLLGNGGD--GGDGGNS--
Mb1121|M.bovis_AF2122/97 ----AGSGGDGGGAG------------GNGAWLFGNGGA--GGGGGKGGN
Rv1759c|M.tuberculosis_H37Rv ----TGGDGGTGGAG------------QITGLRSGFGGA--GGAGGAS--
MUL_1339|M.ulcerans_Agy99 ----DDNNGGAGGDG------------GGAGLLLGAGGA--GGQGGLGG-
TH_3810|M.thermoresistible__bu ----SGNGVFSGGGG---------------TPSAGFGVP-----------
MAB_4284c|M.abscessus_ATCC_199 -----AHTGVGGGVN------------TGVGVGSHVGGGISESLGGSGSV
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ----TPGAGTPGGSG------------GGHLPFPGAGST-----------
Mflv_5091|M.gilvum_PYR-GCK G-----KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAG
Mvan_1264|M.vanbaalenii_PYR-1 G-----KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAG
MSMEG_0868|M.smegmatis_MC2_155 G-----WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNG
MMAR_0478|M.marinum_M ------------LASLAG--------AGGAAGNAGLIGSG----GTGGAG
Mb1121|M.bovis_AF2122/97 GAGGGLGGGSFGLPGLNG--------SGGDGGDGGNGAPGGVLYGNGGAG
Rv1759c|M.tuberculosis_H37Rv ------------DTGAGG--------NGGAGGKAGLYGNG----GDGGAG
MUL_1339|M.ulcerans_Agy99 ------------NTVDGG--------NGGNGGNAALIGDG----GSGGAG
TH_3810|M.thermoresistible__bu ------------TTIQFP---------AGSCTSRAVSREG--IMPSSRAA
MAB_4284c|M.abscessus_ATCC_199 G-----------GSTAVG---------GGAHTSAINDALG----GSGSVG
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 ---------------------------PGGSGGGHLPTPG-----AGTPG
Mflv_5091|M.gilvum_PYR-GCK G-----------AGGEGG----------EGGDGGKGGAGAE--------G
Mvan_1264|M.vanbaalenii_PYR-1 G-----------AGGEGG----------EGGAGGAGGDGSE--------G
MSMEG_0868|M.smegmatis_MC2_155 GNTSVWKSGGQTADGEHN----------TGGNGGNGGDGSEPGPGGNGAG
MMAR_0478|M.marinum_M G------------QSFSG----------TGGKGGDGGSALLIG-----DG
Mb1121|M.bovis_AF2122/97 G------------QGSSGGIGGPGATGGAGGKGGDGGDAQLIG-----DG
Rv1759c|M.tuberculosis_H37Rv G------------DGATS------------GKGGAGGNAVVIG-----NG
MUL_1339|M.ulcerans_Agy99 G------------DGGSGD----------AGDGGAGGDARLVG-----SG
TH_3810|M.thermoresistible__bu S-----------------------------ARAGAACASSTSR-------
MAB_4284c|M.abscessus_ATCC_199 G------------STAVG-----------GGAHTSAINESMNSSINASHS
MLBr_01183|M.leprae_Br4923 --------------------------------------------------
MAV_4827|M.avium_104 G-----------------------------GLGGFGGGHAPAP-----GG
Mflv_5091|M.gilvum_PYR-GCK GAGGGGGAGGSGAGGAG--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 GAGGSGGAGGSGTGGAG--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GAGGNGGTGGTTAGGSGNGGNGGNGGNGGADGTPGTAGTTGANNP
MMAR_0478|M.marinum_M GNGGNGGTGATAG-------VGGTAGTGG--FLFGLDGMNGSP--
Mb1121|M.bovis_AF2122/97 GNGGNGGAGGTGGTPGP-GGPGGSGGLGG--LLFGQTGTAGVSP-
Rv1759c|M.tuberculosis_H37Rv GNGGNAGKAG---------GTAGAGGAGG--LVLGRDGQHGLT--
MUL_1339|M.ulcerans_Agy99 GNGGNGGFSATP-------AAGGTGDAGG--AVFGSDGVAGLP--
TH_3810|M.thermoresistible__bu SRRSFCCSRA-----------------------------------
MAB_4284c|M.abscessus_ATCC_199 SSMNESFGSSMGSHGAAGTGFEAQGHAQGHASETAHTTLPGAEHH
MLBr_01183|M.leprae_Br4923 ---------------------------------------------
MAV_4827|M.avium_104 GLGGGGGHAPAPG--------GGLGGFGGGHSGGGLGGLGGGHK-