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KDFRYARATDIASALATLHHDDTTVIAGGTELLNWYRLGIATEGNVLDIGGVQGLRDITREGDELVIGAL ATLNDVAAHPTVNGGAGVLSSACRQAASAQLRNRATMGGNVLQRTRCPYFRAEEPLPWGCNKRTPGTGCS SLTGQHERQAIFGWTDDCVAVHPSDPAVALAALDAQIEVASAAELRSIPMTQFHLSQQEAAATGDPRRES RLEPGELITGYRLRLRPDEAQAYVKVRERASYEYAIVSAAAVVRISHGVIAAARLALGSVAQRPWRLYEA ESQLVGLPLHRNAVLPVVERALSASDPLPDNGFKAMLAARAAVRALLTAGGAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0081 | coxM_2 | - | 100% (334) | carbon monoxyde dehydrogenase (medium chain), CoxM_2 |
| M. marinum M | MMAR_0835 | coxM_1 | 4e-49 | 36.92% (325) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
| M. marinum M | MMAR_0655 | coxM | 6e-16 | 24.40% (336) | carbon monoxyde dehydrogenase (medium chain), CoxM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0382c | - | 2e-12 | 27.01% (311) | carbon monoxyde dehydrogenase medium subunit |
| M. gilvum PYR-GCK | Mflv_0283 | - | 1e-59 | 42.25% (329) | molybdopterin dehydrogenase, FAD-binding |
| M. tuberculosis H37Rv | Rv0375c | - | 2e-12 | 27.01% (311) | carbon monoxyde dehydrogenase medium subunit |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_0685 | - | 2e-55 | 41.69% (331) | oxidoreductase, molybdopterin-binding subunit |
| M. thermoresistible (build 8) | TH_0174 | - | 2e-15 | 24.85% (334) | PROBABLE CARBON MONOXYDE DEHYDROGENASE (MEDIUM CHAIN) |
| M. ulcerans Agy99 | MUL_4579 | coxM_1 | 3e-48 | 36.62% (325) | carbon monoxyde dehydrogenase (medium chain), CoxM_1 |
| M. vanbaalenii PYR-1 | Mvan_2077 | - | 1e-54 | 39.40% (335) | molybdopterin dehydrogenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0283|M.gilvum_PYR-GCK ---MKPFEYHLATSPADAVATLARHPD-AAYLAGGTNLVDHMKLGVAEPR
MSMEG_0685|M.smegmatis_MC2_155 ---MKAFGYHVATSPADAVATLAGHPG-AAYLAGGTNLVDHMKLGVAEPD
Mvan_2077|M.vanbaalenii_PYR-1 ---MRTFDHRRAGTVDDAIG-LASVPG-ARYFAGGTNLLDLMKSGVENPT
MUL_4579|M.ulcerans_Agy99 ---MFPFRYSKASDEQSALR--AAAAG-GRYIAGGTTLVDLMRETVERPD
MMAR_0081|M.marinum_M ---MKDFRYARATDIASALA-TLHHDD-TTVIAGGTELLNWYRLGIATEG
Mb0382c|M.bovis_AF2122/97 --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
Rv0375c|M.tuberculosis_H37Rv --------------MDHAIGLLDRLGEGARVVAGGHSLLPMMKLRIANPE
TH_0174|M.thermoresistible__bu MQVPGPFEYERATSVDHAIGLLDRLGDGAMIVAGGHSLLPMMKLRIANPE
*: .*** *: : :
Mflv_0283|M.gilvum_PYR-GCK LLVDVSRLD-----LTEVALTDDGGLSIGANVRNSDLAAHPVVRSRYPML
MSMEG_0685|M.smegmatis_MC2_155 LLVDVSRLD-----LDQISVTDDGAVRIGANVRNSDLAADPVIRSHYPVL
Mvan_2077|M.vanbaalenii_PYR-1 VLVDVNRLG-----LDAVVRTAAGGIAIGSGVTNSAVANHPLVRTDYPVL
MUL_4579|M.ulcerans_Agy99 SLVDINALP-----YQSIDVQP-GVIRVGSLVRMSNLAAHPVVRQQVPMV
MMAR_0081|M.marinum_M NVLDIGGVQ-----GLRDITREGDELVIGALATLNDVAAHPTVNGGAGVL
Mb0382c|M.bovis_AF2122/97 YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
Rv0375c|M.tuberculosis_H37Rv YLVDINDLAPELGYVVVGGINNPNLVRLGAMTRHREILDSDALAAVCPIF
TH_0174|M.thermoresistible__bu YLVDINDLAGELGYIVV----NADAVRIGAMTRHREALESAELAQCCPIF
::*:. : . : :*: . : :.
Mflv_0283|M.gilvum_PYR-GCK ARALLSGASGQLRNAATTGGNLLQRTRCVYFQDVTTP---CNKREPGSGC
MSMEG_0685|M.smegmatis_MC2_155 ARALLSGASGQLRNTATTAGNLLQRTRCVYFQDVTTP---CNKREPGSGC
Mvan_2077|M.vanbaalenii_PYR-1 SQAILSGATTQIRNMATVGGNLMQRTRCPYFMDPRFER--CNKRYPGSGC
MUL_4579|M.ulcerans_Agy99 SQALELSASAQLRNMASIGGNLLQRPRCLYFRDVSAA---CNRRGPDAGC
MMAR_0081|M.marinum_M SSACRQAASAQLRNRATMGGNVLQRTRCPYFRAEEPLPWGCNKRTPGTGC
Mb0382c|M.bovis_AF2122/97 RDAERVIADPVVRNRGTLGG------------------------------
Rv0375c|M.tuberculosis_H37Rv RDAERVIADPVVRNRGTLGG------------------------------
TH_0174|M.thermoresistible__bu ADAERVIADPVVRNRGTVGG------------------------------
* * :** .: .*
Mflv_0283|M.gilvum_PYR-GCK AALGGYVRYHAILGASRHCVATHPSDMAVAMSALDAHIVVEGADGSRRIP
MSMEG_0685|M.smegmatis_MC2_155 AALGGYARYHAILGASEHCVAVHPSDMAVAMSALDATVVVQGPDGQRRLP
Mvan_2077|M.vanbaalenii_PYR-1 AARDGFNREHAVFGTGGPCVAVHPSDMAVALAALDAVVHIKGPHGPRAAT
MUL_4579|M.ulcerans_Agy99 AAIEGRNRTHAIFGACRHCCATHPSDLAVALVALDAVVLTRQVAGHRRFG
MMAR_0081|M.marinum_M SSLTGQHERQAIFGWTDDCVAVHPSDPAVALAALDAQIEVASAAELRSIP
Mb0382c|M.bovis_AF2122/97 ----------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIA
Rv0375c|M.tuberculosis_H37Rv ----------------SLCQADPAEDLSTVCTVLDAVCLAKGPSGEREIA
TH_0174|M.thermoresistible__bu ----------------SLCQADPAEDLSTVCTVLDAVCVVRGPAGRREIG
* * ..* :.. .*** *
Mflv_0283|M.gilvum_PYR-GCK ATDFHR-----LPGDEPQFDTVLDHGELITAVELPAPPPHAVSDYRKVRD
MSMEG_0685|M.smegmatis_MC2_155 IDDFHR-----LPGDEPQRDTTLQHAELITAVELPPPPVGAVSDYRKVRD
Mvan_2077|M.vanbaalenii_PYR-1 ISQFFS-----PPAADPDRDNGMAAADFITSVELPAAADTVHGWYLKVRD
MUL_4579|M.ulcerans_Agy99 LAELYR-----HPGDSPHWEHNLHPGELLVAIEIPVGPQLHRSGYLKVRD
MMAR_0081|M.marinum_M MTQFHLSQQEAAATGDPRRESRLEPGELITGYRLRLRPDEAQA-YVKVRE
Mb0382c|M.bovis_AF2122/97 IDDFLVG----------PYETALAHNEVLIEVRIPLRHN-TSSAYAKVER
Rv0375c|M.tuberculosis_H37Rv IDDFLVG----------PYETALAHNEVLIEVRIPLRHN-TSSAYAKVER
TH_0174|M.thermoresistible__bu IDDFLVG----------PYETALAHNEILLEVKIPLRPN-SSNAYAKVER
:: : : :.: .: * **.
Mflv_0283|M.gilvum_PYR-GCK RASYAFALVSVAAELSFVG-ESIATARIALGGVAHKPWRARRAEQMLAGA
MSMEG_0685|M.smegmatis_MC2_155 RASYAFALVSVAAELTFTDTRQISSARIALGGVAHKPWRARRAESVLIGD
Mvan_2077|M.vanbaalenii_PYR-1 RRRYAFALVSVAAVLRFDSDGVVASAAVALGGVADRPWRVPAAEAVLTGR
MUL_4579|M.ulcerans_Agy99 RESYQFALVSAAVALDIAA-GTIRTARVAAGGVGTVPWRLPAVEAALRGR
MMAR_0081|M.marinum_M RASYEYAIVSAAAVVRISH-GVIAAARLALGSVAQRPWRLYEAESQLVGL
Mb0382c|M.bovis_AF2122/97 RVG-DWAITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQ
Rv0375c|M.tuberculosis_H37Rv RVG-DWAITAAGAAVTLDG-QTILAARVGLTAVNPDPVALAELSAGLVGQ
TH_0174|M.thermoresistible__bu RVG-DWAVTAAGAAVTLDG-QTVTAARIGLTAVNPDAAALAEISRRLTGR
* :*:.:... : : : :* :. .* . . * *
Mflv_0283|M.gilvum_PYR-GCK EATDETFAAAADAEISAAEPLPGNE----FKVELARRTLMAQLRMLTERG
MSMEG_0685|M.smegmatis_MC2_155 QPSDETFIAAADAELNAAEPLPGNE----FKVELARRTLVAQLRMLTARR
Mvan_2077|M.vanbaalenii_PYR-1 RPTPQLFRSAADTALADAAPLSHNG----FKLPLARNAVMRALVLATGR-
MUL_4579|M.ulcerans_Agy99 PPDADLFRRAAALSAIGAKPLSENR----FKVELLKRVVEKQLTVVAAMP
MMAR_0081|M.marinum_M PLHRNAVLPVVERALSASDPLPDNG----FKAMLAARAAVRALLTAGGAA
Mb0382c|M.bovis_AF2122/97 PATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRV
Rv0375c|M.tuberculosis_H37Rv PATEEVFAEAGRRAAQACTPVTDVRGTAEYKRHLAGELTVRTLRTAAGRV
TH_0174|M.thermoresistible__bu PATEETFAEAGRLAAQACEPVTDVRGTADYKRHLAAELTTRTLRTAVQRI
: . . . *:. :* * . *
Mflv_0283|M.gilvum_PYR-GCK TR---------
MSMEG_0685|M.smegmatis_MC2_155 QQ---------
Mvan_2077|M.vanbaalenii_PYR-1 -----------
MUL_4579|M.ulcerans_Agy99 -----------
MMAR_0081|M.marinum_M -----------
Mb0382c|M.bovis_AF2122/97 LGAPAAPEA--
Rv0375c|M.tuberculosis_H37Rv LGAPAAPEA--
TH_0174|M.thermoresistible__bu QQRHGGAQPCR